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| {{#invoke:Infobox gene|getTemplateData|QID= Q18049633}} | {{#invoke:Infobox gene|getTemplateData|QID= Q18049633}} | ||
| '''Zinc Finger Protein 816''' (ZNF816) is a ] encoded by the ZNF816 ], located on ] in humans. | '''Zinc Finger Protein 816''' (ZNF816) is a ] encoded by the ZNF816 ], located on ] in humans. | ||
| == Gene == | == Gene == | ||
| The ZNF816 gene is located on the minus-strand of chromosome 19, cytogenetic band 19q13.41<ref name=":0">{{Cite web |title=ZNF816 zinc finger protein 816 - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/125893 |access-date=2024-12-13 |website=www.ncbi.nlm.nih.gov}}</ref> |
The ZNF816 gene is located on the minus-strand of ], cytogenetic band 19q13.41.<ref name=":0">{{Cite web |title=ZNF816 zinc finger protein 816 - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/125893 |access-date=2024-12-13 |website=www.ncbi.nlm.nih.gov}}</ref> It spans 35,746 base pairs, from 52,927,135 to 52,962,881, containing 5 ].<ref name=":0" /> | ||
| ] | |||
| ] | |||
| == Transcripts == | == Transcripts == | ||
| ZNF816 has three transcript variants, the longest is 2,711 base pairs, with 5 exons. The other two have 4 exons, while all three ] encode 651 ]. The ] and ] is consistent across all three |
ZNF816 has three transcript variants, the longest is 2,711 base pairs, with 5 exons.<ref>{{Cite web |title=ZNF816 zinc finger protein 816 - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/125893 |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> The other two have 4 exons, while all three ] encode 651 ]. The ] and ] of is consistent across all three isoforms. | ||
| {| class="wikitable" | {| class="wikitable style="max-width:10em;" | ||
| |'''Isoform number''' | |'''Isoform number''' | ||
| |'''AC#''' | |'''AC#''' | ||
| Line 20: | Line 20: | ||
| |'''AC#''' | |'''AC#''' | ||
| |'''Protein Length (Amino Acids)''' | |'''Protein Length (Amino Acids)''' | ||
| |'''MW''' | |||
| |'''pI''' | |||
| |- | |- | ||
| |1 | |1 | ||
| Line 29: | Line 27: | ||
| |NP_001026835 | |NP_001026835 | ||
| |651 | |651 | ||
| |~75 kDa | |||
| |~9 | |||
| |- | |- | ||
| |2 | |2 | ||
| Line 38: | Line 34: | ||
| |NP_001189385 | |NP_001189385 | ||
| |651 | |651 | ||
| |~75 kDa | |||
| |~9 | |||
| |- | |- | ||
| |3 | |3 | ||
| Line 47: | Line 41: | ||
| |NP_001189386.1 | |NP_001189386.1 | ||
| |651 | |651 | ||
| |~75 kDa | |||
| |~9 | |||
| |} | |} | ||
| Line 54: | Line 46: | ||
| ] | ] | ||
| ] | ] | ||
| The product protein of the ZNF816 gene is 651 amino acids in length, with a predicted molecular weight of 75.7 kDa and an isoelectric point of 9.44. | The product protein of the ZNF816 gene is 651 amino acids in length, with a predicted molecular weight of 75.7 kDa and an isoelectric point of 9.44.<ref>{{Cite web |url=https://www.ebi.ac.uk/jdispatcher/seqstats |access-date=2024-12-14 |website=www.ebi.ac.uk}}</ref> | ||
| === Domains === | === Domains === | ||
| ZNF816 has a ]<ref>{{Cite journal | |
ZNF816 has a ],<ref>{{Cite journal |last1=Yang |first1=Peng |last2=Wang |first2=Yixuan |last3=Macfarlan |first3=Todd S. |date=2017-11-01 |title=The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution |journal=Trends in Genetics |series=Transposable Elements |volume=33 |issue=11 |pages=871–881 |doi=10.1016/j.tig.2017.08.006 |pmid=28935117 |pmc=5659910 |issn=0168-9525}}</ref> which is characterized by a ] domain and an array of fifteen ]. This domain suppresses transcription by recruiting co-repressor proteins, which create heterochromatin, blocking RNA polymerase from accessing the gene. The amino acid sequence includes six ],<ref name=":2">{{Cite web |title=PredictProtein - Protein Sequence Analysis, Prediction of Structural and Functional Features |url=https://predictprotein.org |access-date=2024-12-14 |website=predictprotein.org}}</ref> and eight ].<ref name=":2" /> | ||
| === Structure === | === Structure === | ||
