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Orthomolecular Psychiatry:

Orthomolecular Psychiatry:

In 1979, orthomolecular psychiatry was defined in the Medical Journal of Australia as follows:

"Orthomolecular psychiatry is the study of the genetic, metabolic, endocrine, immunologic and toxic disturbances that are contributing to, perpetuating, exacerbating or even causing the psychiatric symptomatology.

"It is the investigation of vitamin (coenzyme) levels, mineral (cofactor) levels (or toxic levels of lead, copper and other heavy metals), hormone levels, immunoglobulin levels (especially IgA and IgM), electrolyte levels (especially bicarbonate, calcium, blood sugars, and so on). What can be corrected is corrected and the patient is followed up regularly."

However, in 1998, this needs updating because orthomolecular psychiatrists also use amino acids, bioflavonoids such as Quercetin and Rutin, coenzyme Q10 (Ubiquinone or CoQ10) and n-3 and n-6 essential fatty acids. Vitamin therapy is not synonymous with orthomolecular psychiatry. It is only a sub-speciality.

An excellent book discussing Nutritional Influences on Illness (sourcebook on clinical research) is that of Melvyn R Werbach (Assistant Clinical Professor, School of Medicine, UCLA, Los Angeles, California). Also his book Nutritional Influences on Mental Illness.

These books support what I said in 1979 and now with up to date controlled double blind studies for many medical conditions and psychiatric disorders.

However, in 1998 Orthomolecular Psychiatrists also have to be aware of herbicides, pesticides, petrochemicals and other toxins and lectins in foods, and measure these in blood or urine where appropriate. Also antibodies to various tissues and organs, etc., are looked at to exclude autoimmune disease and risk for SLE, coeliac disease, etc.

By DrChrisReading - Orthomolecular Psychiatrst Dr Reading http://www.gutandmentalillness.com

Why is it any different from traditional Psychiatry?

I'd say that the study of such factors and their incidence on psychiatric symptoms and syndrommes is the reponsibility of Psychiatrists in general:

• They know about genetic, metabolic, endocrine, immunologic and toxic influences on psychiatric symptomatology - they are trained medical doctors.
• Levels of vitamins, minerals, electrolytes, other cations and anions, hormones, immunoglobulins and glucose are ordinarily measured by medical doctors and the correction of any abnormal values is a set of medical procedures that any doctor, including a psychiatrist, should be able to perform.
• Most medical doctors undergo training in toxicology that enable them to learn about herbicides, pesticides, petrochemicals and other toxins, measure them and correct imbalances.
• SLE, among other immunological disease, is a known cause of psychiatric symptomatology (i.e., "lupic psychosis").

Besides, the article is terribly written. Since I'm not a Psychiatrist, I'd rather not work on it (I'd probably delete it). --Lmsilva 21:33, 15 November 2005 (UTC)

Assuming that the text hasn't changed enormously, this is a blatant distortion of the debate about orthomolecular medicine. "Levels of vitamins, minerals, electrolytes, other cations and anions, hormones, immunoglobulins and glucose are ordinarily measured by medical doctors and the correction of any abnormal values is a set of medical procedures that any doctor, including a psychiatrist, should be able to perform."

The debate is not whether doctors could and should ordinarily measure "vitamins, minerals, electrolytes, hormones, immunoglobolins" and, for all I care, their patients' distance to alpha centauri, but rather whether they are measuring the most meaningful measures, and whether they understand how best to respond to these measures.--Alterrabe 19:09, 21 January 2007 (UTC)

POV tag

This article is one-sided and needs substantial cleanup; one reading it would never know that orthomolecular psychiatry is generally and rightfully considered quackery. -- FRCP11 08:11, 4 June 2006 (UTC)

Agreed that the article needs cleanup. -- Samir धर्म 08:13, 4 June 2006 (UTC)

You folks obviously agree with QW sentiments but do you actually have any knowledge about this subject or its history? (I have never personally met a doctor that even knew well/used a 50 year old conventional medicine overlap with orthomolecular medicine even though it is obviously cheaper, in many, perhaps most cases, more effective and scientifically documented - even the pharmas have grudgingly started using it to bolster their not so effective products). Orthomolecular medicine & psych are in fact based on an evolving natural biochemical/biological scientific approach, financed on a shoestring and a lot of sweat, that is directly counterposed to pharma commercial interests and pejoratives.--69.178.41.55 22:54, 4 June 2006 (UTC)

I am leaving the cleanup tag but pitching FRCP11's tagging, see tag Talk at npov tag Orhtomolecular medicine and Megavitamin therapies as well as "Dumped for cause".--69.178.41.55 12:40, 9 June 2006 (UTC)

Anon addition

An anon IP added the following to the page:

• There has been research into the link between the protein beta-casomorphin-7, found in milk, and the symptoms of schizophrenia and autism. A small study from the University of Florida examined the effects of a milk free diet on children with schizophrenia and autism who had high amounts of a metabolite of milk protein in their bloodstreams. Of 81 children with autism or schizophrenia, 95% showed 100 times the normal level of this protein in their bloodstream and urine. When these children were placed on a milk free diet 80% saw a remission of their symptoms. This, along with the link between gluten and schizophrenia opens the doorway to highly effective dietary treatments for a subset of schizophrenic patients. R. Malcolm Privette, Dr. Zhongjie Sun, Dr. J. Robert Cade,(2006)

Checking out the reference, it is to a popular publication from 1999 that discusses preliminary results. Unless the scientific reference in a peer-reviewed journal can be provided, it's pretty much out in my mind. WLU 17:55, 2 May 2007 (UTC)

Alternative mental illness treatment

Modern medicine sees all mental illness including, deriving only from the brain - primarily from neurotransmitter imbalance and nothing else - the truth is that in many cases there is often an underlining physical cause (eg: infection, celiac disease, etc) and this is often never investigated, and so its no wonder today we are faced with the current tragedy that the Mentally ill die 25 years earlier, on average!. We have found many interesting medical studies such as: 'Enterocolitis in children with Autism' 'an autopsy of 82 patients who had been diagnosed with schizophrenia. Gastritis was found in 50%, enteritis in 85% and colitis in 92%.' read more... '99% certain of a genetic association between schizophrenia and coeliac disease' Gut and mental illness —Preceding unsigned comment added by 211.30.235.237 (talk) 01:39, 18 September 2007 (UTC)

Spam. Won't go on the page as a reference or link. WLU 23:35, 19 September 2007 (UTC)

WikiProject class rating

This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:30, 10 November 2007 (UTC)

Kidder and the reading list

I moved Margot Kidder from 'support' to 'notable patients' - a single patient is not support, it's anecdotal evidence, but it still deserves a mention.

I'd also like to trim down the reading list; at minimum, I've already removed books already cited within the article. I wouldn't mind taking out more as well, but I don't know which are the big names and which are less important. Unfortunately the Guide to layout isn't much help; this is the best advice it gives, and to my reading it looks like the section is only for books written by the aricle's subject. Seems a bit restrictive to me.

I've also figured out who Pfeiffer is, but I still think the statement looked odd where it was, and didn't really help the page at all. WLU (talk) 16:37, 18 December 2007 (UTC)

Pfeiffer's book is by far the best short introduction to OMP that I've read. (I haven't read Hoffer's.) Edelman's book is an exceptionally thoroughly researched and meticulous vademecum to OMP. The other books at less. I would suggest leaving the two Hoffer books in further reading, and adding Pfeiffer and Edelman in recognition of their value.--Alterrabe (talk) 20:29, 19 December 2007 (UTC)

Given the further reading section is usually for books not cited in the body text, and that both books are cited several times in the body text, I don't think there's a need for their inclusion in further reading. It's similar to external links and see also, if a link can be embedded in the text then it should not be included in a separate section. As it says in the guide to layout, is generally for resources on the topic that are not specifically cited in the article.

Have a gander at WP:TALK, your formatting is still a bit off and it makes the page harder to read and edit. Mostly, add a colon for every reply and undent when you get too far over. Makes it easier to see who said what when. WLU (talk) 20:48, 19 December 2007 (UTC)

This section basically echoes the GTL section. If something is going to be duplicated as an embedded link and in the Further reading section, make sure it is the book to read about orthomolecular psychiatry. WLU (talk) 20:56, 19 December 2007 (UTC)

I've re-phrased the sentence with Pfeiffer's law to relate with the transition between initial conventional treatment and orthomed prescriptions. Pfeiffer and Braverman reflect much of the biochemical diagnostic-pharmacological thinking developed following Pfieffer's dedicated bichemical research for Hoffer in Canada, the state of NJ, and perhaps some other less conspicuous govt agencies. Werbach is more generally nutritionally oriented. Added Edelman as another contemporary view to get as close as what appears fairly complete in some major areas of orthomed focus from authors based on background, clinical and research experience, if not canonical, and realistically reflect what might be available in public & local university libraries.--TheNautilus (talk) 02:37, 24 December 2007 (UTC)

Ashley Bush's research and histapenia with high copper

The scientific support passage needs to be clearer on the fact that Wilson's disease (the acknowledged copper accumulation disease) is always accompanied by liver damage, whereas histapenia with high copper is not.

