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Neurocysticercosis
Magnetic resonance image of a patient with neurocysticercosis demonstrating multiple cysticerci within the brain
Specialty	Infectious diseases

Neurocysticercosis (NCC) is a parasitic infection of the nervous system caused by the tapeworm Taenia solium, also known as the "pork tapeworm". The disease is often caused by eating undercooked food or drinking water contaminated with tapeworm larvae (cysticerci). When cysticerci enter the small intestine, they attach to the intestinal wall and grow into a tapeworm. This tapeworm can travel to the brain, muscles, eyes, and skin. Neurocysticercosis manifests with various signs and symptoms, influenced by the location, number of lesions, and immune response. While some people may have no symptoms, others may experience seizures, increased pressure in the skull, cognitive impairment, or specific neurological problems. In severe cases, the condition can be life-threatening.

Diagnosis relies on imaging and blood tests. Neurocysticercosis can be prevented through improved sanitation, education, awareness, de-worming and vaccines for endemic areas. Treatment options depend on cyst viability, the host's immune response, and the location and number of lesions. Symptoms are treated with anti-seizure, antiedema, pain, or anti-inflammatory drugs. Surgery, steroids, or other medications are used to treat intracranial hypertension. Anti-parasitic medications are used for treating earlier stages of the disease. Steroids are used to manage inflammation in the central nervous system. Surgery can be used to remove cysts.

Neurocysticercosis is common in developing regions, such as Latin America, China, Nepal, Africa, India, and Southeast Asia. Although rare in Europe and the US, immigration has increased its prevalence. Taenia solium has been recognized since 1500 BC and found in ancient Egyptian mummies. The first recorded cases of neurocysticercosis were likely in 1558. In 1792, a Peruvian physician reported simultaneous taeniasis, tapeworm infection in the intestines, and cysticercosis in the same individual. In the 19th century, German pathologists found similarities between T. solium and cysticercus scolex and discovered that consumption of cysticercus in pork caused human intestinal taeniasis.

Signs and symptoms

Neurocysticercosis has a wide range of signs and symptoms, which relate to the location, number of lesions, and immune system's response to the infection. Ranging from asymptomatic to deadly, neurocysticercosis has been referred to as the "great imitator" as it can mimic many other neurological disorders. The most common symptoms are seizures, intracranial hypertension, cognitive impairment, and focal deficits.

Seizures

In areas where neurocysticercosis is common, adult-onset seizures are heavily correlated with the condition. Seizures are more common in parenchymal neurocysticercosis than in other forms of neurocysticercosis; they can occur at any stage of the disease. Partial seizures, which affect only one side of the brain at first, are the most common type of seizures. If neurocysticercosis is left untreated, seizures often persist and recur despite treatment. Seizures are more commonly associated with degenerating cysts, which are often accompanied by swelling, inflammation, nerve damage, and gliosis. They are caused by inflammatory responses in the brain and the space-occupying effect of the cysts. Multiple lesions increase the risk of seizures. Active cysts are associated with first-time seizures while calcified granulomas are associated with chronic epilepsy.

Focal deficits

Those with neurocysticercosis can exhibit a variety of specific neurologic symptoms determined by the size, number, and location of the parasites. Pyramidal tract symptoms, such as weakness, Babinski's sign, spasticity, and overactive reflexes are the most common; however sensory impairments, parkinsonian rigidity, involuntary movements, language disturbances, and signs of brain-stem dysfunction can also occur. Focal neurologic symptoms are most commonly seen in those with large subarachnoid cysts compressing the brain parenchyma. Inflammation in the arachnoid layer can cause focal signs, ischaemic strokes caused by intracranial artery blockage, cranial nerve compression, hearing loss, and facial nerve palsy or trigeminal neuralgia. There may also be focal neurological symptoms caused by brainstem damage. Cysticercosis of the spinal cord often causes radicular pain, weakness, and sensory impairments due to localized mass effects or inflammation in the subarachnoid space.

