| Revision as of 02:21, 16 December 2024 editRA0808 (talk | contribs)Extended confirmed users, New page reviewers, Pending changes reviewers, Rollbackers100,211 edits Requesting speedy deletion (CSD A3).Tag: Twinkle← Previous edit | Latest revision as of 02:55, 16 December 2024 edit undoJJMC89 bot (talk | contribs)Bots1,161,657 editsm Add {{drafts moved from mainspace}} | ||
| (3 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
| {{db-nocontent|help=off}} | |||
| '''<big>Avoiding Immune Destruction</big>''' | '''<big>Avoiding Immune Destruction</big>''' | ||
| == Mechanisms == | |||
| Many strategies exist for cancer cells to evade immune destruction, such as: | |||
| '''1) Immune mimicry''' | |||
| * Myeloid-derived cells are immune cells that stimulate other immune system components, and cancer cells can mimic their actions. As a result, cancer cells are able to avoid the negative effects of inflammation. | |||
| '''2) Hijacking the PD-1/PDL-1 mechanism''' | |||
| * T lymphocytes are rendered inactive by PD-L1, a ligand that binds to PD-1 on their surface and is produced by cancer cells. | |||
| '''3) Modulating immune checkpoints''' | |||
| * To avoid being discovered and eliminated, cancer cells can take use of immunological checkpoints, which are the immune system's natural regulatory systems. | |||
| '''4) Altering the tumor microenvironment''' | |||
| * The extracellular matrix, cytokines, chemokines, and other cell types that make up the tumor microenvironment can all be modified by cancer cells. | |||
| {{Drafts moved from mainspace|date=December 2024}} | |||
Latest revision as of 02:55, 16 December 2024
Avoiding Immune Destruction
Mechanisms
Many strategies exist for cancer cells to evade immune destruction, such as:
1) Immune mimicry
- Myeloid-derived cells are immune cells that stimulate other immune system components, and cancer cells can mimic their actions. As a result, cancer cells are able to avoid the negative effects of inflammation.
2) Hijacking the PD-1/PDL-1 mechanism
- T lymphocytes are rendered inactive by PD-L1, a ligand that binds to PD-1 on their surface and is produced by cancer cells.
3) Modulating immune checkpoints
- To avoid being discovered and eliminated, cancer cells can take use of immunological checkpoints, which are the immune system's natural regulatory systems.
4) Altering the tumor microenvironment
- The extracellular matrix, cytokines, chemokines, and other cell types that make up the tumor microenvironment can all be modified by cancer cells.