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Zinc transporter 3

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Protein found in humans
SLC30A3
Identifiers
AliasesSLC30A3, ZNT3, solute carrier family 30 member 3
External IDsOMIM: 602878; MGI: 1345280; HomoloGene: 74470; GeneCards: SLC30A3; OMA:SLC30A3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)
Chromosome 2 (human)Genomic location for SLC30A3Genomic location for SLC30A3
Band2p23.3Start27,253,684 bp
End27,275,817 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for SLC30A3Genomic location for SLC30A3
Band5 B1|5 16.97 cMStart31,243,450 bp
End31,265,581 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • Brodmann area 10

  • left testis

  • right testis

  • endothelial cell

  • right frontal lobe

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • Brodmann area 46

  • middle temporal gyrus
Top expressed in
  • entorhinal cortex

  • perirhinal cortex

  • zygote

  • CA3 field

  • visual cortex

  • primary visual cortex

  • secondary oocyte

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • Ileal epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7781

22784

Ensembl

ENSG00000115194

ENSMUSG00000029151

UniProt

Q99726

P97441

RefSeq (mRNA)

NM_003459
NM_001318949
NM_001318950
NM_001318951

NM_011773
NM_001347323

RefSeq (protein)

NP_001305878
NP_001305879
NP_001305880
NP_003450

NP_001334252
NP_035903

Location (UCSC)Chr 2: 27.25 – 27.28 MbChr 5: 31.24 – 31.27 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles. In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala. Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway. Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000115194 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029151 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Solute carrier family 30 (zinc transporter), member 3".
  6. Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD (February 1999). "Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1716–21. Bibcode:1999PNAS...96.1716C. doi:10.1073/pnas.96.4.1716. PMC 15571. PMID 9990090.
  7. Sindreu C, Storm DR (2011). "Modulation of neuronal signal transduction and memory formation by synaptic zinc". Frontiers in Behavioral Neuroscience. 5: 68. doi:10.3389/fnbeh.2011.00068. PMC 3211062. PMID 22084630.
  8. Mott DD, Dingledine R (February 2011). "Unraveling the role of zinc in memory". Proceedings of the National Academy of Sciences of the United States of America. 108 (8): 3103–4. Bibcode:2011PNAS..108.3103M. doi:10.1073/pnas.1100323108. PMC 3044369. PMID 21321213.
  9. Patrushev N, Seidel-Rogol B, Salazar G (2012). "Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLOS ONE. 7 (3): e33211. Bibcode:2012PLoSO...733211P. doi:10.1371/journal.pone.0033211. PMC 3299759. PMID 22427991.
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
(1):
(2):
(3):
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(5):
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SLC11–20
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SLC21–30
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SLC31–40
(31):
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SLC41–48
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(48):
SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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