Intracranial hypertension

Intracranial hypertension – a build-up of pressure around the brain – is associated with neurocysticercosis and may be accompanied by other symptoms. More common in extraparenchymal neurocysticercosis, it is most frequently caused by buildup of cerebrospinal fluid in the brain. Hydrocephalus can be related to granular ependymitis, compression of the CSF pathways by cysts, cysticercotic arachnoiditis, and inflammation or cysts blocking ventricles. Large subarachnoid cysts and cyst clumps can also cause a mass effect and intracranial hypertension, with or without hydrocephalus. Intracranial hypertension can present as episodic loss of consciousness when moving the head, known as Bruns syndrome; it may be subacute or chronic. Cysticercotic encephalitis, which is a severe type of neurocysticercosis usually affecting younger women and children can also cause intracranial hypertension. Cysticercotic encephalitis is characterized by seizures, intracranial hypertension, clouding of consciousness, optic disc swelling, headache, reduction of visual acuity, and vomiting.

Cognitive and psychiatric disturbances

Cognitive and psychiatric manifestations of neurocysticercosis can range from mild deficits to severe dementia. Episodes of psychosis which involve paranoia, confusion, and violent behaviour have been reported to occur with neurocysticercosis. Some of these episodes could be associated with psychomotor epilepsy or post-seizure psychosis. Other psychiatric symptoms of neurocysticercosis include anxiety, delirium, sensory changes, depression, and personality disorders. Those with neurocysticercosis may exhibit depression, cognitive impairments, or a decline in quality of life.

Other symptoms

Spinal arachnoiditis can cause subacute root pain and weakness. Cysts in the spinal cord are typically associated with motor and sensory impairments that vary depending on the location of the lesion. Those with cysticerci in the sellar region may have vision and hormonal issues. In the eyes, cysticerci are usually found in the subretinal space, causing a gradual reduction in visual acuity or visual field abnormalities. The cysts can cause inflammation of the vitreous membrane, uveitis, and endophthalmitis, which is the most serious complication of ocular cysticercosis and can result in eye shrinkage. Cysticercal infection in striated muscles can cause weakening and englargment over time.

Causes

Neurocysticercosis is caused by the larvae of the tapeworm Taenia solium. Neurocysticercosis often results from undercooked infected pork or other food, or contaminated water. Once someone consumes Taenia solium, cysticerci are released into the small intestine. The head of the tapeworm (scolex) then evaginates and attaches to the intestinal wall. When the scolex attaches, it grows into a tapeworm which penetrates the intestinal wall and gets into the bloodstream where it can travel the rest of the body.

Mechanism

Taenia solium is a tapeworm in the Cestoda class and is a species of the genus Taenia. It has two hosts, pigs and humans. Pigs and humans can act as intermediate hosts for the larval form, but humans are the only definitive hosts for the adult tapeworm. The larvae are cystic, fluid-filled sacs containing a tapeworm head (scolex) with four suckers and a double row of hooks, along with a narrow neck and a body made up of hundreds of segments called proglottids. When a person eats pork infected with cysts, the scolex (the head of the tapeworm) evaginates and clings to the intestinal wall using its suckers and hooks. Once attached, the segments of the tapeworm, called proglottids, multiply and grow. Within about four months, the tapeworm matures into a ribbon-like structure, measuring 2–4 meters long.

When humans consume T. solium eggs, the eggs hatch into larvae, which penetrate the intestinal wall and spread throughout the body, leading to cysticercosis. Although the cysts can form in any tissue, they are most commonly found in the central nervous system, skeletal muscle, skin, and eyes. Cysticerci enter the central nervous system as live parasites (vesicular stage) with a transparent membrane, clear fluid, and a scolex (head) tucked inside. They can survive for years, but the host’s immune response may sometimes cause them to degenerate into inactive nodules. In the colloidal stage, the fluid inside the cyst becomes cloudy, and the scolex begins to break down. Next, the cyst wall thickens, and the scolex hardens into small mineralized granules, marking the granular stage when the cyst is no longer active. Eventually, the parasite remnants fully calcify, forming hardened nodules in the calcified stage.

Diagnosis

Diagnosing neurocysticercosis can be challenging, especially in resource-limited areas, as available methods are often unreliable or inaccessible. Physical examination and laboratory testing are often not helpful in diagnosing neurocysticercosis. Diagnosis mainly relies on neuroimaging and blood tests. Diagnostic criteria have also been created to help with the diagnostic process.

