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{{short description|Tick-borne disease of dogs}}
'''Ehrlichiosis''' ({{pron-en|ˌɛərlɨkiˈoʊsɨs}}; also known as '''canine rickettsiosis''', '''canine hemorrhagic fever''', '''canine typhus''', '''tracker dog disease''', and '''tropical canine pancytopenia''') is a ] of dogs usually caused by the organism ''Ehrlichia canis''. ''Ehrlichia canis'' is the pathogen of animals. Humans can become infected by E. canis and other species after tick exposure. ] dogs are thought to be particularly affected by the disease, other breeds generally have milder clinical signs. Cats can also be infected. '''Ehrlichiosis''' ({{IPAc-en|ˌ|ɛər|l|ᵻ|k|i|ˈ|oʊ|s|ᵻ|s}}; also known as '''canine rickettsiosis''', '''canine hemorrhagic fever''', '''canine typhus''', '''tracker dog disease''', and '''tropical canine pancytopenia''') is a ] of dogs usually caused by the rickettsial agent '']''. ''Ehrlichia canis'' is the pathogen of animals. Humans can become infected by ''E. canis'' and other species after tick exposure. ]s are thought to be susceptible to a particularly severe form of the disease; other breeds generally have milder clinical signs. Cats can also be infected.


==''Ehrlichia''== ==''Ehrlichia''==
{{contradicts other|Ehrlichia|there|When was Ehrlichia first recognized?|section|date=June 2020}}
''Ehrlichia'' is a ]l bacteria belonging to the family ]. There are several species of ''Ehrlichia'', but the one that most commonly affects dogs and causes the most severe clinical signs is ''Ehrlichia canis''. This species infects ]s in the peripheral blood. The brown dog tick, or ''Rhipicephalus sanguineous'', that passes the organism to the dog is prevalent throughout most of the ], but most cases tend to occur in the Southwest and Gulf Coast regions where there is a high concentration of the tick. ''Ehrlichia'' is found in many parts of the world and was first recognized in ] in 1935. During the ] ehrlichiosis became well known as a dog disease due to the infection and death of many military working dogs.<ref name=Ettinger>{{cite book|author=Ettinger, Stephen J.;Feldman, Edward C.|title=Textbook of Veterinary Internal Medicine(4th ed.)|publisher=W.B. Saunders Company|year=1995|isbn=0-7216-6795-3}}</ref> Two types of human ehrlichiosis have been identified in the United States: human monocytic ehrlichiosis and human granulocytic ehrlichiosis. '']'' is a ]l genus of bacteria belonging to the family ]. There are several species of ''Ehrlichia'', but the one that most commonly affects dogs and causes the most severe clinical signs is ''Ehrlichia canis''. This species infects ]s in the peripheral blood. The brown dog tick, or '']'', which passes the organism to the dog, is prevalent throughout most of the ], but most cases tend to occur in the Southwest and Gulf Coast regions, where there is a high concentration of the tick. ''Ehrlichia'' is found in many parts of the world<ref>{{Cite web|last=Fitzgerald|first=Roxanne|date=2021-07-15|title=This once-rare dog disease appeared in the outback last year. Now it's arrived in the city|url=https://www.abc.net.au/news/2021-07-16/nt-dog-disease-ehrlichiosis-endemic-in-northern-territory/100289234|url-status=live|access-date=2021-07-16|website=www.abc.net.au|language=en-AU|archive-url=https://web.archive.org/web/20210715202826/https://www.abc.net.au/news/2021-07-16/nt-dog-disease-ehrlichiosis-endemic-in-northern-territory/100289234 |archive-date=2021-07-15 }}</ref> and was first recognized in ] in 1935.<ref>{{Cite journal|last1=Sainz|first1=Ángel|last2=Roura|first2=Xavier|last3=Miró|first3=Guadalupe|last4=Estrada-Peña|first4=Agustín|last5=Kohn|first5=Barbara|last6=Harrus|first6=Shimon|last7=Solano-Gallego|first7=Laia|date=2015-02-04|title=Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe|journal=Parasites & Vectors|volume=8|issue=1|pages=75|doi=10.1186/s13071-015-0649-0|issn=1756-3305|pmc=4324656|pmid=25649069 |doi-access=free }}</ref> During the ] ehrlichiosis became well known as a dog disease due to the infection and death of many military working dogs.<ref name=Ettinger>{{cite book|author1=Ettinger, Stephen J. |author2=Feldman, Edward C. |title=Textbook of Veterinary Internal Medicine(4th ed.)|publisher=W.B. Saunders Company|year=1995|isbn=0-7216-6795-3}}</ref> Two types of human ehrlichiosis have been identified in the United States: human monocytic ehrlichiosis and human granulocytic ehrlichiosis.<ref>{{Cite journal|last=Biggs|first=Holly M.|display-authors=et al|date=13 May 2016|title=Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis — United States. A Practical Guide for Health Care and Public Health Professionals|url=https://www.cdc.gov/mmwr/volumes/65/rr/pdfs/rr6502.pdf|journal=Centers for Disease Control and Prevention: Morbidity and Mortality Weekly Report|volume=65: 2|pages=44}}</ref>


