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Vimentin 3′ UTR protein-binding region

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Vimentin 3′ UTR protein-binding region
Predicted secondary structure and sequence conservation of Vimentin3
Identifiers
SymbolVimentin3
RfamRF00109
Other data
RNA typeCis-reg
Domain(s)Eukaryota
SOSO:0000205
PDB structuresPDBe

The vimentin 3′ UTR protein-binding region is an RNA element that contains a Y-shaped structure which has been shown to have protein-binding activity. The same region has been implicated in the control of mRNA localisation to the perinuclear region of the cytoplasm, possibly at sites of intermediate filament assembly. The identity of the proteins involved and the localisation mechanism are not known.

References

  1. Zehner ZE, Shepherd RK, Gabryszuk J, Fu TF, Al-Ali M, Holmes WM (August 1997). "RNA-protein interactions within the 3 ' untranslated region of vimentin mRNA". Nucleic Acids Research. 25 (16): 3362–3370. doi:10.1093/nar/25.16.3362. PMC 146884. PMID 9241253.
  2. Bermano G, Shepherd RK, Zehner ZE, Hesketh JE (May 2001). "Perinuclear mRNA localisation by vimentin 3′-untranslated region requires a 100 nucleotide sequence and intermediate filaments". FEBS Letters. 497 (2–3): 77–81. doi:10.1016/S0014-5793(01)02438-3. PMID 11377416. S2CID 26094181.

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