Tweak or Tweaker may refer to:
Computing
- Tweaking, the act of making small mechanical or electronic improvements
- In cryptography, particularly disk encryption, tweakable refers to a group of modes of operation for block ciphers
- Tweak programming environment
- Tweakers, a Dutch technology website
- TweakVista / Tweak7
- Tweak UI
Other
- Methamphetamine
- Tweak (company)
- Tweak (band)
- Tweaker (band)
- Tweaking (behavior), see Stereotypy, slang term for someone exhibiting compulsive or repetitive behaviour
- Tweek Tweak, a character from the animated television series South Park
- TWEAK, a cytokine encoded by the gene TNFSF12
- Tweak, a character filmed in Octonauts
- "Tweaker", a song by LiAngelo Ball
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