| The predicted secondary structure of ZNF816 from AlphaFold<ref>{{Cite web |title=AlphaFold Protein Structure Database |url=https://alphafold.ebi.ac.uk/entry/Q0VGE8 |access-date=2024-12-13 |website=alphafold.ebi.ac.uk}}</ref> consists of mainly alpha helices, from the C2H2 zinc finger motifs. The tertiary structure of ZNF816 was predicted by iTasser<ref>{{Cite web |title=I-TASSER server for protein structure and function prediction |url=https://zhanggroup.org/I-TASSER/ |access-date=2024-12-13 |website=zhanggroup.org}}</ref> and annotated (Icn3D<ref>{{Cite web |title=iCn3D: Web-based 3D Structure Viewer |url=https://www.ncbi.nlm.nih.gov/Structure/icn3d/ |access-date=2024-12-13 |website=www.ncbi.nlm.nih.gov}}</ref>) according to the characteristics of other zinc finger proteins and prominent domains. | The predicted secondary structure of ZNF816 from ]<ref>{{Cite web |title=AlphaFold Protein Structure Database |url=https://alphafold.ebi.ac.uk/entry/Q0VGE8 |access-date=2024-12-13 |website=alphafold.ebi.ac.uk}}</ref> consists of mainly ], from the C2H2 zinc finger motifs. The ] of ZNF816 was predicted by iTasser<ref>{{Cite web |title=I-TASSER server for protein structure and function prediction |url=https://zhanggroup.org/I-TASSER/ |access-date=2024-12-13 |website=zhanggroup.org}}</ref> and annotated (Icn3D<ref>{{Cite web |title=iCn3D: Web-based 3D Structure Viewer |url=https://www.ncbi.nlm.nih.gov/Structure/icn3d/ |access-date=2024-12-13 |website=www.ncbi.nlm.nih.gov}}</ref>) according to the characteristics of other zinc finger proteins and prominent domains. | ||
| == Gene Level Regulation == | == Gene Level Regulation == | ||
| ZNF816 shows a |
ZNF816 shows a moderately variable expression pattern, with detectable levels in most tissues. While some tissues, like the adrenal gland, testes, thyroid, and salivary gland, exhibit relatively higher expression,<ref>{{Cite web |title=National Center for Biotechnology Information |url=https://www.ncbi.nlm.nih.gov |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov |language=en}}</ref> ZNF816 is generally expressed across a wide range of tissues. | ||
| === RNA-Seq Data === | === RNA-Seq Data === | ||
| Line 71: | Line 63: | ||
| === Protein Localization and Abundance === | === Protein Localization and Abundance === | ||
| ] data show ZNF816 protein is localized in the ] (95.7%)<ref>{{Cite web |title=PSORT WWW Server |url=https://psort.hgc.jp/ |access-date=2024-12-13 |website=psort.hgc.jp}}</ref> across various human tissues. It is seen to be expressed at high levels relative to other proteins<ref>{{Cite web |title=PaxDb: Protein Abundance Database |url=https://pax-db.org/protein/9606/ENSP00000350295 |access-date=2024-12-13 |website=pax-db.org}}</ref> |
] data show ZNF816 protein is localized in the ] (95.7%)<ref>{{Cite web |title=PSORT WWW Server |url=https://psort.hgc.jp/ |access-date=2024-12-13 |website=psort.hgc.jp}}</ref> across various human tissues. It is seen to be expressed at high levels relative to other proteins.<ref>{{Cite web |title=PaxDb: Protein Abundance Database |url=https://pax-db.org/protein/9606/ENSP00000350295 |access-date=2024-12-13 |website=pax-db.org}}</ref> | ||
| == Homology/Evolution == | == Homology/Evolution == | ||
| === Paralogs === | === Paralogs === | ||
| ] | ] | ||
| ZNF816 has several paralogs within the zinc finger protein family. Its closest paralog is ZNF813, which shares 69.74% sequence identity. A more distant paralog is ZNF836, with 52.03% identity. These paralogs likely maintain similar roles in transcriptional regulation, reflecting the conserved functions characteristic of zinc finger proteins. | ZNF816 has several paralogs within the ]. Its closest paralog is ZNF813, which shares 69.74% sequence identity. A more distant paralog is ZNF836, with 52.03% identity.<ref name=":1" /> These paralogs likely maintain similar roles in transcriptional regulation, reflecting the conserved functions characteristic of zinc finger proteins. | ||
