Seppi can be either an Italian family name, or an affectionate abbreviation for the name Joseph or Josef, commonly used in Swiss German.
Surname
- Andreas Seppi (born 1984), Italian tennis player
- Donato Seppi (born 1953), Italian politician
Given name
- Seppi DuMoulin, Canadian Football League player of the early 20th century
- Seppi Hurschler (born 1983), Swiss Nordic skiing competitor
- Josef Ritler (born 1939), Swiss journalist
- Jo Siffert (1936–1971), Swiss racing driver
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