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| {{short description|Indian biochemist, molecular biologist (born 1960)}} | {{short description|Indian biochemist, molecular biologist (born 1960)}} | ||
| {{Use dmy dates|date=January 2019}} | {{Use dmy dates|date=January 2019}} | ||
| {{Use Indian English|date=January 2019}} | {{Use Indian English|date=January 2019}} | ||
| {{Infobox scientist | {{Infobox scientist | ||
| | name = Jayant B. Udgaonkar | | name = Jayant B. Udgaonkar | ||
| | image = Prof. Jayant B. Udgaonkar.jpg | | image = Prof. Jayant B. Udgaonkar.jpg | ||
| | |
| native_name = {{transl|mr|Jayanta Udgāṁvakara}} | ||
| | |
| native_name_lang = mr | ||
| | birth_date = {{Birth date and age |
| birth_date = {{Birth date and age|1960|03|22}} | ||
| | birth_place = |
| birth_place = Maharashtra | ||
| | |
| education = ] (MSc) | ||
| ⚫ | ] (PhD) | ||
| | death_place = | |||
| | |
| alma_mater = ] (BSc) | ||
| | organization = ], ] | |||
| | nationality = ] | |||
| | |
| known_for = ] | ||
| | spouse = Dr. Suhasini Udgaonkar | |||
| | workplaces = {{ublist | ] | ] | ] }} | |||
| | website = {{URL|https://sites.google.com/acads.iiserpune.ac.in/prof-udgaonkar-lab}} | |||
| | alma_mater = {{ublist | ] (]) | ] | ] | ] }} | |||
| | doctoral_advisor = George P. Hess<br>Robert Lesh Baldwin | |||
| | doctoral_students = | |||
| | known_for = Studies on ] | |||
| | awards = 1996 Birla Biology Award<br>2000 ]<br>2011 ] Distinguished Alumnus Award<br>2011 ] G. N. Ramachandran Gold Medal | |||
| }} | }} | ||
| '''Jayant Bhalchandra Udgaonkar''' (]: {{transl|mr|Jayanta Udgāṁvakara}}) is a molecular biologist studying the processes by which a random chain of amino acids stabilises into a functional structure during or after translation.<ref>{{Cite web |title=Jayant B. Udgaonkar - IISER Pune |url=https://www.iiserpune.ac.in/research/department/biology/people/faculty/regular-faculty/jayant-b-udgaonkar/348}}</ref><ref name=felicitation>{{cite web|title=Felicitation Event Honouring Prof. Jayant B. Udgaonkar at IISER Pune |url=https://www.youtube.com/watch?v=FytNVG5cvto}}</ref> | |||
| == Early Life and Education == | |||
| '''Jayant Bhalchandra Udgaonkar''' (born 1960) is an Indian biochemist, molecular biologist, and academic at the ]. He is the former Director of the ],<ref>{{cite news|last1=Nair|first1=Ardhra|title=New IISER director points at lack of funding for research|url=https://timesofindia.indiatimes.com/city/pune/new-iiser-director-points-at-lack-of-funding-for-research/articleshow/61426575.cms|access-date=1 November 2017|agency=The Times of India}}</ref><ref>{{cite news|title=Government clears appointment of top officials of four IIMs, IISER|url=http://www.hindustantimes.com/education/government-clears-appointment-of-top-officials-of-four-iims-iiser/story-Jp2JSglKUe8yOFgTcn1nVP.html|agency=Hindustan Times|date=19 September 2017}}</ref> and was previously a senior professor at the ].<ref name="Prof. Jayant B. Udgaonkar on NCBS">{{cite web | url=https://www.ncbs.res.in/faculty/student/133/1247 | title=Prof. Jayant B. Udgaonkar on NCBS | publisher=National Centre for Biological Sciences | date=2016 | access-date=15 October 2016}}</ref> A J.C. Bose National Fellow, he is known for his studies on ].<ref name="Brief Profile of the Awardee">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=95 | title=Brief Profile of the Awardee | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He is an elected fellow of the ],<ref name="Fellow profile - Udgaonkar">{{cite web | url=http://www.ias.ac.in/describe/fellow/Udgaonkar,_Prof._Jayant_Bhalchandra | title=Fellow profile - Udgaonkar | publisher=Indian Academy of Sciences | date=2016 | access-date=6 October 2016}}</ref> ]<ref name="Indian fellow - Udgaonkar">{{cite web | url=http://insaindia.res.in/detail.php?id=P02-1326 | title=Indian fellow - Udgaonkar | publisher=Indian National Science Academy | date=2016 | access-date=11 October 2016}}</ref> and ].