Misplaced Pages

Tetrachloroethene reductive dehalogenase

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
tetrachloroethene reductive dehalogenase
Identifiers
EC no.1.21.99.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a tetrachloroethene reductive dehalogenase (EC 1.21.99.5, previously 1.97.1.8) is an enzyme that catalyzes the chemical reaction. This is a member of reductive dehalogenase enzyme family.

trichloroethene + chloride + acceptor {\displaystyle \rightleftharpoons } tetrachloroethene + reduced acceptor

The 3 substrates of this enzyme are trichloroethene, chloride, and acceptor, whereas its two products are tetrachloroethene and reduced acceptor.

This enzyme belongs to the family of oxidoreductases. The systematic name of this enzyme class is acceptor:trichloroethene oxidoreductase (chlorinating). This enzyme is also called tetrachloroethene reductase. This enzyme participates in tetrachloroethene degradation.

Note that the physiologically relevant reaction actually occurs in the reverse direction from that shown above. In other words, in the bacterial species where this enzyme is found, tetrachloroethene is reductively dechlorinated to trichloroethene and chloride.

This enzyme is one member of a family of enzymes including trichloroethene dehalogenase and vinyl chloride dehalogenase. The other members of this family do not have their own EC numbers at present.

Reductive dehalogenases are key enzymes for anaerobic respiratory process, termed organohalide respiration.

References

  1. Jugder BE, Ertan H, Lee M, Manefield M, Marquis CP (October 2015). "Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides". Trends in Biotechnology. 33 (10): 595–610. doi:10.1016/j.tibtech.2015.07.004. PMID 26409778.
  2. Jugder BE, Ertan H, Bohl S, Lee M, Marquis CP, Manefield M (2016). "Organohalide Respiring Bacteria and Reductive Dehalogenases: Key Tools in Organohalide Bioremediation". Frontiers in Microbiology. 7: 249. doi:10.3389/fmicb.2016.00249. PMC 4771760. PMID 26973626.

Further reading

Other oxidoreductases (EC 1.15–1.21)
1.15: Acting on superoxide as acceptor
1.16: Oxidizing metal ions
1.17: Acting on CH or CH2 groups
1.18: Acting on iron–sulfur proteins as donors
1.19: Acting on reduced flavodoxin as donor
1.20: Acting on phosphorus or arsenic in donors
1.21: Acting on X-H and Y-H to form an X-Y bond
Enzymes
Activity
Regulation
Classification
Kinetics
Types
Portal:


This EC 1.97 enzyme-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: