Topouzian or Topuzian is an Armenian surname. It may refer to:
- Ara Topouzian (born 1969), Armenian musician and kanon player
- Nshan Topouzian (born 1966), prelate and bishop of the Armenian Apostolic Church See of Cilicia
- Yervant Topouzian, Armenian activist, one of the 20 victims in The 20 Hunchakian gallows
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