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== |
== Undue lead paragraph == | ||
:“An association between circumcision and reduced heterosexual HIV infection rates was first suggested in 1986.” | |||
::Problematic wording. Who made the suggestion in 1986? If a random person made the suggestion in 1985, would that negate this sentence..? | |||
:“Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy” | |||
::Source seems too old. Possibly ] for not mentioning concerns about the trials stopping too early. | |||
:”WHO assessed these as ‘gold standard’ studies and found ‘strong and consistent’ evidence from later studies that confirmed the results of the three RCT trials.” | |||
::Using two different sources to make a conclusion is a violation of ]. ] to talk about the trials that much in the lead compared to the other sentences. | |||
:”A scientific consensus subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.” | |||
::Redundant; already covered by the first sentence in the lead. ] (]) 03:04, 8 September 2022 (UTC) | |||
::: {{tqi|"Source seems too old"}} What citation in particular is too old? The citation is recounting the historical background of the studies. It's not something that needs to be updated. The main sources in the lead are from 2017 and 2021 respectively. Both are extraordinarily recent. I'm uncertain what this is in reference to. | |||
So I happen to be going through this page, specifically the Observational Studies section, and I'm surprised by how many of the articles are poorly represented. For instance, most of the studies seem to be on high-risk African-based studies, but not all of them specify this in the body. Now I have no history with this topic, but is the "African-based" thing just a given? Should I have been assuming that these studies are mostly done in high risk areas to begin with? I only ask because I was confused while reading through the text and I'm sure others would be as well. I've since followed the citations and looked up many of the articles, so it is a bit more clear. But should this section maybe be subdivided into the different types of studies? Like, an African-based section, one for the General population studies, and one for cross studies? Just my brief look through some of the articles tells me that the results of the studies seem to vary a lot. Cheers! ] (]) 18:40, 9 June 2013 (UTC) | |||
::There is tremendous variation in the southern African studies with some showing that the circumcised got HIIV more than the uncut. Conversely the big study was stopped for exactly the opposite result early on ethical grounds. There seems to be a big push to promote circumcision as a partial solution to HIV epidemics in Africa. Some other studies have shown that risk behaviour increases for the cut as some cut men think they have gained a sort of universal immunity and behave accordingly. There is a danger in extrapolating these results to other populations where HIV rates can be higher amongst circumcised too. It may be that some high risk multiple partner groups also have a cosmetic or aesthetic fondness for the cut and so any protective effect it may achieve may be masked in these cases. I agree with your suggestion of regionalizing results --— ] <sup>]</sup>/<sub>]</sub> 19:40, 9 June 2013 (UTC) | |||
:::Thanks for your input! I've now gone through all of the studies in that section and looked at the findings in a bit more detail (for those still accessible). While it is difficult to have a complete picture for every study, many of the comments in this article are misleading or very incomplete (especially with regards to geographic regions). Some of the parsing of the paragraphs also suggests connections between studies that aren't really there. Maybe we should start with a basic updating of the information for each study and then go from there. I'll try to sort something out and suggest it here before I change anything. Anyone else have any thoughts on how to make things more clear? Cheers! ] (]) 21:08, 9 June 2013 (UTC) | |||
::::I'd agree that this article is long overdue for an overhaul. At this point, only secondary sources should be used to support statements of fact about the scientific consensus regarding the effect of circumcision on HIV transmission. This is an extremely well-studied field and primary sources should not be cited at all. They may be interesting for a historical overview but still need to be used within the context of secondary sources, the history of circumcision and HIV is now very well-documented in secondary sources. To start, as with any other medical intervention, you should make use of resources like PubMed, the TRIP database, and up-to-date texts from medical libraries. The Misplaced Pages guideline governing the sourcing for medical content is ] so all the sourcing updates need to be compliant with that guideline. <code>]]</code> 02:15, 10 June 2013 (UTC) | |||
::::To help get you started: There's lots and lots out there discussing the use of circumcision as part of an HIV management program in Africa. Here's the central repository of information on it from the World Health Organization: . Here's a recent review article on the use of circumcision within a larger program for HIV management: PMID 23257232, published in ''The Lancet'', one of the most prestigious medical journals around. The full article text is available . Here's another review article along the same lines, discussing PEPFAR: PMID 22797745, full free text available via PMC; here's a related review PMID 22797743.<p>Outside of Africa: Here's a review discussing reasons to promote neonatal circumcision in Thailand: PMID 23431830. Here's a review arguing against neonatal circumcision in the particular localities of Australia and New Zealand: PMID 21973253. Here's a rebuttal review countering the arguments of advocates against the practice in developed countries: PMID 22452415.<p>Hope these are helpful! <code>]]</code> 02:52, 10 June 2013 (UTC) | |||
::: {{tqi|Possibly ] for not mentioning concerns about the trials stopping too early}} '''It would be ] to include it: as there is an overwhelming consensus among mainstream sources that circumcision is efficacious in the prevention of HIV in high risk populations.''' This has already been discussed a few months ago with {{re|MrOllie}} and {{re|Alexbrn}}. As ''Merson and Inrig (2017)'' states: {{tqi|"This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence"}} and Sharma et al. (2021) states: {{tqi|There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1}}. ] only applies when {{tqi|If a viewpoint is held by a majority ... significant minority...}} There isn't a significant minority that denies that it is efficacous in that context. The main debate over circumcision within the medical literature is predominately: 1.) The ethics of it being routinely performed without the individual's consent (instead of parents or other guardians) 2.) Whether these same benefits apply as significantly and/or counteracted by risks in developed nations. The mention of the debate in that context is preserved in the lead. This article is overwhelmingly about circumcision that is performed on heterosexual men in areas of high, endemic HIV transmission. ] (]) 05:32, 10 September 2022 (UTC) | |||
== Sourcing review == | |||
::::The early cessation of the trials is ''not'' about history. I am sure you can find a newer source that analyzes the reason for why the trials should have/should not have been ended prematurely; your source was from 2009. ] (]) 04:22, 11 September 2022 (UTC) | |||
Here's a review of the current status of the sourcing of this article. There are a lot of problems with the sourcing, hope this is useful for cleaning up the article. | |||
<code>]]</code> 16:30, 9 January 2014 (UTC) | |||
::::: ''Siegfried, et al. (2009)'' is simply used in the reference for the statement: {{tqi|"Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda"}} That's not a fact that's going to change over time. Outdated sources don't apply in that context, {{re|Prcc27}}. ''Siegfried, et al. (2009)'' is not being used to summarize current consensus. | |||
{{collapse top|Sources table}} | |||
In this table: | |||
* '''Source''' lists the source as cited in the article | |||
* '''Seems ]?''' means, "Does this source appear to meet ] for reliable sourcing?" | |||
* '''Use OK?''' means, is the source used appropriately in the article? For the review, a few selected sources will be spot-checked to ensure they aren't plagiarized and support the article content. {{?}} indicates the source was not spot-checked. | |||
* '''Notes''' will summarize problems found and what needs to be done to fix them | |||
::::: ''Merson and Inrig (2017)'' states: {{tqi|"This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence"}}. ''Sharma et al. (2021)'' states: {{tqi|There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1}}.] only applies when {{tqi|If a viewpoint is held by a majority ... significant minority...}}. But every major medical association — including those in non-Anglophonic Europe — state that it is efficacious against the spread of HIV/AIDS in poor, high risk contexts. Both ''Merson and Inrig (2017)'' and ''Sharma et al. (2021)'' are under five years old. | |||
{|class="wikitable" | |||
|- | |||
!Source !! Seems ]? !! Use OK? !! Notes | |||
|- | |||
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| <small><nowiki><ref>{{cite journal | last=Szabo | first=R. | coauthors=R.V. Short | year=2000 | month=June | title=How does male circumcision protect against HIV infection? | journal=BMJ | volume=320 | issue=7249 | pages=1592–1594 | id= | url=http://www.bmj.com/cgi/content/full/320/7249/1592? | accessdate= | quote= | doi=10.1136/bmj.320.7249.1592 | pmid=10845974 | pmc=1127372 }}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 10845974: MEDLINE 2000 Review | |||
|- | |||
| <small><nowiki><ref name="VanHoweHIVmeta">{{cite journal | last= Van Howe | first=R.S. | authorlink= | coauthors= | year= 1999 | month= January | title=Circumcision and HIV infection: review of the literature and meta-analysis | journal=International Journal of STD's and AIDS | volume=10 | issue= | pages=8–16 | id= | doi=10.1258/0956462991913015 | url=http://www.cirp.org/library/disease/HIV/vanhowe4/ | accessdate= 2008-09-23 | quote=Thirty-five articles and a number of abstracts have been published in the medical literature looking at the relationship between male circumcision and HIV infection. Study designs have included geographical analysis, studies of high-risk patients, partner studies and random population surveys. Most of the studies have been conducted in Africa. A meta-analysis was performed on the 29 published articles where data were available. When the raw data are combined, a man with a circumcised penis is at greater risk of acquiring and transmitting HIV than a man with a non-circumcised penis (odds ratio (OR)=1.06, 95% confidence interval (CI)=1.01-1.12). Based on the studies published to date, recommending routine circumcision as a prophylactic measure to prevent HIV infection in Africa, or elsewhere, is scientifically unfounded.}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
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|- | |||
| <small><nowiki><ref>{{cite journal | last= O'Farrell | first=R.S. | authorlink= | coauthors=M. Egger | year=2000 | month= March | title=Circumcision in men and the prevention of HIV infection: a 'meta-analysis' revisited | journal=International Journal of STD's and AIDS | volume=11 | issue=3 | pages=137–142 | id= | doi=10.1258/0956462001915480 | pmid=10726934 | accessdate= 2008-09-25 | quote=The results from this re-analysis thus support the contention that male circumcision may offer protection against HIV infection, particularly in high-risk groups where genital ulcers and other STDs 'drive' the HIV epidemic. A systematic review is required to clarify this issue. Such a review should be based on an extensive search for relevant studies, published and unpublished, and should include a careful assessment of the design and methodological quality of studies. Much emphasis should be given to the exploration of possible sources of heterogeneity. In view of the continued high prevalence and incidence of HIV in many countries in sub-Saharan Africa, the question of whether circumcision could contribute to prevent infections is of great importance, and a sound systematic review of the available evidence should be performed without delay. }}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 10726934: MEDLINE 2000 Comment | |||
|- | |||
| <small><nowiki><ref name="Siegfriedmeta">{{cite journal | last=Siegfried | first=N | authorlink= | coauthors=M Muller, J Volmink, J Deeks, M Egger, N Low, H Weiss, S Walker, P Williamson | year= 2003 | editor1-last=Siegfried | month= July | editor1-first=Nandi | title=Male circumcision for prevention of heterosexual acquisition of HIV in men | journal=Cochrane Database of Systematic Reviews | volume= | issue= 3 | pages=CD003362 | id=CD003362 | doi=10.1002/14651858.CD003362 | url=http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD003362/frame.html | accessdate= 2007-12-27 | quote=We found insufficient evidence to support an interventional effect of male circumcision on HIV acquisition in heterosexual men. The results from existing observational studies show a strong epidemiological association between male circumcision and prevention of HIV, especially among high-risk groups. However, observational studies are inherently limited by confounding which is unlikely to be fully adjusted for. In the light of forthcoming results from RCTs, the value of IPD analysis of the included studies is doubtful. The results of these trials will need to be carefully considered before circumcision is implemented as a public health intervention for prevention of sexually transmitted HIV. | pmid=12917962|}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 12917962: MEDLINE 2003 Review | |||
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| <small><nowiki><ref>{{cite journal | last=Weiss | first=HA | authorlink= | coauthors=Quigley MA, Hayes RJ. | date=Oct 20, 2000 | title=Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. | journal= Aids. 2000 | volume=14 | issue=15 | pages=2361–70 | id= | accessdate= 2007-12-27 | quote=Male circumcision is associated with a significantly reduced risk of HIV infection among men in sub-Saharan Africa, particularly those at high risk of HIV. These results suggest that consideration should be given to the acceptability and feasibility of providing safe services for male circumcision as an additional HIV prevention strategy in areas of Africa where men are not traditionally circumcised. | pmid=11089625 | doi=10.1097/00002030-200010200-00018}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 11089625: MEDLINE 2000 Meta-Analysis, Review | |||
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| <small><nowiki><ref name ="ANRS">{{cite journal | last = Auvert | first = B. | coauthors = D. Taljaard, E. Lagarde, J. Sobngwi-Tambekou, R. Sitta and A. Puren | year = 2005 | month = November | title = Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial | journal = PLoS Medicine | volume = 2 | issue = 11 | pages = 1112–1122 | doi = 10.1371/journal.pmed.0020298 | pmid = 16231970 | url = http://medicine.plosjournals.org/archive/1549-1676/2/11/pdf/10.1371_journal.pmed.0020298-S.pdf | format=PDF| quote = There were 20 HIV infections (incidence rate = 0.85 per 100 person-years) in the intervention group and 49 (2.1 per 100 person-years) in the control group, corresponding to an RR of 0.40 (95% CI: 0.24%-0.68%; p < 0.001). This RR corresponds to a protection of 60% (95% CI: 32%-76%). | accessdate = | pmc = 1262556}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 16231970: MEDLINE 2005 Randomized Controlled Trial | |||
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| <small><nowiki><ref name="baileyrct">{{cite journal | last = Bailey | first = Robert C. | coauthors = Stephen Moses, Corette B Parker, Kawango Agot, Ian Maclean, John N Krieger, Carolyn F M Williams, Richard T Campbell, Jeckoniah O Ndinya-Achola | date = February 24, 2007 | title = Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial | journal = ] | volume = 369 | issue = 9562 | pages = 643–656 | publisher = ] | location = London | pmid = 17321310 | doi = 10.1016/S0140-6736(07)60312-2 | oclc = 1755507 | url = http://download.thelancet.com/pdfs/journals/0140-6736/PIIS0140673607603122.pdf | format = PDF (free registration required) | accessdate = 2008-09-04 | quote = The two year HIV incidence was 2.1% (95% CI 1.2-3.0) in the circumcision group and 4.2% (3.0-5.4) in the control group (p=0.0065); the relative risk of HIV infection in circumcised men was 0.47 (0.28-0.78), which corresponds to a reduction in the risk of acquiring an HIV infection of 53% (22-72).}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 17321310: MEDLINE 2007 Randomized Controlled Trial | |||
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| <small><nowiki><ref>{{cite journal | last=Gray | first=R.H. | authorlink= | coauthors=''et al.'' | year=2007 | month=February | title=Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial | journal=Lancet | volume=369 | issue=9562 | pages=657–666 | pmid=17321311 | url= | accessdate= | quote=In the modified intention-to-treat analysis, HIV incidence over 24 months was 0.66 cases per 100 person-years in the intervention group and 1.33 cases per 100 person-years in the control group (estimated efficacy of intervention 51%, 95% CI 16-72; p=0.006). The as-treated efficacy was 55% (95% CI 22-75; p=0.002); efficacy from the Kaplan-Meier time-to-HIV-detection as-treated analysis was 60% (30-77; p=0.003). | doi=10.1016/S0140-6736(07)60313-4 }}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 17321311: MEDLINE 2007 Randomized Controlled Trial | |||
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| <small><nowiki><ref>{{cite journal |author= E.Mills |coauthors= C.Cooper, A.Anema, G.Guyatt |year=2008 |month=July |title=Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11050 men |journal=HIV Medicine |volume=9 |issue=6 |pages=332–335 |doi=10.1111/j.1468-1293.2008.00596.x |url=http://www3.interscience.wiley.com/journal/120747249/abstract |accessdate=2008-08-24 |quote= |pmid= 18705758 | }}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 18705758: MEDLINE 2008 Meta-Analysis, Review | |||
|- | |||
| <small><nowiki><ref name="WHO_GTPDSA">{{cite web | url = http://whqlibdoc.who.int/publications/2007/9789241596169_eng.pdf | title = Male circumcision: Global trends and determinants of prevalence, safety and acceptability | accessdate = 2009-03-04 | year = 2007 | publisher = ] | format=PDF}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
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| <small><nowiki><ref name="WHO_C_R">{{cite journal | title = New Data on Male Circumcision and HIV Prevention: Policy and Programme Implications | publisher = ] | date = March 28, 2007 | url = http://www.who.int/hiv/mediacentre/MCrecommendations_en.pdf | format = PDF | id = | accessdate = 2007-08-13}}</ref></nowiki></small> | |||
|| {{?}} | |||
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| <small><nowiki><ref name="WHOpr0307">{{cite web |title=WHO and UNAIDS announce recommendations from expert consultation on male circumcision for HIV prevention |publisher=World Health Organisation |month=March |year=2007 |url=http://www.who.int/hiv/mediacentre/news68/en/index.html}}</ref></nowiki></small> | |||
|| {{?}} | |||
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| <small><nowiki><ref name="CDC_2008">{{cite web |title=Male Circumcision and Risk for HIV Transmission and Other Health Conditions: Implications for the United States |publisher=Centers for Disease Control and Prevention |year=2008 |url=http://www.cdc.gov/hiv/resources/factsheets/circumcision.htm}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal|doi=10.1371/journal.pone.0008422|title=The Effects of Circumcision on the Penis Microbiome|year=2010|editor1-last=Bereswill|editor1-first=Stefan|last1=Price|first1=Lance B.|last2=Liu|first2=Cindy M.|last3=Johnson|first3=Kristine E.|last4=Aziz|first4=Maliha|last5=Lau|first5=Matthew K.|last6=Bowers|first6=Jolene|last7=Ravel|first7=Jacques|last8=Keim|first8=Paul S.|last9=Serwadda|first9=David|journal=PLoS ONE|volume=5|pages=e8422|pmid=20066050|issue=1|pmc=2798966}}</ref></nowiki></small> | |||
|| {{?}} | |||
|| {{?}} | |||
||PMID 20066050: MEDLINE 2010 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite web|url=http://www.scientificamerican.com/article.cfm?id=circumcision-penis-microbiome-hiv-infection|title=Clean-Cut: Study Finds Circumcision Helps Prevent HIV and Other Infections|accessdate=2011-04-27}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite web|url=http://www.sciencedaily.com/releases/2010/01/100106003617.htm|title=Why Circumcised Men Are Less Likely to Become Infected With HIV: Changes in Bacteria Within Penis Microbiome|accessdate=2011-04-27}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite web| url=http://www.medpagetoday.com/25106|title=CROI: HIV Protection Lasts After Circumcision|accessdate=2011-04-27}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | journal=JAMA | title=Circumcision Status and Risk of HIV and Sexually Transmitted Infections Among Men Who Have Sex With Men | author=Millett GA, Flores SA, Marks G, et al. | year=2008 | volume=300 | issue=14 | pages=1674–1684 | url=http://jama.ama-assn.org/cgi/content/short/300/14/1674 | doi=10.1001/jama.300.14.1674 | pmid=18840841|}}</ref></nowiki></small> | |||
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||PMID 18840841: MEDLINE 2008 Meta-Analysis, Review | |||
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| <small><nowiki><ref>{{cite journal |last=Carael |first=M. |coauthors=P.H. Van de Perre, P.H. Lepage, S. Allen, F. Nsengumuremyi, C. Van Goethem, M. Ntahorutaba, D. Nzaramba, N. Clumeck |year=1988 |month=June |title=Human immunodeficiency virus transmission among heterosexual couples in Central Africa. |journal=AIDS |volume=2 |issue=3 |pages=201–205 |pmid=3134914 |url= |accessdate= |quote= }}</ref></nowiki></small> | |||
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||PMID 3134914: MEDLINE 1988 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal |last=Grosskurth |first=H. |coauthors=F. Mosha, J. Todd, K. Senkoro, J. Newell, A. Klokke, J. Changalucha, B. West, P. Mayaud, A. Gavyole A, ''et al.'' |year=1995 |month=August |title=A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania: 2. Baseline survey results. |journal=AIDS |volume=9 |issue=8 |pages=927–934 |pmid=7576329 |url= |accessdate= |quote= |doi=10.1097/00002030-199508000-00015 }}</ref></nowiki></small> | |||
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||PMID 7576329: MEDLINE 1995 Clinical Trial, Randomized Controlled Trial | |||
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| <small><nowiki><ref>{{cite journal |last=Barongo |first=L.R. |coauthors=M.W. Borgdorff, F.F. Mosha, A. Nicoll, H. Grosskurth, K.P. Senkoro, J.N. Newell, J. Changalucha, A.H. Klokke, J.Z. Killewo JZ, ''et al.'' |year=1992 |month=December |title=The epidemiology of HIV-1 infection in urban areas, roadside settlements and rural villages in Mwanza Region, Tanzania. |journal=AIDS |volume=6 |issue=12 |pages=1521–1528 |pmid=1492935 |url= |accessdate= |quote= |doi=10.1097/00002030-199212000-00016 }}</ref></nowiki></small> | |||
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||PMID 1492935: MEDLINE 1992 Comparative Study | |||
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| <small><nowiki><ref>{{cite journal |last=Mills |first=J. |coauthors=N. Siegfried |year=2006 |month=October |title=Cautious optimism for new HIV/AIDS prevention strategies. |journal=Lancet |volume=368 |issue=9543 |pages=1236 |pmid=17027724 |url= |accessdate= |quote= "The inferences drawn from the only completed randomised controlled trial (RCT) of circumcision could be weak because the trial stopped early. In a systematic review of RCTs stopped early for benefit, such RCTs were found to overestimate treatment effects. When trials with events fewer than the median number (n=66) were compared with those with event numbers above the median, the odds ratio for a magnitude of effect greater than the median was 28 (95% CI 11--73). The circumcision trial recorded 69 events, and is therefore at risk of serious effect overestimation. We therefore advocate an impartial meta-analysis of individual patients' data from this and other trials underway before further feasibility studies are done. |doi=10.1016/S0140-6736(06)69513-5 }}</ref></nowiki></small> | |||
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||PMID 17027724: MEDLINE 2006 Letter | |||
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| <small><nowiki><ref>{{cite web | last = Alcena | first = Valiere | title = AIDS in Third World countries | work = response to "Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial" | publisher = PLos Medicine | date = 2006-10-16 | url = http://medicine.plosjournals.org/perlserv/?request=read-response&doi=10.1371/journal.pmed.0020298#r1326 | format = | doi = | accessdate = 2008-08-24 }}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Alcena | first = Valiere | title = AIDS in Third World countries | journal = New York State Journal of Medicine | volume = 86 | issue = 8 | pages = 446 | year = 1986 | month = August | url = http://www.popline.org/docs/057476 | doi = | id =kenya | accessdate =2008-08-24 }} {{Dead link|date=November 2010|bot=H3llBot}}.</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal |doi=10.1056/NEJM198610303151818 |last=Fink |first=Aaron J. |authorlink=Aaron J. Fink |year=1986 |month=October |title=A possible explanation for heterosexual male infection with AIDS |journal=New England Journal of Medicine |volume=315 |issue=18 |pages=1167|pmid=3762636 |accessdate=2008-08-24 |quote= }}</ref></nowiki></small> | |||
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||PMID 3762636: MEDLINE 1986 Letter | |||
