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Uncle Frank may refer to:

• Frank Potenza (1933–2011), playing a security guard and the host's uncle on Jimmy Kimmel Live!
• Uncle Frank, an alternative stage name of Frank Benbini, the drummer and one third of the Fun Lovin' Criminals
• Uncle Frank, Kevin McCallister's uncle from the film Home Alone
• Uncle Frank, a term of endearment often used in reference to the musician Frank Zappa
• Uncle Frank, a 2002 HBO documentary by Trigger Street Productions, directed by Matthew Ginsburg, about his 85-year-old great uncle, Frank Pour, a musician
• Uncle Frank (film), a 2020 film directed by Alan Ball

• Disambiguation pages