Unlike Pfeiffer, Bush has not been ostracized.--Alterrabe (talk) 18:05, 19 December 2007 (UTC) I have corrected this.--Alterrabe (talk) 18:12, 19 December 2007 (UTC)

I don't see a need to make the link between the two any clearer. Without a referenced link between the two that's getting closer to original research. The point isn't to prove that AD and copper are linked (that's reported here, not proven, per WP:V and WP:NOT), that they're linked or not linked, the point should be a description of orthomolecular psychiatry. Right now the problem is that Bush isn't linked by sources to OMM/OMP, but the section portrays it as if this were so (this also happens with the schizophrenia info). None of this is explicit evidence that OMM/OMP are valid lines of inquiry, they're just areas where scientific studies appear to agree with the theories of OMM/OMP. Admittedly it's a judgement call, but I think it looks like, if not a textbook synth, then a very suspect one. Are we mutually satisfied enough with the current version that we want to ask for a 3O or did you still want to make some tweaks? From my end, I think it's as good as it's going to get. WLU (talk) 19:06, 19 December 2007 (UTC)

There's a couple problems with this phrasing - first, there's no citation for Pfeiffer saying so (easily fixed with a citation) and the relevant citation would need specific mention of Wilson's disease (less easily fixed if Pfeiffer didn't mention Wilson's). WLU (talk) 19:46, 19 December 2007 (UTC)

Did some re-working of the content, I'm now going to go forward with a RFC on this aspect of OMP - the link between copper, alzheimers and OMP. I still think it's OR, but let's get an outside opinion on the matter. WLU (talk) 19:22, 2 January 2008 (UTC)

Is the section on Current research original research?

Template:RFC error

The section on current research describes scientific support for some ideas within Orthomolecular psychiatry, but references for the supported ideas do not specifically refer to orthomolecular psychiatry. There is disagreement on if this is a valid use of references, or represents a synthesis or other type of original research.

Comment in response to the RfC

I agree that the section on Scientific support is Original Research. My problem is that it takes the findings of Ashley Bush to be a vindication of Carl Pfeiffer's theory. This might be more believable if there were citations both ways (i.e. the OMM people were following Bush's work, and evolving their own theory as a result, or if Bush were citing OMM and using some of their thinking). I haven't seen any data presented for either connection. It's like saying (a) Bush worked on metals, Pfeiffer worked on metals, to they must be colleagues, (b) both scientists faced early opposition, so their scientific viewpoints are analogous. Neither (a) nor (b) is correct, so far as I can tell. The suggestion that these scientists are connected appears fanciful. Anyone is welcome to search for citations to show that OMM influenced Bush, but I imagine there are none. EdJohnston (talk) 20:31, 3 January 2008 (UTC)

I don't think this is where it would go, and the RFC hasn't been answered yet. You're not really neutral given our previous discussion on my talk page, so I'd say the RFC should come from someone else. If the RFC keeps dragging, we could ask some admins for their opinions as well, or post this on talk:OR. WLU (talk) 20:36, 3 January 2008 (UTC)

I would yield to more experienced people on whether my participation is proper. The link to the RfC that you provided over at the official RFC page has a non-working section link on my browser. Isn't the light bulb the place where other people (besides me) ought to put their comments? EdJohnston (talk) 20:42, 3 January 2008 (UTC)

Not sure, sometimes this takes a bit of time for other editors to get to. Plus, it's the holidays. The RFC page link sort-of works, taking you to the talk page but not the relevant section. I'm going to try tweaking it, see if a bot smacks me down. I still would say that for both appearances and reality, the comment should come with someone who's not been involved - otherwise it can look like you'd made up your mind before the comment was requested. WLU (talk) 21:08, 3 January 2008 (UTC)

I've tried tweaking the template, hopefully it'll help. I don't think I'm supposed to link a section heading in a section heading. WLU (talk) 21:14, 3 January 2008 (UTC)

Non RFC discussion

Orthomolecular psychiatry appears in many guises, different names and labels, often the same research viewed from different times & places, describing deeply interrelated topics, often not recognized by the casual passersby. The pioneers of orthomomoecular psychiatry are an important historical and scientific part of "therapeutic nutrition", "psychopharmacology", "molecular medicine" and "biological psychiatry" (among others), for a time in the 1950s and 1960s considered to be at the forefront of scientific research (that's WP:V from mainstream psychopharmacologists). In large part what many people see today in the nebulous "mainstream" is hagiograpic, deletionist history rewritten by the commercial victors, pharmaceutically based psychopharmacology & psychiatry, with incomplete accuracy to say the least.

I have attempted what I consider a valid summary of the area and having avoided drowning it in references. I would appreciate a slower Q&A approach to answer your concerns. I notice that sometimes when I use more WP:V references, that gets complaints too. The version that I support attempts to develop the subject's history and science in a scientifically sensible way on an area still active in experimentation (and dispute) where in fact orthomed has scored a number of WP:V scientific points on the 1973 APA report's shortcomings & bias (the more specific scientifically based critical questions that I have seen were not contained in the 1973 report either and do not seem to have been accepted for journal publication either). The "natural" molecular medicine side may have its shortcomings, as do all scientific subjects in development, but dismissive edits and statements should be heavily scrutinized under WP:V and NPOV. The abbreviated version has naked "well poisoning" terms (e.g the naked "quackery" opinion of the partisan QW site in the lede - at Misplaced Pages not a scientifically reliable source, per arbcom statements, as well as some clearly biased statements on orthomed that *strongly* violate scientific methods and discussion) and aspects of construction that reflect known bias, misrepresentations, and obsolete "facts".--TheNautilus (talk) 01:35, 3 January 2008 (UTC)

I don't think the RFC section is the appropriate place for this, I think it'd be better off in its own subsection. Also, do you have any citation for your statements about OMP changing over time? Are they published in reliable sources? Your comment about the 'commercial victors' raises redflags for me. Unfortunately, 'drowning in references' is what is desired in most article, particularly contentious ones. More references is better, and ideally references from external parties and peer-reviewed journals. OMM in general is a fringe topic/science which means the pool of best sources, peer-reviewed journals, is already pretty shallow and old. I don't mind a slower question and answer, did you want to move this to a separate section? I am fine discussing and changing my individual edits, it's slower but it builds a much better consensus. The fact that OMP and OMM is considered, if not quackery, then at least contentious and is rejected by mainstream research is a very valid point to make in my mind. I used quackwatch because it's a convenient source that purports to represent mainstream science (and is really the extremity of skepticism), but there are probably others that could be used. Unfortunately, with non-mainstream topics, science and scientists tend to ignore it so there's not as much in peer-reviewed journals. I'll see what else I can dig up. But I think the RFC on the support section definitely needs to be answered and is unrelated to my last edits (I think, I haven't had a chance to review my last set of edits yet). WLU (talk) 13:08, 3 January 2008 (UTC)

I agree that the section on Scientific support is Original Research. My problem is that it takes the findings of Ashley Bush to be a vindication of Carl Pfeiffer's theory. This might be more believable if there were citations both ways (i.e. the OMM people were following Bush's work, and evolving their own theory as a result, or if Bush were citing OMM and using some of their thinking). I haven't seen any data presented for either connection. It's like saying (a) Bush worked on metals, Pfeiffer worked on metals, to they must be colleagues, (b) both scientists faced early opposition, so their scientific viewpoints are analogous. Neither (a) nor (b) is correct, so far as I can tell. The suggestion that these scientists are connected appears fanciful. Anyone is welcome to search for citations to show that OMM influenced Bush, but I imagine there are none. EdJohnston (talk) 16:48, 3 January 2008 (UTC)

Are you providing your opinion, or the official RFC? I don't know if your involvement in the discussion on my talk page here precludes an acutal RFC. As far as if it's OR or not, my preference is to wait for the RFC to run its course, though I agree with your comments. WLU (talk) 16:59, 3 January 2008 (UTC)

do you have any citation for your statements about OMP changing over time? the story is more about how psychiatry and medicine have changed over time from the 1940s toward the *much* criticized complex we see even the mainstream editors-in-chief turning against. Abram Hoffer has important details in his books and papers. cont'd next question

Your comment about the 'commercial victors' raises redflags for me. Hoffer more eloquently explains this himself, and even books by conventional psychopharmacologists now sometimes discuss this 50's-60's history to a degree. Basically Hoffer was a leader in the mainstream science charge to displace psychodynamic ("talk") and more brutal therapies (electroshock, insulin, lobotomies) with biochemical hypotheses, molecular medicine, biochemical methods, early double blind RCTs, and developing simple objective test methods (HOD). Unfortunately for Hoffer, the money is in new (patentable) fast acting (club, thunk!) molecules (molecular medicine split into xenobiotic$$$$ and orthomolecular camps) that partially treat & immobilize rather than fill or cure organic deficits - he & orthomed types were first pushed aside and then prejudicially attacked in the 1973 report (his lengthy analysis & rebuttal of that report being highly flawed & severely biased is increasingly accepted, grudgingly in the "mainstream", hence the new, more modern Beersheva trial). He, as well as others, became an APA non-person (even QW doesn't say his name). Parts of this story are noted in recent conventional RCT summaries, books, perhaps the opening wedge of a "Glasnost" in the history of biological psychiatry and psychopharmacology.--TheNautilus (talk) 13:58, 4 January 2008 (UTC)

Also on the "quackery" part, I invite you to dispense that word with greater care since in orthomed it can rapidly make its bearer look like a bigoted, pseudoskeptical, technical illiterate, or some pharmaceutical $dependent, as well as simply being a poorly defined, non-scientific word. As for as research disputes, Orthomolecular medicine redefines and continues the therapeutic research of mainstream medicine, *before* the pharmas abandoned ship, looking for new patentable fields, after exhausting even cheap, patentable, synthetic (dangerous) analogs, with safer, more optimal forms in more sophisticated combinations & protocols, with better diagnostics. By the way, in specialty chemicals (including pharmaceuticals) and advanced electronics, standard corporate operating procedure is to destroy the viability of the previous generation going off patent if brand dominance can't be maintained, or competitors' related lines of technology, by *any* means possible. Just ask Intel. Generics, like most orthomolecular substances, are fair game and soft targets because they have little economic wherewithal in comparison, and hence, much smaller resources for technical support in marketing wars with "competitive research".--TheNautilus (talk) 12:38, 5 January 2008 (UTC)