| === Orthologs === | === Orthologs === | ||
| Orthologs of human ''ZNF816'' are highly conserved in ], specifically ]. The closest ortholog is found in the ] (''Pan paniscus''), with 88.8% identity, indicating strong conservation within the ]. The most divergent ortholog is found in the ] (''Papio anubis''), with 78.2% identity, reflecting moderate divergence within primates. Orthologs are absent in non-mammalian species. | Orthologs of human ''ZNF816'' are highly conserved in ], specifically ]. The closest ortholog is found in the ] (''Pan paniscus''), with 88.8% identity,<ref name=":1" /> indicating strong conservation within the ]. The most divergent ortholog is found in the ] (''Papio anubis''), with 78.2% identity,<ref name=":1" /> reflecting moderate divergence within primates. Orthologs are absent in non-mammalian species. | ||
| {| class="wikitable" | {| class="wikitable" | ||
| |Species name | |Species name | ||
| Line 86: | Line 78: | ||
| |Common name | |Common name | ||
| |Family | |Family | ||
| |Date of div. (MYA)<ref>{{Cite web |title=TimeTree :: The Timescale of Life |url=https://timetree.org/ |access-date=2024-12-13 |website=timetree.org |language=en}}</ref> | |Date of div. (MYA)<ref name=":3">{{Cite web |title=TimeTree :: The Timescale of Life |url=https://timetree.org/ |access-date=2024-12-13 |website=timetree.org |language=en}}</ref> | ||
| |% Identity<ref name=":1">{{Cite web |url=https://www.ebi.ac.uk/jdispatcher/psa |access-date=2024-12-13 |website=www.ebi.ac.uk}}</ref> | |% Identity<ref name=":1">{{Cite web |url=https://www.ebi.ac.uk/jdispatcher/psa |access-date=2024-12-13 |website=www.ebi.ac.uk}}</ref> | ||
| |% similarity<ref name=":1" /> | |% similarity<ref name=":1" /> | ||
| Line 305: | Line 297: | ||
| === Evolutionary Rate === | === Evolutionary Rate === | ||
| ] | ] | ||
| ZNF816 is evolving relatively slowly, as its rate of divergence is not significantly higher than that of Cytochrome C, a highly conserved protein, and is notably slower than proteins like Fibrinogen Alpha, indicating its functional conservation across species. | ZNF816 is evolving relatively slowly, as its rate of divergence is not significantly higher than that of ], a highly conserved protein, and is notably slower than proteins like ], indicating its functional conservation across species. | ||
| === Distant Homologs === | === Distant Homologs === | ||
| While ZNF816 is not present in non-mammalian species, distant homologs containing its zinc finger domains can be found in other vertebrates, including birds and fish<ref>{{Cite web |title=Motif Scan |url=https://myhits.sib.swiss/cgi-bin/motif_scan |access-date=2024-12-13 |website=myhits.sib.swiss |language=en}}</ref> |
While ZNF816 is not present in non-mammalian species, distant homologs containing its zinc finger domains can be found in other vertebrates, including birds and fish.<ref>{{Cite web |title=Motif Scan |url=https://myhits.sib.swiss/cgi-bin/motif_scan |access-date=2024-12-13 |website=myhits.sib.swiss |language=en}}</ref> | ||
| == Interacting Proteins == | == Interacting Proteins == | ||
| ZNF816 interacts with several proteins involved in similar cellular processes. It binds with ], ZNF813, ZNF845, and ZNF468, all of which are linked to ], indicating that ZNF816 likely plays a role in controlling gene expression. Additionally, ], DCAF1, TRIM39, ], and RNF219 are involved in ] and ], suggesting that ZNF816 may help regulate protein turnover through the ]. ], TRIM39, and ] are also associated with ], further supporting the idea that ZNF816 contributes to maintaining genomic stability. These interactions emphasize ZNF816's involvement in transcriptional regulation, protein degradation, and DNA repair. | |||
| , | |||
| == Clinical Significance == | == Clinical Significance == | ||
| === Disease Association === | |||
| Although direct disease associations are still being explored, ZNF816 is considered a potential candidate for diseases such as emphysema<ref>{{Cite journal | |
