William McLaughlin may refer to:
- Bill McLaughlin Australian rugby union player
- Billy McLaughlin, American musician
- Willie McLaughlin (1878–1946), Scottish footballer
- William McLaughlin (baseball) (1861–1936), Major League Baseball shortstop
- William McLaughlin (politician) (born 1932), American politician from Michigan
- William I. McLaughlin (born 1935), retired American space scientist
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