I used quackwatch because it's a convenient source that purports to represent mainstream science (and is really the extremity of skepticism) QW has been noted at arbcom as not being a (technically) reliable source, whereas in some cases it has been said to reflect the opinion of many, although QW and its sponsors driving public opinion for ~39 years, without much independent academic notice or review, with might be more accurate. The QW sympathetic are significantly numerous at Misplaced Pages trying to promote QW as a reliable source, and its article is RS & NPOV problematic and incomplete. Although I have always noted QW's articles myself as a significant sentiment, more substantial scientific critics with statements that are *WP:V current* and accurate should be sought - there is a lot of dangerously (and scientifically) inaccurate POV statements in the press of OM's aggressive competitors - WP:V scientifically demonstrable misrepresentations in economically competing "mainstream publications".--TheNautilus (talk) 12:38, 5 January 2008 (UTC)

<undent>Note that I split the section off from the RFC above since the two are only somewhat related - the RFC was based on my discussion with EJ and Alterrabe from December, and TheNautilus' comments seem to be related, but also refer to a whole different set of edits made by both of us. I think. If there's going to be ongoing discussion of the specific section of Orthomolecular_psychiatry#Scientific_support, then the RFC should probably be removed. If it's discussion about other topics, then the RFC should say and the discussion continue. I've still got issues with the current version, based on my edits on the 2nd. I'll go into greater detail once we know what's the what what. WLU (talk) 17:03, 3 January 2008 (UTC)

I disagree with Ed Johnston's conclusions for the following reasons, which I am willing to insert into the article.

1) Pfeiffer and Bush cannot have been colleagues, because Pfeiffer passed away long before Bush was studying medicine. They both are, rather, doctors who pursued unconventional theories about copper loads.

2) It's clearly evident that Bush's theories do not vindicate Pfeiffer and that Pfeiffer's theories do not vindicate Bush's. In so far as Bush's theories have yet to be proved Bush's theories cannot vindicate Pfeiffer's. What they are is suggestive that the theory that copper toxicities can cause brain problems has once again found a foothold in academia.

I think "scientific support" is the wrong title for this section, because it does suggest that these issues have been resolved. How about I use the title "renewed scientific interest in orthomolecular theories"? Insofar as I am one of the parties to this second opinion, I'll allow myself to remove phrasing I myself disagree with.--Alterrabe (talk) 18:00, 3 January 2008 (UTC)

I moved your comments to the bottom per WP:TALK. The disagreement we're having on this matter is why I sought a RFC - you (and Nautilus?) think it's not OR, while myself and Ed do. The RFC is an independent attempt to get someone else's opinion on who is more correct in interpreting the policy and statements on the page. And the reason why I think it's a synth is because you are saying 'Bush and Pfeiffer both followed theories about copper loads, Pfeiffer was researching orthomolecular medicine, therefore Bush is an orthomolecular researcher as well' or some variant of that set of statements. But let's see what the RFC says about it. Further, 'renewed interest' would also be a mis-nomer or OR/SYNTH - I've yet to see evidence that Bush or anyone else is interested in orthomolecular medicine/psych, they just happen to have theories that involve in this case, a common focus on metals in the brain. This could probably go into the copper page, possibly Alzheimer's, but I think it's OR to say that Bush is doing OMM. Much like the whole omega fatty acids and bipolar doesn't vindicate OMM. From my understanding, OMM says that many diseases and conditions can be cured/managed/treated solely through non-drug use of foods or avoidance of certain substances. Because certain conditions (i.e. bipolar disorder and alzheimer's) happen to have research showing that these particular conditions do respond given these specific interventions, does not mean that all of OMM and it's paradigm and approach is valid. I'm mostly laying off editing the page until the RFC clears, then I'll be more interested in discussing specific aspects of the page I still consider problematic. To clarify a bit more, if Bush says 'oh, yeah, I'm studying this because of OMM/using the OMM paradigm', then all the problems go away. But from my reading, he doesn't mention it at all. Which makes him a scientist doing work that has a single factor in common with OMM, not a scientist studying OMM. Again, this is my opinion, and I put up the RFC because we're disagreeing without resolution. But in a very civil fashion, which I appreciate. WLU (talk) 18:11, 3 January 2008 (UTC)

In an effort to allay your concerns, I have removed all the verbiage to which you object that I can, without, I believe, compromising my best effort to make this a good wiki article.

Bush isn't doing OM research; he's trying to patent a drug that removes copper from the brain. Let me be clear, I have never claimed that Bush is doing orthomolecular research. What I have claimed is that Bush is pursuing a revolutionary theory (copper causation) that dovetails very nicely with a theory of orthomolecular psychiatry. If he were to test the drug he's using on schizophrenics with high copper it definitely would be pertinent. I believe that a mainstream scientist linking copper and dementia is already noteworthy.

To make it clear that there is no synthesis, (i.e. because Bush maybe onto something Pfeiffer must have been right), I've added research into the link between copper and postpartum depression. By doing so, I hope, I've made it clear that there is continuing (mainstream) interest in psychiatric and neurological woes arising out of copper dysregulation. I for one don't claim that because Crayton and Walsh (a good friend of Pfeiffer's) are getting data on copper issues published, that Pfeiffer must have been right, rather I think it's proof that the Pfeiffer's lines of enquiry haven't been forgotten. --Alterrabe (talk) 18:45, 3 January 2008 (UTC)

By adding yet another paper on abnormal copper levels correlating with behavioral disturbances, I hope to have made it clear that I was not implying that if Bush is right, Pfeiffer must also be, but rather that Pfeiffer's line of inquiry into copper levels and behavioral disturbances continues to this very day, whatever the APA may say.--Alterrabe (talk) 19:06, 3 January 2008 (UTC)

Compromise is indeed very nice.

But again, your second paragraph and that third paper looks like a rational for WP:OR, and a synth respectively, which is why I've done the RFC. We're at a fundamental disagreement on if it's OR or not, which is why I'm going for an outside comment. I see your point, I just think it's wrong :) That it dovetails with OMM but isn't OMM means Bush's hypothesis shouldn't be on the page, in my opinion, because it's fundamentally not OMM. But again, that's why there's the RFC. It's possible I'm being overzealous, which is why I'm seeking the RFC rather than edit warring. If the RFC disagrees with my interpretation, then we try to hammer out a wording that's acceptable for all editors to produce WP:CONSENSUS, for now the fundamental nature of the whole paragraph bothers me. I'd rather avoid re-arranging the deckchairs on the Titanic if the paragraph is going to be removed completely; it's a waste of everyone's time to discuss wording of a section that may not be justified at all. WLU (talk) 19:12, 3 January 2008 (UTC)

You clearly misunderstand orthomolecular medicine!

Orthomolecular psychiatry has two aspects: diagnosis and treatment. Neuroleptics are often used as a stopgap measure. Orthomolecular psychiatrists do, however, reach diagnoses according to OM guidelines, and then, when the circumstances merit it, treat histadelia (high histamine) with anti-epileptics, dilantin is particularly effective, rather than methionine and pyroxidine. The idea is to get the patient well, not slavishly adhere to dogma. It's a controversial branch of medicine, and not a religion. Bush's work is quite pertinent to the diagnostic part of OMP. What would be interesting is if OMP is relevant to Bush's research, i.e. can Alzheimer's be treated with supplements.--Alterrabe (talk) 19:36, 3 January 2008 (UTC)

Unless I am completely mistaken, Pfeiffer would use penicillamine to treat histapenia with high copper on rare occasions when he felt it was warranted. Generally he reported that he found that increasing zinc allowed the body to rid itself of excessive copper.--Alterrabe (talk) 19:51, 3 January 2008 (UTC)

General questions about Orthomolecular Psychiatry

For the sake of argument, suppose someone wants to learn more about OMP. Here are some questions that might be germane (I imagine at least some WP readers might want to know this).

1. Are there OMP practitioners who are also conventional doctors? (or do they drum you out if you show any OMP tendencies).
2. What are the most scholarly books about OMP? (Isn't there anything newer than Pfeiffer's work?)
3. Do mainstream journals pay attention to OMP these days, or is it just ignored?

Since OMP is so exotic for most people, I think that a little space could be given to discussing some recent orthomolecular books, and perhaps including conventional responses or reviews of those books if there are any. Just putting then in Further Reading is not too helpful, given that the titles of many of these books sound spacey. (Smart Nutrients: Prevent and Treat Alzheimer's, Enhance Brain Function. That does not sound like a book I am going to rush out to buy). But this article has a chance to convince me it's important, assuming it is recognized by some reliable sources as a significant work. EdJohnston (talk) 21:00, 3 January 2008 (UTC)

1. To my knowledge, every orthomolecular psychiatrist is a board-certified MD. However, anyone who throws vitamins and minerals, even a multivitamin, at another person can claim, with varying degrees of accuracy, to be providing orthomolecular therapy. The regulation of OMP varies from country to country, and often from state to state within each country; in the United States with a few dozen exceptions, more leeway is shown doctors who rape their patients than those who heal their patients using OMP, my understanding is that Brazil is the most liberal country in this regard.
2. There is a Journal of Orthomolecular Medicine, an International Society for Orthomolecular Medicine, and various countries also have associations of doctors who practice orthomolecular psychiatry, with stunning results might I add. David Hawkins and Linus Pauling wrote the best book on OMP. The University of Kansas, I believe, just added a professor who teaches "orthomolecular medicine." At present, I understand, it's mainly about the adjunctive use of orthomolecular medicine, but it still is a big step forward.
3. Ever since the APA declared ex cathedra that orthomolecular medicine doesn't work, it's essentially been a taboo in "mainstream medicine." It's not ignored. It's taboo. The same researchers who had their research published effortlessly in mainstream journals in 1967 found by 1975 that they couldn't even find publishers to publish their books. There is little, almost no, funding for orthomolecular research, and a consequent dearth of subsequent publication. Unfortunately, as long as OMP and OM is banned, it is be next to impossible to get "authorities" to a) conclude that it's legit, and b) stake their reputation on it. In their day, Linus Pauling (2 Nobels), Albert Szent-Györgyi (1 Nobel) and Otto Warburg (1-2 Nobels depending on source) did endorse OM, Pauling was particularly close to OMP. --Alterrabe (talk) 21:42, 3 January 2008 (UTC)

