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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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{{Infobox_gene}} |
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'''Ubiquitin carboxyl-terminal hydrolase 1''' is an ] that in humans is encoded by the ''USP1'' ].<ref name="pmid12838346">{{cite journal | vauthors = Puente XS, Sánchez LM, Overall CM, López-Otín C | title = Human and mouse proteases: a comparative genomic approach | journal = Nature Reviews. Genetics | volume = 4 | issue = 7 | pages = 544–558 | date = July 2003 | pmid = 12838346 | doi = 10.1038/nrg1111 | s2cid = 2856065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398}}</ref> |
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'''Ubiquitin carboxyl-terminal hydrolase 1''' is an ] that in humans is encoded by the ''USP1'' ].<ref name="pmid12838346">{{cite journal | vauthors = Puente XS, Sánchez LM, Overall CM, López-Otín C | title = Human and mouse proteases: a comparative genomic approach | journal = Nature Reviews. Genetics | volume = 4 | issue = 7 | pages = 544–558 | date = July 2003 | pmid = 12838346 | doi = 10.1038/nrg1111 | s2cid = 2856065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398}}</ref> |
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The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" /> |
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The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" /> |
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==Research== |
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UCH-L1 has been studied, in a 2020 paper by Sharma, et al for its association with ] (])<ref>{{cite journal |last1=Sharma |first1=Amit |last2=Liu |first2=Hongde |last3=Tobar-Tosse |first3=Fabian |last4=Chand Dakal |first4=Tikam |last5=Ludwig |first5=Michael |last6=Holz |first6=Frank G. |last7=Loeffler |first7=Karin U. |last8=Wüllner |first8=Ullrich |last9=Herwig-Carl |first9=Martina C. |title=Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration |journal=International Journal of Molecular Sciences |date=30 May 2020 |volume=21 |issue=11 |pages=3910 |doi=10.3390/ijms21113910 |doi-access=free |pmid=32486284 |pmc=7312489 |issn=1422-0067}}</ref> |
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A 2024 paper by Li, et al indicates possible contribution to ] progression. Apparently via stabilizing proteins that promote cell proliferation (in TNBC, UCHL1 deubiquitinates and stabilizes KLF5, as a consequence there is resistance to ]).<ref>{{cite journal |last1=Li |first1=Juan |last2=Liang |first2=Yu |last3=Zhou |first3=Shijie |last4=Chen |first4=Jie |last5=Wu |first5=Chihua |title=UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5 |journal=Breast Cancer Research |date=11 March 2024 |volume=26 |issue=1 |pages=44 |doi=10.1186/s13058-024-01800-1 |doi-access=free |pmid=38468288 |issn=1465-542X}}</ref> |
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== Therapy == |
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USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an ''in vitro'' model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy. <ref>{{cite journal | vauthors = García-Santisteban I, Peters GJ, Giovannetti E, Rodríguez JA | title = USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy | journal = Molecular Cancer | volume = 12 | issue = 1 | pages = 91 | date = August 2013 | pmid = 23937906 | pmc = 3750636 | doi = 10.1186/1476-4598-12-91 }}</ref> |
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== References == |
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== References == |
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* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–292 | date = September 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }} |
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* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–292 | date = September 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }} |
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* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | display-authors = 6 | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–2144 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }} |
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* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | display-authors = 6 | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–2144 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }} |
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* {{cite journal | vauthors = Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R | title = The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway | journal = Molecular Cell | volume = 17 | issue = 3 | pages = 331–339 | date = February 2005 | pmid = 15694335 | doi = 10.1016/j.molcel.2005.01.008 | hdl-access = free | hdl = 1874/17796 }} |
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* {{cite journal | vauthors = Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R | title = The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway | journal = Molecular Cell | volume = 17 | issue = 3 | pages = 331–339 | date = February 2005 | pmid = 15694335 | doi = 10.1016/j.molcel.2005.01.008 | hdl-access = free | hdl = 1874/17796 | s2cid = 19117200 }} |
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* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | display-authors = 6 | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-D418 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }} |
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* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | display-authors = 6 | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–D418 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }} |
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{{refend}} |
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{{refend}} |
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