Sharpless is a surname. Notable people with the surname include:
- Bevan Sharpless (1904–1950), American solar system astronomer
- Christopher Sharpless (born 1945), American 1988 Winter Olympics bobsledder
- Isaac Sharpless (1848–1920), American educator
- Josh Sharpless (born 1988), American baseball player
- Karl Barry Sharpless (born 1941), American chemist and Nobel prize winner
- Mattie R. Sharpless (born 1942), American diplomat
- Nathan J. Sharpless (1823–1893), American politician from Pennsylvania
- Norman Sharpless (born 1966), American oncologist and director of the National Cancer Institute
- Stewart Sharpless (1926–2013), American galactic astronomer
- Sharpless catalog, a 20th-century astronomical catalog with 313 items
- Disappearance of Toni Sharpless (born 1979), American nurse who disappeared in 2009
Fictional characters
- A character in Madama Butterfly
See also
- Sharpless asymmetric dihydroxylation, a chemical reaction
- Sharpless epoxidation, a chemical reaction
- Sharpless oxyamination, a chemical reaction
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