Are there any books currently listed in the article that are written by orthomolecular practitioners who are also MDs, and have published articles in peer-reviewed journals? If there are any such, I think that could be a reason to highlight them. EdJohnston (talk)

I know for sure that every book except Edelman and Werbach are by scientists who did publish in peer-reviewed sources. Pfeiffer was a dept chair at Emory. I think adding MDs and PhDs indicates that these were serious people.--Alterrabe (talk) 22:24, 3 January 2008 (UTC)

Unlike some of the louder critics of OMP, Werbach is a board certified MD in Psychiatry and Neurology, as well as a long time faculty prof at UCLA med school. *Many* of the published orthomed pioneers are physician-scientists (MD+PhD, or some from the 20-30's, +MS).--TheNautilus (talk) 13:43, 4 January 2008 (UTC)

I see you added a section 'Noted orthomolecular research and treatment centers.' You've used the magic word 'noted' which activates the Wikipedian brain to demand some reliable sources for that. EdJohnston (talk) 22:40, 3 January 2008 (UTC)

Removal of the word "noted" doesn't change our inclusion criteria. It looks more like free advertising. Gone now. -- Fyslee / talk 00:52, 4 January 2008 (UTC)

Dear Fyslee, if this article were about services such as parole officers or truancy officers, whose existence and necessity are undisputed, you'd be absolutely correct that mentioning specific instances would smack of free advertising. Since, however, many are unsure, if not confused, by the orthomolecular psychiatry and the controversies it arouses, explaining that there are treatment centers that have been in business for - in one case - decades is highly germane to the discussion at hand. The PTC is particularly interesting since it has been able to help quite a few autists. We can get a third opinion, but any effort exclude such pertinent effort smacks of censorship and NPOV. Do let me know.--Alterrabe (talk) 07:24, 4 January 2008 (UTC)

My only concerns were about free advertising. Usually there are inclusion criteria, either by establishing notability using V & RS, or using V & RS as references. Without them it can be contrued as gratuitous advertising, also known as linkspam. There are thousands of things of interest we can't add here without sourcing. That's what I'm asking for and Misplaced Pages requires. -- Fyslee / talk 08:15, 4 January 2008 (UTC)

I do understand the concerns. I listed the larger centers because the PTC is notable; it has its own wiki page, and because they have the time to establish a web presence explaining their treatments. I have changed notable to larger; if you wish I can change it to largest, or some mutually agreeable phrasing. The idea is simply to establish that OMP is here, and in business.--Alterrabe (talk) 08:35, 4 January 2008 (UTC)

Pfeiffer Trmt Ctr appears in the news(e.g. "Drug-less therapies for kids make waves", 11-28-04, MM Breslin & BM Rubin, Chicago Tribune), but perhaps more often in popular science articles for founder Wm Walsh's work on metals. As for Fyslee's "free advertising" comments, I find them at least ironic given his demonstrated expertise sewing QW plugs even when he was warned about (scientific) source reliability problems at BvR.--TheNautilus (talk) 13:43, 4 January 2008 (UTC)

You will notice that I do not use Quackwatch as a scientific source, but as a very well known and extremely notable source of skeptical opinion that is supported by the mainstream. That's life. Also note that I am not adding it, I am restoring it. POV deletionists who don't like its criticism often remove it using various specious arguments, thus violating NPOV, but it is a referenced source that is being used as a source of opinion./ In this case its removal even turned other references red. I suggest that a certain user who hates Quackwatch take his concerns and misinterpretations of BvR elswhere. NPOV still applies to this article. -- Fyslee / talk 10:02, 6 January 2008 (UTC)

(undent) I agree with Alterrabe that mentioning that a center exists could be done without worrying about advertising, since this is an unusual service that most people probably haven't heard of. (They might assume that OMP was an historical thing from an earlier period). I'd be more willing to accept such an entry if it were a place where one of these noted practitioners works (who I hypothesized above). That is, an OM psychiatrist who was board-certified in his specialty and published the results of his OM work in peer-reviewed journals. I'm happy to agree with Fyslee that sourcing for such an entry is needed, and of course that sourced criticism should be included if there is any. EdJohnston (talk) 14:11, 4 January 2008 (UTC)

Earth House, to which I linked, originally began as the Princeton Bio-Brain Center, with Carl Pfeiffer, one of the big figures in OMP as its physician. The APA having put out a fatwa on OMP, there is no board-certification for OMP doctors. The PTC, whose work has been published in peer-reviewed journals, has the Chair of Loyola U - Chicago's psych dept on its board. Please visit the PTC wiki page. Does this suffice?--Alterrabe (talk) 14:31, 4 January 2008 (UTC)

OK, I'm looking at the entry you made on this page for the Pfeiffer Treatment Center:

* The Pfeiffer Treatment Center and Health Research Institute. The Pfeiffer Treatment Center is a research institute, noted mainly for research into the neurobiology of violent behavior and delinquency, that also provides medical care according to the precepts of orthomolecular psychiatry.

I see that William J. Walsh has peer-reviewed publications. In a quick glance, I saw a paper of his reporting measurements on autism patients, but that paper didn't talk about metal levels. If you have time, perhaps you could locate a paper published by Walsh in the last five years that does talk about metals and is in some sense in the orthomolecular tradition. The closest thing I could find was the second item under 'Publications' at Pfeiffer Treatment Center, but that was only an abstract. Also I think we'd need to see more sources for your claim that the PTC provides 'medical care according to the precepts of orthomolecular psychiatry.' Where is the list of the precepts? Thanks, EdJohnston (talk) 15:50, 4 January 2008 (UTC)

I hope this works. Here's information about the therapies the PTC provides . The precepts of OM are explained in the article.--Alterrabe (talk) 16:41, 4 January 2008 (UTC)

I haven't been reading the talk page as much as I usually do and missed this discussion of the center. Generally an embedded EL in the main page is odd, and looks very much like spam. Rather than playing with the section, I deleted it but moved the EL's to the EL section. If they practice OMP, then there's a case to be made for them being here, though if more get added we should consider trimming. WLU (talk) 20:13, 4 January 2008 (UTC)

I'm thinking the paper by William Walsh et al. (2004) found by Alterrabe (just above) could lead to some additional text in the article. It appears to me to be an observational study and might need a bit of scrutiny to see how believable it is. E.g. was there a control group? Exactly what is the treatment, since it's tailored to each patient? If these questions were addressed in the text it might belong. EdJohnston (talk) 20:38, 4 January 2008 (UTC)

<undent>I see the same problem as with Bush - it doesn't mention orthomolecular anything in the abstract, so it's hard to defend it being related to the article. We have to interpret its methodology as being orthomolecular. Unless the body of the paper has more detail and an explicit mention of OMP, it looks like a) The paper was done at the Pfeiffer treatment center b) the treatment center does OMP, THEREFORE c) the paper is about OMP. I think that's OR territory. WLU (talk) 20:44, 4 January 2008 (UTC)

I beg to differ. The abstract is nothing but OMP related diagnoses: metal-metabolism disorders (possibly copper toxicity) methylation abnormalities (histadelia and histapenia), disordered pyrrole chemistry (pyroluria), heavy-metal overload (heavy metal toxicities), glucose dyscontrol (hypoglycemia), and malabsorption (seen in food allergies.)--Alterrabe (talk) 20:54, 4 January 2008 (UTC)

I do not know if the paper in question featured a control group. It may have been impractical, and even unethical. Mainstream psychiatry has also been known to otherwise influence the control group in such fashion as to promote favorable results. A dearth of funding has been OMP's Achilles heel. William Walsh got involved in OMP by visiting violent criminals, including those on death row, and deciding to investigate what made them the way they were. The other Achilles heel has been that since treatments are tailored to individual the cookie cutter comparisons so beloved of mainstream psychiatry can't be made, even if the overall outcomes are spectacularly superior. Here's more: --Alterrabe (talk) 20:54, 4 January 2008 (UTC)

If WLU agrees that there's a case to be made for including them in the text, in a limited number, I think we should do so. It's not that common, but then neither are physicians who practice orthomolecular medicine.--Alterrabe (talk) 20:58, 4 January 2008 (UTC)

This is a response to WLU's comment that it might be OR to include the paper I mentioned. I did get hold of a copy of Walsh, Glab and Haakenson (2004). It does cite Pfeiffer's work, but the word 'orthomolecular' does not occur in the body of the text. I guess that is an argument against using it here. There exists a 'Journal of Orthomolecular Medicine' though I don't know what their editorial standards are, and the journal archive does not seem to be available online. There is a paper by Hoffer et al. (1990) from J of Orthomolecular Medicine in our current reference list, and a PDF copy is available, but that article reads more like an opinion piece than a scientific study. EdJohnston (talk) 21:11, 4 January 2008 (UTC)

This is a problem of semantics, and nothing else. The treatments are very clearly those pioneered by Pfeiffer, whether or not they have been repackaged as nutritional therapies. If we must do so to get Walsh included, we could rename the entire article to "orthomolecular and nutritional psychiatry." This would allow us to include Truehope a therapy derived from veterinary medicine that has proven to be life-saving in some cases. It too ran into a wall of artificial controversy orchestrated by individuals with very close links to competitors.--Alterrabe (talk) 21:24, 4 January 2008 (UTC)