Although direct disease associations are still being explored, ZNF816 is considered a potential candidate for diseases such as ],<ref>{{Cite journal |last1=Radder |first1=Josiah E. |last2=Zhang |first2=Yingze |last3=Gregory |first3=Alyssa D. |last4=Yu |first4=Shibing |last5=Kelly |first5=Neil J. |last6=Leader |first6=Joseph K. |last7=Kaminski |first7=Naftali |last8=Sciurba |first8=Frank C. |last9=Shapiro |first9=Steven D. |date=2017-07-15 |title=Extreme Trait Whole-Genome Sequencing Identifies <i>PTPRO</i> as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction |url=https://doi.org/10.1164/rccm.201606-1147oc |journal=American Journal of Respiratory and Critical Care Medicine |volume=196 |issue=2 |pages=159–171 |doi=10.1164/rccm.201606-1147oc |pmid=28199135 |pmc=5519967 |issn=1073-449X}}</ref> ],<ref>{{Cite journal |last1=Chen |first1=M.-J. |last2=Wei |first2=S.-Y. |last3=Yang |first3=W.-S. |last4=Wu |first4=T.-T. |last5=Li |first5=H.-Y. |last6=Ho |first6=H.-N. |last7=Yang |first7=Y.-S. |last8=Chen |first8=P.-L. |date=2015-04-29 |title=Concurrent exome-targeted next-generation sequencing and single nucleotide polymorphism array to identify the causative genetic aberrations of isolated Mayer-Rokitansky-Kuster-Hauser syndrome |url=https://doi.org/10.1093/humrep/dev095 |journal=Human Reproduction |volume=30 |issue=7 |pages=1732–1742 |doi=10.1093/humrep/dev095 |pmid=25924657 |issn=0268-1161}}</ref> and early-onset psoriasis<ref>{{Cite journal |last1=Sun |first1=Liang-Dan |last2=Cheng |first2=Hui |last3=Wang |first3=Zai-Xing |last4=Zhang |first4=An-Ping |last5=Wang |first5=Pei-Guang |last6=Xu |first6=Jin-Hua |last7=Zhu |first7=Qi-Xing |last8=Zhou |first8=Hai-Sheng |last9=Ellinghaus |first9=Eva |last10=Zhang |first10=Fu-Ren |last11=Pu |first11=Xiong-Ming |last12=Yang |first12=Xue-Qin |last13=Zhang |first13=Jian-Zhong |last14=Xu |first14=Ai-E |last15=Wu |first15=Ri-Na |date=2010-10-17 |title=Association analyses identify six new psoriasis susceptibility loci in the Chinese population |url=https://doi.org/10.1038/ng.690 |journal=Nature Genetics |volume=42 |issue=11 |pages=1005–1009 |doi=10.1038/ng.690 |pmid=20953187 |pmc=3140436 |issn=1061-4036}}</ref> due to the relationship of the diseases to variants in the gene. | ||
| == References == | == References == | ||
Revision as of 02:11, 19 December 2024
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| Aliases | ZNF816, ZNF816A, zinc finger protein 816 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | HomoloGene: 134445; GeneCards: ZNF816; OMA:ZNF816 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Zinc Finger Protein 816 (ZNF816) is a protein encoded by the ZNF816 gene, located on chromosome 19 in humans.
Gene
The ZNF816 gene is located on the minus-strand of chromosome 19, cytogenetic band 19q13.41. It spans 35,746 base pairs, from 52,927,135 to 52,962,881, containing 5 exons.
Transcripts
ZNF816 has three transcript variants, the longest is 2,711 base pairs, with 5 exons. The other two have 4 exons, while all three isoforms encode 651 amino acids. The molecular weight and isoelectric point of is consistent across all three isoforms.
| Isoform number | AC# | mRNA length (base pairs) | Exons | AC# | Protein Length (Amino Acids) |
| 1 | NM_001031665 | 2711 | 5 | NP_001026835 | 651 |
| 2 | NM_001202456.3 | 2570 | 4 | NP_001189385 | 651 |
| 3 | NM_001202457.3 | 2560 | 4 | NP_001189386.1 | 651 |
Proteins
The product protein of the ZNF816 gene is 651 amino acids in length, with a predicted molecular weight of 75.7 kDa and an isoelectric point of 9.44.
Domains
ZNF816 has a Krüppel-associated box, which is characterized by a KRAB domain and an array of fifteen C2H2 Zinc fingers. This domain suppresses transcription by recruiting co-repressor proteins, which create heterochromatin, blocking RNA polymerase from accessing the gene. The amino acid sequence includes six disordered regions, and eight protein binding sites.