Immunodiagnosis

The lentil lectin purified glycoprotein (LLGP) enzyme-linked immunoelectrotransfer blot (EITB) assay, is the most reliable test for detecting T. solium antibodies in the blood. This method uses specific proteins to identify the presence of these antibodies. Antibodies can be identified in EITB as early as five weeks after infection. The LLGP-EITB has a sensitivity of 98% for individuals with multiple brain cysts and a specificity of 100%. However, its sensitivity is lower in cases with just one cyst. The ELISA test for detecting anticysticercal antibodies in cerebrospinal fluid (CSF) is 89% sensitive and 93% specific for active neurocysticercosis infections. It is often used as an alternative when the EITB test is unavailable.

As many as 37% of those with neurocysticercosis have high eosinophils, making it the most common blood abnormality in neurocysticercosis. The number of people with positive stool tests for Taenia solium eggs in neurocysticercosis varies and seems to depend on how severe the infection is. Recognizing Taenia eggs is difficult, and many cases may go undetected during testing.

Neuroimaging

CT and MRI give objective information about number and pattern of lesions, the stage of healing, and how the immune system is responding to the parasites. MRI is better for evaluating different spatial planes and provides clearer images, which helps in identifying small lesions at the back of the brain or near the skull that may be missed on CT scans. CT is more sensitive at detecting calcium buildup in the brain due to its ability detect calcifications in the brain.

Live vesicular cysts are small, round lesions with little swelling around them and do not need contrast for imaging. The tapeworm head (scolex) usually appears as an asymmetric nodule inside the cysts. Multiple live cysts with these heads corroborate the diagnosis. Once the cysts begin to break down (colloid cysts), their borders become unclear, they are surrounded by swelling and exhibit significant ring or nodular contrast enhancement. Calcified cysticerci are shown on CT scans as non-enhancing hyperdense nodules without swelling.

Diagnostic criteria

Neurocysticercosis diagnostic criteria:

• Absolute criteria:
  • Confirmation of the parasite through tissue analysis from a biopsy of a brain or spinal cord lesion.
  • Visualization of cysticercus under the retina.
  • Clear evidence of a scolex (head of the tapeworm) within a cystic lesion on neuroimaging studies.
• Neuroimaging criteria:
  • Major neuroimaging criteria:
    • Cystic lesions without a visible scolex.
    • Enhancing lesions.
    • Cystic lesions with multiple lobes in the subarachnoid space.
    • Typical parenchymal brain calcifications.
  • Confirmative neuroimaging criteria:
    • Resolution of cystic lesions after antiparasitic drug therapy.
    • Spontaneous resolution of single small enhancing lesions.
    • Migration of ventricular cysts documented on sequential neuroimaging studies.
  • Minor neuroimaging criteria:
    • Obstructive hydrocephalus (symmetric or asymmetric) or abnormal enhancement of basal leptomeninges.
• Clinical/exposure criteria:
  • Major clinical/exposure:
    • Detection of specific antibodies or antigens related to cysticercosis by well-standardized immunodiagnostic tests.
    • Cysticercosis outside the central nervous system.
    • Evidence of household contact with T. solium infection.
  • Minor clinical/exposure:
    • Clinical manifestations suggestive of neurocysticercosis.
    • Individuals coming from or living in an area where cysticercosis is endemic.

Classification

Neurocysticercosis can be classified into two main types: parenchymal, which affects the brain tissue, and extraparenchymal, which occurs outside the brain tissue.

• Parenchymal neurocysticercosis: neurocysticercosis lesions within brain parenchyma.
  • Viable parenchymal cysts: contains the scolex, typically between 0.5 and 2 cm in diameter.
  • Single enhancing lesion (solitary cysticercal granuloma): One or two smaller cysts.
  • Massive infections: hundreds of cysts and a large number of larvae.
• Extraparenchymal neurocysticercosis: lesions in ventricles or subarachnoid spaces.
  • Ventricular neurocysticercosis: cysts in the brain ventricles.
  • Subarachnoid neurocysticercosis: cysticerci in the subarachnoid space.
• Other locations
  • Spinal neurocysticercosis: neurocysticercosis in the spine, often the extramedullary subarachnoid spaces.
  • Retinal neurocysticercosis: cysts effecting the retina.