I looked at the PDF by William Walsh that was supplied above by Alterrabe. Unfortunately even in this PDF Walsh refers to what he does as 'nutritional therapy' and doesn't use the word orthomolecular. Maybe WLU can see if there is any rewriting or repackaging possible that gets this material in (actually, not the PDF file itself but any scientific papers that may have been submitted by Walsh and colleagues based on this program). EdJohnston (talk) 21:58, 4 January 2008 (UTC)

Semantics, logic and 'it's very close' are all words for original research in my mind. Again, this is why I want the RFC - an independent examination of the page and its ideas to see if it's OR or not. If it's been repackaged, that repackaging needs to be sourced, and theoretically the page could be moved, or at least linked to the new packaging. Just because something was pioneered by someone doesn't mean that it is the same thing. Again, it looks like a syllogism to me - a) Pfiffer studied x b) Pfiffer was an OM pracititoner c) Y studies x d) therefore y is an orthomolecular practitioner. It looks like a classic synth to me - in my mind, anything other than an explicit statement saying X is orthomolecular medicine IS a synth. It might be worth bringing in some others for comment, seeing as the RFC appears to be lingering like a dead woodchuck rather than moving forward. Alt - how do you feel about trying to find some admins we can both agree will give a valid, neutral opinion, or bring this up at Talk:WP:OR? I keep running into an aversion to the sources and edits you suggest because if WP:REDFLAG, WP:FRINGE and WP:SYNTH, which I interpret as precluding all of your 'this is OMM/OMP even if it doesn't say so.' User:FisherQueen I know quite well, trust very much, and she's said 'no' to me many times. Plus, she's not a doctor, so she wouldn't have preconceptions on the topic. Most of the other admins I rumble with are doctors, so I don't think they'd be acceptable. I'm not the last gasp here, I just have persistent concerns that haven't been addressed to everyone's satisfaction (mostly mine). I'm deliberately holding back from editing the page proper because until these basic issues are addressed, it's not really worth discussing other concerns I have. And there are a fair amount, as you'd imagine :) WLU (talk) 23:21, 4 January 2008 (UTC)

It may appear to be a syllogism to you because of your (and others') unfamiliarity with the OM subject, this is one of the bases of my comment about drowning the article in references. Linking trivial information steps, word-by-doubly referenced-word (or name), for the utterly uninformed or some adversarial editors seems unusually burdensome to me, and distracting for readers.

...which I interpret as precluding all of your 'this is OMM/OMP even if it doesn't say so. Sounds like an open invitation for what Fyslee might want to describe as "free advertising" because OM book and papers do describe it so, but I have to admit it would/will be tedious to match (or explain) sound bytes so literally every 2-3 words with several references. As far as "fringe" goes, there are a lot of overlaps and absorptions of prior OM positions but then there simply is not much to discuss - with conventional medicine (or nutritionists), the attitude is more or less "so, its mainstream (now), wasn't it always so?" (e.g. prenatal folate), unless you are one of the spinal bifida or other birth defect victims, or their relatives (secondary victims).

PTC founder, William Walsh, has long & repeatedly participated in orthomolecular functions. He is clearly identified, w/o any protest known to me, by a number of organizations, as "orthomolecular" or the orthomolecular advisor/director, starting with Hoffer et al's Int'l Orthomolecular Society (ISOM) Feature Speakers include internationally known leading pioneers in Orthomolecular Medicine:...William Walsh, PhD (co-founder, Chief scientist, and PTC's public persona).

Also ISOM seems to have a strong impression that the Pfeiffer Treatment Center is orthomolecular: on its page listing of "Web Resources" Orthomolecular treatment and Research Institutes, ISOM lists and directly links to Pfeiffer Trmt Ctr as Health Research Institute (the parent org) - Since 1989, HRI's Pfeiffer Treatment Center has...

Finally, the Pfeiffer Treatment Center literature, explicitly named after orthomolecular pioneer Carl C Pfeiffer, cites CC Pfeiffer's specific orthomolecular positions, chapter and verse, as its own, The Pfeiffer Treatment Center has observed that most victims of depression fall into one of five biochemical classes: (1) high histamine, (2) low histamine, (3) pyroluric, (4) high copper, and (5) toxic overload. (Biochemcial Treatment of Mental Illness and Behavior Disorders, p.3, WJ Walsh, 13 July 2001). The PTC self-identities with, lives and breathes OM psychiatry.--TheNautilus (talk) 12:38, 5 January 2008 (UTC)

I've other concerns about the JoOM being a reliable source for anything other than what doctors of OMM believe, since WP:MEDRS probably precludes it from making any claims about effectiveness or cures. WLU (talk) 23:21, 4 January 2008 (UTC)

ISOM and JOM are WP:RS for a number of things, among others: (1) describing who and what is orthomolecular, and those that are not, (2) describing the history of (ortho)molecular medicine pertaining to orthomolecular medicine, (3) describing what the clinical and scientific evidence is', which often (surprising to incredulous newbies) is more than "conventional medical commentators" position of *nothing* experimentally *relevant* or correct on the subject - some literally rigged "dbRCT" experiment (e.g. long known (50+ yrs?)& stated wrong molecules, quantities, patient subgroup, and/or protocol), Enron accounting, or simply adversarial intrepretations with low science scores. (4) Describing the technical rationale of an actual OM practice or recommendation as OM's claim.--TheNautilus (talk) 12:38, 5 January 2008 (UTC)

I've thought about your concerns, and can understand your trains of thought. I would urge you to get your hands on Pfeiffer's short, or Edelman's more extensive book. Once you understand that what Walsh did with violent adults is exactly what Pfeiffer did with schizophrenics, you'll understand that it's exactly orthomolecular medicine. Furthermore using specific nutrients to change behavioral disorders is orthomolecular by definition. This is neither OR nor synthesis. Reading Pfeiffer and Edelman explain OMP so much better than I ever could. This discussion is somewhat pedantic, or about splitting hairs. But that, alas, is precisely what editing encyclopedias is about. Before we get comments or third opinions, it behooves us to see what differences we can resolve ourselves. In this spirit, I'll answer in a new section.--Alterrabe (talk) 12:01, 5 January 2008 (UTC)

I am satisfied with the current format of that section. My original concerns about advertising were based on the formatting (using direct links rather than references to second or third party sources) and lack of referencing, and I simply didn't notice the wikilink to the PTC, my bad. It's notability is already established by the existence of the wiki article, and its relevance to this subject is obvious. PTC should be mentioned. -- Fyslee / talk 09:55, 6 January 2008 (UTC)

MOS and further reading, other stuff

I'm re-ordering per the MOS (see standard appendicies) and trimming the grossly bloated further reading section (see Misplaced Pages:Citing_sources#Further_reading.2FExternal_links). The section should include the most relevant, and be kept to a minimum. Further, it should related to orthomolecular psychiatry specifically, not sub-topics liek alzheimer's. Also, it should be alphabetized. I also moved the links to treatment centers to the EL section, and deleted the EL to Pauling's paper - that should be a source, not an external link. I've also commented out the info about Kidder's role in the Kent treatment facility - per WP:BLP, that kind of information should be sourced either to Kidder herself (including a blog if she's got it) or a reliable source - a news paper, magazine, major organization, something like that. WLU (talk) 17:52, 4 January 2008 (UTC)

Speaking of MOS, what would you say to putting up a first section of "introduction". It would move that bothersome contents box above the main text, making it clearer and easier to follow. The box is in an unnatural place.--Alterrabe (talk) 20:14, 4 January 2008 (UTC)

I'm pretty sure that's 100% against the MOS actually - the lead should not have any section headings above it. As far as an 'intro' section, what would you put in it that's not duplicating the lead? There's manipulations that the wikisoftware can make to move the TOC around - it's actually in the standard position. The page may look odd to you because it lacks pictures and/or an infobox, but I'm not sure what would work. Perhaps a pic of Pauling or Pfieffer. WLU (talk) 20:21, 4 January 2008 (UTC)

Misplaced Pages specifically doesn't use an "introduction", but a WP:LEAD, and they aren't totally identical. -- Fyslee / talk 09:45, 6 January 2008 (UTC)

A New Title?

WLU has expressed concern that some research using orthomolecular diagnostic methods and prescribing orthomolecular treatments may not fall within the scope of this article on orthomolecular psychiatry because the author doesn't specifically describe his work as "orthomolecular" in nature. OMP clearly is a contentious topic, and I can easily understand that skeptics may feel that pedantic levels of precision are of utmost importance in what is meant to be a reference source; I agree whole-heartedly with these concerns. So before we seek comments and even third opinions, why don't we see which differences we can resolve ourselves.

In this spirit, I suggest that this page be renamed "Orthomolecular and other nutritional therapies in psychiatry." This allows us to discuss OMP and therapies that would fit Linus Pauling's description of orthomolecular medicine (i.e. nutritional therapies in general), but do not describe themselves in these terms, without having to worry about just how to split certain hairs. It would also allow us to enrich this page with more research on omega-fatty acids in bipolar disorder, which has already become mainstream, Truehope's product, and perhaps other products of which I'm ignorant. This shouldn't be about ego, but about making the wiki article as informative, helpful and accurate as possible.--Alterrabe (talk) 12:25, 5 January 2008 (UTC)

As the articles develop, and sources and text accrue, we could of course then separate this proposed new article into two articles: orthomolecular psychiatry, and non-orthomolecular nutritional treatments in psychiatry. Incidentally water with high lithium concentrations, but "subtherapeutic" by today's standards, has long been used as a tonic for frayed nerves, in Doctor Pepper if memory serves me right.--Alterrabe (talk) 13:26, 5 January 2008 (UTC)

Trying to establish that orthomolecular medicine is a coherent body of teaching that has remained steady over time may be too difficult. Attempting to 'tack on' nutritional therapy as though it was organically connected would probably defy any sourcing that we might come up with. Instead, I suggest that the main effort be put into scientific biographies of the leading practitioners such as Linus Pauling. Carl Pfeiffer and Abram Hoffer. It might even be justifiable to create an article on William J. Walsh. It is easy to establish that Pfeiffer's work is by Pfeiffer, while it is not always easy to show that a given paper should be considered part of orthomolecular medicine, as in the recent effort to make Ashley Bush an outlying member of the club. Let me know if this sounds workable to anyone. EdJohnston (talk) 17:20, 5 January 2008 (UTC)

This article is about OMP, not OM. I would imagine that Pauling et al. and others did organically connect nutritional therapy with OMP, when you remember pellagra (niacin), scurvy (vitamin C), lithium and bipolar disorder. I could find sources. Putting details into biographies is an excellent idea, and ought to be done.

