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SEBOX
Identifiers
Aliases	SEBOX, OG-9, OG9, OG9X, Sebox homeobox
External IDs	OMIM: 610975; MGI: 108012; HomoloGene: 32052; GeneCards: SEBOX; OMA:SEBOX - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 28,363,506 bp End 28,365,199 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 46.74 cM Start 78,394,273 bp End 78,395,907 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right lobe of liver granulocyte skeletal muscle tissue blood monocyte duodenum left adrenal cortex right adrenal gland prefrontal cortex Top expressed in zygote gastrula secondary oocyte neural layer of retina primary oocyte CA3 field morula granular layer of epidermis Region II of hippocampus proper submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding molecular function Cellular component nucleus cellular component Biological process multicellular organism development cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated biological process embryo development ending in birth or egg hatching oogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 645832 18292 Ensembl ENSG00000274529 ENSMUSG00000001103 UniProt Q9HB31 P70368 RefSeq (mRNA) NM_001083896 NM_001080837 NM_008759 RefSeq (protein) NP_001074306 NP_032785 Location (UCSC) Chr 17: 28.36 – 28.37 Mb Chr 11: 78.39 – 78.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SEBOX homeobox is a protein that in humans is encoded by the SEBOX gene. Sebox homeobox has a 92% similarity to genes found within rhesus macaque, or the rhesus monkey. It is thought that this is what causes the reddened glutius maximus coloring. If the protein is turned on within a person, it may cause discoloring in the human rear.

Function

Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000274529 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000001103 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SEBOX homeobox". Archived from the original on 2016-04-08. Retrieved 2017-09-11.
6. Cinquanta M, Rovescalli AC, Kozak CA, Nirenberg M (2000). "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8904–9. Bibcode:2000PNAS...97.8904C. doi:10.1073/pnas.97.16.8904. PMC 16794. PMID 10922053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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