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| <small><nowiki><ref>{{cite journal |last=Cameron |first=DW |authorlink= |coauthors=Simonsen JN, D'Costa LJ, Ronald AR, Maitha GM, Gakinya MN, Cheang M, Ndinya-Achola JO, Piot P, Brunham RC, et al. |year=1989 |month=August |title=Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men. |journal=Lancet |volume=2 |issue=8660 |pages=403–7 |pmid= 2569597 |url= |accessdate= |quote= |doi=10.1016/S0140-6736(89)90589-8 }}</ref></nowiki></small> | |||
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||PMID 2569597: MEDLINE 1989 (unspecified, possibly primary) | |||
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| <small><nowiki><ref name ="Szabo">{{cite journal | last = Szabo | first = Robert | coauthors = Roger V. Short | year = 2000 | month = June | title = How does male circumcision protect against HIV infection? | journal = BMJ | volume = 320 | issue = 7249 | pages = 1592–1594 | doi = 10.1136/bmj.320.7249.1592 | pmid = 10845974 | url = http://bmj.bmjjournals.com/cgi/reprint/320/7249/1592 | format = PDF | accessdate = 2006-07-09 | pmc = 1127372}}</ref></nowiki></small> | |||
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||PMID 10845974: MEDLINE 2000 Review | |||
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| <small><nowiki><ref>{{cite journal | last = Ndozi | first = | coauthors = | year = 1995 | month = April | title = The East African AIDS epidemic and the absence of male circumcision: what is the link? Using circumcision to prevent HIV infection in sub-Saharan Africa: the view of an African | journal = Health Transition Review | volume = 5 | issue = 1 | pages = 97–117 | doi = | pmid = | url = http://htc.anu.edu.au/pdfs/Forum5_1.pdf | format = PDF | accessdate = 2008-10-18}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal |author=O'Farrell N, Egger M |title=Circumcision in men and the prevention of HIV infection: a 'meta-analysis' revisited |journal=Int J STD AIDS |volume=11 |issue=3 |pages=137–42 |year=2000 |month=March |pmid=10726934 |url=http://ijsa.rsmjournals.com/cgi/pmidlookup?view=long&pmid=10726934 |quote=The results from this re-analysis thus support the contention that male circumcision may offer protection against HIV infection, particularly in high-risk groups where genital ulcers and other STDs 'drive' the HIV epidemic. A systematic review is required to clarify this issue. Such a review should be based on an extensive search for relevant studies, published and unpublished, and should include a careful assessment of the design and methodological quality of studies. Much emphasis should be given to the exploration of possible sources of heterogeneity. In view of the continued high prevalence and incidence of HIV in many countries in sub-Saharan Africa, the question of whether circumcision could contribute to prevent infections is of great importance, and a sound systematic review of the available evidence should be performed without delay. |doi=10.1258/0956462001915480}}</ref></nowiki></small> | |||
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||PMID 10726934: MEDLINE 2000 Comment | |||
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| <small><nowiki><ref>{{cite journal |author=Moses S, Nagelkerke NJ, Blanchard J |title=Analysis of the scientific literature on male circumcision and risk for HIV infection |journal=International journal of STD & AIDS |volume=10 |issue=9 |pages=626–8 |year=1999 |month=September |pmid=10492434 |doi= 10.1258/0956462991914681|url=http://ijsa.rsmjournals.com/cgi/reprint/10/9/626?ijkey=a1ca8d961969d1a6970456a1a43f7ac7aa24304a&keytype2=tf_ipsecsha | format= PDF}}</ref></nowiki></small> | |||
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||PMID 10492434: MEDLINE 1999 Comment, Letter | |||
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| <small><nowiki><ref name=Weiss2000>{{cite journal | last = Weiss | first = H.A. | coauthors= Quigley M.A., Hayes R.J. | year = 2000 | month = October | title = Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis | journal = AIDS | volume = 14 | issue = 15 | pages = 2361–70 | pmid = 11089625 | url = http://www.aidsonline.com/pt/re/aids/pdfhandler.00002030-200010200-00018.pdf;jsessionid=L57hvrjhsS0JsXGZmmHZ2gpTTbZ7x5wqJh2CTXFDpNvpC8rNxmL1!949623904!181195628!8091!-1 | format = PDF | accessdate = 2008-09-25 | doi = 10.1097/00002030-200010200-00018}}</ref></nowiki></small> | |||
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||PMID 11089625: MEDLINE 2000 Meta-Analysis, Review | |||
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| <small><nowiki><ref>{{cite conference | last = USAID/AIDSMark | title = Conference Report | booktitle = Program and Policy Implications For HIV Prevention and Reproductive Health | pages = 1–48 | publisher = USAID/AIDSMark | date = 18–19 September 2002 | location = Washington, DC | url = http://www.psi.org/resources/pubs/male-circ.pdf | format = PDF | accessdate = 2008-10-04 | id =}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name="Siegfried2003">{{cite journal |author=Siegfried N, Muller M, Volmink J, ''et al'' |editor1-last=Siegfried |editor1-first=Nandi |title=Male circumcision for prevention of heterosexual acquisition of HIV in men |journal=Cochrane database of systematic reviews (Online) |volume= |issue=3 |pages=CD003362 |year=2003 |pmid=12917962 |doi=10.1002/14651858.CD003362 |url=}}</ref></nowiki></small> | |||
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||PMID 12917962: MEDLINE 2003 Review | |||
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| <small><nowiki><ref>{{cite journal |author=Siegfried N, Muller M, Deeks J, ''et al'' |title=HIV and male circumcision--a systematic review with assessment of the quality of studies |journal=The Lancet infectious diseases |volume=5 |issue=3 |pages=165–73 |year=2005 |month=March |pmid=15766651 |doi=10.1016/S1473-3099(05)01309-5 |url=}}</ref></nowiki></small> | |||
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||PMID 15766651: MEDLINE 2005 Review | |||
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| <small><nowiki><ref>{{cite conference | first = Noah | last = Kiwanuka | authorlink = | coauthors = Gray R., Sewankambo N.K., Serwadda D., Wawer M., Li C. | title = International Conference AIDS. | booktitle = Religion, behaviours, and circumcision as determinants of HIV dynamics in rural Uganda | pages = | publisher = | date = 7–12 July 1996 | location = ], ] | url = http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102221633.html | accessdate = 2008-09-25 | id =}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | author=Kelly R, Kiwanuka N, Wawer MJ, ''et al'' |title=Age of male circumcision and risk of prevalent HIV infection in rural Uganda |journal=AIDS |volume=13 |issue=3 |pages=399–405 |year=1999 |month=February |pmid=10199231 |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0269-9370&volume=13&issue=3&spage=399 | doi=10.1097/00002030-199902250-00013}}</ref></nowiki></small> | |||
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||PMID 10199231: MEDLINE 1999 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | last = Buvé | first = Anne | coauthors= M. Laga, E. Van Dyck, W. Janssens, L. Heyndricks; S. Anagonou ; M. Laourou; L. Kanhonou; Evina Akam, M. de Loenzien ; S-C. Abega ; Zekeng ; J. Chege ; V Kimani, J Olenja ; M Kahindo; F. Kaona, R Musonda, T. Sukwa ; N. Rutenberg ; B Auvert, E Lagarde ; B Ferry, N Lydié ; R. Hayes, L Morison, H Weiss, J. Glynn ; N.J. Robinson ; M. Caraël | year = 1999 | month = September | title = Differences in HIV spread in four sub-Saharan African cities | journal = UNAIDS | volume = | issue = | pages = UNAIDS fact sheet | pmid = | url = http://data.unaids.org/Publications/IRC-pub03/lusaka99_en.html | accessdate = 2008-09-25 | nopp = true}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Buvé | first = Anne | coauthors= Carael M., Hayes R. J., Auvert B., Ferry B., Robinson N. J., Anagonou S., Kanhonou L., Laourou M., Abega S., Akam E., Zekeng L., Chege J., Kahindo M., Rutenberg N., Kaona F., Musonda R., Sukwa T., Morison L., Weiss H, A., Laga M. | year = 2001 | month = August | title = Multicentre study on factors determining differences in rate of spread of HIV in sub-Saharan Africa: methods and prevalence of HIV infection | journal = AIDS | volume = 15 | issue = Supplement 4 | pages = S5–S14 | pmid = | url = http://www.aidsonline.com/pt/re/aids/pdfhandler.00002030-200108004-00002.pdf;jsessionid=LbgSyTLVTgklp7Ns1JPGXpczTGPLmS80XKGVQtY1rtwgrGTPXBNt!1455807198!181195628!8091!-1 | format = PDF | accessdate = 2008-09-25}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | author=Bailey RC, Neema S, Othieno R |title=Sexual behaviors and other HIV risk factors in circumcised and uncircumcised men in Uganda |journal=] |volume=22 |issue=3 |pages=294–301 |year=1999 |month=November |pmid=10770351 |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1525-4135&volume=22&issue=3&spage=294}}</ref></nowiki></small> | |||
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||PMID 10770351: MEDLINE 1999 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | last = Bonner | first = Kate | year = 2001 | month = November | title = Male circumcision as an HIV control strategy: not a 'natural condom'. | journal = Reproductive health matters | volume = 9 | issue = 18 | pages = 143–155 | doi = 10.1016/S0968-8080(01)90101-6 | pmid = 11765391 | format=PDF| accessdate = 2008-10-08}}</ref></nowiki></small> | |||
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||PMID 11765391: MEDLINE 2001 Review | |||
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| <small><nowiki><ref>{{cite conference | first = S.M | last = Changedia | coauthors = Gilada I.S. | title = International Conference AIDS. | booktitle = Religion, behaviours, and circumcision as determinants of HIV dynamics in rural Uganda | pages = | publisher = aegis.com | date = 7–12 July 2002 | location = ], ] | url = http://www.aegis.com/conferences/iac/2002/ThPeC7420.html | accessdate = 2008-10-04 | id =}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Fonck | first = K. | coauthors = Kidula N, Kirui P, Ndinya-Achola J, Bwayo J, Claeys P, Temmerman M | year = 2000 | month = August | title = Pattern of sexually transmitted diseases and risk factors among women attending an STD referral clinic in Nairobi, Kenya | journal = Sexually transmitted diseases | volume = 27 | issue = 7 | pages = 417–423 | doi = 10.1097/00007435-200008000-00007 | pmid = 10949433 | url = http://cat.inist.fr/?aModele=afficheN&cpsidt=1455493 | accessdate = 2008-10-04}}</ref></nowiki></small> | |||
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||PMID 10949433: MEDLINE 2000 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | last = Marck | first = Jeff | coauthors= | year = 1997 | title = Aspects of male circumcision in subequatorial African culture history | journal = Health Transition Review | volume = 7 | issue = Supplement | pages = 337–60 | pmid = 10173099 | url = http://htc.anu.edu.au/pdfs/Marck1.pdf | format = PDF | accessdate = 2008-10-16}}</ref></nowiki></small> | |||
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||PMID 10173099: MEDLINE 1997 Review | |||
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| <small><nowiki><ref>{{cite journal | last = | first = | coauthors= | year = 2007 | title = Male circumcision: global trends and determinants of prevalence, safety and acceptability | journal = Who/Unaids | volume = | issue = | pages = | pmid = | url = http://whqlibdoc.who.int/publications/2007/9789241596169_eng.pdf | format = PDF | accessdate = 2008-10-16}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = | first = | coauthors= | year = 2008 | title = Towards Universal access: Scaling up priority HIV/AIDS interventions in the health sector | journal = Who/Unaids/Unicef | volume = | issue = | pages = 75 | pmid = | url = http://www.unicef.org/aids/files/towards_universal_access_report_2008.pdf | format = PDF | accessdate = 2008-10-16}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Kebaabetswe | first = P. | coauthors= S. Lockman, S. Mogwe, R. Mandevu, I Thior, M Essex, R. L. Shapiro | year = 2003 | month = | title = Male circumcision: an acceptable strategy for HIV prevention in Botswana | journal = Sexually Transmitted Infections | volume = 79 | issue = 3 | pages = 214–219 | pmid = 12794204 | accessdate = 2008-09-25 | doi = 10.1136/sti.79.3.214 | pmc = 1744675}}</ref></nowiki></small> | |||
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||PMID 12794204: MEDLINE 2003 Multicenter Study | |||
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| <small><nowiki><ref>{{cite journal | last = Boyle | first = G. J. | coauthors= | year = 2003 | month = November | title = Issues associated with the introduction of circumcision into a non-circumcising society | journal = Sexually transmitted infections | volume = 79 | issue = 5 | pages = 427–428 | pmid = 14573850 | doi = 10.1136/sti.79.5.427 | url = http://www.cirp.org/library/disease/HIV/boyle-sti/ | format = | pmc = 1744753}}</ref></nowiki></small> | |||
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||PMID 14573850: MEDLINE 2003 Comment, Letter | |||
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| <small><nowiki><ref>{{cite conference | first = Robert C. | last = Bailey | authorlink = | coauthors = Opeya C.J., Ayieko B.O., Kawango A., Onyango M.O, Moses S, Ndinya-Achola J.O., Krieger J.N. | title = International Conference AIDS | booktitle = Adult male circumcision in Kenya: safety and patient satisfaction | pages = | publisher = | date = 11–16 July 2004 | location = Bangkok | url = http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102282470.html | accessdate = 2008-09-25 | id =}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite web |url=http://www.aids2004.org/ |title=15th International AIDS Conference, 2004, Bangkok,Thailand |accessdate=2008-09-25 |work= |publisher= |date=11–14 July 2004 }}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite conference |first=C.A. |last=Connolly |authorlink= |coauthors=O. Shisana, L. Simbayi, M. Colvin |title=15th International AIDS Conference |booktitle=HIV and circumcision in South Africa. |pages= |publisher= |date=11–16 July 2004 |location= ], ] |url=http://www.aegis.com/conferences/iac/2004/MoPeC3491.html |accessdate= |id= }}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite conference |first=A.G. |last=Thomas |authorlink= |coauthors=, L.N. Bakhireva, S.K. Brodine, R.A. Shaffer|title=15th International AIDS Conference |booktitle=Prevalence of male circumcision and its association with HIV and sexually transmitted infections in a U.S. navy population |pages= |publisher= |date=11–16 July 2004 |location= ], ] |url=http://www.aegis.com/conferences/iac/2004/TuPeC4861.html |accessdate= |id= }}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | author=Reynolds SJ, Shepherd ME, Risbud AR, ''et al'' |title=Male circumcision and risk of HIV-1 and other sexually transmitted infections in India |journal=Lancet |volume=363 |issue=9414 |pages=1039–40 |year=2004 |month=March |pmid=15051285 |doi=10.1016/S0140-6736(04)15840-6 }}</ref></nowiki></small> | |||
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||PMID 15051285: MEDLINE 2004 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | author=Baeten JM, Richardson BA, Lavreys L, ''et al'' |title=Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan men |journal=J. Infect. Dis. |volume=191 |issue=4 |pages=546–53 |year=2005 |month=February |pmid=15655778 |doi=10.1086/427656 |url=http://www.journals.uchicago.edu/doi/abs/10.1086/427656}}</ref></nowiki></small> | |||
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||PMID 15655778: MEDLINE 2005 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite conference |first=Thomas C. |last=Quinn |authorlink= |coauthors=''et al'' |title=Conference on Retroviruses and Opportunistic Infections |booktitle=Review shows male circumcision protects female partners from HIV and other STDs |pages= |publisher= |date=5–9 February 2006 |location= ], ] |url=http://www.eurekalert.org/pub_releases/2006-02/jhmi-rsm020306.php |accessdate= |id= }}</ref></nowiki></small> | |||
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| <small><nowiki><ref name ="Newell">{{cite journal | last = Newell | first = Marie-Lousie | coauthors = Till Bärnighausen | date = February 24, 2007 | title = Male circumcision to cut HIV risk in the general population | journal = ] | volume = 369 | issue = 9562 | pages = 617–619 | pmid = 17321292 | doi = 10.1016/S0140-6736(07)60288-8 | url = http://download.thelancet.com/pdfs/journals/0140-6736/PIIS0140673607602888.pdf | format = PDF | accessdate = 2007-04-01}}</ref></nowiki></small> | |||
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||PMID 17321292: MEDLINE 2007 Comment | |||
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| <small><nowiki><ref>{{cite web | url = http://apha.confex.com/apha/134am/techprogram/paper_136814.htm | title = Risk behaviors and patterns of HIV seroprevalence in countries with generalized epidemics: Results from the Demographic and Health Surveys | accessdate = 2008-10-08 | year = 2006 | publisher = APHA Scientific Session and Event Listing}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite conference | first = A. | last = Way | coauthors = V. Mishra, R. Hong, K. Johnson | title = AIDS 2006 - XVI International AIDS Conference | booktitle = Is male circumcision protective of HIV infection? | pages = | publisher = International Aids Society | date = 7–12 July 2006 | location = ], ] | url = http://www.iasociety.org/Default.aspx?pageId=11&abstractId=2197431 | accessdate = 2008-10-08}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name ="Garenne">{{cite journal | last = Garenne | first = Michel | year = 2006 | month = January | title = Male Circumcision and HIV Control in Africa | journal = ] | volume = 3 | issue = 1 | pages = e78 | pmid = 16435906 | doi = 10.1371/journal.pmed.0030078 | url = http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0030078 | accessdate = 2007-04-01 | pmc = 1360650}}</ref></nowiki></small> | |||
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||PMID 16435906: MEDLINE 2006 Comment, Letter | |||
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| <small><nowiki><ref>{{cite journal | last = Halperin | first = Daniel | year = 2007 | month = June | title = Male Circumcision Matters (as One Part of an Integrated HIV Prevention Response) | journal = ] | volume = | issue = | pages = | pmid = | doi = | url = http://www.plosone.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F723&root=info%3Adoi%2F10.1371%2Fannotation%2F723 | accessdate = 2008-09-25}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name ="PROSTITUTION">{{cite journal | last = Talbott | first = John R. | year = 2007 | month = June | title = Size Matters: The Number of Prostitutes and the Global HIV/AIDS Pandemic | journal = ] | volume = 2 | editor1-first = Cesar | issue = 6 | pages = e543 | editor1-last = Ugarte-Gil | doi = 10.1371/journal.pone.0000543 | url = http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.000054 | accessdate = 2007-07-09 | last2 = Ugarte-Gil | first2 = Cesar | pmid = 17579715 | pmc = 1891093 | archiveurl = http://web.archive.org/web/20070927194947/http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.000054 |archivedate = 2007-09-27}}</ref></nowiki></small> | |||
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||PMID 17579715: MEDLINE 2007 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal |title=Circumcision for HIV needs follow-up |author=Butler, D; Odling-Smee, L |journal=Nature |year=2007 |month=June |volume=447 |pages=1040–1 |url=http://www.nature.com/nature/journal/v447/n7148/box/4471040a_BX1.html |doi=10.1038/4471040a |pmid=17597727 |issue=7148}}</ref></nowiki></small> | |||
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||PMID 17597727: MEDLINE 2007 News | |||
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| <small><nowiki><ref name ="CSAI_99">{{cite web | year = 1999 | month = December | url = http://www.ama-assn.org/ama/no-index/about-ama/13585.shtml | title = Report 10 of the Council on Scientific Affairs (I-99):Neonatal Circumcision | work = 1999 AMA Interim Meeting: Summaries and Recommendations of Council on Scientific Affairs Reports | pages = 17 | publisher = ] | accessdate = 2006-06-13}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Brewer | first= Devon | year = 2007| month= February | title = Male and Female Circumcision Associated with Prevalent HIV Infection in Virgins and Adolescents in Kenya, Lesotho, and Tanzania | journal = Annals of Epidemiology | volume = 17 | issue = 3 |pages=217–26 |url=http://www.annalsofepidemiology.org/article/PIIS1047279706002651/abstract | doi = 10.1016/j.annepidem.2006.10.010 | pmid = 17320788 | last2 = Potterat | first2 = JJ | last3 = Roberts Jr | first3 = JM | last4 = Brody | first4 = S}}</ref></nowiki></small> | |||
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||PMID 17320788: MEDLINE 2007 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | last = Van Howe | first = Robert | coauthors= J. Steven Svoboda, Frederick M. Hodges, | year = 2005 | month = November | title = HIV infection and circumcision: cutting through the hyperbole | journal = Journal of the royal society for the promotion of health | volume = 125 | issue = 6 | pages = 259–65 | pmid = 16353456 | doi = 10.1177/146642400512500607 | url = http://www.cirp.org/library/disease/HIV/vanhowe2005a/ | quote = We contend that the rush to intervene has little to do with preventing HIV infection in Africa and may have more to do with a conscious and/or unconscious impulse to help perpetuate and promote the practice in North America. There is ample indirect evidence to support this contention.}}</ref></nowiki></small> | |||
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||PMID 16353456: MEDLINE 2005 Historical Article | |||
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| <small><nowiki><ref>{{cite journal | last = Connolly | first = Catherine | coauthors = Leickness C. Simbayi, Rebecca Shanmugam, Ayanda Nqeketo | month = October | year = 2008 | title = Male circumcision and its relationship to HIV infection in South Africa: Results of a national survey in 2002 | journal = ] | volume = 98 | issue = 10 | pages = 789–94 | pmid = | doi = | url = http://www.samj.org.za/index.php/samj/article/viewFile/254/2144 | format = PDF}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Sidler | first = D. | coauthors = J. Smith, H. Rode | date = 29 September 2008 | title = Neonatal circumcision does not reduce HIV/AIDS infection rates | journal = South African medical journal | volume = 8 | issue = 10 | pages = 762–766 | pmid = | doi = | url = http://www.samj.org.za/index.php/samj/article/viewFile/1811/2152 | format = PDF}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Boiley | first = MC | coauthors = K Desai1, B Masse2, A Gumel3 | month = October | year = 2008 | title = Incremental role of male circumcision on a generalised HIV epidemic through its protective effect against other sexually transmitted infections: from efficacy to effectiveness to population-level impact | journal = Sexually Transmitted Infections | volume = 84 | issue = Supplement 2 | pages = ii28–34 | doi = 10.1136/sti.2008.030346 | url = http://sti.bmj.com/cgi/content/abstract/84/Suppl_2/ii28 | format = | pmid=18799489|}}</ref></nowiki></small> | |||
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||PMID 18799489: MEDLINE 2008 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | last = Millett | first = G.A. | coauthors = Ding H., Lauby J., Flores S., Stueve A., Bingham T., Carballo-Dieguez A., Murrill C., Liu K.L., Wheeler D., Liau A., Marks G. | year = 2007 | month = December | title = Circumcision status and HIV infection among Black and Latino men who have sex with men in 3 US cities | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 46 | issue = 5 | pages = 643–50 | pmid = 18043319 | url = http://www.jaids.org/pt/re/jaids/abstract.00126334-200712150-00017.htm;jsessionid=Lb9TQkjvDPZQYf0xc27xyTDQNBfjDQGC6mqwRpmzHJFXb2yk1GyQ!1455807198!181195628!8091!-1 | accessdate = 2007-07-09 | doi = 10.1097/QAI.0b013e31815b834d}}</ref></nowiki></small> | |||
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||PMID 18043319: MEDLINE 2007 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | last = Lagarde | first = Emmanuel | coauthors= Dirk Taljaard, Puren Adrian, Reathe Rain-Taljaard, Bertran Auvert | year = 2003 | month = January | title = Acceptability of male circumcision as a tool for preventing HIV infection in a highly infected community in South Africa | journal = AIDS | volume = 17 | issue = 1 | pages = 89–95 | pmid = 12478073 | issn = 0269-9370 | url = http://cat.inist.fr/?aModele=afficheN&cpsidt=14470835 | format = | accessdate = 2008-09-25 | doi = 10.1097/00002030-200301030-00012}}</ref></nowiki></small> | |||
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||PMID 12478073: MEDLINE 2003 (unspecified, possibly primary) | |||
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| <small><nowiki><ref name=millett>{{cite journal |author=Millett GA, Flores SA, Marks G, Reed JB, Herbst JH |title=Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: a meta-analysis |journal=JAMA |volume=300 |issue=14 |pages=1674–84 |year=2008 |month=October |pmid=18840841 |doi=10.1001/jama.300.14.1674 |url=http://jama.ama-assn.org/cgi/content/short/300/14/1674}}</ref></nowiki></small> | |||
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||PMID 18840841: MEDLINE 2008 Meta-Analysis, Review | |||
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| <small><nowiki><ref name=vermund>{{cite journal |author=Vermund SH, Qian HZ |title=Circumcision and HIV prevention among men who have sex with men: no final word |journal=JAMA |volume=300 |issue=14 |pages=1698–700 |year=2008 |month=October |pmid=18840846 |doi=10.1001/jama.300.14.1698 |url=http://jama.ama-assn.org/cgi/content/short/300/14/1698}}</ref></nowiki></small> | |||