It might take a phone call to the PTC to determine if Walsh, a friend of Pfeiffer's, identifies himself as orthomolecular per WP:RS, as opposed to colloquia. The idea of starting a wiki page on William J Walsh is a good one. One way to overcome concerns about OR and SYNTH would be to spin the copper discussion off into a separate page on research into copper toxicities as a cause of neurological and psychiatric disorders. This would allow a discussion of the subject without any implication that Ashley Bush himself endorses OMP. A similar page about food allergies and neurological and psychological issues would also be exceptionally useful. How does this sound?--Alterrabe (talk) 17:44, 5 January 2008 (UTC)

If you want an article on copper toxicities I think it would have to be scientifically based. Then its coverage of OM would be limited by WP:UNDUE, and might have to be small. There are probably some articles around about the significance of trace metals in medicine, and to the extent that the OM people have done any studies, they might be discussed there. OMP is allowed to get more coverage in a dedicated article, but then you can only include material that identifies itself as OMP. EdJohnston (talk) 17:52, 5 January 2008 (UTC)

An article on copper toxicities has to be scientifically based. Since Kuhn's work, we (scientifically) know that science, too, has its ideologies, and makes mistakes; I wouldn't hesitate that to mention that OMP has been a subject of controversy among scientists. For me, reading about Bush in an article on OMP is neither an endorsement of OMP nor a claim that Bush does OMP, but I understand how more superficial readings could allow such an impression to arise. Particularly in encyclopedias, precision is of essence. My goal is not to eke out the maximum possible cyber column inches for OMP, but rather to get the pertinent facts - in a non-confusing manner - into the wikipedia record. This may be an elegant way to explain in the OMP article that the copper brain problem link is not dead, without befuddling the less sophisticated reader, and allow an article on Ashley Bush's work and similar theses to eventually grow out of it. To me this sounds like win win. OMP gets better, and Ashley Bush's work, WJ Walsh's work and parenthetically Pfeiffer's work, all get better. Any suggestions for what the title should be?--Alterrabe (talk) 18:24, 5 January 2008 (UTC)

Can you find a secondary source that defines this field differently than just 'Orthomolecular psychiatry' and includes the additional topics that you have mentioned? Are there multiple sources that would agree on such a broadened definition of this field? EdJohnston (talk) 18:53, 5 January 2008 (UTC)

If I understood your question correctly, Ashley Bush has been published in Neurology, which is as mainstream a medical journal as there is, had an image of his face grace the front page of the Wall Street Journal and more. A link in the article links to the USA Today. OMP is stuck in a backwater, but not Ashley Bush. ,--Alterrabe (talk) 19:05, 5 January 2008 (UTC)

You may have misunderstood. You want to change the article title to 'Orthomolecular psychiatry + X', and I'm suggesting you find a secondary source that does likewise, and evidence that multiple secondary sources all have the same conception of the broadened field. I don't think WP should do its own unique broadening. EdJohnston (talk) 19:11, 5 January 2008 (UTC)

In so far as OMP has always been defined as a work in progress, virtually every book on OMP will allow for, generally even suggest, that additional nutritional therapies will be of use. For my example, to my knowledge, Hoffer wasn't into omega-3 fatty acids. "OMP and further nutritional therapies" would be nothing more than to reiterate OMP's manifesto. Braverman and Pfeiffer did work with therapeutic aminoacids that wasn't "classical OMP," and may not even have been defined as OMP stricto sensu.--Alterrabe (talk) 19:24, 5 January 2008 (UTC)

<undent>I'm short on time so this is short and doesn't represent my thoughts after reading the comments since my last post. Here's my one comment - has someone brought up WP:POVFORK yet? It was my first thought after reading the suggested page re-name. WLU (talk) 00:25, 6 January 2008 (UTC)

So far it doesn't seem so. We can't make up the name of a field "A + B" and have an article about it, when the literature doesn't recognize A + B as being a 'thing,' or a coherent subject of study. I know that the early OM people such as Pauling were also into megavitamin therapy. That's why an expanded bio article on Pauling with a section on his OM work would be logical. We could include his megavitamin ideas there, since they have the common property of all being interests of Pauling. I see that Alt. has used the term "classical OMP", and "OMP strictu sensu", but we can't use either term in the article unless the term is widely used in the literature. I suppose an option is to arbitrarily pick somebody like Pfeiffer, and just say that our article is about what Pfeiffer thought that OMP was. So long as it's given as his opinion, it might be OK. EdJohnston (talk) 03:39, 6 January 2008 (UTC)

To really get a definition of what orthomolecular is, you'd have to dig up Pauling's 1968 article in Science, in which he coined, and defined the term. Any therapy that meets Pauling's definition would be orthomolecular.--Alterrabe (talk) 07:43, 6 January 2008 (UTC)

Separating two very closely related, but not identical topics, in order to avoid confusing the less sophisticated is not, and cannot be, a povfork. What it is instead is a WP:Spinout. I find it tiresome to deal with editors in whose eyes I seem unable to do any right.

Here's a summary of what OMP is: "In the case of phenylketonuria, treatment has consisted of restricting the amount of dietary phenylalanine. Similarly, galactosemia can be treated by eliminating milk, which contains galactose, from the diet. Pauling cited these strategies as examples of orthomolecular psychiatric therapy, which he defined in "Orthomolecular Psychiatry" as "the treatment of mental disease by the provision of the optimum molecular environment for the mind, especially the optimum concentrations of substances normally present in the body." He later broadened this definition to include orthomolecular medicine, which he defined as "the preservation of good health and the treatment of disease by varying the concentrations in the human body of substances that are normally present in the body". He sometimes appended "and are required for health" to this definition and noted, "the adjective orthomolecular is used to express the idea of the right molecules in the right concentration" (emphasis added). The treatment of diabetes by the injection of insulin and the prevention of goiter with iodine are other instances of orthomolecular medicine.

As you can see from the examples of orthomolecular medicine discussed above, sometimes decreasing the amount of a substance in the body is beneficial (see also the article on homocysteine in this newsletter). Orthomolecular medicine is not "alternative"; rather, it should be considered as an adjunct to appropriate conventional medicine. Pauling became especially fascinated with vitamin C in the mid-1960s and quickly recognized that the intake of this vitamin and, consequently, its concentration in the body, significantly influences health and disease. "

Obviously, prescribing multivitamins, folate to prevent spina bifida, Vitamin C to those with scurvy, niacin to those with pellagra, these are all orthomolecular therapies, the last arguably OMP. Even if they don't realize it, or announce it, many physicians practice OM on a daily basis, and this cannot be ignored.--Alterrabe (talk) 12:08, 6 January 2008 (UTC)

This is very broad. You have now made all drug treatment, and all conventional medicine, be orthomolecular. Pauling's views as you summarize them above seem rather simplistic. Now treating pellagra with vitamin B is orthomolecular? Is there any medical therapy that is *not* orthomolecular? EdJohnston (talk) 17:07, 6 January 2008 (UTC)

I agree, it is broad. But it doesn't encompass all drug treatment. Lipitor, viagra, prozac, and all other patented drugs are not orthomolecular. They are not natural substances that occur within the body normally. Similarly herbs, e.g. aloe vera, chamomille, and more, who have been a mainstay of medicine for millennia cannot be orthomolecular. A good example is that some patients with depression have reduced levels of tryptophan and or serotonin. Mainstream medicine generally plugs them up with an SSRI, which mimics serotonin in the brain, and has a plethora of side-effects (sexual dysfunction, possible suicide and more.) The occasional OMP practitioner will prescribe tryptophan, or some precursor, which is a serotonin precursor. The end-effect is essentially the same, but the side-effects and costs are much less. Whether or not mainstream medicine acknowledges that treating pellagra with niacin and or dietary changes (the southerners disabled by it had awful diets) is orthomolecular, the fact remains that it is per Pauling's definition. What would not be orthomolecular would be if they'd develop a pill that prevents niacin from being metabolized, and market it as a cure for niacin.

Ideally we should work in references to the therapeutic use of aminoacids in psychiatry; tryptophan and analogs are useful in some cases of depression, tyrosine in others, and gamma-aminobutric acid is just as good as valium, which acts primarily at the gaba receptor, without the side-effects. But this article is only about the use of orthomolecular treatments in psychiatry. There is a fair amount of evidence that there are specific plasma aminoacid anomalies in some psychiatric disorders.--Alterrabe (talk) 18:18, 6 January 2008 (UTC)

More problems

Hi all,

I haven't had a chance to review the talk page in a while, I'll be doing so today, so please see my comments in this section with this uninformed view.

I've still my concerns about the page containing original research, and have added a tag to the Current research section to this end.