<ref name="TWAS fellow">{{cite web | url=http://twas.org/member/udgaonkar-jayant | title=TWAS fellow | publisher=TWAS | date=2016 | access-date=15 October 2016}}</ref> The ], the apex agency of the Government of India for scientific research, awarded him the ], one of the highest Indian science awards, in 2000, for his contributions to biological sciences.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/Detail.aspx?AID=201 | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}}</ref> He is the son of noted scientist Padmabhushan ].<ref>{{cite book|last1=Phondke|first1=Bal|last2=Sheth|first2=Parul R.|last3=Naik-Satam|first3=Suhas|last4=Deshpande|first4=A.P.|title=B.M. Udgaonkar: Eminent Scientist and Educationist|date=2007|publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication|location=Mumbai|url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf}}</ref> | |||
| Born on 22 March 1960 to Dr. ], a theoretical physicist, and Dr. Suhasini Udgaonkar, a renowned historian, Dr. Jayant Udgaonkar studied Chemistry at ] (BSc, 1979) and ] (MSc, 1981), and Biochemistry at ].<ref name="felicitation" /><ref>{{cite book |last1=Phondke |first1=Bal |url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf |title=B.M. Udgaonkar: Eminent Scientist and Educationist |last2=Sheth |first2=Parul R. |last3=Naik-Satam |first3=Suhas |last4=Deshpande |first4=A.P. |date=2007 |publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication |location=Mumbai}}</ref><ref name="Profile on NCBS">{{cite web |date=2016 |title=Profile on NCBS |url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf |access-date=15 October 2016 |publisher=National Centre for Biological Sciences}}</ref> | |||
| == Biography == | |||
| ].]] | |||
| Jayant Udgaonkar, born on 22 March 1960 in the Indian state of ], did his graduate studies in chemistry at ] during 1976–79 and secured his master's degree from the ] in 1981.<ref name="Profile on NCBS">{{cite web | url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf | title=Profile on NCBS | publisher=National Centre for Biological Sciences | date=2016 | access-date=15 October 2016}}</ref> Moving to ], he completed his doctoral studies under the guidance of George P. Hess to obtain a PhD for his thesis on ] in 1986 after which did his post-doctoral studies under Robert Lesh Baldwin at ] during 1986–89.<ref name="Indian fellow - Udgaonkar" /> Returning to India, he joined ] of ] as a reader in 1990 and has been serving as a senior professor since 2007. In between, he held the positions of an associate professor (1995–98), Dean (1997–2008), Head of Administration (1997–2008), Head of Research (1997–2008), Head of Technical Services (1998–2000) and a professor (1998–2007) at the institute and served as an honorary faculty member at the ] in 1999.<ref name="Profile on NCBS" /> On 1 November 2017, he became the Director of the ], succeeding Prof. ].<ref>{{cite web|title=Director|url=http://www.iiserpune.ac.in/the-institute/director|website=IISER Pune|access-date=1 November 2017}}</ref> | |||
| == |
== Protein Folding == | ||
| During his doctoral studies at Cornell University, Udgaonkar is known to have developed a protocol for rapid chemical kinetic studies at the cell surface.<ref name="Indian fellow - Udgaonkar" /> Later, while pursuing his post-doctoral studies, he developed methodologies for hydrogen exchange using ] for exploring the ''intermediates populating ] pathways''. Furthering his Stanford studies on protein folding at NCBS, he propounded the theory that ''initial ]'' is the first stage in protein folding, which he demonstrated using a model protein ] and elucidated the various transition stages of protein folding and unfolding.