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||PMID 18840846: MEDLINE 2008 Comment, Editorial | |||
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| <small><nowiki><ref name=NIAIDQA>{{cite web | url = http://www3.niaid.nih.gov/news/QA/AMC12_QA.htm | title = NIAID QUESTIONS AND ANSWERS Sponsored Adult Male Circumcision Trials in Kenya and Uganda | accessdate = 2008-07-11 | date = December 13, 2006 | publisher = National Institute of Allergy and Infectious Diseases (]0}} {{Dead link|date=November 2010|bot=H3llBot}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>http://www.phru.co.za/pdf/circumcision/pitfalls.pdf</ref></nowiki></small> | |||
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| <small><nowiki><ref name ="ANRS">{{cite journal | last = Auvert | first = Bertran | coauthors = Dirk Taljaard, Emmanuel Lagarde, Joëlle Sobngwi-Tambekou, Rémi Sitta, Adrian Puren | year = 2005 | month = November | title = Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial | journal = PLoS Medicine | volume = 2 | issue = 11 | pages = 1112–22 | doi = 10.1371/journal.pmed.0020298 | pmid = 16231970 | url = http://medicine.plosjournals.org/archive/1549-1676/2/11/pdf/10.1371_journal.pmed.0020298-S.pdf | format = PDF | accessdate = 2006-07-09 | pmc = 1262556}}</ref></nowiki></small> | |||
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||PMID 16231970: MEDLINE 2005 Randomized Controlled Trial | |||
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| <small><nowiki><ref name ="PLoS_7_06">{{cite journal | last = Williams | first = Brian G. | authorlink = | coauthors = James O. Lloyd-Smith, Eleanor Gouws, Catherine Hankins, Wayne M. Getz, John Hargrove, Isabelle de Zoysa, Christopher Dye, Bertran Auvert | year = 2006 | month = July | title = The Potential Impact of Male Circumcision on HIV in Sub-Saharan Africa | journal = ] | volume = 3 | issue = 7 | pages = e262 | doi = 10.1371/journal.pmed.0030262 | pmid = 16822094 | url = http://medicine.plosjournals.org/archive/1549-1676/3/7/pdf/10.1371_journal.pmed.0030262-p-L.pdf | format = PDF | accessdate = 2006-07-13 | pmc = 1489185}}</ref></nowiki></small> | |||
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||PMID 16822094: MEDLINE 2006 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal | coauthors = Edward Mills, Nandi Siegfried | year = 2006 | month = October | title = Cautious optimism for new HIV/AIDS prevention strategies | journal = Lancet | volume = 368 | issue = 9543 | pages = 1236 | doi = 10.1016/S0140-6736(06)69513-5 | pmid = 17027724 | url = http://www.thelancet.com/journals/lancet/article/PIIS0140673606695135/fulltext | format = | accessdate = 2008-09-18 | last1 = Mills | first1 = E}}</ref></nowiki></small> | |||
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||PMID 17027724: MEDLINE 2006 Letter | |||
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| <small><nowiki><ref>http://hivinsite.ucsf.edu/InSite?page=jl-11-03 Male Circumcision for HIV Prevention in Men in Rakai, Uganda: A Randomised Trial</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite web | url = http://hivinsite.ucsf.edu/InSite?page=jl-11-03 | title = Male Circumcision for HIV Prevention in Men in Rakai, Uganda: A Randomised Trial | accessdate = 2008-07-11 | date = March 26, 2007 | publisher = UCSF Institute for Global Health Literature Digest}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name="baileyrct">{{cite journal | last = Bailey | first = Robert C | coauthors = Stephen Moses, Corette B Parker, Kawango Agot, Ian Maclean, John N Krieger, Carolyn F M Williams, Richard T Campbell, Jeckoniah O Ndinya-Achola | date = February 24, 2007 | title = Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial | journal = ] | volume = 369 | issue = 9562 | pages = 643–656 | pmid = 17321310 | doi = 10.1016/S0140-6736(07)60312-2 | url = http://download.thelancet.com/pdfs/journals/0140-6736/PIIS0140673607603122.pdf | format = PDF | accessdate = 2007-04-01}}</ref></nowiki></small> | |||
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||PMID 17321310: MEDLINE 2007 Randomized Controlled Trial | |||
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| <small><nowiki><ref name="grayrct">{{cite journal | last = Gray | first = Ronald H | coauthors = Godfrey Kigozi, David Serwadda, Frederick Makumbi, Stephen Watya, Fred Nalugoda, Noah Kiwanuka, Lawrence H Moulton, Mohammad A Chaudhary, Michael Z Chen, Nelson K Sewankambo, Fred Wabwire-Mangen, Melanie C Bacon, Carolyn F M Williams, Pius Opendi, Steven J Reynolds, Oliver Laeyendecker, Thomas C Quinn, Maria J Wawer | date = February 24, 2007 | title = Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial | journal = ] | volume = 369 | issue = 9562 | pages = 657–66 | pmid = 17321311 | doi = 10.1016/S0140-6736(07)60313-4 | url = http://hssp.ph/pubdocs/HIV-Lancet%20-%20MC%20Uganda%2002.24.07.pdf | format = PDF | accessdate = 2007-07-11}}</ref></nowiki></small> | |||
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||PMID 17321311: MEDLINE 2007 Randomized Controlled Trial | |||
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| <small><nowiki><ref>{{cite web | url = http://www.newscientist.com/article.ns?id=dn11481&feedId=online-news_rss20 | title = WHO hails circumcision as vital in HIV fight | accessdate = 2008-09-18 | date = March 28, 2007 | publisher = ]}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name="WHOsec">{{cite web | url = http://www.who.int/mediacentre/news/statements/2007/s04/en/index.html | title = WHO and UNAIDS Secretariat welcome corroborating findings of trials assessing impact of male circumcision on HIV risk | accessdate = 2007-02-23 | date = February 23, 2007 | publisher = World Health Organization}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite web | url = http://www.who.int/mediacentre/news/statements/2006/s18/en/index.html | title = Male circumcision reduces the risk of becoming infected with HIV, but does not provide complete protection | accessdate = 2006-07-20 | date = December 13, 2006 | publisher = World Health Organization}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite web | url = http://news.bbc.co.uk/2/hi/health/4371384.stm | title = Circumcision 'reduces HIV risk' | date = October 25, 2005 | publisher = BBC News}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name="Dowsett2007">{{cite journal |last=Dowsett |first=G.W. |coauthors=M. Couch |year=2007 |month=May |title=Male circumcision and HIV prevention: is there really enough of the right kind of evidence? |journal=Reproductive Health Matters |volume=15 |issue=29 |pages= 33–44 |pmid=17512372 |url=http://download.journals.elsevierhealth.com/pdfs/journals/0968-8080/PIIS0968808007293024.pdf | format= PDF |accessdate= |quote= |doi=10.1016/S0968-8080(07)29302-4 }}</ref></nowiki></small> | |||
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||PMID 17512372: MEDLINE 2007 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite web | url =http://www.aidsmap.com/en/news/3CBF12A3-A1AC-4A0E-A79C-54FC6EF93E28.asp | author = Virginia Differding | title = Women may be at heightened risk of HIV infection immediately after male partner is circumcised | accessdate = 2007-03-14 | date = March 12, 2007 | publisher = Aidsmap News}}</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Green | first = Lawrence W | coauthors = McAllister, Ryan G; Peterson, Kent W; Travis, John W | month = May | year = 2008 | title = Male circumcision is not the vacine we have been waiting for | journal = Future HIV therapy | volume = 2 | issue = 3 | pages = 193–199 | pmid = | doi = 10.2217/17469600.2.3.193 | url = http://www.futuremedicine.com/doi/pdf/10.2217/17469600.2.3.193 | format = PDF}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name="weiss2008">{{cite journal | author=Weiss HA, Halperin D, Bailey RC, Hayes RJ, Schmid G, Hankins CA | title=Male circumcision for HIV prevention: from evidence to action? | journal=AIDS | volume=22 | issue=5 | pages=567–74 | year=2008 | month=March | pmid=18316997 | doi=10.1097/QAD.0b013e3282f3f406 | url= http://www.aidsvaccineclearinghouse.org/pdf/MC/Weiss_AIDS_2008.pdf|format=PDF}}</ref></nowiki></small> | |||
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||PMID 18316997: MEDLINE 2008 Editorial, Review | |||
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| <small><nowiki><ref name="mills2008">{{cite journal | author=Mills E, Cooper C, Anema A, Guyatt G | title=Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men | journal=HIV Med. | volume=9 | issue=6 | pages=332–5 | year=2008 | month=July | pmid=18705758 | doi=10.1111/j.1468-1293.2008.00596.x | url=}}</ref></nowiki></small> | |||
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||PMID 18705758: MEDLINE 2008 Meta-Analysis, Review | |||
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| <small><nowiki><ref name="byakika2008">{{cite journal | author=Byakika-Tusiime J | title=Circumcision and HIV Infection: Assessment of Causality | journal=AIDS Behav | volume=12 | issue=6 | pages=835–41 | year=2008 | month=September | pmid=18800244 | doi=10.1007/s10461-008-9453-6 | url=}}</ref></nowiki></small> | |||
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||PMID 18800244: MEDLINE 2008 Meta-Analysis, Review | |||
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| <small><nowiki><ref>{{cite journal |author=Podder CN, Sharomi O, Gumel AB, Moses S |title=To cut or not to cut: a modeling approach for assessing the role of male circumcision in HIV control |journal=Bull. Math. Biol. |volume=69 |issue=8 |pages=2447–66 |year=2007 |month=November |pmid=17557187 |doi=10.1007/s11538-007-9226-9 |url=}}</ref></nowiki></small> | |||
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||PMID 17557187: MEDLINE 2007 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal |author=Hallett TB, Singh K, Smith JA, White RG, Abu-Raddad LJ, Garnett GP |editor1-last=Fretheim |editor1-first=Atle |title=Understanding the impact of male circumcision interventions on the spread of HIV in southern Africa |journal=PLoS ONE |volume=3 |issue=5 |pages=e2212 |year=2008 |pmid=18493593 |pmc=2387228 |doi=10.1371/journal.pone.0002212 |url=}}</ref></nowiki></small> | |||
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||PMID 18493593: MEDLINE 2008 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal |author=Kahn JG, Marseille E, Auvert B |title=Cost-effectiveness of male circumcision for HIV prevention in a South African setting |journal=PLoS Med |year=2006 |volume=3 |issue=12 |pages=e157 |pmid=17194197 |doi=10.1371/journal.pmed.0030517 |pmc=1716193}}</ref></nowiki></small> | |||
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||PMID 17194197: MEDLINE 2006 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal |author=White RG, Glynn JR, Orroth KK, Freeman EE, Bakker R, Weiss HA, Kumaranayake L, Habbema JD, Buvé A, Hayes RJ |title=Male circumcision for HIV prevention in sub-Saharan Africa: who, what and when? |journal=AIDS |year=2008 |volume=22 |issue=14 |pages=1841–50 |pmid=18753931 |doi=10.1097/QAD.0b013e32830e0137}}</ref></nowiki></small> | |||
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||PMID 18753931: MEDLINE 2008 (unspecified, possibly primary) | |||
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| <small><nowiki><ref>{{cite journal |author=UNAIDS/WHO/SACEMA Expert Group on Modelling the Impact and Cost of Male Circumcision for HIV Prevention |title=Male Circumcision for HIV Prevention in High HIV Prevalence Settings: What Can Mathematical Modelling Contribute to Informed Decision Making? |journal=PLoS Med |volume=6 |issue=9 |pages=e1000109 |url=http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000109 |doi=10.1371/journal.pmed.1000109 |pmid=19901974 |year=2009 |pmc=2731851}}</ref></nowiki></small> | |||
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||PMID 19901974: MEDLINE 2009 Review | |||
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| <small><nowiki><ref>{{cite journal | author = Mcallister RG, Travis JW, Bollinger D, Rutiser C, Sundar V| title = The cost to circumcise Africa | journal = ] | publisher = Men's Studies Press | volume = 7| issue = 3 | year = Fall 2008 | doi = 10.3149/jmh.0703.307 | pages = 307–316 | url = http://www.thefreelibrary.com/The+cost+to+circumcise+Africa.-a0189486243 | issn = 1532-6306 }}(Online ISSN: 1933-0278)</ref></nowiki></small> | |||
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| <small><nowiki><ref>{{cite journal | last = Hussain LA | first = LA | authorlink = | coauthors = T. Lehner | year = 1995 | month = July | title = Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia | journal = Immunology | volume = 85 | issue = 3 | pages = 475–484 | doi = | pmid = 7558138 | url = | format = Abstract | accessdate = 2006-07-09 | pmc = 1383923}}</ref></nowiki></small> | |||
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||PMID 7558138: MEDLINE 1995 Comparative Study | |||
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| <small><nowiki><ref>{{cite journal | last = Donoval | first = BA | authorlink = | coauthors = AL Landay, S Moses, K Agot, JO Ndinya-Achola, EA Nyagaya, I MacLean, and RC Bailey | year = 2006 | month = March | title = HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections | journal = American Journal of Clinical Pathology | volume = 125 | issue = 3 | pages = 386–391 | doi = 10.1309/JVHQ-VDJD-YKM5-8EPH | pmid = 16613341 | url = http://ajcp.metapress.com/link.asp?id=jvhqvdjdykm58eph | format = Abstract | accessdate = 2006-07-09}}</ref></nowiki></small> | |||
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||PMID 16613341: MEDLINE 2006 Randomized Controlled Trial | |||
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| <small><nowiki><ref>{{cite journal | author= McCoombe SG, Cameron PU, Short RV | date= July 7, 2002 | url= http://www.aegis.com/conferences/iac/2002/WePeA5739.html | format= Abstract | title= The distribution of HIV-1 target cells and keratin in the human penis. | publisher= International AIDS Society | version= | accessdate= 2006-07-09}}</ref></nowiki></small> | |||
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| <small><nowiki><ref name=Fleiss>{{cite journal | last = Van Howe | first = Robert | coauthors = Christopher J. Cold,Michelle R. Storms | year = 2000 | month = December | title = Male circumcision and HIV prevention: Some science would not have gone amiss | journal = BMJ | volume = 321 | issue = 7274 | pages = 1467 | doi = | pmid = 11187941 | url = http://www.bmj.com/cgi/content/full/321/7274/1467/a | format = | accessdate = 2008-10-16 | pmc = 1119176}}</ref></nowiki></small> | |||
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||PMID 11187941: MEDLINE 2000 Comment, Letter | |||
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||PMID 10195034: MEDLINE 1998 Review | |||
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| <small><nowiki><ref>{{cite journal | author=de Witte L, Nabatov A, Pion M, ''et al.'' | title=Langerin is a natural barrier to HIV-1 transmission by Langerhans cells | journal=Nature Medicine | volume=13 | issue=3 | pages=367–71 | year=2007 | month=March | pmid=17334373 | doi=10.1038/nm1541}}</ref></nowiki></small> | |||
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||PMID 17334373: MEDLINE 2007 (unspecified, possibly primary) | |||
::::: We've had repeated discussions on the ] talk page with consensus on this matter: that it would only become undue if a major medical organization (or World Health Organization) denied that it was efficacious. As {{re|MrOllie}} ] a few days ago: {{tqi|we going to undermine the well established consensus of mainstream medical science based on a few people publishing in questionable journals}}. ] doesn't mean the promotion of fringe theories denying a link in high risk populations. (Where heterosexually transmitted HIV/AIDS is common and the predominant form of transmission.) The disputed efficacy of it in developed nations is already covered. ] (]) 06:25, 11 September 2022 (UTC) | |||
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::::::No, that is not the only sentence that the old source was used for. That source was also used for the “All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy” sentence. This is ]. Also, please make sure you are careful about tagging users on talk pages– it can be seen as a violation of ]. ] (]) 07:03, 11 September 2022 (UTC) | |||
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::::::Once again, “This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence” is redundant. We do not need to say essentially the same thing twice in the lead.. ] (]) 07:12, 11 September 2022 (UTC) | |||
:::::::{{tqi|“No, that is not the only sentence that the old source was used for. That source was also used for the “All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy”}} What's problematic with it? Were the three RCT's not stopped early by their monitoring boards? There's nothing problematic about citing it from there. | |||
:::::::] doesn't apply to fringe viewpoints: only those with a majority/significant minority following. ''Merson and Inrig (2017)'' states: {{tqi|"This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence"}}. ''Sharma et al. (2021)'' states: {{tqi|There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1}}.] only applies when {{tqi|If a viewpoint is held by a majority ... significant minority...}}. But every major medical association — including those in non-Anglophonic Europe — state that it is efficacious against the spread of HIV/AIDS in poor, high risk contexts. Both ''Merson and Inrig (2017)'' and ''Sharma et al. (2021)'' citations are under five years old. It's a ''violation'' of ] to include fringe viewpoints. | |||
:::::::{{tqi|Also, please make sure you are careful about tagging users on talk pages– it can be seen as a violation of WP:CANVASS.}} Both {{re|MrOllie}} and {{re|Alexbrn}} have been directly involved in conversations with you surrounding this topic on this article's talk page and on ]'s. ] doesn't apply here. I tagged others previously involved with this discussion because there's not going to be an established resolution to this otherwise. (Outside of the RfC's already performed on the issue and how consensus should be characterized) There's already been a RfC on the circumcision talk page establishing a consensus on the matter among heterosexuals in high-risk, undeveloped contexts. But I'll tag {{re|TiggyTheTerrible}} as well. A discussion on this matter has already taken place. If a major medical organization (such as the British Medical Association, American Academy of Pediatrics, World Health Organization, et al.) denies a link between HIV and circumcision in high risk contexts, feel free to start another RfC on it. (And in that circumstance I think a dissenting view on the matter should be included.) ''Merson and Inrig (2017)'''s quote is only five years old. ''Sharma et al. (2021)''s quote stating a consensus is only a year old. | |||
:::::::{{tqi|We do not need to say essentially the same thing twice in the lead}} A consensus didn't emerge until after the three RCT's (and subsequent history.) '''Before then, there was widespread open debate among the scientific community over whether it was efficacious.''' That's why the sentence is there. It establishes what the consensus is based upon. However, I don't have a really significant opinion on the matter either way. We can keep it removed from the lead if preference. ] (]) 04:29, 13 September 2022 (UTC) | |||
:::::::Tagging {{re|Prcc27}} ] (]) 04:30, 13 September 2022 (UTC) | |||
:::::::*You are trying to state an ethical view as factual: “hence that it would be unethical to withhold the treatment”. Not to mention, non-therapeutic circumcision isn’t “treatment”, it is often seen as “prevention” though. It is definitely ]/] to use an old source to say there is “overwhelming evidence of prophylactic efficacy.” ] (]) 05:00, 13 September 2022 (UTC) | |||
::::::::: {{tqi|You are trying to state an ethical view as factual: “hence that it would be unethical to withhold the treatment”. }} It's widespread in medical ethics to end studies early in those types of situations. Within context, it's clearly referring to the study's author's and monitor boards concluding it. Something such as {{tqi|Hence that it would be unethical to withhold the treatment '''by the monitoring board(s)'''}} could easily be added unto it. ] (]) 06:12, 13 September 2022 (UTC) | |||
::::::::: {{tqi|Non-therapeutic circumcision isn’t “treatment”, it is often seen as “prevention” though.}} "Treatment" is widely used in the and is a ''verbatim'' wording of what the sources state. It meets the criteria for the word. | |||
::::::::: {{tqi|It is definitely ]/] to use an old source to say there is “overwhelming evidence of prophylactic efficacy.” }} '''Recent sources such as ''Merson and Inrig (2017)'' and ''Sharma et al. (2021)'' (as mentioned above) as well as major medical organizations universally state the same.''' ]/] doesn't apply. | |||
::::::::: Tag, {{re|Prcc27}}. ] (]) | |||
:::::::::*”Consensus” and “overwhelming evidence” are two very different things. Also, it is not a universal consensus among major medical organizations, if you recognize the Royal Dutch Medical Association as a major medical organization. ] (]) 14:59, 13 September 2022 (UTC) | |||
::::::::::FFS, we're not going to do this *again* are we. I return to this page after a long hiatus and see the same POV pushing. As has previously been stated by others, the view that circumcision does not reduce the risk of HIV is a fringe view per Misplaced Pages policy. We are not going to indulge fringe views. That circumcision reduces HIV risk in certain circumstances is established medical fact. ] (]) 15:46, 13 September 2022 (UTC) | |||
:::::::::::As stated in a previous discussion, there is a difference between a “fringe viewpoint” and a significant minority viewpoint. Just because a view is in the minority, does not automatically make it fringe. ] (]) 17:34, 13 September 2022 (UTC) | |||
::::::::::::] I don't know if you've seen one, but this goes into why the African trials were suspect - if not outright fraudulent. https://www.researchgate.net/publication/272498905_Sub-Saharan_African_randomised_clinical_trials_into_male_circumcision_and_HIV_transmission_Methodological_ethical_and_legal_concerns ] (]) 07:12, 13 September 2022 (UTC) | |||
:::::::::::::Also, worth mentioning that since most doctors outside the USA/Africa think circ should NOT be routine, the APA guidelines on this would qualify as fringe in a lot of places. So I think we should be careful about that word. ] (]) 17:47, 13 September 2022 (UTC) | |||
::::::::::::::1) Any paper from 'Doctors Opposing Circumcision' is suspect itself. The authors have no relevant expertise. 2) The question here is not whether circumcision should be routine, it is whether it reduces HIV infection rates. The position that it doesn't is clearly fringe. ] (]) 16:14, 14 September 2022 (UTC) | |||
{{OD}}This discussion is partly about whether the evidence is “overwhelming”. I think that is a problematic and POV word to use. “Strong” would probably be a better alternative. Although I still am not sure the information about the trials belongs in the lead.. ] (]) 17:35, 14 September 2022 (UTC) | |||
: {{tqi|I think that is a problematic and POV word to use.}} It's not a violation of NPOV to reproduce what major medical organizations and multiple metastudies have uniformly concluded (including those referenced above): as {{re|MrOllie}} and {{re|Alexbrn}} have also mentioned. The wording would only be problematic if a {{tqi|majority or significant minority}} denied that viewpoint. They don't. | |||
: '''If their positions are modified or new evidence emerges: of course that the lead could be altered.''' | |||
: {{tqi|Not sure about the trials belongs in the lead}} There was no scientific consensus that circumcision prevented HIV/AIDS before those three RCT's. ] (]) 22:44, 15 September 2022 (UTC) | |||
::Which sources use the term “overwhelming”? How old are those sources? ] (]) 20:40, 16 September 2022 (UTC) | |||
::: '''' uses it : {{tqi|"There is '''overwhelming''' immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1."}} There's other numerous ''verbatim'' examples — all within the past five years — from medical journals, major medical organizations, ''et cetera'' on the issue, dating back to at . Any objections , per this conversation and previous (and repeated) RfC consensus, {{re|MrOllie}} or {{re|Alexbrn}}? ] (]) 03:28, 18 September 2022 (UTC) | |||
:::*Your proposed wording for the lead talks specifically about the African trials. That quote you just cited says nothing about the trials. Using that source for what you’re proposing would be a violation of ]. You do not need to tag those users, I am sure they are already following along and reading this discussion. Plus, I still feel like it comes off as canvassing. ] (]) 04:45, 18 September 2022 (UTC) | |||
::::: {{tqi|That quote you just cited says nothing about the trials}} ''Sharma, et al. (2021)'' states: {{tqi|MC is... strongly supported by the data from three large RCTs conducted in Africa}} right before that. It directly mentions the three RCT trials as part of the {{tqi|"overwhelming evidence"}} for circumcision in high risk contexts. | |||
::::: '''' states: {{tqi|all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.}} | |||
:::::'''' states: {{tqi|Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.}} | |||
::::: '''' states: {{tqi|Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas}} | |||
::::: ''Holmes, Bertozzi, & Bloom (2017)'' states: {{tqi|Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).}} | |||
::::: ''Piontek and Albani, (2019)'' states: {{tqi|Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.}} | |||
::::: ''World Health Organization (2020)'' states: {{tqi|The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs}}. | |||
::::: And so on and so forth. There's numerous other metastudies and/or major medical organizations — easily findable online — that call the three RCTs provide "overwhelming", "very strong", or "strong" evidence. In the context of ''high-risk populations'', anything to the contrary is a fringe perspective at this point. ] (]) 06:06, 18 September 2022 (UTC) | |||