==Disease overview== ==Disease overview==
Dogs get ehrlichiosis from the brown dog tick, which passes an ehrlichia organism into the bloodstream when it bites. It is also possible for dogs to become infected through a ] from an infected dog. <ref name="Ettinger"/> There are three stages of ehrlichiosis, each varying in severity. The acute stage, occurring several weeks after infection and lasting for up to a month, can lead to fever and lowered peripheral blood cell counts due to ] suppression. The second stage, called the subclinical phase, has no outward signs and can last for the remainder of the dog's life, during which the dog remains infected with the organism. Some dogs are able to successfully eliminate the disease during this time. In some dogs the third and most serious stage of infection, the chronic phase, will commence. Very low blood cell counts (]), ], bacterial infection, lameness, ] and ], and ], can result. Chronic ehrlichiosis can be fatal. Dogs get ehrlichiosis from the ], which passes an ehrlichia organism into the bloodstream when it bites. It is also possible for dogs to become infected through a ] from an infected dog.<ref name="Ettinger"/> There are three stages of ehrlichiosis, each varying in severity.<ref>{{Cite journal|last=Harrus|first=Shimon|display-authors=et al|date=21 December 2020|title=Recent Advances in Determining the Pathogenesis of Canine Monocytic Ehrlichiosis|url=https://journals.asm.org/doi/abs/10.1128/JCM.37.9.2745-2749.1999|access-date=2021-07-16|journal=Journal of Clinical Microbiology|volume=37 |issue=9 |pages=2745–2749 |language=en|doi=10.1128/jcm.37.9.2745-2749.1999|doi-access=free|pmc=85367}}</ref> The acute stage, occurring several weeks after infection and lasting for up to a month, can lead to fever and lowered peripheral blood cell counts due to ] suppression. The second stage, called the subclinical phase, has no outward signs and can last for the remainder of the dog's life, during which the dog remains infected with the organism. Some dogs are able to successfully eliminate the disease during this time. In some dogs the third and most serious stage of infection, the chronic phase, will commence. Very low blood cell counts (]), ], bacterial infection, lameness, ] and ], and ] can result. Chronic ehrlichiosis can be fatal.


==Signs and symptoms== ==Signs and symptoms==
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==Diagnosis== ==Diagnosis==
] is achieved most commonly by ] of the blood for the presence of ] against the ehrlichia organism. Many veterinarians routinely test for the disease, especially in enzootic areas. It should be noted, however, that during the acute phase of infection, the test can be falsely negative because the body will not have had time to make antibodies to the infection. As such, the test should be repeated. In addition, ]s may show abnormalities in the numbers of ]s, ]s, and most commonly ]s, if the disease is present. Uncommonly, a diagnosis can be made by looking under a ] at a ] for the presence of the ''ehrlichia'' ]e, which sometimes can be seen as intracytoplasmic ] within a ]. ] is achieved most commonly by ] of the blood for the presence of ] against the ehrlichia organism. Many veterinarians routinely test for the disease, especially in enzootic areas. During the acute phase of infection, the test can be falsely negative because the body will not have had time to make antibodies to the infection. As such, the test should be repeated. A PCR (polymerase chain reaction) test can be performed during this stage to detect genetic material of the bacteria. The PCR test is more likely to yield a negative result during the subclinical and chronic disease phases.<ref>{{cite web|title=Canine Monocytic Ehrlichiosis: An In-depth Review|url=http://www.idexx.com|publisher=Idexx Laboratories|accessdate=2012-09-26}}</ref> In addition, ]s may show abnormalities in the numbers of ]s, ]s, and most commonly ]s, if the disease is present. Uncommonly, a diagnosis can be made by looking under a ] at a ] for the presence of the ''ehrlichia'' ]e, which sometimes can be seen as intracytoplasmic ] within a ].


