Protein-coding gene in the species Homo sapiens
Zinc finger protein 598 (ZNF598 ) is a protein that in humans is encoded by the ZNF598 gene .
Function
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation , differentiation , and apoptosis . This protein and Grb10 -interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development . ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.
References
^ GRCh38: Ensembl release 89: ENSG00000167962 – Ensembl , May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000041130 – Ensembl , May 2017
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine ."Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine ."Entrez Gene: Zinc finger protein 598" .Morita, Masahiro; Ler, Lian Wee; Fabian, Marc R.; Siddiqui, Nadeem; Mullin, Michael; Henderson, Valerie C.; Alain, Tommy; Fonseca, Bruno D.; Karashchuk, Galina; Bennett, Christopher F.; Kabuta, Tomohiro; Higashi, Shinji; Larsson, Ola; Topisirovic, Ivan; Smith, Robert J. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development" . Molecular and Cellular Biology . 32 (17): 3585–3593. doi :10.1128/MCB.00455-12 . ISSN 1098-5549 . PMC 3422012 . PMID 22751931 .
Juszkiewicz S, Hegde RS (February 2017). "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination" . Molecular Cell . 65 (4): 743–750.e4. doi :10.1016/j.molcel.2016.11.039 . PMC 5316413 . PMID 28065601 .
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ (February 2017). "ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation" . Molecular Cell . 65 (4): 751–760.e4. doi :10.1016/j.molcel.2016.12.026 . PMC 5321136 . PMID 28132843 .
Sitron CS, Park JH, Brandman O (May 2017). "Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation" . RNA . 23 (5): 798–810. doi :10.1261/rna.060897.117 . PMC 5393187 . PMID 28223409 .
Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T (July 2017). "Ubiquitination of stalled ribosome triggers ribosome-associated quality control" . Nature Communications . 8 (1): 159. Bibcode :2017NatCo...8..159M . doi :10.1038/s41467-017-00188-1 . PMC 5534433 . PMID 28757607 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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