Prevention

Neurocysticercosis is preventable. Some factors that make T. solium potentially eradicable are humans being the only definitive host, the intermediate host being an animal whose exposure to ova can be controlled, well-developed diagnostic testing allowing infected individuals to be identified, effective treatments available, and the availability of pig vaccines.

Neurocysticercosis is more prevalent in areas where the transmission of T. solium is more likely, such as areas with improper disposal of waste, lower levels of education, improper slaughter of pigs, and free-roaming pigs. Unsanitary conditions and domestic pigs are required for T. solium to be transmitted. Urbanization and development reduce these factors, therefore transmission goes down. Because neurocysticercosis takes years to develop, intervention programs can take decades.

To prevent neurocysticercosis, interventions such as increasing education, improving sanitary conditions, and strict animal husbandry and meat inspection procedures are needed. Medical prevention includes de-worming people with medications such as niclosamide or praziquantel, and vaccinating and treating pigs with oxfendazole. Raised awareness of neurocysticercosis in non-endemic countries where rates are increasing is also important. The TSOL18 vaccine, which is made up of a recombinant protein from a T. solium oncosphere is a promising solution for the prevention and control of neurocysticercosis. Increasing public health surveillance, such as obligatory notification of neurocysticercosis cases, could also be beneficial. Properly identifying neurocysticercosis is needed to target interventions.

In 1985 in Ecuador praziquantel was used for de-worming, and was eventually used in other countries. In Honduras, transmission and morbidity decreased after the health education and control program. A big elimination program managed to eliminate transmission in 105 out of 107 villages by using pig vaccines, human and porcine mass chemotherapy, and stool coproantigen case confirmation.

Treatment

A single treatment method is not appropriate for every person with neurocysticercosis. The disease has to be characterized in terms of cyst viability, the degree of the host's immunological response to the parasite, and the location and number of lesions to provide proper treatment. Symptomatic and antiparasitic medications are typically used in conjunction for treatment. Surgery can also be used to remove cysts.

Neurocysticercosis is a persistent infection, with symptoms appearing months or years later. As a result, removing the parasite is not an emergency, and the first step in treating those with neurocysticercosis is often aimed at minimizing the symptoms. This may be done with the use of antiepileptic, antiedema, analgesic, or anti-inflammatory drugs. Carbamazepine is commonly used to control seizures. Antiepileptic medications may be used till after a year without seizures. Surgery, acetazolamide, steroids, or mannitol may be used to help manage intracranial hypertension.

Antiparasitic drugs are contradicted when there is a preexisting risk of developing hydrocephalus, such as with sub-arachnoid neurocysticercosis or encephalitic neurocysticercosis; in these cases, the inflammation that occurs after treatment may pose a significant risk of rapidly raising intracranial pressure and death. The two most commonly used antiparasitic medications are albendazole, an imidazole that inhibits glucose absorption and metabolism in the parasite, and praziquantel, an isoquinoline which triggers parasite paralysis by altering calcium pathways and homeostasis. Antiparasitic drugs may take days to months to work. These medications are only appropriate for the treatment of vesicular viable cysts or cysts in the early colloidal phases of development, and they are ineffective against calcified cysts.

Steroid administration is an important step in the modulation of neurocysticercosis-related inflammation in the central nervous system, since it controls the acute inflammatory response that occurs following the destruction of live cysts. Prednisolone and dexamethasone are frequently used as adjuncts to antiparasitic therapy.

Antiparasitic medication may be ineffective in cases of severe infection due to the hazards associated with mass inflammation, but these forms of neurocysticercosis carry a high risk of consequences if left untreated. In some circumstances, a more aggressive treatment plan, including surgery, may be required. Surgical treatments include ventricle-peritoneal shunts and excision of cysts.

Outlook

The prognosis for neurocysticercosis depends on the number and location of the cysts. Single enhancing lesion neurocysticercosis typically has a good prognosis, with lesions resolving within 6 months in over 60% of cases. Multiple or calcified lesions increase the risk of seizure relapses. Although psychiatric and cognitive changes are common with neurocysticercosis, they are usually not severe enough to affect day-to-day behaviour.

