Saxer is a surname of German origin meaning "of Saxony". Notable people with the surname include:
- Mary Saxer (born 1987), American pole vaulter
- Walter Saxer, producer and screenwriter of Scream of Stone
See also
- Saxer Brewing Company, American brewer now owned by Portland Brewing Company
- Saxer Avenue (SEPTA Route 101 station), trolleybus stop in Pennsylvania
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