==Prognosis== ==Prognosis==
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==Treatment== ==Treatment==
Supportive care must be provided to animals that have clinical signs. Subcutaneous or intravenous fluids are given to dehydrated animals, and severely anemic dogs may require a ]. Treatment for ehrlichiosis involves the use of antibiotics such as ] or ] for a period of at least six to eight weeks; response to the drugs may take one month. In addition, steroids may be indicated in severe cases in which the level of platelets is so low that the condition is life threatening. Supportive care must be provided to animals that have clinical signs. Subcutaneous or intravenous fluids are given to dehydrated animals, and severely anemic dogs may require a ]. Treatment for ehrlichiosis involves the use of antibiotics such as ] or ] for a period of three to four weeks; Alternatively ] or ] can be used as a second option.<ref>{{Cite journal |last=Mylonakis |first=Mathios E. |last2=Harrus |first2=Shimon |last3=Breitschwerdt |first3=Edward B. |date=April 2019 |title=An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis) |journal=The Veterinary Journal |language=en |volume=246 |pages=45–53 |doi=10.1016/j.tvjl.2019.01.015 |pmid=30902188 |s2cid=85456868}}</ref> Treatment with ] antibiotics like clarithromycin and azithromycin is being studied. In addition, steroids may be indicated in severe cases in which the level of ]s is so low that the condition is life-threatening.{{Citation needed|date=June 2024}}


==Prevention== ==Prevention==
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==References== ==References==
<references/> <references />

== Humans ==
* basic Q&A
* basic facts
* detailed medical treatment
* basic facts and advice


==External links== ==External links==
⚫ *

{{Wikispecies|Rhipicephalus}} {{Wikispecies|Rhipicephalus}}
⚫ *


] ]
] ]

]
]
]
]
]
]

Latest revision as of 16:21, 22 June 2024

Tick-borne disease of dogs

Ehrlichiosis (/ˌɛərlɪkiˈoʊsɪs/; also known as canine rickettsiosis, canine hemorrhagic fever, canine typhus, tracker dog disease, and tropical canine pancytopenia) is a tick-borne disease of dogs usually caused by the rickettsial agent Ehrlichia canis. Ehrlichia canis is the pathogen of animals. Humans can become infected by E. canis and other species after tick exposure. German Shepherd Dogs are thought to be susceptible to a particularly severe form of the disease; other breeds generally have milder clinical signs. Cats can also be infected.

Ehrlichia

Accuracy disputeThis section appears to contradict the article Ehrlichia. Please discuss at the talk page and do not remove this message until the contradictions are resolved. (June 2020)

Ehrlichia is a rickettsial genus of bacteria belonging to the family Ehrlichiaceae. There are several species of Ehrlichia, but the one that most commonly affects dogs and causes the most severe clinical signs is Ehrlichia canis. This species infects monocytes in the peripheral blood. The brown dog tick, or Rhipicephalus sanguineous, which passes the organism to the dog, is prevalent throughout most of the United States, but most cases tend to occur in the Southwest and Gulf Coast regions, where there is a high concentration of the tick. Ehrlichia is found in many parts of the world and was first recognized in Algeria in 1935. During the Vietnam War ehrlichiosis became well known as a dog disease due to the infection and death of many military working dogs. Two types of human ehrlichiosis have been identified in the United States: human monocytic ehrlichiosis and human granulocytic ehrlichiosis.

Disease overview

Dogs get ehrlichiosis from the brown dog tick, which passes an ehrlichia organism into the bloodstream when it bites. It is also possible for dogs to become infected through a blood transfusion from an infected dog. There are three stages of ehrlichiosis, each varying in severity. The acute stage, occurring several weeks after infection and lasting for up to a month, can lead to fever and lowered peripheral blood cell counts due to bone marrow suppression. The second stage, called the subclinical phase, has no outward signs and can last for the remainder of the dog's life, during which the dog remains infected with the organism. Some dogs are able to successfully eliminate the disease during this time. In some dogs the third and most serious stage of infection, the chronic phase, will commence. Very low blood cell counts (pancytopenia), bleeding, bacterial infection, lameness, neurological and ophthalmic disorders, and kidney disease can result. Chronic ehrlichiosis can be fatal.