Parenchymal neurocysticercosis also has a good prognosis. Parenchymal neurocysticercosis prognosis is mediated by the number of lesions and the severity of the inflammation. Over half of those with calcified parenchymal neurocysticercosis have relapses in seizures and need antiseizure medications long-term.

Extraparenchymal neurocysticercosis does not respond to antiparasitic treatment as well as parenchymal neurocysticercosis, meaning that multiple types or courses of treatment are sometimes needed. Complications from treatment such as shunt blockage or vasculitis are also more prevalent with extraparenchymal neurocysticercosis. Extraparenchymal neurocysticercosis can lead to obstructive hydrocephalus and death.

Epidemiology

Neurocysticercosis is endemic in most developing countries, except predominantly Muslim countries. It is endemic in Latin America, China, Nepal, Africa, India, and Southeast Asia. It is more common in poorer countries with improper sanitation and a lack of clean water. Taenia solium is considered rare in developed countries and is usually a result of people contracting Taenia solium while travelling or immigration. Reports of neurocysticercosis are growing from several wealthy nations, including the USA and the UK, as a result of increased globalization and worldwide travel. Most cases of neurocysticercosis in the US have been reported in the southwestern states. Around 90% of neurocysticercosis diagnoses in the US were immigrants from Mexico or South America.

Studies conducted in endemic countries have shown that neurocysticercosis is a common cause of increased rates of epilepsy. In endemic regions, CNS infection is extremely common; in many of these groups, the frequency of certain serum antibodies is more than 10%, and residual intraparenchymal brain calcifications on CT scans are seen in 10–20% of the general population. Neurocysticercosis is estimated to affect 29% of those with epilepsy. About 15% of the pig farming community in India has asymptomatic neurocysticercosis. According to a North Indian study, the prevalence of neurocysticercosis in rural India was 4.5 per 1000. Twenty-five percent of individuals with active epilepsy had antibodies against T. solium, based on another study from North India. In an Indian hospital series, neurocysticercosis was responsible for more than half of the instances of children with partial seizures.

History, society, and culture

Descriptions of Taenia solium tapeworms date back to 1500 BC. Taenia solium cysticerci have even been found in ancient Egyptian mummies. The first recorded cases of neurocysticercosis were most likely described by German physician John Wolfgang Rumler in 1558. Hipólito Unanue, a Peruvian physician and journalist, is believed to have first recorded simultaneous taeniasis and cysticercosis in the same individual in 1792: he reported a case involving a soldier with taeniasis who died following a violent seizure. During the 19th century, German pathologists noticed the morphological parallels between the adult T. solium head and the cysticercus scolex. Friedrich Küchenmeister showed that the consumption of cysticercus from pork caused human intestinal taeniasis by feeding a prisoner food that included cysticerci gathered from a recently killed pig. In the second part of the 19th century, research showed that feeding Taenia eggs from infected humans to pigs caused cysticercosis.

Neurocysticercosis was featured in the "Pilot" episode of House M.D. The episode followed a young woman who contracted neurocysticercosis after eating contaminated ham.

Sebastián Ferrat, a Mexican television star, died in 2019 at age 41 from neurocysticercosis. The New York Times stated that RFK Jr. had contracted neurocysticercosis after travelling to Africa, South America, and Asia. Gaius Julius Caesar is believed to have had epilepsy related to cysticercosis.

See also

• Effects of parasitic worms on the immune system

Notes

1. Round, well-defined lesions filled with fluid that looks similar to cerebrospinal fluid on CT or MRI scans.
2. One or more ring-shaped or nodular lesions, 10-20mm in size, with or without swelling, without displacing midline structures.
3. One or more solid lesions, usually smaller than 10mm.
4. The administration of corticosteroids renders this criterion invalid.
5. Follow-up CT or MRI scans show that the locations of the cystic lesions in the ventricles change over time.
6. Antibody identification by enzyme-linked immunoelectrotransfer blot test employing lentil lectin-purified T. solium antigens, and cysticercal antigen detection by monoclonal antibody-based ELISA.
7. Cysticerci can be identified through a biopsy of subcutaneous lumps, X-ray films or CT scans that reveal cigar-shaped calcifications in soft tissues, or detection of the parasite in the anterior chamber of the eye.
8. Mostly seizures (typically beginning in persons aged 20-49 years; the diagnosis of seizures in this setting is not disregarded if patients are outside of the normal age range), but other signs include chronic headaches, focal neurologic impairments, intracranial hypertension, and cognitive deterioration.
9. A location where active transmission is recorded.