From that section, the following text seems problematic:

J. Robert Cade, the inventor of Gatorade and an academic physician at the University of Florida found links between certain foods and autism and schizophrenia.J. Robert Cade, Gatorade Inventor

At minimum, the 'qualifications' need to be removed - he's a wikipage, no need for them. Second, it's sourced to a obituary in a newspaper. Per WP:MEDRS, his peer-reviewed articles and contributions should be included. Also, his hypothesis is mentioned only tangentially and briefly - this should be sourced to a more substantive reference, that actually discusses his beliefs (assuming that it should be in the page at all).

The section on violent behavior I've deleted as well - it's sourced to Edelman, which is starting to look like a catch-all reference. Promising results should be published somewhere else I think, beyond a book that is now 7 years old. Those publications should be sourced, and it should be discussed. Also, citations to books should probably start being linked to specific pages using Edelman, 2001, p. XX.. WLU (talk) 14:51, 9 January 2008 (UTC)

I'll be more than happy to remove the qualifications. I'll also be happy to reword it. If you consult WP:MEDRS, you'll find that:

Newspapers can make a good source for social, biographical, current-affairs and historical information in a medical article. They should not be used as a source for medical facts and figures.

Higher up on this talk page is a removed edit to the main page noting Cade's work with food allergies in contexts of note to OMP. It was removed because the source, a press release from the University of Florida, wasn't a reliable source. I think the text should be rephrased to "J. Robert Cade, reported finding links between certain foods and autism and schizophrenia." This way it doesn't imply that his findings are universally accepted as medical fact, which they are not - but rather that there still are scientists who believe that food allergies can cause psychiatric problems, and are researching it. I think this is fair. Can we agree on this?

I have also mulled putting page numbers to Edelman citations, and even tracking down the sources on which she cites to add more sources. I can't recommend Edelman highly enough. Time and circumstances, alas, have not permitted.--Alterrabe (talk) 16:12, 9 January 2008 (UTC)

Time and circumstances never do - I've named my 'to do list' "things I will never do". I think adding <ref>Edelman, 2007, p. XX</ref> would be a great way to bring up the referencing of the page. With regards to over-referencing comments made above, I think we're better off, for now, over-referencing, deciding on what is justified by references, then trimming once we've a got something stable. Even adding <!-- Commented references --> rather than the full <ref></ref> tags would allow referencing for us editors, while not uglying up the page with thousands of .

I've noticed the support for the inclusion of the PTC in the body text, which I'm fine with, but I don't think a subsection of 'Current research' is the right place for it. I've put it back in the 'history' section, I could also see it going into the lead of the Current research section. I don't really like the section because it refers to a small number of researches, and that's a bit weaselly. What do people think of adding a sentence to CR saying 'The PTC is a facility that uses exclusively orthomolecular psychiatry in the treatment of aut/pyro/viol cb'? WLU (talk) 17:00, 9 January 2008 (UTC)

I disagree emphatically with your move of William Walsh's research. Pfeiffer, Hoffer and others dedicated their lives to finding cures for schizophrenia and cancer. Walsh has dedicated himself to discovering why people become criminals, even killers, using the same techniques that Hoffer, and in particular Pfeiffer used. He and his groundbreaking research definitely deserve their own subsection. As his research becomes more widely accepted, it stands to influence the debate on capital punishment and much, much more.--Alterrabe (talk) 17:23, 9 January 2008 (UTC)

Meaning the section I removed in this section? I think the removal of Walsh is warranted because he doesn't have a wikipage (yet?). Claiming success for a treatment, particularly one in a source that doesn't meet WP:MEDRS is problematic Edelman is published by Borage Books, which appears to publish only one book, Natural healing for Schizophrenia., making it verge on self-publication in my mind. What editorial oversight is there? Are these results reported anywhere else? Is there a primary source that can be cited, or other reports of this success? I'd say source to some other publications documenting Walsh's success and it might warrant a more detailed mention.

Regards Cade specifically, first off I'd like a more detailed source on his links between foods and autism, Downs and schizophrenia. Right now the only mention is a single clause, and half the article is about gatorade. There must be better, more detailed references for this information - Cade's publications, a university page, something better than a single, virtually detail-free sentence. For all the reference says, the 'certain foods' could be cake baked with freebase cocaine rather than flour or eating pesticide-filled apples while pregnant. What are the links, what foods, how are they linked. And again, without a specific disclosure of orthomolecular psychiatry, I think it's a stretch to call it OMP. Again, for me the question is, is this orthomolecular psychiatry? Did he use an orthomolecular paradigm? Is he citing, quoting, sourcing from Pfeiffer, Pauling and Hoffer's work? Saying Robert Cade found links between foods and autism, schizophrenia and Downs syndrome isn't saying much. Putting this up on autism, Downs syndrome or schizophrenia would not not last long I don't think, particularly not with this reference. Let's find his work rather than cite his obituary.

I still feel the the addition of sources for some involvement of single nutrients with specific diseases is OR. To keep adding more before this basic question has been added, I like even less. Could we either put new ones up on a sub-page for discussion first or agree on a suitable means of answering this question? Our options include trying another request for comment (maybe someone else will have more luck), asking some admins, posting this on Talk:OR, the village pump, and it's possible that there's a message board I don't know about. I've deliberately avoided going outside this page until there's a consensus, but I really would like to resolve this. WLU (talk) 22:10, 9 January 2008 (UTC)

Sections

I'd written a bit for this already, it got wiped. Crap. Basically it's a section-by-section breakdown of what I see are the problems with the page. This is going to be short and ugly 'cause I'm kinda pissed at my web browser. WLU (talk) 21:29, 9 January 2008 (UTC)

Lead

First sentence OK. Second links too specifically to a specific conclusion which should be in the body. Third has criticisms of the APA's analysis of OMP - this isn't in the body and is too specific for the lead. Should be moved to history and this can be lumped in the lead into a generic statement of how the approach has been rejected by mainstream medicine. Specifics involving problems in how the APA dealt with the first batch of OMP findings should be in the article, but they should not be in the lead. The final sentence can also be moved into the body, and its intention lumped into the general statement about the controversial status of the approach. WLU (talk) 21:29, 9 January 2008 (UTC)

The criticisms of the 1973 APA report's severe flaws, slowly vetted in the mainstream, are summarized at the bottom of the Criticsim section. AMP actually reflects ongoing research and disputes in acience and medicine, with nutritional, genomic and metabalomic research covering OMP topics where only an idiot would hang a target like "OMP" on their research proposal. Only some of the emeritus professors are willing to too clearly "out" themselves even at that late date, so the rejection part is touchy given the grossly misrepresentative slams are so often what Pauling warned about prejudice and bad science parading as "medicine", where the repeated retreats of the (self?) supposed mainstream go less reported with few mea culpas.--TheNautilus (talk) 11:53, 10 January 2008 (UTC)

Sure, and that the APA report was criticized should be mentioned in the article. I think it's arguable that it should be in the lead, more accurately I think the lead should summarize OMP and point out that there is controversy. I don't think it should have specific criticisms. I think that the APA and other organizations rejected OMP should be pointed out, and that there have been responses from OMPists that disagree with the APA's reasoning and conclusions. I just don't think the specifics should be in the lead. I think a better lead could be:

Orthomolecular psychiatry is a branch of orthomolecular medicine whose proponents claim that dietary supplements and other treatments can be effective in treating mental illness. The approach uses individualized testing and diagnosis to establish an etiology for each patient's specific symptoms, and tailors the treatment accordingly using a combination of nutrients, dietary changes and medications to enhance quality of life and reduce symptoms. The origins of orthomolecular psychiatry date to the 1920s, and the work of Abram Hoffer in the 1950s established the orthodoxy of the field. In 1973, a task force of the American Psychiatric Association examined and rejected the practice and it has been considered an alternative therapy since that time. The methods and conclusions of used by the APA to reject orthomolecular psychiatry have been challenged, rejected and strongly criticized by proponents of orthomolecular psychiatry for being politically motivated and scientifically unfounded. Current scientific research appears to support some of the theories advanced by orthomolecular psychiatrists.

I don't like the final sentence for OR reasons, but it does represent the current contents of the article. Note the lack of citations within the lead - in my mind the ones currently in the lead should be moved to the appropriate sections further down. The lead is written based on the contents of the body text, not the contents of specific references. WLU (talk) 13:42, 10 January 2008 (UTC)

Any comments on the new potential lead? Like it? Hate it? Can I paste it in? WLU (talk) 16:12, 11 January 2008 (UTC)

I've taken a lack of comments to be tacit consent, so I've pasted in the new lead and moved text from the old lead into the body - mostly history but also in diangosis. WLU (talk) 20:46, 11 January 2008 (UTC)

History

Just way too short. Much of the criticisms section could be moved here, and I think it should be. WP:CRITICISM provides some guidance, but I haven't given it a thorough read. WLU (talk) 21:29, 9 January 2008 (UTC)

This will be complex to cover well and NPOV. Hoffer et al and Pfeiffer's history from ca 1950 to 1967 are reflective of conflicts (of interests) in the mainstream between the old guard with psychodynamic and more invasive procedures vs the emerging (and diverging) molecular, biochemical approaches, one with the fast acting patented neuroleptics, the other with still evolving, cheap chemically, expensive diagnostically, more complex, more fundamental biochemical-nutrional approaches (OMP related). After the neuroleptic crowd vanquishes its older rivals, it turns to the still immature field and utterly trashes it (in retrospect Hoffer's criticisms have panned out). Between ca 1968 - 1972 is a cold war, and in 1973-1975 the rupture is complete with relatively few overt OMP authors in mainstream journals after that, Hoffer in CMAJ occasionally and Pfeiffer et al doing somewhat better Biological Psychology and some other mainstream journals.--TheNautilus (talk) 11:53, 10 January 2008 (UTC)

Sure, complex doesn't mean not worth doing though! Write it and cite it. Remember to be WP:NPOV. WLU (talk) 14:15, 10 January 2008 (UTC)

Diagnoses, treatments, and scope

This title encapsulates three separate ideas. They should be split into three sections or subsections, and each expanded separately. I've already moved some text from the specific treatments, but this should be refined. A brief summary of each condition that OMP has treatments for looks like a good idea to me. A section called 'approach' or 'paradigm' would be good here as well - the talk page has had comments that indicate OMP tries for a more individualized approach, and objects to conventional treatment and research approaches. This should be sourced, summarized, and the 'why' made clear. Edelman is referenced a lot here, there should be page numbers.