:::::*Exactly. “Strong” is one of the words used to describe the RCTs. There is no reason to use “overwhelming”, in light of more accurate terms. Significant minority viewpoints are not “fringe”. We’ve all made ourselves clear whether we think it is fringe or not; I see no point in continuing to argue about this, especially since it has little to do with the “strong” vs. “overwhelming” issue. ] (]) 12:53, 18 September 2022 (UTC) | |||
::::::: "Strong" and "overwhelming" isn't a contradiction. | |||
::::::: {{tqi|Significant minority viewpoints}} Which, as established, doesn't apply here. | |||
::::::: {{tqi|We’ve all made ourselves clear whether we think it is fringe or not}} Multiple RfC's have as well. ] (]) 22:00, 18 September 2022 (UTC) | |||
:::::::: '''We've had numerous, multiple RFC's on circumcision and this article's talk page about it: all with a similar consensus.''' Saying that {{tqi|a significant minority}} of researchers deny a link between HIV/AIDS transmission in circumcision in high-risk contexts (heterosexual transmission) is obviously wrong: as major medical organizations such as the WHO/UNAIDS and all the above sources state. If you're not going to going to participate in discussion: I'm going to add it back unless a new RfC about the matter concludes otherwise. (Since multiple RFC's on the matter have all concluded uniformly the same.) | |||
:::::::: Given the multitude of sources listed above, it shouldn't be an article of dispute. ] (]) 22:12, 18 September 2022 (UTC) | |||
::::::::*If you actually read the RFCs on this talk page, you would see that there actually was no consensus on whether that view qualifies as “fringe” or a “significant minority viewpoint”. I did not say I would not participate in discussion..? I pretty much said you are wasting our time by focusing on something that is not relevant to the merits of the issue, but in a more civil way. A lot of your information is already in the body paragraphs of this article, but there seems to be no consensus to make the lead disproportionately about the African trials. Consensus that the African trials have “strong” (or even “overwhelming”) evidence ≠ consensus to add that information into the lead. ] (]) 22:55, 18 September 2022 (UTC) | |||
== Outdated/fringe POV == | |||
{{u|Prcc27}} evidently wants to re-insert this 2010 "viewpoint" material. It's ] and a bit fringey so this would harm the article I think. ] (]) 05:09, 6 October 2022 (UTC) | |||
:I am okay with cleaning up older content, but I feel this would be problematic to the section if newer recommendations are lacking or not as thorough as older recommendations. Keep in mind, we actually have older content than the KNMG viewpoint in that paragraph right now (from 2007). We have had the fringe argument many times on this talk page before, and there was never a consensus to treat KNMG as “fringe”. There was a split view about whether their viewpoint is “fringe” or a “significant minority viewpoint”. Regardless, the original consensus has not changed thus far. ] (]) 05:18, 6 October 2022 (UTC) | |||
::I'm not see any justification, or even argument, for inserting this content (and yes, there is yet more old cruft that needs removing too). It's just an outdated unimportant fringey view. Is there anything at all in its favour? ] (]) 05:34, 6 October 2022 (UTC) | |||
:::As stated in prior discussions, it is important to include recommendations from around the world, and to include significant minority viewpoints. The debate around the timing of circumcision and comparing and contrasting circumcision vs. other prevention methods is something the KNMG touches on, as well as something the other recommendations touch on. It is okay to use older sources when newer sourcing is lacking, as evident by the AAP (2012) and WHO (2007) sources being included currently. ] (]) 05:51, 6 October 2022 (UTC) | |||
::::I don't think we can undercut established science with fringe views. Those prior discussions never got anywhere anyway. We've already got some KNMG/Dutch stuff now. That's enough (maybe too much and should go too?). ] (]) 05:56, 6 October 2022 (UTC) | |||
::::*The consensus was/is for KNMG to be included. The raw science belongs in the other sections. The recommendations section should show readers different perspectives on how the science should be applied. ] (]) 06:21, 6 October 2022 (UTC) | |||
::::*:{{tq|The consensus was/is for KNMG to be included}} ← don't think so. Where was this "consensus" assessed and recorded? If you want something like that maybe start an RfC if this thread doesn't result in something clear-cut. ] (]) 06:26, 6 October 2022 (UTC) | |||
::::*::View the archives. Start with the “2013 position paper of small Dutch medical organization - ] and ]” and “Recommendations section”. MEDDATE & MEDRS concerns were addressed there. ] (]) 22:08, 6 October 2022 (UTC) | |||
::::*: I don't think there was ever a consensus to include KNMG. Prcc27 has just spoken more loudly than anyone else and threatened others who disagreed with his viewpoint. The fact remains that KNMG is an outlier and encyclopedias do not exist to give equal space to outliers. The AAP, ACOG, and CDC recommendations are mainstream, consistent with WHO recommendations, and that should be the end of it. ] (]) 19:50, 6 October 2022 (UTC) | |||
::::*::You’re welcome to view the archives, there were others on board with KNMG. Also, I never threatened anyone. Please quit spreading lies! ] (]) 22:03, 6 October 2022 (UTC) | |||
::::] WHO sources were updated to 2020 and CDC/AAP/ACOG reconditions haven't changed ] (]) 21:05, 6 October 2022 (UTC) | |||
:::::There is a 2007 WHO quote in the article, and the expired AAP viewpoint is from 2012. ] (]) 22:02, 6 October 2022 (UTC) | |||
:::::IP is Petersmillard just in case anyone is confused. ] (]) 22:12, 6 October 2022 (UTC) | |||
== RfC: Is there a consensus surrounding circumcision and HIV + should it be in lead? == | |||
{{Archive top|result=Procedural self-close due to improper formatting of the RfC. Will reopen as another RFC per recommendation by ]. Please check back in a few days after the formatting is fixed. Thanks! ] (]) 04:35, 12 October 2022 (UTC) |status=Failed proposal}} | |||
<!-- ] 17:01, 11 November 2022 (UTC) -->{{User:ClueBot III/DoNotArchiveUntil|1668186084}} | |||
The two questions asked are: | |||
* Is there a ''general'' consensus in the scientific community that circumcision reduces HIV/AIDS transmission in high-risk contexts: particularly sub-Saharan Africa? | |||
* Is the strikethroughed material ] for the the lead?''' (e.g. version #1) '''In particular, the wording that has been struckthrough by Prcc27: who argues there is a substantive debate in the scientific community over the issue of circumcision's prophylactic effects against HIV/AIDS in the context of high risk populations? | |||
Leading to the question: | |||
* Which version is the best? Version #1, #2, or #3? | |||
] (]) 16:25, 7 October 2022 (UTC) | |||
There has been a dispute among editors on whether the article should portray (medically performed) circumcision's prophylactic effect on HIV/AIDS transmission in high-risk contexts — in particular, sub-Saharan Africa — as a ''general ''consensus among scientists and how the lead should cover it. The full details of | |||
Per usual formatting: Text that has been deleted in each version of the lead is {{strikethrough|strikethroughed like this}}. Text that is added '''is bolded like this.''' | |||
: | |||
<blockquote>Male circumcision reduces the risk of human immunodeficiency virus (HIV) transmission from HIV positive women to men in high risk populations. | |||
The first academic paper suggesting a protective association between circumcision and reduced heterosexual HIV infection rates was published in 1986. Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence it was concluded that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy. WHO assessed the trials as "gold standard" studies and found "strong and consistent" evidence from later studies that confirmed the results of the three RCT trials. A scientific consensus since subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations. | |||
In 2020, the World Health Organization (WHO) reiterated that male circumcision is an efficacious intervention for HIV prevention if carried out by medical professionals under safe conditions. Circumcision reduces the risk that a man will acquire HIV and other sexually transmitted infections (STIs) from an infected female partner through vaginal sex. The evidence regarding whether circumcision helps prevent HIV is not as clear among men who have sex with men (MSM). The effectiveness of using circumcision to prevent HIV in the developed world is not determined.</blockquote> | |||
(See for edit summary/justification.) | |||
<blockquote>'''There is evidence that''' male circumcision reduces the risk of human immunodeficiency virus (HIV) transmission from HIV positive women to men in high risk populations. | |||
{{strikethrough|The first academic paper suggesting a protective association between circumcision and reduced heterosexual HIV infection rates was published in 1986. Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence it was concluded that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy. WHO assessed the trials as "gold standard" studies and found "strong and consistent" evidence from later studies that confirmed the results of the three RCT trials. A scientific consensus since subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.}} | |||
In 2020, the World Health Organization (WHO) reiterated that male circumcision is an efficacious intervention for HIV prevention if carried out by medical professionals under safe conditions. Circumcision reduces the risk that a man will acquire HIV and other sexually transmitted infections (STIs) from an infected female partner through vaginal sex. The evidence regarding whether circumcision helps prevent HIV is not as clear among men who have sex with men (MSM). The effectiveness of using circumcision to prevent HIV in the developed world is not determined.</blockquote> | |||
<blockquote>Male circumcision reduces the risk of human immunodeficiency virus (HIV) transmission from HIV positive women to men in high risk populations. | |||
{{strikethrough|The first academic paper suggesting a protective association between circumcision and reduced heterosexual HIV infection rates was published in 1986. Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence it was concluded that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy. WHO assessed the trials as "gold standard" studies and found "strong and consistent" evidence from later studies that confirmed the results of the three RCT trials. A scientific consensus since subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.}} | |||
In 2020, the World Health Organization (WHO) reiterated that male circumcision is an efficacious intervention for HIV prevention if carried out by medical professionals under safe conditions. Circumcision reduces the risk that a man will acquire HIV and other sexually transmitted infections (STIs) from an infected female partner through vaginal sex. The evidence regarding whether circumcision helps prevent HIV is not as clear among men who have sex with men (MSM). The effectiveness of using circumcision to prevent HIV in the developed world is not determined.</blockquote> | |||
Thanks! ] (]) 16:25, 7 October 2022 (UTC) | |||
=== Survey === | |||
*'''Yes, there is consensus that circumcision lowers risk of HIV; no, do not explain much in the lead''' The problem with explaining is that doing so communicates that the issue is debatable. It is not. There is an established scientific consensus. Any arguments to the contrary start from either exceptions not worth mentioning, or from fringe views. The highest medical authoritative sources are unambiguous and it would be ] to present dissenting, fringe views in the lead. ]] 17:17, 7 October 2022 (UTC) | |||
*'''Version #1:''' (Note to other editors: That I started this RfC + have been directly involved in this discussion/dispute. See above on the talk page.) Both a brief summarization of the topic and the statement that there is a consensus is ] and in line with other article related to scientific topics. '''Sources that state alternatively are ] and shouldn't be included in the article. ''' | |||
Some relevant sources addressing the topic include: | |||
:: '''' states: {{tqi|all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.}} | |||
:: '''' states: {{tqi|Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.}} | |||
:: '''' states: {{tqi|Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas}} | |||
:: ''Holmes, Bertozzi, & Bloom (2017)'' states: {{tqi|Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).}} | |||
:: ''Piontek and Albani, (2019)'' states: {{tqi|Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.}} | |||
:: ''World Health Organization (2020)'' states: {{tqi|The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs}}. | |||
:: states: {{tqi|There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1.}} ] (]) 18:52, 7 October 2022 (UTC) | |||
*'''Version 1''', the consensus seems to agree that circumcision lowers risk of HIV.--] (]) 21:54, 7 October 2022 (UTC) | |||
*'''Version 2''' (maybe even version 3). Is there a “general consensus”? Perhaps. But there are significant minority viewpoints that question the efficacy of circumcision for HIV prevention (i.e. the Royal Dutch Medical Association). That view should be given at least some coverage in the article (not necessarily in the lead), per ]. There is not a “universal consensus” that circumcision prevents HIV (especially when we are talking about the developed world). The lead proposal is UNDUE per reasoning I gave in previous sections on this talk page. ] (]) 22:42, 7 October 2022 (UTC) | |||
*'''Version 2'''. WP doesn't deal in absolutes, there's a significant minority viewpoint counter to the absolute claim, and the lead is no place for a paragraph of source detailia that dense. <span style="white-space:nowrap;font-family:'Trebuchet MS'"> — ] ] ] 😼 </span> 21:58, 9 October 2022 (UTC) | |||
*:{{tq|WP doesn't deal in absolutes}} Who knows? Perhaps we are The Sith? -- ] (]) 20:56, 11 October 2022 (UTC) | |||
*'''First choice: version 3, Second choice: version 2 (and this RfC is highly problematic in it's format).''' Two different changes should not be the subject of the same !vote as has been done here: as it stands, the way this RfC is formatted, it almost gives the impression that it was purposefully designed to the "split the !vote" between those wishing to support a strong the position that there is strong consensus in the sources for the prophylactic value of the procedures in question, dividing such !votes among options 2 and 3, whereas all !votes supporting a different read on the sources will be aggregated into a single choice, making it easier for that option to reach a higher threshold in responses. I'm going to AGF that this was not intentional--the OP seems to think that version 1 actually advances the argument for strong consensus, afterall; I am not sure I agree with that assessment, but regardless this is specifically why RfCs are not meant to be formatted in such a fashion where two different additions/deletions are contemplated at once. For that matter, there easily could have been a forth option here that dismissed both the proposed added and deleted content. | |||
:All that said, and assuming the RfC doesn't get a procedural close and a re-start, I think the corpus of sources as presented is pretty straightforward here: there is a clear scientific consensus on the existence of a statistically significant prophylactic effect of the medical procedures in question with regard to HIV infection rates (whatever the rest of the cultural conflict surrounding customs regarding circumcision). Version 3 most clearly aligns with the balance of the sources, but version 2 is marginally better than version 1. While version 1 does include reference to some of the more robust studies in question, I don't think the lead is the right place for this level of granularity, and I agree with others who have already noted that it actually undermines an accurate portrayal of the overall strength of the broader consensus. And if steps are not taken to reform the RfC, I certainly hope the closer takes the possible bias inherent in the way the !vote has been constructed into question. '']]'' 06:58, 10 October 2022 (UTC) | |||
:: You're probably right. (And from the comments: there's not going to be a current consensus from the RfC.) I'm procedurally self-closing and restarting in a few days. ] (]) 04:35, 12 October 2022 (UTC) | |||
*'''Version 2''' is my first choice. Instead of striking the paragraph, though, I would change it to something representative of the past three decades of research and not just the beginning. I remember reading that circumcision increased the transmission rate in one study, but it was because the men were resuming sexual activity before they were fully healed. ] (]) 01:14, 12 October 2022 (UTC) | |||
=== Discussion === | === Discussion === | ||
*It's not a debatable point which needs consensus (an odd circumstance which requires ] sourcing); it's just settled science. Any "debate" seemingly died years ago (except in fringe circles and on this Talk page). ] (]) 16:36, 7 October 2022 (UTC) | |||
{{ul|Alexbrn}}, you asked where to start. I have removed the obviously outdated letters, editorials and comments. I would say next is to add the type=Review or type= Meta-analysis parameter to the cite journal template on those known, and then the rest can be more easily examined. If a review is more than about seven years old, I would also add {{tl|old fact}} or {{tl|MEDRS}} depending on the info. ] (]) 17:47, 9 January 2014 (UTC) | |||
:: {{ul|Alexbrn}}, I did a bit, but don't have time to finish. There is still a whole lot of text that might be merged to History, then History needs to be rationalized, then article still needs to incorporate newer sources. That's all I have time for today-- nowhere near finished. ] (]) 12:49, 10 January 2014 (UTC) | |||
:: I obviously agree with you. But (including other IP editors) who kept reverting the paragraph + wording that stated there was a consensus. (As I'm sure you're aware.) I felt like the start of a RfC was the only way to definitely establish a consensus on the matter + the wording within the lead. Or else we would be going back and forth upon this topic for monthsc: without anything productive occuring + and more reversions/edit wars. ] (]) 18:37, 7 October 2022 (UTC) | |||
* Relevant links from discussions above: | |||
:: '''' states: {{tqi|all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.}} | |||
:: '''' states: {{tqi|Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.}} | |||
:: '''' states: {{tqi|Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas}} | |||
:: ''Holmes, Bertozzi, & Bloom (2017)'' states: {{tqi|Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).}} | |||
:: ''Piontek and Albani, (2019)'' states: {{tqi|Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.}} | |||
:: ''World Health Organization (2020)'' states: {{tqi|The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs}}. | |||
:: states: "There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1."" | |||
:: '''Version #1''' is the best. (Per these sources, discussion above, and various other reasons.) More about it is stated in survey subsection. ] (]) 18:46, 7 October 2022 (UTC) | |||
All are written bad even if the science is right. What makes a 2020 reiteration of settled science so notable? ] (]) 13:10, 9 October 2022 (UTC) | |||
{{archivebottom}} | |||
== The evidence on HIV prevention is very unclear == | |||
There are a great number of studies that show it has not effect, r even increases infection rates. So why is the lede so adimant that its only a good thing? ] (]) 13:51, 6 November 2022 (UTC) | |||
:I agree. 2013 meta analysis, and a 2022 study from Canada finds no correlation with HIV. https://www.hindawi.com/journals/isrn/2013/109846/<nowiki/>https://www.auajournals.org/doi/10.1097/JU.0000000000002234 ] (]) 00:47, 25 September 2023 (UTC) | |||
::Neither of those meets ] - the 2013 van Howe paper isn't published in a medline indexed journal, and the Candian study - is a single study. We cannot use lower quality sources to undercut the conclusions of higher quality ones such as a WHO policy statement. ] (]) 01:00, 25 September 2023 (UTC) | |||
:::The 2013 meta analysis is a DOI link. I should've linked the Pubmed. Here's the Pubmed: | |||
:::https://pubmed.ncbi.nlm.nih.gov/23710368/ | |||
:::And the single Canadian study shows how HIV transmission may not apply in the first world. ] (]) 12:39, 25 September 2023 (UTC) | |||
::::Both weak sources, of no use to this article. ] (]) 12:43, 25 September 2023 (UTC) | |||
:::::A meta analysis from pubmed is "weak"? Really now? & the second one still highlights regional differences. ] (]) 17:59, 30 September 2023 (UTC) | |||
::::::Don't known what "from pubmed" is meant to mean, but ] is in a weak, non-MEDLINE journal. We have really strong sources, so why scrape the barrel? ] (]) 18:04, 30 September 2023 (UTC) | |||
:::::::PUBMED is not scraping the barrel; PUBMED is MEDLINE. You could read that here, or you could've thought for a second before edit warring & shitting yourself in a audience of people who don't have lukewarm IQs (https://www.nlm.nih.gov/medline/index.html) ] (]) 18:38, 30 September 2023 (UTC) | |||
::::::::No, that is plainly incorrect. As the link you cite says: {{tq|MEDLINE content is searchable via PubMed and constitutes the primary component of PubMed,}} - that means Pubmed contains other material besides MEDLINE content. The van Howe paper being discussed here is an example of that. ] (]) 18:43, 30 September 2023 (UTC) | |||
::::::Pubmed is an indiscriminate listing. The minimum standard for medical content is considered to be the MEDLINE index. ] (]) 18:11, 30 September 2023 (UTC) | |||
== RFC on the Royal Dutch Medical Association == | |||
Which version of the Royal Dutch Medical Association's recommendations should be included in the article, the full version or the shortened version? | |||
*'''Full version''': "Because the evidence that circumcision prevents HIV mainly comes from studies conducted in Africa, the Royal Dutch Medical Association (KNMG) in 2010 questioned the applicability of those studies to developed countries. Circumcision has not been included in their HIV prevention recommendations. The KNMG viewpoint document said that the relationship between HIV transmission and circumcision was unclear, and that behavioral factors seemed to have more of an effect on HIV prevention than circumcision. The KNMG also said that the choice of circumcision should be put off until an age when a possible HIV risk reduction would be relevant, so that boys could decide for themselves whether to undergo the procedure or choose other prevention alternatives. This KNMG circumcision policy statement was endorsed by several Dutch medical associations." | |||
*'''Shortened version''': "Because the evidence that circumcision prevents HIV mainly comes from studies conducted in Africa, the Royal Dutch Medical Association (KNMG) in 2010 questioned the applicability of those studies to developed countries. Circumcision has not been included in their HIV prevention recommendations." | |||
Some users have argued that the Royal Dutch Medical Association (KNMG) viewpoint is ] and out-of-date, while others have argued that the KNMG recommendations qualify as a "significant minority viewpoint" per ] and that it is important to include recommendations on circumcision & HIV from different regions of the world. ] (]) 00:20, 20 November 2022 (UTC) | |||
*'''Full version:''' The Royal Dutch Medical Association is a large medical organization with over 65,000 doctors and medical students as members. The recommendations section of the article, is where "significant minority viewpoints" belong. Of course, if we get more up-to-date and higher quality recommendations, we should replace the older recommendations with the newer ones. But it is worth noting, that the AAP's viewpoint is technically expired, and that there is a quote from The WHO's 2007 viewpoint which is currently in the article, that is actually older than the KNMG viewpoint. ] (]) 00:28, 20 November 2022 (UTC) | |||
*'''Full version'''. I tend to agree with Prcc27's points, and in reading the two versions, I find the longer one is considerably more informative about KNMG's position (the additional material is not fluff or blather). <span style="white-space:nowrap;font-family:'Trebuchet MS'"> — ] ] ] 😼 </span> 06:34, 20 November 2022 (UTC) | |||
*<b>Full.</b> The Dutch Royal Medical Association is a major institution with a minority viewpoint. Also, the full version gives more details and isn't fluff.<span id="ClydeFranklin:1668978871569:TalkFTTCLNCircumcision_and_HIV" class="FTTCmt"> — <big>]]</big> 21:14, 20 November 2022 (UTC)</span> | |||
*'''Shortened version''': I'm not sure if it's fringe or not but it is certainly a bit out of date and not needing every detail. Other out of date viewpoints in the article can also be appropriately um trimmed or replaced with newer ones if available. ] (]) 23:49, 22 November 2022 (UTC) | |||
*'''Shorter summary of the KNMG position.''' Let me preface this by saying I think the KNMG stance is, at most, FRINGE-adjacent, not truly fringe: yes, it is a significant minority opinion in some respects as compared against consensus medical science on the topic, but let's remember that we are talking about legitimate national-scale body representing tens of thousands of physicians, and at least some of what it has to say on the topic is not altogether controversial. The timeliness issues does raise some concerns in terms of ], but sources in Misplaced Pages articles covering this topic are kind of all over the place on the timeline of research as is. | |||
