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XL-413

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Chemical compound Pharmaceutical compound
XL-413
Identifiers
IUPAC name
  • 8-chloro-2--3H-benzofuropyrimidin-4-one
CAS Number
PubChem CID
DrugBank
ChemSpider
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H12ClN3O2
Molar mass289.72 g·mol
3D model (JSmol)
SMILES
  • C1C(NC1)C2=NC3=C(C(=O)N2)OC4=C3C=C(C=C4)Cl
InChI
  • InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m1/s1
  • Key:JJWLXRKVUJDJKG-SECBINFHSA-N

XL-413 is a drug which acts as a selective inhibitor of the enzyme cell division cycle 7-related protein kinase (CDC7). It is being researched for the treatment of some forms of cancer, and also has applications in genetic engineering.

References

  1. Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, et al. (June 2012). "Discovery of XL413, a potent and selective CDC7 inhibitor". Bioorganic & Medicinal Chemistry Letters. 22 (11): 3727–31. doi:10.1016/j.bmcl.2012.04.024. PMID 22560567.
  2. Sasi NK, Tiwari K, Soon FF, Bonte D, Wang T, Melcher K, et al. (2014). "The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds". PLOS ONE. 9 (11): e113300. Bibcode:2014PLoSO...9k3300S. doi:10.1371/journal.pone.0113300. PMC 4239038. PMID 25412417.
  3. Jin S, Ma H, Yang W, Ju H, Wang L, Zhang Z (June 2018). "Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1". Journal of Molecular Medicine. 96 (6): 513–525. doi:10.1007/s00109-018-1636-7. PMID 29713760. S2CID 14036264.
  4. Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, et al. (April 2020). "Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair". Nature Communications. 11 (1): 2109. Bibcode:2020NatCo..11.2109W. doi:10.1038/s41467-020-15845-1. PMC 7193628. PMID 32355159.


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