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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''Brain-specific angiogenesis inhibitor 3''' is a ] that in humans is encoded by the ''BAI3'' ].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1–2 | pages = 103–108 | date = Apr 1998 | pmid = 9533023 | doi = 10.1159/000134693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577}}</ref> |
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BAI1, a p53-target gene, encodes brain-specific ] inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez" /> The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.<ref>{{cite journal | vauthors = Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F | title = The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons | journal = Molecular Psychiatry | volume = 18 | issue = 8 | pages = 943–950 | date = August 2013 | pmid = 23628982 | pmc = 3730300 | doi = 10.1038/mp.2013.46 }}</ref> |
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{{GNF_Protein_box |
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| image = |
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| image_source = |
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| PDB = |
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| Name = Brain-specific angiogenesis inhibitor 3 |
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| HGNCid = 945 |
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| Symbol = BAI3 |
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| AltSymbols =; KIAA0550; MGC133100 |
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| OMIM = 602684 |
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| ECnumber = |
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| Homologene = 1289 |
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| MGIid = 2441837 |
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| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0016527 |text = brain-specific angiogenesis inhibitor activity}} |
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| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} |
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| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 577 |
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| Hs_Ensembl = ENSG00000135298 |
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| Hs_RefseqProtein = NP_001695 |
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| Hs_RefseqmRNA = NM_001704 |
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| Hs_GenLoc_db = |
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| Hs_GenLoc_chr = 6 |
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| Hs_GenLoc_start = 69401980 |
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| Hs_GenLoc_end = 70156124 |
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| Hs_Uniprot = O60242 |
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| Mm_EntrezGene = 210933 |
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| Mm_Ensembl = ENSMUSG00000033569 |
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| Mm_RefseqmRNA = NM_175642 |
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| Mm_RefseqProtein = NP_783573 |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = 1 |
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| Mm_GenLoc_start = 25012714 |
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| Mm_GenLoc_end = 25771306 |
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| Mm_Uniprot = Q499E3 |
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}} |
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}} |
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'''Brain-specific angiogenesis inhibitor 3''', also known as '''BAI3''', is a human ].<ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577| accessdate = }}</ref> |
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The adhesion GPCR BaI3 is an orphan receptor that has a long ] consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.<ref>{{cite journal | vauthors = Bolliger MF, Martinelli DC, Südhof TC | title = The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 6 | pages = 2534–2539 | date = February 2011 | pmid = 21262840 | doi = 10.1073/pnas.1019577108 | pmc = 3038708 | bibcode = 2011PNAS..108.2534B | doi-access = free }}</ref> BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses. |
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{{PBB_Summary |
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| section_title = |
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| summary_text = BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577| accessdate = }}</ref> |
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==References== |
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== References == |
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{{reflist}} |
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==Further reading== |
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== Further reading == |
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* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = June 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }} |
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| citations = |
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*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }} |
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* {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 1 | pages = 31–39 | date = February 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 | doi-access = free }} |
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*{{cite journal | author=Shiratsuchi T, Nishimori H, Ichise H, ''et al.'' |title=Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 103-8 |year= 1998 |pmid= 9533023 |doi= }} |
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* {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = July 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }} |
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*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }} |
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*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }} |
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*{{cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }} |
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*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} |
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{{refend}} |
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{{refend}} |
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== External links == |
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{{protein-stub}} |
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* {{UCSC gene info|ADGRB3}} |
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{{NLM content}} |
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{{G protein-coupled receptors}} |
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] |
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{{transmembranereceptor-stub}} |