:All of that said, the portions that come in under the extended version are definitely those which are either a) closest to fringe statements, relative to the broad corpus of research, such as the claim that {{tq|"the relationship between HIV transmission and circumcision was unclear"}} (the particulars may be up for debate but consensus research is pretty clear about the existences of a statistically significant observable relationship), or b) so non-controversial I'm not sure it bears lengthening the article and muddying the waters to include it, as with {{tq|"behavioral factors seemed to have more of an effect on HIV prevention than circumcision"}} (no researchers that I have ever heard of are really arguing that the effects of circumcision are at the same scale of impact as the factors of the sex acts engaged in by individuals, their choice of whether to use safe sex practices, their choices with regard to sexual partners, and their medication choices, the only really physiologically relevant "behavioural factors" at play here, making this rather something of a strawman argument that doesn't do much to inform the reader of the actual dimensions of legitimate medical debate about this topic). | |||
:Meanwhile, the shorter version still includes the less fringe-y and informative content: {{tq|"Because the evidence that circumcision prevents HIV mainly comes from studies conducted in Africa, the Royal Dutch Medical Association (KNMG) in 2010 questioned the applicability of those studies to developed countries."}} Now this in itself is still a little wishy-washy in terms of the grounds on which it takes issue with the majority/consensus research position, because obviously there is no significant observed physiological difference between African and non-African peoples which would lead to statistically different outcomes for individuals exposed to HIV; that is to say, a circumcised African and a circumcised non-African would (on average) get just as much benefit (or just as little, depending on your position) when exposed to HIV--so there are some problems with that statement as framed. But I presume the KNMG would explain this position more fully as "in non-African contexts, the benefits of circumcision on the larger epidemiological scale might render different statistical outcomes in terms of benefits to the larger population resulting from the practice." That's a questionable argument in itself, insofar as the KNMG doesn't point to countervailing research outside of Africa in support of that possibility, so much as casts doubt on the existing Africa-centric research, but that possibility does nevertheless get the statement farther past the smell test than some other aspects of their position. And then of course {{tq|"Circumcision has not been included in their HIV prevention recommendations."}} is just simply perfectly factual. | |||
:On the whole, I don't see a strong argument for the ] value of the elements included in the longer version, whereas I can see the benefit of the shorter version. I'd also like to note that (though I am sure it was a subconscious and unintentional choice, there seems to me to be some rhetorical bias built into how the two choices are presented here in terms of the nomenclature of the RfC: the "full version" of the "KNMG's recommendations" is just the summary of their position as advanced by one of our editors. The choice therefore is not between a "full" or "shortened" version, but rather between a longer and shorter version, and there's a suggestion in the language employed that we are somehow taking something naturally fulsome and cutting it down for convenience. That's not really appropriate framing any more than if the choices had been labelled a "punchy" version and "verbose" version, imo. Not a huge thing, but worth noting as something that could introduce bias into the discussion. Additionally, looking at the dispute as it is framed further up on the talk page, it seems the dispute was about whether to include the KNMG's positions at all, not how much of their position to include, so including nothing probably should have been offered as an option here. That said, I didn't look at the edit history of this dispute, so there may have been movement/discussion/compromise on the foundational issue of whether to include KNMG positions at all which took place in edit summaries. '']]'' 20:31, 23 November 2022 (UTC) | |||
::“Behavioral factors seemed to have more of an effect on HIV prevention than circumcision” isn’t a strawman argument. It is a statement that KNMG ties into their view, that circumcision does not have a significant effect on national HIV prevalence, between the different countries. | |||
::“The relationship between HIV transmission and circumcision was unclear” is not undue, when you read the entire paragraph, which adds context to that statement. | |||
::Questioning the applicability of those studies to developed countries makes sense for two reasons: MSM HIV rates vs. Men who have sex with women and considering that the predominant HIV strain is different in Africa vs. other parts of the world. I’m not going to try to interpret their reasoning, but the KNMG’s argument here, does not seem far off from the mainstream view on generalizability to developed countries. | |||
::I wanted to avoid “fuller” (doesn’t work grammatically) and “original”. But “shorter” and “longer” would have been better alternatives. ] (]) 02:10, 24 November 2022 (UTC) | |||
::::{{tq|“Behavioral factors seemed to have more of an effect on HIV prevention than circumcision” isn’t a strawman argument. It is a statement that KNMG ties into their view, that circumcision does not have a significant effect on national HIV prevalence, between the different countries.}} | |||
:::Well, it's both. The sub-argument/proof being advanced by the KNMG towards the larger interpretation here is that "other factors exist which have a bigger impact". But researchers advancing evidence of the empirically observable effect of circumcision on likelihood of infection aren't contesting that, and it simply doesn't serve to impact the findings about physiological, biophysical effects observed in the research on individual transmission, even if the cost-benefit in different regional contexts were brought into question by the general medical establishment--it's a red herring with regard to what consensus conclusions have been reached, or more formally a ]. And we in our discretion as to considering ] have to decide if it is worth including in our summary of statements and positions which describe the bounds of the academic debate on this issue, per ]: not everything verifiable is necessary or advisable for inclusion, and I just don't think this statement is. | |||
::::{{tq|“The relationship between HIV transmission and circumcision was unclear” is not undue, when you read the entire paragraph, which adds context to that statement.}} | |||
:::Well, I just re-read the section, and I still find that, again, though I would not describe the complete position as summarized as really FRINGE, as some have described, this is surely the most fringe-leaning element of the KNMG position presented here. It's at best a half-accurate summary of the state of research: the existence of a direct statistical (and statistically relevant) relationship is generally agreed upon by the scientific establishment examining this issue. The degree of the effect, however, is a little more subject to disagreement. Again, this is a matter of ], and these calls aren't super obvious: I would define this as a "reasonable minds may vary" area of the topic, and we are after all talking about an attributed set of statements. Nevertheless, I still think this is dead weight and more likely to muddy the waters than to clarify the present state of research for the reader. | |||
::::{{tq|Questioning the applicability of those studies to developed countries makes sense for two reasons: MSM HIV rates vs. Men who have sex with women and considering that the predominant HIV strain is different in Africa vs. other parts of the world. I’m not going to try to interpret their reasoning, but the KNMG’s argument here, does not seem far off from the mainstream view on generalizability to developed countries.}} | |||
:::Sure, I mean, again, it's a close call, but that's why I come down the way I do on the rest of the content and support its inclusion, even though it requires asking the reader to parse a fine distinction regarding personal infection risk in the individual physiological context and the epidemiological risk on the population scale. But under a weight analysis, I can't support all of the proposed content as due. | |||
::::{{tq|I wanted to avoid “fuller” (doesn’t work grammatically) and “original”. But “shorter” and “longer” would have been better alternatives.}} | |||
:::I mean, I almost didn't mention it: it's not like its a big enough effect to really throw the discussion, but I thought it and the other matter with the framing (and probably that one somewhat more so) were still worth bearing in mind. '']]'' 03:02, 24 November 2022 (UTC) | |||
*'''Shortened version''' largely per {{u|Snow Rise}}. The long version is undue and needlessly takes Misplaced Pages into fringey territory. ] (]) 06:27, 24 November 2022 (UTC) | |||
*'''Full version''' – It's better since it makes it clear why the Royal Dutch Medical Association took its position, and gives context for this minority position. Studies from the developing world are not always directly applicable to Western countries because of differences in wealth and behaviour. (The cost and ease of purchasing condoms, condom usage rates, sexual practices, preventative medication, access to clean water, etc. can all play a much larger role in HIV prevention; and thereby, swamp out any physiological benefits of circumcision. There is also the possibility that circumcised individuals could get a false sense of security from getting HIV, which would in fact result in risky sexual behaviour, which led to higher chances of HIV in comparison to a more cautious uncircumcised individual.) The full version makes it clear that what is important for the KNMG is empowering the individual with a toolkit of HIV preventing options that the person can chose from to avoid HIV infection. --] (]) 14:31, 24 November 2022 (UTC) | |||
*'''Full version''', simply because it gives a much clearer understanding of KNMG's position. Per ], it seems clear that KNMG's position is a significant viewpoint, not a FRINGE one. —] (] '''·''' ]) 10:37, 25 November 2022 (UTC) | |||
* '''Full version''', per Prcc27 ] (]) 19:17, 25 November 2022 (UTC) | |||
* '''Shortened version - lean''' - Per SnowRise. I don't have an objection to ''including'' objections to extending the findings to developed countries. That's something that is mainstream (if not a majority view) within the scientific and medical communities. However, the 2010 KNMG statement was released ''before'' a consensus in the scientific community was established. There's almost no major, respected medical organization or even doctor today (as of 2022) that would state that VMMC doesn't reduce HIV transmission from HIV positive women to men in high risk populations. Questions of consent/ethics when it's done on minors (EIMC programs) are ''mainstream''. Denying that vol. male circumcision in high-risk areas doesn't reduce transmission is ] and is outdated. '''The KNMG statement saying it is uncertain that circumcision reduces the incidence of HIV transmission in high risk populations was written in (and before) 2010. A scientific consensus on the matter didn't emerge until ~2011-2013.''' | |||
: Some users have attempted to draw parallels with similar quotations dating back to the late-2000s/early-2010s in the article - such as the WHO or AAP - but this is an inaccurate comparison. | |||
:The large majority of these statements have been reiterated. (e.g. {{tqi|In 2020, WHO again concluded that male circumcision is an efficacious intervention for HIV prevention and that the promotion of male circumcision is an essential strategy}}.) The WHO first recommended it in 2007. '''It reiterated its recommendation in 2020.''' The KNMG position should be expanded, in my opinion. But denying a link between circumcision and HIV transmission in high risk areas is indisputably fringe, and it would be wrong for the article to include it. ] (]) | |||
:: As I mentioned above - other sources have made similar statements. | |||
:: ''Sharma, et al. (2021)'' states: {{tqi|MC is... strongly supported by the data from three large RCTs conducted in Africa}} right before that. It directly mentions the three RCT trials as part of the {{tqi|"overwhelming evidence"}} for circumcision in high risk contexts. | |||
:: '''' states: {{tqi|all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.}} | |||
::'''' states: {{tqi|Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.}} | |||
:: '''In 2011,''' '''' states: {{tqi|'''Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas'''}} | |||
:: ''Holmes, Bertozzi, & Bloom (2017)'' states: {{tqi|Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).}} | |||
:: ''Piontek and Albani, (2019)'' states: {{tqi|Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.}} | |||
:: ''World Health Organization (2020)'' states: {{tqi|The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs}}. | |||
:: And so on and so forth. There's numerous other metastudies and/or major medical organizations — easily findable online — that call the three RCTs provide "overwhelming", "very strong", or "strong" evidence. In the context of ''high-risk populations'', anything to the contrary is a fringe perspective at this point. | |||
:: '''It wasn't a fringe statement in 2010. It is now. It shouldn't be included in the article.''' ] (]) 16:18, 22 December 2022 (UTC) | |||
*'''Short''' KNMG is not a mainstream global source so hardly merits attention anyway, 2010 was a long time ago and if this was an issue about which they cared they would have reiterated it, and the longer statement is prone to misinterpretation. ]] 15:39, 22 December 2022 (UTC) | |||
* '''Short'''. Assuming for the sake of argument that the KNMG statement is further on the "significant minority view" side of the spectrum than on the "fringe" side, the short version is still better. The length of the summary outweighs significant majority sources like the most current meta-analysis. And the added content is not particularly on-topic or useful. {{blist|The whole bit about the "unclear" relationship" is evident from the short version|"behavioral factors" is obviously true, to the point of uselessness | I have no quarrel with "several Dutch medical associations" and would be fine with adding that into the short version. Maybe something like {{tqd|"the Royal Dutch Medical Association (KNMG) and seven other Dutch medical associations ..."}}}} Both versions do not make it clear enough that the KNMG recommendation is focused on male minors. I'd suggest tweaking to {{tqd|"Circumcision of male minors has not been ..."}}. Assuming I get no takers on my suggestions, I'd still support the short version over the long. ] (] / ]) 06:05, 4 January 2023 (UTC) | |||
**I obviously support including the part about several Dutch medical associations endorsing the KNMG viewpoint. That is clearly better than the shorter version. ] (]) 22:40, 4 January 2023 (UTC) | |||
== RfC closure == | |||
Note I have raised a query about the just-closed RfC above, at ]. Also note that {{u|OntologicalTree}} is going beyond the RfC decision to edit-war content into the lede calling the established science into question. ] (]) 16:36, 1 January 2023 (UTC) | |||
* And now {{u|KlayCax}} is compounding the problem. A minor source from 2010 cannot be used to undercut weighty sources from more recent years. Furthermore for statements about "consenus" in science the high bar of ] sourcing is needed. ] (]) 17:05, 1 January 2023 (UTC) | |||
:: Apologies. I haven't been involved in this RFC that much. (Until after 30 days were passed on it: Which I wasn't aware of until I checked watchlist.) | |||
:: I was under the presumption that {{re|OntologicalTree}}'s edits were in line with the results of the RFC. {{re|Bon courage}}. You as well as anyone knows my position on the matter . | |||
:: In my opinion, the edits from {{re|Prcc27}} and {{re|OntologicalTree}} should probably be kept until someone reviews Trykid's closure. However, the RFC definitely needs to be reviewed. There was nowhere near a consensus on the matter. Most of the quality responses (such as {{re|User:Snow Rise}}'s) were directly ''against'' the RFC's results. ] (]) 17:12, 1 January 2023 (UTC) | |||
::: Svoboda and Van Howe's comments are definitely ]'y, though. They should be removed under either scenario. ] (]) 17:13, 1 January 2023 (UTC) | |||
:::: The RfC was tightly asking about whether to adopt one or other specific versions of text, it did not give cart blanche to insert fringe positions into the lede. I agree the close was poor. ] (]) 17:15, 1 January 2023 (UTC) | |||
::::: I agree. It's just that a narrow interpretation of the RFC closure ''brings its own problems''. (Or at least invites clarification) How is it ] to state that the Royal Dutch Medical Association denies/doubts a linkage between circumcision '''and''' there's a consensus on the matter that it does? | |||
::::: At the very least — for the average viewer — a narrow interpretation of the RFC leads the article into being: 1.) Not very clear 2.) Self-contradicting. ] (]) 17:28, 1 January 2023 (UTC) | |||
::::::We state the current accepted science. And we state what this minor medical body had as a "viewpoint" 13 years ago. There's no contradiction. ] (]) 17:35, 1 January 2023 (UTC) | |||
::::::: It may not be a contradiction. At the very least, it's extensively confusing and unclear to the average reader. | |||
::::::: Exactly why: 1.) The RFC was wrongly decided 2.) It's ]. 3.) Shouldn't be in the article. {{re|Bon courage}}. ] (]) 17:41, 1 January 2023 (UTC) | |||
*'''Propose compromise - remove in 2024 if no updated source''' Both sides cannot have their way at this, but RfCs need to close somehow. Per ] when a source is more than 5 years old then it is usually out of date. For this topic plenty of recommendations are published every year, and for this view, there is one respected publication from 13 years ago. I say keep the content in the article through 2023 to give anyone time to find a newer source. If no one finds one in the next year, then remove it without additional discussion in 2024. If this information is worth stating then giving all the medical organizations in the world 14 years to come up with something is long enough, especially when Misplaced Pages's standard is 5 years. ]] 20:54, 1 January 2023 (UTC) | |||
**The longer version of the KNMG paragraph, has been the consensus for the past few years. MEDDATE concerns did come up when I first proposed including the KNMG viewpoint, but we decided that MEDDATE did not apply, because the recommendations were being portrayed as a KNMG-specific viewpoint, not an indisputable scientific fact. Yes there are newer sources, but many of the newer sources are not as comprehensive as some of the most prominent sources during the 2010ish time period (e.g. old AAP and WHO statements). ] (]) 05:55, 4 January 2023 (UTC) | |||
**:The consensus version was as was at the start of the RfC. Per ] for inclusion of disputed content, consensus is needed. ] (]) ] (]) 08:14, 4 January 2023 (UTC) | |||
**::Prior to you and Petersmillard reverting me, consensus on the talk page had been established in favor of including the KNMG viewpoint. Yes ], but it was a consensus nonetheless. ] (]) 22:51, 4 January 2023 (UTC) | |||
**:::There was never consensus for your long version, and the article has existed without it for most of its existence. Inclusion of disputed content needs consensus. Bottom line: the long version is not going in without an RfC establishing that it belongs. ] (]) 07:23, 5 January 2023 (UTC) | |||
**::::I obviously disagree. There was a consensus at the talk (even if weak consensus), and a consensus through editing. “My” long version was written with the collaboration of other users, it was not written unilaterally. This RfC has not been resolved yet, although it looks like “no consensus” will be the end result. But I think we should at least explore Blueraspberry’s compromise proposal and see if we can get a consensus on that. ] (]) 20:28, 5 January 2023 (UTC) | |||
**:{{ping|Prcc27}} It has been 13 years. Can you give a personal opinion of how long you expect this publication to be relevant? Are you thinking 15, 20, 30 years? To me this seems like a statement where anticipating an expiration date is a reasonable direction for conversation. ]] 16:25, 4 January 2023 (UTC) | |||
**::I do not have a ]. I support including the longer version, even if that means having an expiration date as a compromise. But I do not think MEDDATE mandates an expiration date. ] (]) 22:47, 4 January 2023 (UTC) | |||
**Thank you, Bon Courage. The current version is the appropriate one. It does acknowledge the Dutch statement, which is a clear outlier which contradicts WHO, CDC, and every other consensus statement. But it doesn't put it above the CDC statement (as it was previously) or give it a separate paragraph. ] (]) 15:52, 4 January 2023 (UTC) | |||
Prcc27 says that | |||
The KNMG circumcision policy statement was endorsed by several Dutch medical associations. The policy statement was initially released in 2010, but was reviewed again and accepted in 2022." However, there is no reference for the "reviewed again in 2022." Where is this documented? ] (]) 00:38, 30 May 2023 (UTC) | |||
*{{reply|Petersmillard}} Thank you for bringing this concern to the talk, I updated the source. ] (]) 01:26, 30 May 2023 (UTC) | |||
::Well, it looks like this RfC still is not resolved. Since KNMG reaffirming their 2010 policy by saying "the above documents were reviewed in March 2022: content is still correct" wouldn't this make the ] concerns moot? Is there anyone in the shorter summary camp that would like to change their !vote to the longer summary, in light of this information we did not have at the beginning of the RfC? {{ping|SMcCandlish}}{{ping|ClydeFranklin}}{{ping|BogLogs}}{{ping|Snow Rise}}{{ping|Bon courage}}{{ping|Guest2625}}{{ping|Mx. Granger}}{{ping|A455bcd9}}{{ping|KlayCax}}{{ping|Bluerasberry}}{{ping|Firefangledfeathers}}{{ping|Petersmillard}} ] (]) 01:26, 30 May 2023 (UTC) | |||
:::FWIW, my position on this hasn't shifted: it's a minority viewpoint but from a major medical organization, and now that they've reaffirmed their position in 2022, its relevance is renewed. <span style="white-space:nowrap;font-family:'Trebuchet MS'"> — ] ] ] 😼 </span> 01:44, 30 May 2023 (UTC) | |||
:::With that update, the case for including the longer summary is stronger. We should include the longer summary, possibly adjusted to mention that KNMG reaffirmed their position in 2022. —] (] '''·''' ]) 02:23, 30 May 2023 (UTC) | |||
::::Mx. Granger, it probably makes sense in a situation like this, when you are responding to a post that ends with the express question {{tq|"Is there anyone in the shorter summary camp that would like to change their !vote to the longer summary?"}}, to flag in your response (calling for a change) that you were actually someone who supported a longer version in the previous !vote as well. Otherwise people might assume that you were one of the people specifically being queried and interpret your response as a change in the balance of the perspectives, when it isn't. '']]'' 05:33, 30 May 2023 (UTC) | |||
:::::Apologies for the lack of clarity – I supported the longer version before, and with this update I think the case for the longer version is even stronger. —] (] '''·''' ]) 13:12, 30 May 2023 (UTC) | |||
:::My perspective also hasn't changed and I still favour the short version, all factors considered: in the original instance, I did not view the dated nature of the source as a major issue militating against it's use, so my previous !vote is already balanced in that respect. And I don't see much in the other !votes which suggest this was a major issue for other respondents. I mean, either the source is in date and worth using in general or it isn't. It's datedness is unlikely to be an issue for supporting some MEDRS content but not others. Rather, the !votes seemed to mostly focus on whether or not particular claims were fringe or due, and this detail of the org's support being "renewed" (for whatever that's worth) doesn't really impact the ] analysis upon which the support for a shorter version generally relied. '']]'' 05:28, 30 May 2023 (UTC) | |||
:::It inclines me to prefer the short version over deletion. ] (]) 05:31, 30 May 2023 (UTC) | |||
::::Yeah, that's probably the best way to describe my take as well. I always thought of the shorter version as the reasonable middle ground solution between three options. There's something to discuss here, but there's a fair bit of nuance needed to insert any of it, even in the form of attributed statements, without creating false balance and unsettling our discussion of the subject by untethering it from ]. I feel like there was already a fair bit of effort put into sorting out what content was useable and what was not, and taking another bite at that apple on account of this very trivial change in the posture of the sourcing is probably not going to lead to any improvement. '']]'' 05:42, 30 May 2023 (UTC) | |||
::: I still think the short version is better, and my reasons for thinking so were not significantly tied to the MEDDATE concerns. ] (] / ]) 15:43, 30 May 2023 (UTC) |
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Undue lead paragraph
- “An association between circumcision and reduced heterosexual HIV infection rates was first suggested in 1986.”
