Spidola may refer to:
- Spīdola (or Spīdala), a witch from the Latvian national epic poem Lāčplēsis
- VEF Spidola, the first Soviet mass-produced transistor manufactured by VEF
- Spidola (submarine) [lv], a Ronis-class submarine of the Latvian Navy
- Spīdola Award [lv], an award presented by the Latvian Culture Foundation; see Roberts Zīle
- Spidola (Latvian ship), a Latvian merchant ship that was taken over by Germany in World War II
- Spīdola (sorority) [lv], Latvian national sorority
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