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In molecular biology, WT1 antisense RNA (non-protein coding), also known as WT1-AS or WIT1, is a long non-coding RNA. In humans, it is found on chromosome 11 and is expressed in kidney. It is transcribed in the opposite direction to the WT1 gene. It is functionally imprinted in the human kidney, where only the paternal allele is expressed, but not in the foetal kidney.
See also
References
- Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-MacNeill S, Coppes MJ, et al. (1990). "Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor". Science. 250 (4983): 991–994. doi:10.1126/science.2173145. PMID 2173145.
- Gessler M, Bruns GA (1993). "Sequence of the WT1 upstream region including the Wit-1 gene". Genomics. 17 (2): 499–501. doi:10.1006/geno.1993.1355. PMID 8406502.
- Malik K, Salpekar A, Hancock A, Moorwood K, Jackson S, Charles A, et al. (2000). "Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor". Cancer Res. 60 (9): 2356–2360. PMID 10811108.
Further reading
- Hancock AL, Brown KW, Moorwood K, Moon H, Holmgren C, Mardikar SH, et al. (2007). "A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis". Hum Mol Genet. 16 (3): 343–354. CiteSeerX 10.1.1.551.9843. doi:10.1093/hmg/ddl478. PMID 17210670.