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | pages=34 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 | url-status=dead }}</ref> He has also demonstrated that, contrary to the general understanding that a single dominant barrier slows down the protein folding, several distributed small barriers can also influence the reaction.<ref name="Indian fellow - Udgaonkar" /> His current work focuses on formation of ] ] and his research has shown multiple pathways of aggregation in the formation of amyloid fibrils of different morphologies.<ref name="Summary of Achievements">{{cite web | url=http://www.serb.gov.in/pdfs/research/Prof_Jayant_Udgaonkar.pdf | title=Summary of Achievements | publisher=SERB | date=2016 | access-date=16 October 2016}}</ref> | |||
| While studying the kinetics of ] in response to the binding of ] at ], he was struck by the structural precision of protein molecules that enabled them to perform highly specialized tasks with extreme precision. Consequently, he focused his attention on the processes that make these structures possible, and what may go wrong in these highly accurate processes. In one of his earliest studies, he found that a certain '']'' is the first stage in a typical protein folding process. His current work focuses on the formation of ]<nowiki/>s.<ref name="Jayant Udgaonkar on Google Scholar">{{cite web |date=2016 |title=Jayant Udgaonkar on Google Scholar |url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en |access-date=16 October 2016 |work=Author profile |publisher=Google Scholar}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web |date=2016 |title=Jayant Udgaonkar on ResearchGate |url=https://www.researchgate.net/profile/Jayant_Udgaonkar |access-date=16 October 2016 |work=Author profile}}</ref> | |||
| Udgaonkar has published a number of articles in peer reviewed journals detailing his researches,{{Refn|group=note|Please see Selected bibliography section}} ] and ], two online repositories of scientific articles, have listed several of them.<ref name="Jayant Udgaonkar on Google Scholar">{{cite web | url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en | title=Jayant Udgaonkar on Google Scholar | publisher=Google Scholar | work=Author profile | date=2016 | access-date=16 October 2016}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web | url=https://www.researchgate.net/profile/Jayant_Udgaonkar | title=Jayant Udgaonkar on ResearchGate | work=Author profile | date=2016 | access-date=16 October 2016}}</ref> A former guest editor of the ] of ] (2013 and 2015) and a former editorial board member of ''Folding and Design'' (1996–98), he is an associate editor of the ] journal<ref name="Profile on NCBS" /> and a member of the editorial board of ''Protein Engineering, Design and Selection'' (since 2003), an Oxford journal.<ref name="Editorial Office">{{cite web | url=http://www.oxfordjournals.org/our_journals/proeng/for_authors/editorial_board.html | archive-url=https://web.archive.org/web/20160321195455/http://www.oxfordjournals.org/our_journals/proeng/for_authors/editorial_board.html | url-status=dead | archive-date=2016-03-21 | title=Editorial Office | publisher=Oxford Journals | date=2016 | access-date=16 October 2016}}</ref> He is also a member of the Asia-Pacific International Molecular Biology Network since 2001 and has mentored several scholars in their doctoral researches.<ref name="Indian fellow - Udgaonkar" /> | |||
| == Awards and |
== Awards and Honors == | ||
| * Vigyan Shri Award under ] scheme (2024).<ref>{{cite web |title=Rashtriya Vigyan Puraskar (RVP) - 2024 : Final List of Awardees |url=https://awards.gov.in/Home/GoToIndex?filename=Award%2FCommunication%2F202488013634H24ZU2.pdf|website=awards.gov.in |publisher=CASU, Ministry of Home Affairs, Government of India |access-date=15 August 2024}}</ref><ref>{{cite news |title=Rashtriya Vigyan Puraskar: Chandrayaan-3 team and 32 others selected for first ever edition |url=https://economictimes.indiatimes.com/news/science/rashtriya-vigyan-puraskar-chandrayaan-3-team-and-32-others-selected-for-first-ever-edition-here-is-full-list/articleshow/112349033.cms?from=mdr |newspaper=The Economic Times | date=7 August 2024 |access-date=15 August 2024}}</ref> | |||