References

Citations

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2. ^ Del Brutto 2014, p. 1448.
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5. ^ Del Brutto 2014, p. 1449.
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7. ^ Rodríguez‐Leyva et al. 2023, p. 98.
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11. ^ Bustos et al. 2021, p. 5.
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13. Rodríguez‐Leyva et al. 2023, pp. 97–98.
14. Kelesidis & Tsiodras 2011, p. 2.
15. Garcia, Nash & Del Brutto 2014, pp. 1205–1206.
16. ^ Del Brutto 2014, p. 1450.
17. ^ Garcia, Nash & Del Brutto 2014, p. 1206.
18. El-Kady et al. 2021, p. 1604.
19. Steyn et al. 2023, p. 105.
20. ^ Del Brutto 2014, p. 1446.
21. Garcia 2018, pp. 851–852.
22. ^ Gripper & Welburn 2017, p. 219.
23. ^ Garcia, Nash & Del Brutto 2014, p. 1202.
24. Rodríguez‐Leyva et al. 2023, p. 97.
25. Del Brutto 2014, p. 1447.
26. ^ Gripper & Welburn 2017, p. 221.
27. ^ Guzman & Garcia 2021, p. 198.
28. Garcia 2018, p. 857.
29. Garcia, Nash & Del Brutto 2014, p. 1208.
30. Garcia, Nash & Del Brutto 2014, p. 1207.
31. Bazan et al. 2016, p. 7.
32. Kavanaugh, Fox & Maves 2014, p. 5.
33. ^ Del Brutto et al. 2017, p. 204.
34. ^ Bustos et al. 2021, p. 1.
35. ^ Bustos et al. 2021, p. 2.
36. Bustos et al. 2021, p. 3.
37. Bustos et al. 2021, p. 4.
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39. Garcia, Nash & Del Brutto 2014, p. 1211.
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49. World Health Organization 2021, p. 22.
50. Singhi & Suthar 2015, p. 169.
51. White et al. 2018, pp. e61–e63.
52. ^ White et al. 2018, p. e51.
53. Del Brutto 2014, pp. 1455.
54. World Health Organization 2021, p. 12.
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56. Garcia 2018, p. 858.
57. Wandra et al. 2015, p. 3.
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Further reading

• Arroyo, Gianfranco; Bustos, Javier A.; Lescano, Andres G.; Gonzales, Isidro; Saavedra, Herbert; Pretell, E. Javier; Castillo, Yesenia; Perez, Erika; Dorny, Pierre; Gilman, Robert H.; O’Neal, Seth E.; Gonzalez, Armando E.; Garcia, Hector H. (February 16, 2022). "Improved Diagnosis of Viable Parenchymal Neurocysticercosis by Combining Antibody Banding Patterns on Enzyme-Linked Immunoelectrotransfer Blot (EITB) with Antigen Enzyme-Linked Immunosorbent Assay (ELISA)". Journal of Clinical Microbiology. 60 (2). American Society for Microbiology: e0155021. doi:10.1128/jcm.01550-21. ISSN 0095-1137. PMC 8849202. PMID 34851685.
• Wang, Zhe; Garcia, Roxanna M.; Huff, Hanalise V.; Niquen-Jimenez, Milagros; Marcos, Luis A.; Lam, Sandi K. (December 20, 2021). "Neurocysticercosis control for primary epilepsy prevention: a systematic review". Pathogens and Global Health. 116 (5). Informa UK Limited: 282–296. doi:10.1080/20477724.2021.2015869. ISSN 2047-7724. PMC 9248947. PMID 34928183.

External links

• "Neurocysticercosis is a preventable parasitic infection". World Health Organization (WHO). February 22, 2018.
• "Neurocysticercosis" (PDF). Centres for Disease Control and Prevention.

• Brain disorders
• Helminthiases
• Parasitic diseases associated with beef and pork consumption