- Problematic wording. Who made the suggestion in 1986? If a random person made the suggestion in 1985, would that negate this sentence..?
- “Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy”
- Source seems too old. Possibly WP:POV for not mentioning concerns about the trials stopping too early.
- ”WHO assessed these as ‘gold standard’ studies and found ‘strong and consistent’ evidence from later studies that confirmed the results of the three RCT trials.”
- ”A scientific consensus subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.”
- Redundant; already covered by the first sentence in the lead. Prcc27 (talk) 03:04, 8 September 2022 (UTC)
"Source seems too old"
What citation in particular is too old? The citation is recounting the historical background of the studies. It's not something that needs to be updated. The main sources in the lead are from 2017 and 2021 respectively. Both are extraordinarily recent. I'm uncertain what this is in reference to.
Possibly WP:POV for not mentioning concerns about the trials stopping too early
It would be WP:POV to include it: as there is an overwhelming consensus among mainstream sources that circumcision is efficacious in the prevention of HIV in high risk populations. This has already been discussed a few months ago with @MrOllie: and @Alexbrn:. As Merson and Inrig (2017) states:"This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence"
and Sharma et al. (2021) states:There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1
. WP: Due only applies whenIf a viewpoint is held by a majority ... significant minority...
There isn't a significant minority that denies that it is efficacous in that context. The main debate over circumcision within the medical literature is predominately: 1.) The ethics of it being routinely performed without the individual's consent (instead of parents or other guardians) 2.) Whether these same benefits apply as significantly and/or counteracted by risks in developed nations. The mention of the debate in that context is preserved in the lead. This article is overwhelmingly about circumcision that is performed on heterosexual men in areas of high, endemic HIV transmission. KlayCax (talk) 05:32, 10 September 2022 (UTC)
- The early cessation of the trials is not about history. I am sure you can find a newer source that analyzes the reason for why the trials should have/should not have been ended prematurely; your source was from 2009. Prcc27 (talk) 04:22, 11 September 2022 (UTC)
- Siegfried, et al. (2009) is simply used in the reference for the statement:
"Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda"
That's not a fact that's going to change over time. Outdated sources don't apply in that context, @Prcc27:. Siegfried, et al. (2009) is not being used to summarize current consensus.
- Siegfried, et al. (2009) is simply used in the reference for the statement:
- Merson and Inrig (2017) states:
"This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence"
. Sharma et al. (2021) states:There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1
.WP: Due only applies whenIf a viewpoint is held by a majority ... significant minority...
. But every major medical association — including those in non-Anglophonic Europe — state that it is efficacious against the spread of HIV/AIDS in poor, high risk contexts. Both Merson and Inrig (2017) and Sharma et al. (2021) are under five years old.
- Merson and Inrig (2017) states:
- We've had repeated discussions on the circumcision talk page with consensus on this matter: that it would only become undue if a major medical organization (or World Health Organization) denied that it was efficacious. As @MrOllie: stated on this very topic a few days ago:
we going to undermine the well established consensus of mainstream medical science based on a few people publishing in questionable journals
. WP: Undue doesn't mean the promotion of fringe theories denying a link in high risk populations. (Where heterosexually transmitted HIV/AIDS is common and the predominant form of transmission.) The disputed efficacy of it in developed nations is already covered. KlayCax (talk) 06:25, 11 September 2022 (UTC)- No, that is not the only sentence that the old source was used for. That source was also used for the “All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy” sentence. This is WP:UNDUE. Also, please make sure you are careful about tagging users on talk pages– it can be seen as a violation of WP:CANVASS. Prcc27 (talk) 07:03, 11 September 2022 (UTC)
- Once again, “This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence” is redundant. We do not need to say essentially the same thing twice in the lead.. Prcc27 (talk) 07:12, 11 September 2022 (UTC)
- We've had repeated discussions on the circumcision talk page with consensus on this matter: that it would only become undue if a major medical organization (or World Health Organization) denied that it was efficacious. As @MrOllie: stated on this very topic a few days ago:
“No, that is not the only sentence that the old source was used for. That source was also used for the “All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy”
What's problematic with it? Were the three RCT's not stopped early by their monitoring boards? There's nothing problematic about citing it from there.- WP:UNDUE doesn't apply to fringe viewpoints: only those with a majority/significant minority following. Merson and Inrig (2017) states:
"This led to a consensus that male circumcision should be a priority for HIV prevention in countries and regions with heterosexual epidemics and high HIV and low male circumcision prevalence"
. Sharma et al. (2021) states:There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1
.WP: Due only applies whenIf a viewpoint is held by a majority ... significant minority...
. But every major medical association — including those in non-Anglophonic Europe — state that it is efficacious against the spread of HIV/AIDS in poor, high risk contexts. Both Merson and Inrig (2017) and Sharma et al. (2021) citations are under five years old. It's a violation of WP: Undue to include fringe viewpoints. Also, please make sure you are careful about tagging users on talk pages– it can be seen as a violation of WP:CANVASS.
Both @MrOllie: and @Alexbrn: have been directly involved in conversations with you surrounding this topic on this article's talk page and on circumcision's. WP:CANVASS doesn't apply here. I tagged others previously involved with this discussion because there's not going to be an established resolution to this otherwise. (Outside of the RfC's already performed on the issue and how consensus should be characterized) There's already been a RfC on the circumcision talk page establishing a consensus on the matter among heterosexuals in high-risk, undeveloped contexts. But I'll tag @TiggyTheTerrible: as well. A discussion on this matter has already taken place. If a major medical organization (such as the British Medical Association, American Academy of Pediatrics, World Health Organization, et al.) denies a link between HIV and circumcision in high risk contexts, feel free to start another RfC on it. (And in that circumstance I think a dissenting view on the matter should be included.) Merson and Inrig (2017)'s quote is only five years old. Sharma et al. (2021)s quote stating a consensus is only a year old.
We do not need to say essentially the same thing twice in the lead
A consensus didn't emerge until after the three RCT's (and subsequent history.) Before then, there was widespread open debate among the scientific community over whether it was efficacious. That's why the sentence is there. It establishes what the consensus is based upon. However, I don't have a really significant opinion on the matter either way. We can keep it removed from the lead if preference. KlayCax (talk) 04:29, 13 September 2022 (UTC)
- Tagging @Prcc27: KlayCax (talk) 04:30, 13 September 2022 (UTC)
- You are trying to state an ethical view as factual: “hence that it would be unethical to withhold the treatment”. Not to mention, non-therapeutic circumcision isn’t “treatment”, it is often seen as “prevention” though. It is definitely WP:UNDUE/WP:POV to use an old source to say there is “overwhelming evidence of prophylactic efficacy.” Prcc27 (talk) 05:00, 13 September 2022 (UTC)
You are trying to state an ethical view as factual: “hence that it would be unethical to withhold the treatment”.
It's widespread in medical ethics to end studies early in those types of situations. Within context, it's clearly referring to the study's author's and monitor boards concluding it. Something such asHence that it would be unethical to withhold the treatment by the monitoring board(s)
could easily be added unto it. KlayCax (talk) 06:12, 13 September 2022 (UTC)Non-therapeutic circumcision isn’t “treatment”, it is often seen as “prevention” though.
"Treatment" is widely used in the context of clinical trials and is a verbatim wording of what the sources state. It meets the criteria for the word.It is definitely WP:UNDUE/WP:POV to use an old source to say there is “overwhelming evidence of prophylactic efficacy.”
Recent sources such as Merson and Inrig (2017) and Sharma et al. (2021) (as mentioned above) as well as major medical organizations universally state the same. WP:UNDUE/WP:POV doesn't apply.- Tag, @Prcc27:. KlayCax (talk)
- ”Consensus” and “overwhelming evidence” are two very different things. Also, it is not a universal consensus among major medical organizations, if you recognize the Royal Dutch Medical Association as a major medical organization. Prcc27 (talk) 14:59, 13 September 2022 (UTC)
- FFS, we're not going to do this *again* are we. I return to this page after a long hiatus and see the same POV pushing. As has previously been stated by others, the view that circumcision does not reduce the risk of HIV is a fringe view per Misplaced Pages policy. We are not going to indulge fringe views. That circumcision reduces HIV risk in certain circumstances is established medical fact. Bon courage (talk) 15:46, 13 September 2022 (UTC)
- As stated in a previous discussion, there is a difference between a “fringe viewpoint” and a significant minority viewpoint. Just because a view is in the minority, does not automatically make it fringe. Prcc27 (talk) 17:34, 13 September 2022 (UTC)
- @Prcc27 I don't know if you've seen one, but this goes into why the African trials were suspect - if not outright fraudulent. https://www.researchgate.net/publication/272498905_Sub-Saharan_African_randomised_clinical_trials_into_male_circumcision_and_HIV_transmission_Methodological_ethical_and_legal_concerns Tiggy The Terrible (talk) 07:12, 13 September 2022 (UTC)
- Also, worth mentioning that since most doctors outside the USA/Africa think circ should NOT be routine, the APA guidelines on this would qualify as fringe in a lot of places. So I think we should be careful about that word. Tiggy The Terrible (talk) 17:47, 13 September 2022 (UTC)
- 1) Any paper from 'Doctors Opposing Circumcision' is suspect itself. The authors have no relevant expertise. 2) The question here is not whether circumcision should be routine, it is whether it reduces HIV infection rates. The position that it doesn't is clearly fringe. MrOllie (talk) 16:14, 14 September 2022 (UTC)
- Also, worth mentioning that since most doctors outside the USA/Africa think circ should NOT be routine, the APA guidelines on this would qualify as fringe in a lot of places. So I think we should be careful about that word. Tiggy The Terrible (talk) 17:47, 13 September 2022 (UTC)
- @Prcc27 I don't know if you've seen one, but this goes into why the African trials were suspect - if not outright fraudulent. https://www.researchgate.net/publication/272498905_Sub-Saharan_African_randomised_clinical_trials_into_male_circumcision_and_HIV_transmission_Methodological_ethical_and_legal_concerns Tiggy The Terrible (talk) 07:12, 13 September 2022 (UTC)
- As stated in a previous discussion, there is a difference between a “fringe viewpoint” and a significant minority viewpoint. Just because a view is in the minority, does not automatically make it fringe. Prcc27 (talk) 17:34, 13 September 2022 (UTC)
This discussion is partly about whether the evidence is “overwhelming”. I think that is a problematic and POV word to use. “Strong” would probably be a better alternative. Although I still am not sure the information about the trials belongs in the lead.. Prcc27 (talk) 17:35, 14 September 2022 (UTC)
I think that is a problematic and POV word to use.
It's not a violation of NPOV to reproduce what major medical organizations and multiple metastudies have uniformly concluded (including those referenced above): as @MrOllie: and @Alexbrn: have also mentioned. The wording would only be problematic if amajority or significant minority
denied that viewpoint. They don't.
- If their positions are modified or new evidence emerges: of course that the lead could be altered.
Not sure about the trials belongs in the lead
There was no scientific consensus that circumcision prevented HIV/AIDS before those three RCT's. KlayCax (talk) 22:44, 15 September 2022 (UTC)
- Which sources use the term “overwhelming”? How old are those sources? Prcc27 (talk) 20:40, 16 September 2022 (UTC)
- Sharma, et al. (2021) uses it :
"There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1."
There's other numerous verbatim examples — all within the past five years — from medical journals, major medical organizations, et cetera on the issue, dating back to at least 2008. Any objections to restoration, per this conversation and previous (and repeated) RfC consensus, @MrOllie: or @Alexbrn:? KlayCax (talk) 03:28, 18 September 2022 (UTC)- Your proposed wording for the lead talks specifically about the African trials. That quote you just cited says nothing about the trials. Using that source for what you’re proposing would be a violation of WP:OR. You do not need to tag those users, I am sure they are already following along and reading this discussion. Plus, I still feel like it comes off as canvassing. Prcc27 (talk) 04:45, 18 September 2022 (UTC)
- Sharma, et al. (2021) uses it :
That quote you just cited says nothing about the trials
Sharma, et al. (2021) states:MC is... strongly supported by the data from three large RCTs conducted in Africa
right before that. It directly mentions the three RCT trials as part of the"overwhelming evidence"
for circumcision in high risk contexts.
- Scientific American (2008) states:
all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.
- Scientific American (2008) states:
- Thomas, et al. (2011) states:
Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.
- Thomas, et al. (2011) states:
- Lie and Miller (2011) states:
Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas
- Lie and Miller (2011) states:
- Holmes, Bertozzi, & Bloom (2017) states:
Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).
- Holmes, Bertozzi, & Bloom (2017) states:
- Piontek and Albani, (2019) states:
Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.
- Piontek and Albani, (2019) states:
- World Health Organization (2020) states:
The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs
.
- World Health Organization (2020) states:
- And so on and so forth. There's numerous other metastudies and/or major medical organizations — easily findable online — that call the three RCTs provide "overwhelming", "very strong", or "strong" evidence. In the context of high-risk populations, anything to the contrary is a fringe perspective at this point. KlayCax (talk) 06:06, 18 September 2022 (UTC)
- Exactly. “Strong” is one of the words used to describe the RCTs. There is no reason to use “overwhelming”, in light of more accurate terms. Significant minority viewpoints are not “fringe”. We’ve all made ourselves clear whether we think it is fringe or not; I see no point in continuing to argue about this, especially since it has little to do with the “strong” vs. “overwhelming” issue. Prcc27 (talk) 12:53, 18 September 2022 (UTC)
- "Strong" and "overwhelming" isn't a contradiction.
Significant minority viewpoints
Which, as established, doesn't apply here.We’ve all made ourselves clear whether we think it is fringe or not
Multiple RfC's have as well. KlayCax (talk) 22:00, 18 September 2022 (UTC)- We've had numerous, multiple RFC's on circumcision and this article's talk page about it: all with a similar consensus. Saying that
a significant minority
of researchers deny a link between HIV/AIDS transmission in circumcision in high-risk contexts (heterosexual transmission) is obviously wrong: as major medical organizations such as the WHO/UNAIDS and all the above sources state. If you're not going to going to participate in discussion: I'm going to add it back unless a new RfC about the matter concludes otherwise. (Since multiple RFC's on the matter have all concluded uniformly the same.)
- We've had numerous, multiple RFC's on circumcision and this article's talk page about it: all with a similar consensus. Saying that
- Given the multitude of sources listed above, it shouldn't be an article of dispute. KlayCax (talk) 22:12, 18 September 2022 (UTC)
- If you actually read the RFCs on this talk page, you would see that there actually was no consensus on whether that view qualifies as “fringe” or a “significant minority viewpoint”. I did not say I would not participate in discussion..? I pretty much said you are wasting our time by focusing on something that is not relevant to the merits of the issue, but in a more civil way. A lot of your information is already in the body paragraphs of this article, but there seems to be no consensus to make the lead disproportionately about the African trials. Consensus that the African trials have “strong” (or even “overwhelming”) evidence ≠ consensus to add that information into the lead. Prcc27 (talk) 22:55, 18 September 2022 (UTC)
- Given the multitude of sources listed above, it shouldn't be an article of dispute. KlayCax (talk) 22:12, 18 September 2022 (UTC)
Outdated/fringe POV
Prcc27 evidently wants to re-insert this 2010 "viewpoint" material. It's WP:UNDUE and a bit fringey so this would harm the article I think. Bon courage (talk) 05:09, 6 October 2022 (UTC)
- I am okay with cleaning up older content, but I feel this would be problematic to the section if newer recommendations are lacking or not as thorough as older recommendations. Keep in mind, we actually have older content than the KNMG viewpoint in that paragraph right now (from 2007). We have had the fringe argument many times on this talk page before, and there was never a consensus to treat KNMG as “fringe”. There was a split view about whether their viewpoint is “fringe” or a “significant minority viewpoint”. Regardless, the original consensus has not changed thus far. Prcc27 (talk) 05:18, 6 October 2022 (UTC)
- I'm not see any justification, or even argument, for inserting this content (and yes, there is yet more old cruft that needs removing too). It's just an outdated unimportant fringey view. Is there anything at all in its favour? Bon courage (talk) 05:34, 6 October 2022 (UTC)
- As stated in prior discussions, it is important to include recommendations from around the world, and to include significant minority viewpoints. The debate around the timing of circumcision and comparing and contrasting circumcision vs. other prevention methods is something the KNMG touches on, as well as something the other recommendations touch on. It is okay to use older sources when newer sourcing is lacking, as evident by the AAP (2012) and WHO (2007) sources being included currently. Prcc27 (talk) 05:51, 6 October 2022 (UTC)
- I don't think we can undercut established science with fringe views. Those prior discussions never got anywhere anyway. We've already got some KNMG/Dutch stuff now. That's enough (maybe too much and should go too?). Bon courage (talk) 05:56, 6 October 2022 (UTC)
- The consensus was/is for KNMG to be included. The raw science belongs in the other sections. The recommendations section should show readers different perspectives on how the science should be applied. Prcc27 (talk) 06:21, 6 October 2022 (UTC)
The consensus was/is for KNMG to be included
← don't think so. Where was this "consensus" assessed and recorded? If you want something like that maybe start an RfC if this thread doesn't result in something clear-cut. Bon courage (talk) 06:26, 6 October 2022 (UTC)- View the archives. Start with the “2013 position paper of small Dutch medical organization - WP:MEDDATE and WP:REDFLAG” and “Recommendations section”. MEDDATE & MEDRS concerns were addressed there. Prcc27 (talk) 22:08, 6 October 2022 (UTC)
- I don't think there was ever a consensus to include KNMG. Prcc27 has just spoken more loudly than anyone else and threatened others who disagreed with his viewpoint. The fact remains that KNMG is an outlier and encyclopedias do not exist to give equal space to outliers. The AAP, ACOG, and CDC recommendations are mainstream, consistent with WHO recommendations, and that should be the end of it. Petersmillard (talk) 19:50, 6 October 2022 (UTC)
- You’re welcome to view the archives, there were others on board with KNMG. Also, I never threatened anyone. Please quit spreading lies! Prcc27 (talk) 22:03, 6 October 2022 (UTC)
- The consensus was/is for KNMG to be included. The raw science belongs in the other sections. The recommendations section should show readers different perspectives on how the science should be applied. Prcc27 (talk) 06:21, 6 October 2022 (UTC)
- @Prcc27 WHO sources were updated to 2020 and CDC/AAP/ACOG reconditions haven't changed 74.75.197.221 (talk) 21:05, 6 October 2022 (UTC)
- There is a 2007 WHO quote in the article, and the expired AAP viewpoint is from 2012. Prcc27 (talk) 22:02, 6 October 2022 (UTC)
- IP is Petersmillard just in case anyone is confused. Prcc27 (talk) 22:12, 6 October 2022 (UTC)
- I don't think we can undercut established science with fringe views. Those prior discussions never got anywhere anyway. We've already got some KNMG/Dutch stuff now. That's enough (maybe too much and should go too?). Bon courage (talk) 05:56, 6 October 2022 (UTC)
- As stated in prior discussions, it is important to include recommendations from around the world, and to include significant minority viewpoints. The debate around the timing of circumcision and comparing and contrasting circumcision vs. other prevention methods is something the KNMG touches on, as well as something the other recommendations touch on. It is okay to use older sources when newer sourcing is lacking, as evident by the AAP (2012) and WHO (2007) sources being included currently. Prcc27 (talk) 05:51, 6 October 2022 (UTC)
- I'm not see any justification, or even argument, for inserting this content (and yes, there is yet more old cruft that needs removing too). It's just an outdated unimportant fringey view. Is there anything at all in its favour? Bon courage (talk) 05:34, 6 October 2022 (UTC)
RfC: Is there a consensus surrounding circumcision and HIV + should it be in lead?