| Udgaonkar, who stood first in the BSc chemistry examinations of the ] in 1979, received several scholarships and research fellowships including the National Merit Scholarship of the Government of India, Merit Scholarship of the Indian Institute of Technology, Madras, ] fellowship, Biotechnology Career Fellowship of ], Golden Jubilee Biotechnology fellowship of the ], Swarnajayanti fellowship of the ] and Senior Research fellowship of ] and is a J. C. Bose National Fellow of the ], the tenancy of the fellowship running from 2007 till 2017.<ref name="Profile on NCBS" /> He received the Birla Award in Biology in 1996 and the Indian Academy of Sciences elected him as a fellow in 1997.<ref name="Fellow profile - Udgaonkar" /> The ] awarded him the ], one of the highest Indian science awards, in 2000.<ref name="View Bhatnagar Awardees" /> He became an elected fellow of the ] in 2002 and ] elected him as a fellow in 2007.<ref name="TWAS fellow" />Vigyan Shri Award under ] scheme (2024). | |||
| * Udgaonkar stood first in the BSc chemistry examinations of the ] in 1979.<ref name="Profile on NCBS" /> | |||
| == Selected bibliography == | == Selected bibliography == | ||
| * {{cite journal | |
* {{cite journal |title=Early folding intermediate of ribonuclease A. |author=Jayant B Udgaonkar, Robert L Baldwin |journal=Proceedings of the National Academy of Sciences |date=November 1990 |volume=87 |issue=21 |pages=8197–8201 |doi=10.1073/pnas.87.21.8197 |pmc=54922 |pmid=2236032 |bibcode=1990PNAS...87.8197U |doi-access=free}} | ||
| * {{cite journal | title=How cooperative are protein folding and unfolding transitions?: Cooperativity in protein folding/unfolding reactions | author=Pooja Malhotra, Jayant B Udgaonkar | journal=Protein Science | date=August 2016 | doi=10.1002/pro.3015 | volume=25 | issue=11 | pages=1924–1941| pmc=5079258 | pmid=27522064}} | |||
| * {{cite journal | title=Microsecond Rearrangements of Hydrophobic Clusters in an Initially Collapsed Globule Prime Structure Formation during the Folding of a Small Protein | author=Rama Reddy Goluguri, Jayant B Udgaonkar | journal=Journal of Molecular Biology | date=June 2016 | volume=428 | issue=15 | doi=10.1016/j.jmb.2016.06.015 | pages=3102–3117 | pmid=27370109}} | |||
| *{{Cite journal|last1=Singh|first1=Jogender|last2=Kumar|first2=Harish|last3=Sabareesan|first3=Ambadi T.|last4=Udgaonkar|first4=Jayant B.|date=2014-12-03|title=Rational Stabilization of Helix 2 of the Prion Protein Prevents Its Misfolding and Oligomerization|journal=Journal of the American Chemical Society|language=en|volume=136|issue=48|pages=16704–16707|doi=10.1021/ja510964t|pmid=25407394|issn=0002-7863}} | |||
| *{{Cite journal|last1=Zaidi|first1=Faisal N.|last2=Nath|first2=Utpal|last3=Udgaonkar|first3=Jayant B.|date=December 1997|title=Multiple intermediates and transition states during protein unfolding|journal=Nature Structural Biology|volume=4|issue=12|pages=1016–1024|doi=10.1038/nsb1297-1016|pmid=9406552|s2cid=1692527|issn=1072-8368}} | |||
| * {{cite journal | title=Thermodynamics of denaturation of barstar: evidence for cold denaturation and evaluation of the interaction with guanidine hydrochloride | author=Vishwas R Agashe, Jayant B Udgaonkar | journal=Biochemistry | date=March 1995 | volume=34 | issue=10 | pages=3286–99 | doi=10.1021/bi00010a019| pmid=7880824 }} | |||
| * {{cite journal | title=Equilibrium unfolding studies of barstar: evidence for an alternative conformation which resembles a molten globule | author=Ritu Khurana, Jayant B Udgaonkar | journal=Biochemistry | date=January 1994 | volume=33 | issue=1 | pages=106–115 | doi=10.1021/bi00167a014| pmid=8286327 }} | |||