Signs and symptoms

The acute stage of the disease, occurring most often in the spring and summer, begins one to three weeks after infection and lasts for two to four weeks. Clinical signs include a fever, petechiae, bleeding disorders, vasculitis, lymphadenopathy, discharge from the nose and eyes, and edema of the legs and scrotum. There are no outward signs of the subclinical phase. Clinical signs of the chronic phase include weight loss, pale gums due to anemia, bleeding due to thrombocytopenia, vasculitis, lymphadenopathy, dyspnea, coughing, polyuria, polydipsia, lameness, ophthalmic diseases such as retinal hemorrhage and anterior uveitis, and neurological disease. Dogs that are severely affected can die from this disease.

Although people can get ehrlichiosis, dogs do not transmit the bacteria to humans; rather, ticks pass on the ehrlichia organism. Clinical signs of human ehrlichiosis include fever, headache, eye pain, and gastrointestinal upset. It is quite similar to Rocky Mountain spotted fever, but rash is not seen in patients.

Diagnosis

Diagnosis is achieved most commonly by serologic testing of the blood for the presence of antibodies against the ehrlichia organism. Many veterinarians routinely test for the disease, especially in enzootic areas. During the acute phase of infection, the test can be falsely negative because the body will not have had time to make antibodies to the infection. As such, the test should be repeated. A PCR (polymerase chain reaction) test can be performed during this stage to detect genetic material of the bacteria. The PCR test is more likely to yield a negative result during the subclinical and chronic disease phases. In addition, blood tests may show abnormalities in the numbers of red blood cells, white blood cells, and most commonly platelets, if the disease is present. Uncommonly, a diagnosis can be made by looking under a microscope at a blood smear for the presence of the ehrlichia morulae, which sometimes can be seen as intracytoplasmic inclusion bodies within a white blood cell.

Prognosis

The prognosis is good for dogs with acute ehrlichiosis. For dogs that have reached the chronic stage of the disease, the prognosis is guarded. When bone marrow suppression occurs and there are low levels of blood cells, the animal may not respond to treatment.

Treatment

Supportive care must be provided to animals that have clinical signs. Subcutaneous or intravenous fluids are given to dehydrated animals, and severely anemic dogs may require a blood transfusion. Treatment for ehrlichiosis involves the use of antibiotics such as tetracycline or doxycycline for a period of three to four weeks; Alternatively minocycline or rifampicin can be used as a second option. Treatment with macrolide antibiotics like clarithromycin and azithromycin is being studied. In addition, steroids may be indicated in severe cases in which the level of platelets is so low that the condition is life-threatening.

Prevention

Tick control is the most effective method of prevention, but tetracycline at a lower dose can be given daily for 200 days during the tick season in endemic regions.

References

  1. Fitzgerald, Roxanne (2021-07-15). "This once-rare dog disease appeared in the outback last year. Now it's arrived in the city". www.abc.net.au. Archived from the original on 2021-07-15. Retrieved 2021-07-16.
  2. Sainz, Ángel; Roura, Xavier; Miró, Guadalupe; Estrada-Peña, Agustín; Kohn, Barbara; Harrus, Shimon; Solano-Gallego, Laia (2015-02-04). "Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe". Parasites & Vectors. 8 (1): 75. doi:10.1186/s13071-015-0649-0. ISSN 1756-3305. PMC 4324656. PMID 25649069.
  3. ^ Ettinger, Stephen J.; Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine(4th ed.). W.B. Saunders Company. ISBN 0-7216-6795-3.
  4. Biggs, Holly M.; et al. (13 May 2016). "Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis — United States. A Practical Guide for Health Care and Public Health Professionals" (PDF). Centers for Disease Control and Prevention: Morbidity and Mortality Weekly Report. 65: 2: 44.
  5. Harrus, Shimon; et al. (21 December 2020). "Recent Advances in Determining the Pathogenesis of Canine Monocytic Ehrlichiosis". Journal of Clinical Microbiology. 37 (9): 2745–2749. doi:10.1128/jcm.37.9.2745-2749.1999. PMC 85367. Retrieved 2021-07-16.
  6. "Canine Monocytic Ehrlichiosis: An In-depth Review". Idexx Laboratories. Retrieved 2012-09-26.
  7. Mylonakis, Mathios E.; Harrus, Shimon; Breitschwerdt, Edward B. (April 2019). "An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis)". The Veterinary Journal. 246: 45–53. doi:10.1016/j.tvjl.2019.01.015. PMID 30902188. S2CID 85456868.

External links

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