FAILED PROPOSAL Procedural self-close due to improper formatting of the RfC. Will reopen as another RFC per recommendation by User:Snow Rise. Please check back in a few days after the formatting is fixed. Thanks! KlayCax (talk) 04:35, 12 October 2022 (UTC)The following discussion is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
The two questions asked are:
- Is there a general consensus in the scientific community that circumcision reduces HIV/AIDS transmission in high-risk contexts: particularly sub-Saharan Africa?
- Is the strikethroughed material WP: DUE for the the lead? (e.g. version #1) In particular, the wording that has been struckthrough by Prcc27: who argues there is a substantive debate in the scientific community over the issue of circumcision's prophylactic effects against HIV/AIDS in the context of high risk populations?
Leading to the question:
- Which version is the best? Version #1, #2, or #3?
KlayCax (talk) 16:25, 7 October 2022 (UTC)
There has been a dispute among editors on whether the article should portray (medically performed) circumcision's prophylactic effect on HIV/AIDS transmission in high-risk contexts — in particular, sub-Saharan Africa — as a general consensus among scientists and how the lead should cover it. The full details of which can be seen in the edit history of the article and in the talk page above.
Per usual formatting: Text that has been deleted in each version of the lead is strikethroughed like this. Text that is added is bolded like this.
Male circumcision reduces the risk of human immunodeficiency virus (HIV) transmission from HIV positive women to men in high risk populations.
The first academic paper suggesting a protective association between circumcision and reduced heterosexual HIV infection rates was published in 1986. Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence it was concluded that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy. WHO assessed the trials as "gold standard" studies and found "strong and consistent" evidence from later studies that confirmed the results of the three RCT trials. A scientific consensus since subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.
In 2020, the World Health Organization (WHO) reiterated that male circumcision is an efficacious intervention for HIV prevention if carried out by medical professionals under safe conditions. Circumcision reduces the risk that a man will acquire HIV and other sexually transmitted infections (STIs) from an infected female partner through vaginal sex. The evidence regarding whether circumcision helps prevent HIV is not as clear among men who have sex with men (MSM). The effectiveness of using circumcision to prevent HIV in the developed world is not determined.
Version #2 (original Prcc27's edit; deleting the lead paragraph, portraying the scientific community as divided on the issue): (See here for edit summary/justification.)
There is evidence that male circumcision reduces the risk of human immunodeficiency virus (HIV) transmission from HIV positive women to men in high risk populations.
The first academic paper suggesting a protective association between circumcision and reduced heterosexual HIV infection rates was published in 1986. Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence it was concluded that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy. WHO assessed the trials as "gold standard" studies and found "strong and consistent" evidence from later studies that confirmed the results of the three RCT trials. A scientific consensus since subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.In 2020, the World Health Organization (WHO) reiterated that male circumcision is an efficacious intervention for HIV prevention if carried out by medical professionals under safe conditions. Circumcision reduces the risk that a man will acquire HIV and other sexually transmitted infections (STIs) from an infected female partner through vaginal sex. The evidence regarding whether circumcision helps prevent HIV is not as clear among men who have sex with men (MSM). The effectiveness of using circumcision to prevent HIV in the developed world is not determined.
Male circumcision reduces the risk of human immunodeficiency virus (HIV) transmission from HIV positive women to men in high risk populations.
The first academic paper suggesting a protective association between circumcision and reduced heterosexual HIV infection rates was published in 1986. Experimental evidence was needed to establish a causal relationship, so three randomized controlled trials (RCT) were commissioned as a means to reduce the effect of any confounding factors. Trials took place in South Africa, Kenya and Uganda. All three trials were stopped early by their monitoring boards because those in the circumcised group had a substantially lower rate of HIV contraction than the control group, and hence it was concluded that it would be unethical to withhold the treatment in light of overwhelming evidence of prophylactic efficacy. WHO assessed the trials as "gold standard" studies and found "strong and consistent" evidence from later studies that confirmed the results of the three RCT trials. A scientific consensus since subsequently developed that circumcision reduces heterosexual HIV infection rates in high-risk populations.In 2020, the World Health Organization (WHO) reiterated that male circumcision is an efficacious intervention for HIV prevention if carried out by medical professionals under safe conditions. Circumcision reduces the risk that a man will acquire HIV and other sexually transmitted infections (STIs) from an infected female partner through vaginal sex. The evidence regarding whether circumcision helps prevent HIV is not as clear among men who have sex with men (MSM). The effectiveness of using circumcision to prevent HIV in the developed world is not determined.
Thanks! KlayCax (talk) 16:25, 7 October 2022 (UTC)
Survey
- Yes, there is consensus that circumcision lowers risk of HIV; no, do not explain much in the lead The problem with explaining is that doing so communicates that the issue is debatable. It is not. There is an established scientific consensus. Any arguments to the contrary start from either exceptions not worth mentioning, or from fringe views. The highest medical authoritative sources are unambiguous and it would be WP:UNDUE to present dissenting, fringe views in the lead. Bluerasberry (talk) 17:17, 7 October 2022 (UTC)
- Version #1: (Note to other editors: That I started this RfC + have been directly involved in this discussion/dispute. See above on the talk page.) Both a brief summarization of the topic and the statement that there is a consensus is WP: Due and in line with other article related to scientific topics. Sources that state alternatively are WP: Fringe and shouldn't be included in the article.
Some relevant sources addressing the topic include:
- Scientific American (2008) states:
all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.
- Scientific American (2008) states:
- Thomas, et al. (2011) states:
Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.
- Thomas, et al. (2011) states:
- Lie and Miller (2011) states:
Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas
- Lie and Miller (2011) states:
- Holmes, Bertozzi, & Bloom (2017) states:
Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).
- Holmes, Bertozzi, & Bloom (2017) states:
- Piontek and Albani, (2019) states:
Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.
- Piontek and Albani, (2019) states:
- World Health Organization (2020) states:
The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs
.
- World Health Organization (2020) states:
- Sharma, et al. (2021) states:
There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1.
KlayCax (talk) 18:52, 7 October 2022 (UTC)
- Sharma, et al. (2021) states:
- Version 1, the consensus seems to agree that circumcision lowers risk of HIV.--Ortizesp (talk) 21:54, 7 October 2022 (UTC)
- Version 2 (maybe even version 3). Is there a “general consensus”? Perhaps. But there are significant minority viewpoints that question the efficacy of circumcision for HIV prevention (i.e. the Royal Dutch Medical Association). That view should be given at least some coverage in the article (not necessarily in the lead), per WP:DUE. There is not a “universal consensus” that circumcision prevents HIV (especially when we are talking about the developed world). The lead proposal is UNDUE per reasoning I gave in previous sections on this talk page. Prcc27 (talk) 22:42, 7 October 2022 (UTC)
- Version 2. WP doesn't deal in absolutes, there's a significant minority viewpoint counter to the absolute claim, and the lead is no place for a paragraph of source detailia that dense. — SMcCandlish ☏ ¢ 😼 21:58, 9 October 2022 (UTC)
WP doesn't deal in absolutes
Who knows? Perhaps we are The Sith? -- Emir of Misplaced Pages (talk) 20:56, 11 October 2022 (UTC)
- First choice: version 3, Second choice: version 2 (and this RfC is highly problematic in it's format). Two different changes should not be the subject of the same !vote as has been done here: as it stands, the way this RfC is formatted, it almost gives the impression that it was purposefully designed to the "split the !vote" between those wishing to support a strong the position that there is strong consensus in the sources for the prophylactic value of the procedures in question, dividing such !votes among options 2 and 3, whereas all !votes supporting a different read on the sources will be aggregated into a single choice, making it easier for that option to reach a higher threshold in responses. I'm going to AGF that this was not intentional--the OP seems to think that version 1 actually advances the argument for strong consensus, afterall; I am not sure I agree with that assessment, but regardless this is specifically why RfCs are not meant to be formatted in such a fashion where two different additions/deletions are contemplated at once. For that matter, there easily could have been a forth option here that dismissed both the proposed added and deleted content.
- All that said, and assuming the RfC doesn't get a procedural close and a re-start, I think the corpus of sources as presented is pretty straightforward here: there is a clear scientific consensus on the existence of a statistically significant prophylactic effect of the medical procedures in question with regard to HIV infection rates (whatever the rest of the cultural conflict surrounding customs regarding circumcision). Version 3 most clearly aligns with the balance of the sources, but version 2 is marginally better than version 1. While version 1 does include reference to some of the more robust studies in question, I don't think the lead is the right place for this level of granularity, and I agree with others who have already noted that it actually undermines an accurate portrayal of the overall strength of the broader consensus. And if steps are not taken to reform the RfC, I certainly hope the closer takes the possible bias inherent in the way the !vote has been constructed into question. SnowRise 06:58, 10 October 2022 (UTC)
- You're probably right. (And from the comments: there's not going to be a current consensus from the RfC.) I'm procedurally self-closing and restarting in a few days. KlayCax (talk) 04:35, 12 October 2022 (UTC)
- Version 2 is my first choice. Instead of striking the paragraph, though, I would change it to something representative of the past three decades of research and not just the beginning. I remember reading that circumcision increased the transmission rate in one study, but it was because the men were resuming sexual activity before they were fully healed. Darkfrog24 (talk) 01:14, 12 October 2022 (UTC)
Discussion
- It's not a debatable point which needs consensus (an odd circumstance which requires WP:RS/AC sourcing); it's just settled science. Any "debate" seemingly died years ago (except in fringe circles and on this Talk page). Bon courage (talk) 16:36, 7 October 2022 (UTC)
- I obviously agree with you. But there were dissenting voices (including other IP editors) who kept reverting the paragraph + wording that stated there was a consensus. (As I'm sure you're aware.) I felt like the start of a RfC was the only way to definitely establish a consensus on the matter + the wording within the lead. Or else we would be going back and forth upon this topic for monthsc: without anything productive occuring + and more reversions/edit wars. KlayCax (talk) 18:37, 7 October 2022 (UTC)
- Relevant links from discussions above:
- Scientific American (2008) states:
all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.
- Scientific American (2008) states:
- Thomas, et al. (2011) states:
Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.
- Thomas, et al. (2011) states:
- Lie and Miller (2011) states:
Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas
- Lie and Miller (2011) states:
- Holmes, Bertozzi, & Bloom (2017) states:
Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).
- Holmes, Bertozzi, & Bloom (2017) states:
- Piontek and Albani, (2019) states:
Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.
- Piontek and Albani, (2019) states:
- World Health Organization (2020) states:
The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs
.
- World Health Organization (2020) states:
- Sharma, et al. (2021) states: "There is overwhelming immunological evidence in support of MC in preventing the heterosexual acquisition of HIV-1.""
- Version #1 is the best. (Per these sources, discussion above, and various other reasons.) More about it is stated in survey subsection. KlayCax (talk) 18:46, 7 October 2022 (UTC)
All are written bad even if the science is right. What makes a 2020 reiteration of settled science so notable? Emir of Misplaced Pages (talk) 13:10, 9 October 2022 (UTC)
The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.The evidence on HIV prevention is very unclear
There are a great number of studies that show it has not effect, r even increases infection rates. So why is the lede so adimant that its only a good thing? Tiggy The Terrible (talk) 13:51, 6 November 2022 (UTC)
- I agree. 2013 meta analysis, and a 2022 study from Canada finds no correlation with HIV. https://www.hindawi.com/journals/isrn/2013/109846/https://www.auajournals.org/doi/10.1097/JU.0000000000002234 Gastropod Gaming (talk) 00:47, 25 September 2023 (UTC)
- Neither of those meets WP:MEDRS - the 2013 van Howe paper isn't published in a medline indexed journal, and the Candian study - is a single study. We cannot use lower quality sources to undercut the conclusions of higher quality ones such as a WHO policy statement. MrOllie (talk) 01:00, 25 September 2023 (UTC)
- The 2013 meta analysis is a DOI link. I should've linked the Pubmed. Here's the Pubmed:
- https://pubmed.ncbi.nlm.nih.gov/23710368/
- And the single Canadian study shows how HIV transmission may not apply in the first world. Gastropod Gaming (talk) 12:39, 25 September 2023 (UTC)
- Both weak sources, of no use to this article. Bon courage (talk) 12:43, 25 September 2023 (UTC)
- A meta analysis from pubmed is "weak"? Really now? & the second one still highlights regional differences. Gastropod Gaming (talk) 17:59, 30 September 2023 (UTC)
- Don't known what "from pubmed" is meant to mean, but PMID:23710368 is in a weak, non-MEDLINE journal. We have really strong sources, so why scrape the barrel? Bon courage (talk) 18:04, 30 September 2023 (UTC)
- PUBMED is not scraping the barrel; PUBMED is MEDLINE. You could read that here, or you could've thought for a second before edit warring & shitting yourself in a audience of people who don't have lukewarm IQs (https://www.nlm.nih.gov/medline/index.html) Francis e Dec's warrior (talk) 18:38, 30 September 2023 (UTC)
- No, that is plainly incorrect. As the link you cite says:
MEDLINE content is searchable via PubMed and constitutes the primary component of PubMed,
- that means Pubmed contains other material besides MEDLINE content. The van Howe paper being discussed here is an example of that. MrOllie (talk) 18:43, 30 September 2023 (UTC)
- No, that is plainly incorrect. As the link you cite says:
- PUBMED is not scraping the barrel; PUBMED is MEDLINE. You could read that here, or you could've thought for a second before edit warring & shitting yourself in a audience of people who don't have lukewarm IQs (https://www.nlm.nih.gov/medline/index.html) Francis e Dec's warrior (talk) 18:38, 30 September 2023 (UTC)
- Pubmed is an indiscriminate listing. The minimum standard for medical content is considered to be the MEDLINE index. MrOllie (talk) 18:11, 30 September 2023 (UTC)
- Don't known what "from pubmed" is meant to mean, but PMID:23710368 is in a weak, non-MEDLINE journal. We have really strong sources, so why scrape the barrel? Bon courage (talk) 18:04, 30 September 2023 (UTC)
- A meta analysis from pubmed is "weak"? Really now? & the second one still highlights regional differences. Gastropod Gaming (talk) 17:59, 30 September 2023 (UTC)
- Both weak sources, of no use to this article. Bon courage (talk) 12:43, 25 September 2023 (UTC)
- Neither of those meets WP:MEDRS - the 2013 van Howe paper isn't published in a medline indexed journal, and the Candian study - is a single study. We cannot use lower quality sources to undercut the conclusions of higher quality ones such as a WHO policy statement. MrOllie (talk) 01:00, 25 September 2023 (UTC)
RFC on the Royal Dutch Medical Association
Which version of the Royal Dutch Medical Association's recommendations should be included in the article, the full version or the shortened version?
- Full version: "Because the evidence that circumcision prevents HIV mainly comes from studies conducted in Africa, the Royal Dutch Medical Association (KNMG) in 2010 questioned the applicability of those studies to developed countries. Circumcision has not been included in their HIV prevention recommendations. The KNMG viewpoint document said that the relationship between HIV transmission and circumcision was unclear, and that behavioral factors seemed to have more of an effect on HIV prevention than circumcision. The KNMG also said that the choice of circumcision should be put off until an age when a possible HIV risk reduction would be relevant, so that boys could decide for themselves whether to undergo the procedure or choose other prevention alternatives. This KNMG circumcision policy statement was endorsed by several Dutch medical associations."
- Shortened version: "Because the evidence that circumcision prevents HIV mainly comes from studies conducted in Africa, the Royal Dutch Medical Association (KNMG) in 2010 questioned the applicability of those studies to developed countries. Circumcision has not been included in their HIV prevention recommendations."
Some users have argued that the Royal Dutch Medical Association (KNMG) viewpoint is WP:FRINGE and out-of-date, while others have argued that the KNMG recommendations qualify as a "significant minority viewpoint" per WP:DUE and that it is important to include recommendations on circumcision & HIV from different regions of the world. Prcc27 (talk) 00:20, 20 November 2022 (UTC)
- Full version: The Royal Dutch Medical Association is a large medical organization with over 65,000 doctors and medical students as members. The recommendations section of the article, is where "significant minority viewpoints" belong. Of course, if we get more up-to-date and higher quality recommendations, we should replace the older recommendations with the newer ones. But it is worth noting, that the AAP's viewpoint is technically expired, and that there is a quote from The WHO's 2007 viewpoint which is currently in the article, that is actually older than the KNMG viewpoint. Prcc27 (talk) 00:28, 20 November 2022 (UTC)
- Full version. I tend to agree with Prcc27's points, and in reading the two versions, I find the longer one is considerably more informative about KNMG's position (the additional material is not fluff or blather). — SMcCandlish ☏ ¢ 😼 06:34, 20 November 2022 (UTC)
- Full. The Dutch Royal Medical Association is a major institution with a minority viewpoint. Also, the full version gives more details and isn't fluff. — Franklin! 21:14, 20 November 2022 (UTC)
- Shortened version: I'm not sure if it's fringe or not but it is certainly a bit out of date and not needing every detail. Other out of date viewpoints in the article can also be appropriately um trimmed or replaced with newer ones if available. BogLogs (talk) 23:49, 22 November 2022 (UTC)
- Shorter summary of the KNMG position. Let me preface this by saying I think the KNMG stance is, at most, FRINGE-adjacent, not truly fringe: yes, it is a significant minority opinion in some respects as compared against consensus medical science on the topic, but let's remember that we are talking about legitimate national-scale body representing tens of thousands of physicians, and at least some of what it has to say on the topic is not altogether controversial. The timeliness issues does raise some concerns in terms of WP:DUE, but sources in Misplaced Pages articles covering this topic are kind of all over the place on the timeline of research as is.
- All of that said, the portions that come in under the extended version are definitely those which are either a) closest to fringe statements, relative to the broad corpus of research, such as the claim that
"the relationship between HIV transmission and circumcision was unclear"
(the particulars may be up for debate but consensus research is pretty clear about the existences of a statistically significant observable relationship), or b) so non-controversial I'm not sure it bears lengthening the article and muddying the waters to include it, as with"behavioral factors seemed to have more of an effect on HIV prevention than circumcision"
(no researchers that I have ever heard of are really arguing that the effects of circumcision are at the same scale of impact as the factors of the sex acts engaged in by individuals, their choice of whether to use safe sex practices, their choices with regard to sexual partners, and their medication choices, the only really physiologically relevant "behavioural factors" at play here, making this rather something of a strawman argument that doesn't do much to inform the reader of the actual dimensions of legitimate medical debate about this topic).
- Meanwhile, the shorter version still includes the less fringe-y and informative content:
"Because the evidence that circumcision prevents HIV mainly comes from studies conducted in Africa, the Royal Dutch Medical Association (KNMG) in 2010 questioned the applicability of those studies to developed countries."
Now this in itself is still a little wishy-washy in terms of the grounds on which it takes issue with the majority/consensus research position, because obviously there is no significant observed physiological difference between African and non-African peoples which would lead to statistically different outcomes for individuals exposed to HIV; that is to say, a circumcised African and a circumcised non-African would (on average) get just as much benefit (or just as little, depending on your position) when exposed to HIV--so there are some problems with that statement as framed. But I presume the KNMG would explain this position more fully as "in non-African contexts, the benefits of circumcision on the larger epidemiological scale might render different statistical outcomes in terms of benefits to the larger population resulting from the practice." That's a questionable argument in itself, insofar as the KNMG doesn't point to countervailing research outside of Africa in support of that possibility, so much as casts doubt on the existing Africa-centric research, but that possibility does nevertheless get the statement farther past the smell test than some other aspects of their position. And then of course"Circumcision has not been included in their HIV prevention recommendations."
is just simply perfectly factual.
