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WLS
Identifiers
Aliases	WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDs	OMIM: 611514; MGI: 1915401; HomoloGene: 11779; GeneCards: WLS; OMA:WLS - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 68,098,473 bp End 68,233,120 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 H4 Start 159,545,309 bp End 159,644,300 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium Epithelium of choroid plexus retinal pigment epithelium corpus epididymis gastric mucosa islet of Langerhans gallbladder optic nerve endothelial cell bronchial epithelial cell Top expressed in calvaria molar left lung lobe olfactory epithelium pineal gland choroid plexus of fourth ventricle maxillary prominence right kidney corneal stroma seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Wnt-protein binding mu-type opioid receptor binding Cellular component integral component of membrane endocytic vesicle membrane endosome Golgi apparatus early endosome membrane membrane plasma membrane dendrite membrane trans-Golgi network early endosome dendrite cytoplasm extracellular exosome cytoplasmic vesicle membrane endoplasmic reticulum membrane cytoplasmic vesicle Golgi membrane endoplasmic reticulum Biological process exocrine pancreas development positive regulation of canonical Wnt signaling pathway positive regulation of Wnt protein secretion mesoderm formation hindbrain development multicellular organism development positive regulation of Wnt signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular protein transport anterior/posterior axis specification midbrain development Wnt signaling pathway Wnt protein secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79971 68151 Ensembl ENSG00000116729 ENSMUSG00000028173 UniProt Q5T9L3 Q6DID7 RefSeq (mRNA) NM_001002292 NM_001193334 NM_024911 NM_026582 NM_001356349 NM_001356350 RefSeq (protein) NP_001002292 NP_001180263 NP_079187 NP_080858 NP_001343278 NP_001343279 Location (UCSC) Chr 1: 68.1 – 68.23 Mb Chr 3: 159.55 – 159.64 Mb PubMed search
Wikidata
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Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene . Wntless is a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000116729 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028173 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein". www.uniprot.org. Retrieved 30 May 2022.
6. ^ Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
7. Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–898. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.
8. Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, et al. (September 2021). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". The New England Journal of Medicine. 385 (14): 1292–1301. doi:10.1056/NEJMoa2033911. PMC 9017221. PMID 34587386.

Further reading

• Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–522. doi:10.1016/j.cell.2006.02.049. PMID 16678095. S2CID 7841408.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.

See also

• GPR177+receptor,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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