Structure
The predicted secondary structure of ZNF816 from AlphaFold consists of mainly alpha helices, from the C2H2 zinc finger motifs. The tertiary structure of ZNF816 was predicted by iTasser and annotated (Icn3D) according to the characteristics of other zinc finger proteins and prominent domains.
Gene Level Regulation
ZNF816 shows a moderately variable expression pattern, with detectable levels in most tissues. While some tissues, like the adrenal gland, testes, thyroid, and salivary gland, exhibit relatively higher expression, ZNF816 is generally expressed across a wide range of tissues.
RNA-Seq Data
RNA-seq data confirm that ZNF816 is broadly expressed at varying levels across tissues. In normal tissues, it shows moderate to high mRNA levels, suggesting consistent transcriptional activity. Data from 20 human tissues further support the gene's widespread expression, with some variability in transcription levels.
In Situ Hybridization
In situ hybridization results from the Allen Brain Atlas confirm widespread expression across human brain regions, including the hippocampus, cortex, and cerebellum.
Protein Localization and Abundance
Immunohistochemistry data show ZNF816 protein is localized in the nucleus (95.7%) across various human tissues. It is seen to be expressed at high levels relative to other proteins.
Homology/Evolution
Paralogs
ZNF816 has several paralogs within the zinc finger protein family. Its closest paralog is ZNF813, which shares 69.74% sequence identity. A more distant paralog is ZNF836, with 52.03% identity. These paralogs likely maintain similar roles in transcriptional regulation, reflecting the conserved functions characteristic of zinc finger proteins.
Orthologs
Orthologs of human ZNF816 are highly conserved in mammals, specifically primates. The closest ortholog is found in the Bonobo (Pan paniscus), with 88.8% identity, indicating strong conservation within the Hominidae family. The most divergent ortholog is found in the Olive Baboon (Papio anubis), with 78.2% identity, reflecting moderate divergence within primates. Orthologs are absent in non-mammalian species.
| Species name | Genus | Common name | Family | Date of div. (MYA) | % Identity | % similarity | Protein length (Amino Acids) | Accession Number |
| Homo sapiens | Homo | Human | Hominidae | 0 | 100.00% | 100.00% | 651 | NP_001189386 |
| Pan paniscus | Pan | Bonobo | Hominidae | 6.4 | 88.80% | 90.00% | 598 | XP_024782426.3 |
| Pan troglodytes | Pan | Common chimpanzee | Hominidae | 6.4 | 80.50% | 81.30% | 730 | XP_054528711.1 |
| Gorilla gorilla gorilla | Gorilla | Western lowland gorilla | Hominidae | 8.6 | 51.70% | 52.60% | 681 | XP_030860498.2 |
| Pongo pygmaeus | Pongo | Bornean orangutan | Hominidae | 15.2 | 86.60% | 88.30% | 642 | XP_054321989.1 |
| Pongo abelii | Pongo | Sumatran orangutan | Hominidae | 15.2 | 80.40% | 81.80% | 698 | XP_024093826.3 |
| Symphalangus syndactylus | Symphalangus | Siamang | Hylobatidae | 19.5 | 79.30% | 81.8% | 749 | XP_063471613.1 |
| Hylobates moloch | Hylobates | Silvery gibbon | Hylobatidae | 19.5 | 83.00% | 85.90% | 721 | XP_058281887.1 |
| Cercocebus atys | Cercocebus | Sooty mangabey | Cercopithecidae | 28.8 | 80.50% | 85.10% | 697 | XP_011936585.1 |
| Macaca fascicularis | Macaca | Long-tailed macaque (Crab-eating macaque) | Cercopithecidae | 28.8 | 80.80% | 85.10% | 697 | XP_005590270.3 |
| Rhinopithecus bieti | Rhinopithecus | Black snub-nosed monkey | Cercopithecidae | 28.8 | 82.00% | 86.20% | 694 | XP_017714826.1 |
| Colobus angolensis palliatus | Colobus | Angolan black-and-white colobus | Cercopithecidae | 28.8 | 82.10% | 85.80% | 641 | XP_011801561.1 |
| Papio anubis | Papio | Olive baboon | Cercopithecidae | 28.8 | 78.20% | 83.00% | 717 | XP_009193448.2 |
| Rhinopithecus roxellana | Rhinopithecus | Golden snub-nosed monkey | Cercopithecidae | 28.8 | 74.20% | 77.70% | 776 | XP_010374801.2 |
| Theropithecus gelada | Theropithecus | Gelada | Cercopithecidae | 28.8 | 77.60% | 82.10% | 695 | XP_025222771.1 |
