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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''Ubiquitin carboxyl-terminal hydrolase 1''' is an ] that in humans is encoded by the ''USP1'' ].<ref name="pmid12838346">{{cite journal | vauthors = Puente XS, Sánchez LM, Overall CM, López-Otín C | title = Human and mouse proteases: a comparative genomic approach | journal = Nature Reviews. Genetics | volume = 4 | issue = 7 | pages = 544–558 | date = July 2003 | pmid = 12838346 | doi = 10.1038/nrg1111 | s2cid = 2856065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398}}</ref> |
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| require_manual_inspection = no |
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| update_protein_box = yes |
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This gene encodes a member of the ]-specific processing (UBP) family of proteases that is a ] (DUB) with His and Cys domains. This protein is located in the ] and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. |
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{{GNF_Protein_box |
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| image = |
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| image_source = |
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| PDB = |
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| Name = Ubiquitin specific peptidase 1 |
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| HGNCid = 12607 |
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| Symbol = USP1 |
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| AltSymbols =; UBP |
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| OMIM = 603478 |
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| ECnumber = |
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| Homologene = 2528 |
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| MGIid = 2385198 |
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| GeneAtlas_image1 = PBB_GE_USP1_202413_s_at_tn.png |
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| GeneAtlas_image2 = PBB_GE_USP1_202412_s_at_tn.png |
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| Function = {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} |
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| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} |
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| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 7398 |
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| Hs_Ensembl = ENSG00000162607 |
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| Hs_RefseqProtein = NP_001017415 |
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| Hs_RefseqmRNA = NM_001017415 |
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| Hs_GenLoc_db = |
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| Hs_GenLoc_chr = 1 |
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| Hs_GenLoc_start = 62674563 |
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| Hs_GenLoc_end = 62690063 |
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| Hs_Uniprot = O94782 |
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| Mm_EntrezGene = 230484 |
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| Mm_Ensembl = ENSMUSG00000028560 |
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| Mm_RefseqmRNA = NM_146144 |
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| Mm_RefseqProtein = NP_666256 |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = 4 |
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| Mm_GenLoc_start = 98415828 |
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| Mm_GenLoc_end = 98427551 |
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| Mm_Uniprot = |
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}} |
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}} |
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'''Ubiquitin specific peptidase 1''', also known as '''USP1''', is a human ].<ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398| accessdate = }}</ref> |
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The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" /> |
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==Research== |
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{{PBB_Summary |
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UCH-L1 has been studied, in a 2020 paper by Sharma, et al for its association with ] (])<ref>{{cite journal |last1=Sharma |first1=Amit |last2=Liu |first2=Hongde |last3=Tobar-Tosse |first3=Fabian |last4=Chand Dakal |first4=Tikam |last5=Ludwig |first5=Michael |last6=Holz |first6=Frank G. |last7=Loeffler |first7=Karin U. |last8=Wüllner |first8=Ullrich |last9=Herwig-Carl |first9=Martina C. |title=Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration |journal=International Journal of Molecular Sciences |date=30 May 2020 |volume=21 |issue=11 |pages=3910 |doi=10.3390/ijms21113910 |doi-access=free |pmid=32486284 |pmc=7312489 |issn=1422-0067}}</ref> |
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| section_title = |
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| summary_text = This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: USP1 ubiquitin specific peptidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7398| accessdate = }}</ref> |
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}} |
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A 2024 paper by Li, et al indicates possible contribution to ] progression. Apparently via stabilizing proteins that promote cell proliferation (in TNBC, UCHL1 deubiquitinates and stabilizes KLF5, as a consequence there is resistance to ]).<ref>{{cite journal |last1=Li |first1=Juan |last2=Liang |first2=Yu |last3=Zhou |first3=Shijie |last4=Chen |first4=Jie |last5=Wu |first5=Chihua |title=UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5 |journal=Breast Cancer Research |date=11 March 2024 |volume=26 |issue=1 |pages=44 |doi=10.1186/s13058-024-01800-1 |doi-access=free |pmid=38468288 |issn=1465-542X}}</ref> |
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==References== |
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== References == |
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{{reflist}} |
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{{reflist}} |
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==Further reading== |
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== Further reading == |
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{{refbegin | 2}} |
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{{refbegin | 2}} |
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* {{cite journal | vauthors = D'Andrea A, Pellman D | title = Deubiquitinating enzymes: a new class of biological regulators | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 33 | issue = 5 | pages = 337–352 | year = 1999 | pmid = 9827704 | doi = 10.1080/10409239891204251 }} |
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{{PBB_Further_reading |
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* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }} |
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| citations = |
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* {{cite journal | vauthors = Fujiwara T, Saito A, Suzuki M, Shinomiya H, Suzuki T, Takahashi E, Tanigami A, Ichiyama A, Chung CH, Nakamura Y, Tanaka K | display-authors = 6 | title = Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease | journal = Genomics | volume = 54 | issue = 1 | pages = 155–158 | date = November 1998 | pmid = 9806842 | doi = 10.1006/geno.1998.5554 }} |
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*{{cite journal | author=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337-52 |year= 1999 |pmid= 9827704 |doi= }} |
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*{{cite journal | author=Puente XS, Sánchez LM, Overall CM, López-Otín C |title=Human and mouse proteases: a comparative genomic approach. |journal=Nat. Rev. Genet. |volume=4 |issue= 7 |pages= 544-58 |year= 2003 |pmid= 12838346 |doi= 10.1038/nrg1111 }} |
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* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–1795 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} |
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* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | display-authors = 6 | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–435 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }} |
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*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }} |
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*{{cite journal | author=Fujiwara T, Saito A, Suzuki M, ''et al.'' |title=Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. |journal=Genomics |volume=54 |issue= 1 |pages= 155-8 |year= 1999 |pmid= 9806842 |doi= }} |
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* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–292 | date = September 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }} |
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*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }} |
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* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | display-authors = 6 | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–2144 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }} |
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*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }} |
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* {{cite journal | vauthors = Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R | title = The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway | journal = Molecular Cell | volume = 17 | issue = 3 | pages = 331–339 | date = February 2005 | pmid = 15694335 | doi = 10.1016/j.molcel.2005.01.008 | hdl-access = free | hdl = 1874/17796 | s2cid = 19117200 }} |
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*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }} |
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* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | display-authors = 6 | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–D418 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }} |
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*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }} |
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*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} |
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*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} |
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*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }} |
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*{{cite journal | author=Nijman SM, Huang TT, Dirac AM, ''et al.'' |title=The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 331-9 |year= 2005 |pmid= 15694335 |doi= 10.1016/j.molcel.2005.01.008 }} |
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*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }} |
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