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Revision as of 11:09, 17 December 2024 editMo18ekula (talk | contribs)248 edits ←Created page with '{{Infobox drug | drug_name = Vamicamide | image = Vamicamide.svg | width = 250px | caption = <!-- Clinical data --> | pronounce = | tradename = | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = | licence_US = | pregnancy_AU = | pregnancy_category = | dependency_liability = | addiction_liability = | routes_of_administration = | class = | ATC_prefix = | ATC_suffix = <!-- Legal status --> | legal_status = <!-- Phar...'  Latest revision as of 03:14, 29 December 2024 edit undoInnerstream (talk | contribs)Autopatrolled, Extended confirmed users4,014 editsNo edit summary 
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{{Infobox drug {{Infobox drug
| drug_name = Vamicamide | drug_name = Vamicamide
| image = Vamicamide.svg | image = Vamicamide v2.svg
| width = 250px | width = 200px
| caption = | caption =


<!-- Clinical data --> <!-- Clinical data -->
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| class = | class =
| ATC_prefix = | ATC_prefix =
| ATC_suffix = | ATC_suffix =


<!-- Legal status --> <!-- Legal status -->
| legal_status = | legal_status = Investigational


<!-- Pharmacokinetic data --> <!-- Pharmacokinetic data -->
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| elimination_half-life = | elimination_half-life =
| duration_of_action = | duration_of_action =
| excretion = | excretion =


<!-- Identifiers --> <!-- Identifiers -->
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| DrugBank = | DrugBank =
| ChemSpiderID = 59369 | ChemSpiderID = 59369
| UNII = | UNII = RU10K34QRU
| KEGG = | KEGG =
| ChEBI = | ChEBI =
| ChEMBL = | ChEMBL = 2114366
| NIAID_ChemDB = | NIAID_ChemDB =
| PDB_ligand = | PDB_ligand =
| synonyms = Urocut | synonyms = Urocut, FK-176


<!--Chemical data--> <!--Chemical data-->
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| StdInChIKey = BWNLUIXQIHPUGO-RDTXWAMCSA-N | StdInChIKey = BWNLUIXQIHPUGO-RDTXWAMCSA-N
}} }}
'''Vamicamide''', also known as FK-176 or Urocut, is a ] (mAChR) ] that was developed by ] (now part of ]) for the treatment of ] and ].<ref name = "PatSnap"/> This small molecule drug acts by blocking muscarinic receptors, which play a role in bladder function. Despite showing promise in preclinical studies for increasing bladder capacity without affecting other urinary parameters,<ref name="Yamamoto_1995">{{cite journal | vauthors = Yamamoto T, Koibuchi Y, Miura S, Sawada T, Ozaki R, Esumi K, Ohtsuka M | title = Effects of vamicamide on urinary bladder functions in conscious dog and rat models of urinary frequency | journal = The Journal of Urology | volume = 154 | issue = 6 | pages = 2174–8 | date = December 1995 | pmid = 7500484 | doi = 10.1016/S0022-5347(01)66723-5| url = }}</ref> vamicamide has never been approved for medical use. The drug's development was ultimately discontinued, with its highest research and development status reaching the ] (NDA) phase in Japan.<ref name = "PatSnap">{{cite web | title = Vamicamide | url = https://synapse.patsnap.com/drug/eaf5bdd08c71489181d6c8f1bc01a636 | work = PatSnap }}</ref>
Vamicamide is an antimuscarinic drug.<ref> Yamamoto T, Honbo T, Tokoro K, Kojimoto Y, Kodama R, Ohtsuka M, Shimomura K. General pharmacology of the new antimuscarinic compound vamicamide. Arzneimittelforschung. 1995 Dec;45(12):1274-84. PMID: 8595084.
</ref>

Vamicamide should be useful for the treatment of urinary frequency.<ref> Yamamoto T, Koibuchi Y, Miura S, Sawada T, Ozaki R, Esumi K, Ohtsuka M. Effects of vamicamide on urinary bladder functions in conscious dog and rat models of urinary frequency. J Urol. 1995 Dec;154(6):2174-8. PMID: 7500484.</ref>

See also: ] (]).


== References == == References ==
{{reflist}} {{reflist}}


]
{{Acetylcholine receptor modulators}}
] ]
]
]
]

Latest revision as of 03:14, 29 December 2024

Pharmaceutical compound
Vamicamide
Clinical data
Other namesUrocut, FK-176
Legal status
Legal status
  • Investigational
Identifiers
IUPAC name
  • (2R,4R)-4-(dimethylamino)-2-phenyl-2-pyridin-2-ylpentanamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC18H23N3O
Molar mass297.402 g·mol
3D model (JSmol)
SMILES
  • C(C(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)N(C)C
InChI
  • InChI=1S/C18H23N3O/c1-14(21(2)3)13-18(17(19)22,15-9-5-4-6-10-15)16-11-7-8-12-20-16/h4-12,14H,13H2,1-3H3,(H2,19,22)/t14-,18-/m1/s1
  • Key:BWNLUIXQIHPUGO-RDTXWAMCSA-N

Vamicamide, also known as FK-176 or Urocut, is a muscarinic acetylcholine receptor (mAChR) antagonist that was developed by Fujisawa (now part of Astellas Pharma) for the treatment of urinary incontinence and overactive bladder. This small molecule drug acts by blocking muscarinic receptors, which play a role in bladder function. Despite showing promise in preclinical studies for increasing bladder capacity without affecting other urinary parameters, vamicamide has never been approved for medical use. The drug's development was ultimately discontinued, with its highest research and development status reaching the New Drug Application (NDA) phase in Japan.

References

  1. ^ "Vamicamide". PatSnap.
  2. Yamamoto T, Koibuchi Y, Miura S, Sawada T, Ozaki R, Esumi K, Ohtsuka M (December 1995). "Effects of vamicamide on urinary bladder functions in conscious dog and rat models of urinary frequency". The Journal of Urology. 154 (6): 2174–8. doi:10.1016/S0022-5347(01)66723-5. PMID 7500484.
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