| Macaca mulatta | Macaca | Rhesus macaque | Cercopithecidae | 28.8 | 80.80% | 85.10% | 697 | XP_014980263.2 |
| Chlorocebus sabaeus | Chlorocebus | Green monkey (Savanna monkey) | Cercopithecidae | 28.8 | 78.30% | 83.30% | 647 | XP_037847362.1 |
| Trachypithecus francoisi | Trachypithecus | François' langur | Cercopithecidae | 28.8 | 75.70% | 80.20% | 726 | XP_033084859.1 |
| Macaca nemestrina | Macaca | Southern pig-tailed macaque | Cercopithecidae | 28.8 | 65.90% | 71.00% | 721 | XP_011766059.1 |
| Mandrillus leucophaeus | Mandrillus | Drill | Cercopithecidae | 28.8 | 76.30% | 81.10% | 669 | XP_011835608.1 |
| Piliocolobus tephrosceles | Piliocolobus | Ugandan red colobus | Cercopithecidae | 28.8 | 70.20% | 73.80% | 812 | XP_023051555.1 |
Evolutionary Rate
ZNF816 is evolving relatively slowly, as its rate of divergence is not significantly higher than that of Cytochrome C, a highly conserved protein, and is notably slower than proteins like Fibrinogen Alpha, indicating its functional conservation across species.
Distant Homologs
While ZNF816 is not present in non-mammalian species, distant homologs containing its zinc finger domains can be found in other vertebrates, including birds and fish.
Interacting Proteins
ZNF816 interacts with several proteins involved in similar cellular processes. It binds with TRIM28, ZNF813, ZNF845, and ZNF468, all of which are linked to transcriptional regulation, indicating that ZNF816 likely plays a role in controlling gene expression. Additionally, CUL3, DCAF1, TRIM39, TRIM37, and RNF219 are involved in ubiquitination and protein degradation, suggesting that ZNF816 may help regulate protein turnover through the ubiquitin-proteasome pathway. TRIM28, TRIM39, and VPRBP are also associated with DNA repair, further supporting the idea that ZNF816 contributes to maintaining genomic stability. These interactions emphasize ZNF816's involvement in transcriptional regulation, protein degradation, and DNA repair.
Clinical Significance
Disease Association
Although direct disease associations are still being explored, ZNF816 is considered a potential candidate for diseases such as emphysema, MRKH syndrome, and early-onset psoriasis due to the relationship of the diseases to variants in the gene.
References
- ^ GRCh38: Ensembl release 89: ENSG00000180257 – Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "ZNF816 zinc finger protein 816 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-13.
- Database, GeneCards Human Gene. "GeneCards - Human Genes | Gene Database | Gene Search". www.genecards.org. Archived from the original on 2024-05-14. Retrieved 2024-12-14.
- "ZNF816 zinc finger protein 816 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
- www.ebi.ac.uk https://www.ebi.ac.uk/jdispatcher/seqstats. Retrieved 2024-12-14.
{{cite web}}: Missing or empty|title=(help) - Yang, Peng; Wang, Yixuan; Macfarlan, Todd S. (2017-11-01). "The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution". Trends in Genetics. Transposable Elements. 33 (11): 871–881. doi:10.1016/j.tig.2017.08.006. ISSN 0168-9525. PMC 5659910. PMID 28935117.
- ^ "PredictProtein - Protein Sequence Analysis, Prediction of Structural and Functional Features". predictprotein.org. Retrieved 2024-12-14.
- "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Retrieved 2024-12-13.
- "I-TASSER server for protein structure and function prediction". zhanggroup.org. Retrieved 2024-12-13.
- "iCn3D: Web-based 3D Structure Viewer". www.ncbi.nlm.nih.gov. Retrieved 2024-12-13.
- "National Center for Biotechnology Information". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
- "ZNF816 zinc finger protein 816 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-13.
- "Microarray Data :: Allen Brain Atlas: Human Brain". human.brain-map.org. Retrieved 2024-12-13.
- "PSORT WWW Server". psort.hgc.jp. Retrieved 2024-12-13.
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