- On the whole, I don't see a strong argument for the WP:WEIGHT value of the elements included in the longer version, whereas I can see the benefit of the shorter version. I'd also like to note that (though I am sure it was a subconscious and unintentional choice, there seems to me to be some rhetorical bias built into how the two choices are presented here in terms of the nomenclature of the RfC: the "full version" of the "KNMG's recommendations" is just the summary of their position as advanced by one of our editors. The choice therefore is not between a "full" or "shortened" version, but rather between a longer and shorter version, and there's a suggestion in the language employed that we are somehow taking something naturally fulsome and cutting it down for convenience. That's not really appropriate framing any more than if the choices had been labelled a "punchy" version and "verbose" version, imo. Not a huge thing, but worth noting as something that could introduce bias into the discussion. Additionally, looking at the dispute as it is framed further up on the talk page, it seems the dispute was about whether to include the KNMG's positions at all, not how much of their position to include, so including nothing probably should have been offered as an option here. That said, I didn't look at the edit history of this dispute, so there may have been movement/discussion/compromise on the foundational issue of whether to include KNMG positions at all which took place in edit summaries. SnowRise 20:31, 23 November 2022 (UTC)
- “Behavioral factors seemed to have more of an effect on HIV prevention than circumcision” isn’t a strawman argument. It is a statement that KNMG ties into their view, that circumcision does not have a significant effect on national HIV prevalence, between the different countries.
- “The relationship between HIV transmission and circumcision was unclear” is not undue, when you read the entire paragraph, which adds context to that statement.
- Questioning the applicability of those studies to developed countries makes sense for two reasons: MSM HIV rates vs. Men who have sex with women and considering that the predominant HIV strain is different in Africa vs. other parts of the world. I’m not going to try to interpret their reasoning, but the KNMG’s argument here, does not seem far off from the mainstream view on generalizability to developed countries.
- I wanted to avoid “fuller” (doesn’t work grammatically) and “original”. But “shorter” and “longer” would have been better alternatives. Prcc27 (talk) 02:10, 24 November 2022 (UTC)
“Behavioral factors seemed to have more of an effect on HIV prevention than circumcision” isn’t a strawman argument. It is a statement that KNMG ties into their view, that circumcision does not have a significant effect on national HIV prevalence, between the different countries.
- Well, it's both. The sub-argument/proof being advanced by the KNMG towards the larger interpretation here is that "other factors exist which have a bigger impact". But researchers advancing evidence of the empirically observable effect of circumcision on likelihood of infection aren't contesting that, and it simply doesn't serve to impact the findings about physiological, biophysical effects observed in the research on individual transmission, even if the cost-benefit in different regional contexts were brought into question by the general medical establishment--it's a red herring with regard to what consensus conclusions have been reached, or more formally a irrelevant conclusion. And we in our discretion as to considering WP:WEIGHT have to decide if it is worth including in our summary of statements and positions which describe the bounds of the academic debate on this issue, per WP:ONUS: not everything verifiable is necessary or advisable for inclusion, and I just don't think this statement is.
“The relationship between HIV transmission and circumcision was unclear” is not undue, when you read the entire paragraph, which adds context to that statement.
- Well, I just re-read the section, and I still find that, again, though I would not describe the complete position as summarized as really FRINGE, as some have described, this is surely the most fringe-leaning element of the KNMG position presented here. It's at best a half-accurate summary of the state of research: the existence of a direct statistical (and statistically relevant) relationship is generally agreed upon by the scientific establishment examining this issue. The degree of the effect, however, is a little more subject to disagreement. Again, this is a matter of WP:WEIGHT, and these calls aren't super obvious: I would define this as a "reasonable minds may vary" area of the topic, and we are after all talking about an attributed set of statements. Nevertheless, I still think this is dead weight and more likely to muddy the waters than to clarify the present state of research for the reader.
Questioning the applicability of those studies to developed countries makes sense for two reasons: MSM HIV rates vs. Men who have sex with women and considering that the predominant HIV strain is different in Africa vs. other parts of the world. I’m not going to try to interpret their reasoning, but the KNMG’s argument here, does not seem far off from the mainstream view on generalizability to developed countries.
- Sure, I mean, again, it's a close call, but that's why I come down the way I do on the rest of the content and support its inclusion, even though it requires asking the reader to parse a fine distinction regarding personal infection risk in the individual physiological context and the epidemiological risk on the population scale. But under a weight analysis, I can't support all of the proposed content as due.
I wanted to avoid “fuller” (doesn’t work grammatically) and “original”. But “shorter” and “longer” would have been better alternatives.
- I mean, I almost didn't mention it: it's not like its a big enough effect to really throw the discussion, but I thought it and the other matter with the framing (and probably that one somewhat more so) were still worth bearing in mind. SnowRise 03:02, 24 November 2022 (UTC)
- Shortened version largely per Snow Rise. The long version is undue and needlessly takes Misplaced Pages into fringey territory. Bon courage (talk) 06:27, 24 November 2022 (UTC)
- Full version – It's better since it makes it clear why the Royal Dutch Medical Association took its position, and gives context for this minority position. Studies from the developing world are not always directly applicable to Western countries because of differences in wealth and behaviour. (The cost and ease of purchasing condoms, condom usage rates, sexual practices, preventative medication, access to clean water, etc. can all play a much larger role in HIV prevention; and thereby, swamp out any physiological benefits of circumcision. There is also the possibility that circumcised individuals could get a false sense of security from getting HIV, which would in fact result in risky sexual behaviour, which led to higher chances of HIV in comparison to a more cautious uncircumcised individual.) The full version makes it clear that what is important for the KNMG is empowering the individual with a toolkit of HIV preventing options that the person can chose from to avoid HIV infection. --Guest2625 (talk) 14:31, 24 November 2022 (UTC)
- Full version, simply because it gives a much clearer understanding of KNMG's position. Per Prcc27, it seems clear that KNMG's position is a significant viewpoint, not a FRINGE one. —Mx. Granger (talk · contribs) 10:37, 25 November 2022 (UTC)
- Full version, per Prcc27 A455bcd9 (talk) 19:17, 25 November 2022 (UTC)
- Shortened version - lean - Per SnowRise. I don't have an objection to including objections to extending the findings to developed countries. That's something that is mainstream (if not a majority view) within the scientific and medical communities. However, the 2010 KNMG statement was released before a consensus in the scientific community was established. There's almost no major, respected medical organization or even doctor today (as of 2022) that would state that VMMC doesn't reduce HIV transmission from HIV positive women to men in high risk populations. Questions of consent/ethics when it's done on minors (EIMC programs) are mainstream. Denying that vol. male circumcision in high-risk areas doesn't reduce transmission is WP: Fringe and is outdated. The KNMG statement saying it is uncertain that circumcision reduces the incidence of HIV transmission in high risk populations was written in (and before) 2010. A scientific consensus on the matter didn't emerge until ~2011-2013.
- Some users have attempted to draw parallels with similar quotations dating back to the late-2000s/early-2010s in the article - such as the WHO or AAP - but this is an inaccurate comparison.
- The large majority of these statements have been reiterated. (e.g.
In 2020, WHO again concluded that male circumcision is an efficacious intervention for HIV prevention and that the promotion of male circumcision is an essential strategy
.) The WHO first recommended it in 2007. It reiterated its recommendation in 2020. The KNMG position should be expanded, in my opinion. But denying a link between circumcision and HIV transmission in high risk areas is indisputably fringe, and it would be wrong for the article to include it. KlayCax (talk)- As I mentioned above - other sources have made similar statements.
- Sharma, et al. (2021) states:
MC is... strongly supported by the data from three large RCTs conducted in Africa
right before that. It directly mentions the three RCT trials as part of the"overwhelming evidence"
for circumcision in high risk contexts.
- Scientific American (2008) states:
all three trials were stopped early due to the overwhelming evidence of circumcision's protective effect.
- Scientific American (2008) states:
- Thomas, et al. (2011) states:
Overwhelming evidence, including three clinical trials, shows that male circumcision (MC) reduces the risk of HIV infection among men.
- Thomas, et al. (2011) states:
- In 2011, Lie and Miller (2011) states:
Only after the results of three RCTs were available was the public health community convinced that there was sufficient evidence to initiate provision of circumcision services in high prevalence areas
- In 2011, Lie and Miller (2011) states:
- Holmes, Bertozzi, & Bloom (2017) states:
Circumcision of adult males is 70 percent effective in reducing transmission from females to males based on three RCTs... (very strong evidence).
- Holmes, Bertozzi, & Bloom (2017) states:
- Piontek and Albani, (2019) states:
Randomized controlled trials have demonstrated circumcision results in a 50–60% reduction in risk of acquiring HIV infection in heterosexual males. In three clinical trials performed in sub-Saharan Africa, uncircumcised men were randomly assigned to one of two groups. One group was offered immediate circumcision (treatment group) and those in the other group (control group) were offered circumcision at the end of the trial. All participants received HIV testing and counseling, condoms, and safe sex counseling. All three trials were stopped early due to the overwhelming evidence that circumcision offered a protective effect against HIV, and it was felt to be unethical to ask the control group to wait to be circumcised.
- Piontek and Albani, (2019) states:
- World Health Organization (2020) states:
The evidence that circumcision reduces the risk of HIV infection in men is strong. Results come from diverse settings, span 32 years (1986 to 2017), and are very consistent... Data from three RCTs
.
- World Health Organization (2020) states:
- And so on and so forth. There's numerous other metastudies and/or major medical organizations — easily findable online — that call the three RCTs provide "overwhelming", "very strong", or "strong" evidence. In the context of high-risk populations, anything to the contrary is a fringe perspective at this point.
- It wasn't a fringe statement in 2010. It is now. It shouldn't be included in the article. KlayCax (talk) 16:18, 22 December 2022 (UTC)
- Short KNMG is not a mainstream global source so hardly merits attention anyway, 2010 was a long time ago and if this was an issue about which they cared they would have reiterated it, and the longer statement is prone to misinterpretation. Bluerasberry (talk) 15:39, 22 December 2022 (UTC)
- Short. Assuming for the sake of argument that the KNMG statement is further on the "significant minority view" side of the spectrum than on the "fringe" side, the short version is still better. The length of the summary outweighs significant majority sources like the most current meta-analysis. And the added content is not particularly on-topic or useful.
- The whole bit about the "unclear" relationship" is evident from the short version
- "behavioral factors" is obviously true, to the point of uselessness
- I have no quarrel with "several Dutch medical associations" and would be fine with adding that into the short version. Maybe something like
"the Royal Dutch Medical Association (KNMG) and seven other Dutch medical associations ..."
"Circumcision of male minors has not been ..."
. Assuming I get no takers on my suggestions, I'd still support the short version over the long. Firefangledfeathers (talk / contribs) 06:05, 4 January 2023 (UTC)- I obviously support including the part about several Dutch medical associations endorsing the KNMG viewpoint. That is clearly better than the shorter version. Prcc27 (talk) 22:40, 4 January 2023 (UTC)
RfC closure
Note I have raised a query about the just-closed RfC above, at WP:AN. Also note that OntologicalTree is going beyond the RfC decision to edit-war content into the lede calling the established science into question. Bon courage (talk) 16:36, 1 January 2023 (UTC)
- And now KlayCax is compounding the problem. A minor source from 2010 cannot be used to undercut weighty sources from more recent years. Furthermore for statements about "consenus" in science the high bar of WP:RS/AC sourcing is needed. Bon courage (talk) 17:05, 1 January 2023 (UTC)
- Apologies. I haven't been involved in this RFC that much. (Until after 30 days were passed on it: Which I wasn't aware of until I checked watchlist.)
- I was under the presumption that @OntologicalTree:'s edits were in line with the results of the RFC. @Bon courage:. You as well as anyone knows my position on the matter from past disputes.
- In my opinion, the edits from @Prcc27: and @OntologicalTree: should probably be kept until someone reviews Trykid's closure. However, the RFC definitely needs to be reviewed. There was nowhere near a consensus on the matter. Most of the quality responses (such as @Snow Rise:'s) were directly against the RFC's results. KlayCax (talk) 17:12, 1 January 2023 (UTC)
- Svoboda and Van Howe's comments are definitely WP: Fringe'y, though. They should be removed under either scenario. KlayCax (talk) 17:13, 1 January 2023 (UTC)
- The RfC was tightly asking about whether to adopt one or other specific versions of text, it did not give cart blanche to insert fringe positions into the lede. I agree the close was poor. Bon courage (talk) 17:15, 1 January 2023 (UTC)
- I agree. It's just that a narrow interpretation of the RFC closure brings its own problems. (Or at least invites clarification) How is it WP: Due to state that the Royal Dutch Medical Association denies/doubts a linkage between circumcision and there's a consensus on the matter that it does?
- At the very least — for the average viewer — a narrow interpretation of the RFC leads the article into being: 1.) Not very clear 2.) Self-contradicting. KlayCax (talk) 17:28, 1 January 2023 (UTC)
- We state the current accepted science. And we state what this minor medical body had as a "viewpoint" 13 years ago. There's no contradiction. Bon courage (talk) 17:35, 1 January 2023 (UTC)
- It may not be a contradiction. At the very least, it's extensively confusing and unclear to the average reader.
- Exactly why: 1.) The RFC was wrongly decided 2.) It's WP: Undue. 3.) Shouldn't be in the article. @Bon courage:. KlayCax (talk) 17:41, 1 January 2023 (UTC)
- We state the current accepted science. And we state what this minor medical body had as a "viewpoint" 13 years ago. There's no contradiction. Bon courage (talk) 17:35, 1 January 2023 (UTC)
- The RfC was tightly asking about whether to adopt one or other specific versions of text, it did not give cart blanche to insert fringe positions into the lede. I agree the close was poor. Bon courage (talk) 17:15, 1 January 2023 (UTC)
- Svoboda and Van Howe's comments are definitely WP: Fringe'y, though. They should be removed under either scenario. KlayCax (talk) 17:13, 1 January 2023 (UTC)
- Propose compromise - remove in 2024 if no updated source Both sides cannot have their way at this, but RfCs need to close somehow. Per WP:MEDDATE when a source is more than 5 years old then it is usually out of date. For this topic plenty of recommendations are published every year, and for this view, there is one respected publication from 13 years ago. I say keep the content in the article through 2023 to give anyone time to find a newer source. If no one finds one in the next year, then remove it without additional discussion in 2024. If this information is worth stating then giving all the medical organizations in the world 14 years to come up with something is long enough, especially when Misplaced Pages's standard is 5 years. Bluerasberry (talk) 20:54, 1 January 2023 (UTC)
- The longer version of the KNMG paragraph, has been the consensus for the past few years. MEDDATE concerns did come up when I first proposed including the KNMG viewpoint, but we decided that MEDDATE did not apply, because the recommendations were being portrayed as a KNMG-specific viewpoint, not an indisputable scientific fact. Yes there are newer sources, but many of the newer sources are not as comprehensive as some of the most prominent sources during the 2010ish time period (e.g. old AAP and WHO statements). Prcc27 (talk) 05:55, 4 January 2023 (UTC)
- The consensus version was as was at the start of the RfC. Per WP:ONUS for inclusion of disputed content, consensus is needed. Bon courage (talk) Bon courage (talk) 08:14, 4 January 2023 (UTC)
- Prior to you and Petersmillard reverting me, consensus on the talk page had been established in favor of including the KNMG viewpoint. Yes consensus can change, but it was a consensus nonetheless. Prcc27 (talk) 22:51, 4 January 2023 (UTC)
- There was never consensus for your long version, and the article has existed without it for most of its existence. Inclusion of disputed content needs consensus. Bottom line: the long version is not going in without an RfC establishing that it belongs. Bon courage (talk) 07:23, 5 January 2023 (UTC)
- I obviously disagree. There was a consensus at the talk (even if weak consensus), and a consensus through editing. “My” long version was written with the collaboration of other users, it was not written unilaterally. This RfC has not been resolved yet, although it looks like “no consensus” will be the end result. But I think we should at least explore Blueraspberry’s compromise proposal and see if we can get a consensus on that. Prcc27 (talk) 20:28, 5 January 2023 (UTC)
- There was never consensus for your long version, and the article has existed without it for most of its existence. Inclusion of disputed content needs consensus. Bottom line: the long version is not going in without an RfC establishing that it belongs. Bon courage (talk) 07:23, 5 January 2023 (UTC)
- Prior to you and Petersmillard reverting me, consensus on the talk page had been established in favor of including the KNMG viewpoint. Yes consensus can change, but it was a consensus nonetheless. Prcc27 (talk) 22:51, 4 January 2023 (UTC)
- @Prcc27: It has been 13 years. Can you give a personal opinion of how long you expect this publication to be relevant? Are you thinking 15, 20, 30 years? To me this seems like a statement where anticipating an expiration date is a reasonable direction for conversation. Bluerasberry (talk) 16:25, 4 January 2023 (UTC)
- I do not have a crystal ball. I support including the longer version, even if that means having an expiration date as a compromise. But I do not think MEDDATE mandates an expiration date. Prcc27 (talk) 22:47, 4 January 2023 (UTC)
- The consensus version was as was at the start of the RfC. Per WP:ONUS for inclusion of disputed content, consensus is needed. Bon courage (talk) Bon courage (talk) 08:14, 4 January 2023 (UTC)
- Thank you, Bon Courage. The current version is the appropriate one. It does acknowledge the Dutch statement, which is a clear outlier which contradicts WHO, CDC, and every other consensus statement. But it doesn't put it above the CDC statement (as it was previously) or give it a separate paragraph. Petersmillard (talk) 15:52, 4 January 2023 (UTC)
- The longer version of the KNMG paragraph, has been the consensus for the past few years. MEDDATE concerns did come up when I first proposed including the KNMG viewpoint, but we decided that MEDDATE did not apply, because the recommendations were being portrayed as a KNMG-specific viewpoint, not an indisputable scientific fact. Yes there are newer sources, but many of the newer sources are not as comprehensive as some of the most prominent sources during the 2010ish time period (e.g. old AAP and WHO statements). Prcc27 (talk) 05:55, 4 January 2023 (UTC)
Prcc27 says that The KNMG circumcision policy statement was endorsed by several Dutch medical associations. The policy statement was initially released in 2010, but was reviewed again and accepted in 2022." However, there is no reference for the "reviewed again in 2022." Where is this documented? Petersmillard (talk) 00:38, 30 May 2023 (UTC)
- @Petersmillard: Thank you for bringing this concern to the talk, I updated the source. Prcc27 (talk) 01:26, 30 May 2023 (UTC)
- Well, it looks like this RfC still is not resolved. Since KNMG released a statement reaffirming their 2010 policy by saying "the above documents were reviewed in March 2022: content is still correct" wouldn't this make the WP:MEDDATE concerns moot? Is there anyone in the shorter summary camp that would like to change their !vote to the longer summary, in light of this information we did not have at the beginning of the RfC? @SMcCandlish:@ClydeFranklin:@BogLogs:@Snow Rise:@Bon courage:@Guest2625:@Mx. Granger:@A455bcd9:@KlayCax:@Bluerasberry:@Firefangledfeathers:@Petersmillard: Prcc27 (talk) 01:26, 30 May 2023 (UTC)
- FWIW, my position on this hasn't shifted: it's a minority viewpoint but from a major medical organization, and now that they've reaffirmed their position in 2022, its relevance is renewed. — SMcCandlish ☏ ¢ 😼 01:44, 30 May 2023 (UTC)
- With that update, the case for including the longer summary is stronger. We should include the longer summary, possibly adjusted to mention that KNMG reaffirmed their position in 2022. —Mx. Granger (talk · contribs) 02:23, 30 May 2023 (UTC)
- Mx. Granger, it probably makes sense in a situation like this, when you are responding to a post that ends with the express question
"Is there anyone in the shorter summary camp that would like to change their !vote to the longer summary?"
, to flag in your response (calling for a change) that you were actually someone who supported a longer version in the previous !vote as well. Otherwise people might assume that you were one of the people specifically being queried and interpret your response as a change in the balance of the perspectives, when it isn't. SnowRise 05:33, 30 May 2023 (UTC)- Apologies for the lack of clarity – I supported the longer version before, and with this update I think the case for the longer version is even stronger. —Mx. Granger (talk · contribs) 13:12, 30 May 2023 (UTC)
- Mx. Granger, it probably makes sense in a situation like this, when you are responding to a post that ends with the express question
- My perspective also hasn't changed and I still favour the short version, all factors considered: in the original instance, I did not view the dated nature of the source as a major issue militating against it's use, so my previous !vote is already balanced in that respect. And I don't see much in the other !votes which suggest this was a major issue for other respondents. I mean, either the source is in date and worth using in general or it isn't. It's datedness is unlikely to be an issue for supporting some MEDRS content but not others. Rather, the !votes seemed to mostly focus on whether or not particular claims were fringe or due, and this detail of the org's support being "renewed" (for whatever that's worth) doesn't really impact the WP:WEIGHT analysis upon which the support for a shorter version generally relied. SnowRise 05:28, 30 May 2023 (UTC)
- It inclines me to prefer the short version over deletion. Bon courage (talk) 05:31, 30 May 2023 (UTC)
- Yeah, that's probably the best way to describe my take as well. I always thought of the shorter version as the reasonable middle ground solution between three options. There's something to discuss here, but there's a fair bit of nuance needed to insert any of it, even in the form of attributed statements, without creating false balance and unsettling our discussion of the subject by untethering it from WP:WEIGHT. I feel like there was already a fair bit of effort put into sorting out what content was useable and what was not, and taking another bite at that apple on account of this very trivial change in the posture of the sourcing is probably not going to lead to any improvement. SnowRise 05:42, 30 May 2023 (UTC)
- I still think the short version is better, and my reasons for thinking so were not significantly tied to the MEDDATE concerns. Firefangledfeathers (talk / contribs) 15:43, 30 May 2023 (UTC)
- Well, it looks like this RfC still is not resolved. Since KNMG released a statement reaffirming their 2010 policy by saying "the above documents were reviewed in March 2022: content is still correct" wouldn't this make the WP:MEDDATE concerns moot? Is there anyone in the shorter summary camp that would like to change their !vote to the longer summary, in light of this information we did not have at the beginning of the RfC? @SMcCandlish:@ClydeFranklin:@BogLogs:@Snow Rise:@Bon courage:@Guest2625:@Mx. Granger:@A455bcd9:@KlayCax:@Bluerasberry:@Firefangledfeathers:@Petersmillard: Prcc27 (talk) 01:26, 30 May 2023 (UTC)