Zaca may refer to:
- Huehue Zaca, a 15th-century Aztec noble and a warrior
- The Zaca Fire, the second largest wildfire in modern California history
- Zaca Creek, an American country music group
- Zaca Creek, a tributary of the Santa Ynez River
- Zaca Oil Field, along Zaca Creek
- Two U.S. Navy ships named USS Zaca
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