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Visinin-like protein 1

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Protein-coding gene in the species Homo sapiens
VSNL1
Identifiers
AliasesVSNL1, HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1, visinin like 1
External IDsOMIM: 600817; MGI: 1349453; HomoloGene: 2542; GeneCards: VSNL1; OMA:VSNL1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)
Chromosome 2 (human)Genomic location for VSNL1Genomic location for VSNL1
Band2p24.2Start17,539,126 bp
End17,657,018 bp
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)
Chromosome 12 (mouse)Genomic location for VSNL1Genomic location for VSNL1
Band12|12 A1.1Start11,375,243 bp
End11,486,614 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 23

  • orbitofrontal cortex

  • Pons

  • superior frontal gyrus

  • endothelial cell

  • Brodmann area 10

  • Brodmann area 46

  • Occipital Lobe

  • primary visual cortex
Top expressed in
  • lateral septal nucleus

  • primary motor cortex

  • superior colliculus

  • pontine nuclei

  • ventral tegmental area

  • mammillary body

  • medial dorsal nucleus

  • central gray substance of midbrain

  • lobe of cerebellum

  • lateral hypothalamus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7447

26950

Ensembl

ENSG00000163032

ENSMUSG00000054459

UniProt

P62760

P62761

RefSeq (mRNA)

NM_003385

NM_012038
NM_001378929

RefSeq (protein)

NP_003376
NP_001353732
NP_001353733
NP_001353734
NP_001353735

NP_036168
NP_001365858

Location (UCSC)Chr 2: 17.54 – 17.66 MbChr 12: 11.38 – 11.49 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Visinin-like protein 1 is a protein that in humans is encoded by the VSNL1 gene.

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins.

The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000163032Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000054459Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Polymeropoulos MH, Ide S, Soares MB, Lennon GG (Feb 1996). "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1". Genomics. 29 (1): 273–5. doi:10.1006/geno.1995.1244. PMID 8530085.
  6. Kose A, Ito A, Saito N, Tanaka C (Oct 1990). "Electron microscopic localization of gamma- and beta II-subspecies of protein kinase C in rat hippocampus". Brain Res. 518 (1–2): 209–17. doi:10.1016/0006-8993(90)90974-G. hdl:20.500.14094/D2001395. PMID 2202488. S2CID 54401066.
  7. ^ "Entrez Gene: VSNL1 visinin-like 1".
  8. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

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