| * {{cite journal | title=Early folding intermediate of ribonuclease A. | author=Jayant B Udgaonkar, Robert L Baldwin | journal=Proceedings of the National Academy of Sciences | date=November 1990 | volume=87 | issue=21 | pages=8197–8201 | doi=10.1073/pnas.87.21.8197| pmc=54922 | pmid=2236032| bibcode=1990PNAS...87.8197U | doi-access=free }} | |||
| == See also == | |||
| {{Div col}} | |||
| * ] | |||
| * ] | |||
| * ] | |||
| * ] | |||
| {{div col end}} | |||
| {{portal|India|Biology}} | |||
| == Notes == | |||
| {{reflist|group=note}} | |||
| == References == | == References == | ||
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Revision as of 03:08, 1 January 2025
Indian biochemist, molecular biologist (born 1960)
| Jayant B. Udgaonkar | |
|---|---|
| Jayanta Udgāṁvakara | |
 | |
| Born | (1960-03-22) March 22, 1960 (age 64) Maharashtra |
| Education | IIT Madras (MSc) Cornell University (PhD) |
| Alma mater | St. Xavier's College, Mumbai (BSc) |
| Organization(s) | National Centre for Biological Sciences, IISER Pune |
| Known for | Protein-folding |
| Spouse | Dr. Suhasini Udgaonkar |
| Website | sites |
Jayant Bhalchandra Udgaonkar (Marathi: Jayanta Udgāṁvakara) is a molecular biologist studying the processes by which a random chain of amino acids stabilises into a functional structure during or after translation.
Early Life and Education
Born on 22 March 1960 to Dr. Bhalchandra Udgaonkar, a theoretical physicist, and Dr. Suhasini Udgaonkar, a renowned historian, Dr. Jayant Udgaonkar studied Chemistry at St. Xavier's College, Mumbai (BSc, 1979) and IIT Madras (MSc, 1981), and Biochemistry at Cornell University.
Protein Folding
While studying the kinetics of acetylcholine receptors in response to the binding of ACh at Stanford University, he was struck by the structural precision of protein molecules that enabled them to perform highly specialized tasks with extreme precision. Consequently, he focused his attention on the processes that make these structures possible, and what may go wrong in these highly accurate processes. In one of his earliest studies, he found that a certain hydrophobic collapse is the first stage in a typical protein folding process. His current work focuses on the formation of amyloids.
Awards and Honors
- Vigyan Shri Award under Rashtriya Vigyan Puraskar scheme (2024).
- Udgaonkar stood first in the BSc chemistry examinations of the University of Mumbai in 1979.
Selected bibliography
- Jayant B Udgaonkar, Robert L Baldwin (November 1990). "Early folding intermediate of ribonuclease A." Proceedings of the National Academy of Sciences. 87 (21): 8197–8201. Bibcode:1990PNAS...87.8197U. doi:10.1073/pnas.87.21.8197. PMC 54922. PMID 2236032.
References
- "Jayant B. Udgaonkar - IISER Pune".
- ^ "Felicitation Event Honouring Prof. Jayant B. Udgaonkar at IISER Pune".
- Phondke, Bal; Sheth, Parul R.; Naik-Satam, Suhas; Deshpande, A.P. (2007). B.M. Udgaonkar: Eminent Scientist and Educationist (PDF). Mumbai: National Center for Science Communication; Homi Bhabha Centre for Science Communication.
- ^ "Profile on NCBS" (PDF). National Centre for Biological Sciences. 2016. Retrieved 15 October 2016.
- "Jayant Udgaonkar on Google Scholar". Author profile. Google Scholar. 2016. Retrieved 16 October 2016.
- "Jayant Udgaonkar on ResearchGate". Author profile. 2016. Retrieved 16 October 2016.
- "Rashtriya Vigyan Puraskar (RVP) - 2024 : Final List of Awardees" (PDF). awards.gov.in. CASU, Ministry of Home Affairs, Government of India. Retrieved 15 August 2024.
- "Rashtriya Vigyan Puraskar: Chandrayaan-3 team and 32 others selected for first ever edition". The Economic Times. 7 August 2024. Retrieved 15 August 2024.
External links
- "Jayant Udgaonkar, Ph.D. on Chemistry Tree". Scientist profile. Chemistry Tree. 2016. Retrieved 16 October 2016.