Bipolar and schizophrenia are two different conditions, so there's no reason to put them into a single sub-section. And what's a HOD test?

Depression looks SYNTHy. Reference 14 discusses the difference between normal and depressed levels of plasma tryptophan, sourced to Pfeiffer. There should be a page number for such a specific finding; if Pfeiffer is a tertiary source and cites a study, then the primary source is preferred. The use of SSRI's by mainstream psychiatry is dangling and looks odd, it gave me a 'so what' moment - is someone trying to be subtle, has the link between the two been erased, or is it just unrelated? The publication of a study by the Lancet more than 20 years ago doesn't vindicate Pfeiffer, but that looks like what it's trying to say (more of my OR/SYNTH bugbear); has this been bourne out by later studies? If a study is going to be cited, is there a more recent one that can be found?

I'm still not thrilled by the placement or wording of the Treatment centers section (not to mention I used 'centers' rather than 'center', but it invites further notable ones to be added). WLU (talk) 21:29, 9 January 2008 (UTC)

HOD is the Hoffer - Osmond Diagnostic perceptual (distortions) test they developed and used 50+ years ago to split out their specific treatable group from the then broad schizophrenias of the day into something that more closely resembles the mainstream grouping of acute schizophenia today. Apparently psychiatrists of the 1950s and 60s did not formally differentiate various schizophrenic disorders well. Perhaps one of the big reasons the 1973 APA test had all those other types of patients contaminating (dominating) the results.--TheNautilus (talk) 11:53, 10 January 2008 (UTC)

Moved your comment. HOD should either have it's own page, or be spelled out. I'll put in the full text, it'd be nice to have a link, external or wiki, to either a descrption, or better yet a journal article describing it and its use. WLU (talk) 14:17, 10 January 2008 (UTC)

I've trimmed the schizophrenia section in this section, and removed bipolar from the subsection title since it wasn't mentioned. I've also commented out the 'ongoing research on niacin flush' bit, because it was sourced to a webcache rather than current page; I think the use of the niacin flush is still viable, and appears to have some ongoing research or interest , but medical journals are better if possible. Note that the above page appears to be teh personal page of one of the members, not an official page, here is the main page for niacin. Also, this appears to be a company (?) and companies aren't reliable sources for much beyond that they sell their products. If they publish results, those are of course suitable. WLU (talk) 14:33, 10 January 2008 (UTC)

Criticisms

As above, I think much of this could be fruitfully integrated with History.

Further, I don't think it's a bad thing if it ends up looking somewhat like a 'he-said, she-said' between the APA and OMPsychiatrists, at least initially. That way we'd get a clear view of what each side was saying about the other, and in a historical section, chronological order isn't a bad thing at all.

There's weasel words and unsourced statements. The first sentence could be sourced to quackwatch. The second uses unnamed 'critics', when we've got at least two - the NIMH and the AAP. The section on the APA task force could doubtless be elaborated on, and I think the use of long quotations is unnecessary - its findings could be summarized as 'didn't find megavitamin therapy very credible, and this enhanced by the failure to evaluate OMP through scientific research and publications. They also criticized the extensive use of advertising to promote OMM as "deplorable".' The second long quote is also strange, and there's a citation mid-quote, to the citation, not to a citation within the quote. I also think that reference 26 to Hoffer would be better portrayed as Hoffer's opinion (looks weaselly as is, as if implying that Wittenborn didn't get further funding; there's no need for this, since Hoffer says Witenborn may have lost further funding from the NIMH). Also, the Mosher statement is suspect, since according to his obituary he supported behavioral or psychogenic interventions, not orthomolecular, vitamin or nutrition-based interventions. As portrayed, it looks like Mosher supported orthomolecular psychiatry, when it would more accurately be portrayed in my mind as Mosher didn't support the American Psychiatric Association. Weakening the APicA does not strenghten OMP, so I think it's inappropriate here. It was a pretty quick scan of the references though, perhaps I'm missing something. WLU (talk) 21:29, 9 January 2008 (UTC)

Let's work on a better general sketch first.--TheNautilus (talk) 11:53, 10 January 2008 (UTC)

There is already too much of QW severely biased opinions referenced here for just the sentiment note, where we have a rather interesting phenomenon several MD-PhD with distinct medical breakthroughs (in the mainstream) with hundreds of pubs and remarkable recoveries from devastating illness, including many subsequent MDs and PhDs(!), criticized by an author with 2 less technical articles in the main trade group's publication, one controversially co-authored for a 4th grade science project, investigative reporting even more controversially published in the trade journal, and criticized for its deceptive methods (Hufford, 2003) in research.

I think a sketch of the history would be better, the criticism has turns that need to be treated separately to be comprehensible that we don't just turn this into the anticompetitive soapbox of certain obsolete elements known to broadcast their rather severe biases as the mainstream of something (certainly not science). Wittenborn didn't get later NIMH funding, that's historical according to Hoffer, the why is Hoffer's story and opinion. The Mosher obit merely shows notable commonality of perception by MD camps less impressed with a purely pharma psychiatric approach about the APA's rather close association with the drug companies (in some current med schools, the first and second yr students coming out of the main lecture hall only need to cross a 4 or 5 foot sidewalk to head into a big drug company building after the prof imparts natural human biochem with his latest research on something patentable in case they get confused :). Also Mosher seems to emphasize two of Hoffer's four treatment elements without the fourth, natural biochemistry. Mosher's criticism backs up Hoffer's statements where Hoffer and Mosher do not see eye to eye, an independent agreement.--TheNautilus (talk) 11:53, 10 January 2008 (UTC)

Moved your comment again, left a note on your talk page about it. Note that QuackWatch itself is only used once in the lead, which disappears if the lead is re-worked per my above text. It is used as a convenience link to justify the rejection by the NIMH and a verbatim of the APtricA statement - we're citing the APA statement, using QW to link to actual text. I looked for the original on-line, based on this page, no weblink is available. It does not appear to have been superseded, but it could be replaced by a non-weblinked citation to the actual report, though naturally this reduces ease of access for readers to the text. I think QW should remain on the page, if not as a reference then as an EL; I think someone had mentioned Quackwatch coming up in arbitration, could they point it out to me so I could familiarize myself? I've sent an e-mail to the NIMH to see if we can get something more solid, you can't cite an e-mail but they might be able to clarify a reference.

I think the APA controversy could be placed in a sub-section of history, called APA controversy where an extensive history can take place. It was over 30 years ago, so it's definitely history. Placement in history puts in in this context. As far as working out a sketch first, we can sketch it in 'criticisms' or in 'history', either way the sketch needs to be done. Or we could use a sub page.

Mosher 'seeming' to practice OMP tickles my OR radar again. An explicit statement by Mosher makes this redundant, but interpreting his work to fit into OMP, particularly when we don't seem to have a coherent definition of OMP and when he appears to focus almost exclusively on behavioral treatment, seems like a very thin rational for including him on the page. Suitable for the APA page and criticisms of psychiatry, yes, but for this page, I don't see it as relevant.

As far as further agencies that have rejected OMP, the Canadian Paediatric society did in 2004, archive, though I've no luck in finding a current version or revision of their earlier statement. I also found this, which seems to have some valuable references though not for this page. This page mentions some mental conditions and references. WLU (talk) 15:28, 10 January 2008 (UTC)

The point is that Mosher *is not* OMP, he was a 1973 APA report author and NIMH rep against OMP where Hoffer directly describes the extremely prejudical behaviors he (AH) had encountered with some of various APA Task Force members, especially its "putatively unbiased" chairman with some choice examples. Hoffer in various venues discusses the pharmaceutical interests in (and against) new vitamin forms as well as offers (and extortions) on patent control for some of his own niacin related work. Mosher's quote, independent of OMP, related an expression of serious concern by someone on the 1973 task force and (then) a NIMH associate.

As for the cancer.org ref, they are repeating BC Cancer Agency (see below) statements that seem to be addressed to unfamiliar or biased audiences, that drown out the known mainstream science results, many from 50+ years ago, about what previously would be recognizable as malpractices or subterfuges in a test. Today the medical & younger science population, unfamiliar with the old literature, is ripe for every kind of rigged test (tests that a knowledge of older literature should have known would produce an "unfavorable" result - or favorable if one were in opposition or COI with one's industry). In my discussions at OMM, I had come across a mainstream (Nobelist Henrik Dam) reference (and warning) about the complex interactions of vitamins A & E together in oxidative or liver stress situations that is routinely ignored or violated in the modern tests disparaging the bad results with smokers. hmmm, poor (no) decent literature search? or just "oops, I did again"? The Vitamin A result is then disparged for the general population, then the *combined result with vitamin E* is used to generally disparge vitamin E (both use alone, w/o high vit A, and for the whole population, hmmmmmmm). Last month, I found a fragment on the internet that quoted Vitamins in Medicine (1953 ed?) as saying that the presence (i.e. continuous levels) of vitamin C was necessary for vitamin A + E to deal with the deletrious vitamin A metabolism effects in the oxidatively stressed, but I don't have a copy of Vitamins in Medicine (1953) available in my part of the world.

I have previously dissected why the BC Cancer Agency is prejudical, WP:V *very* bad science (not scientifically current and not really about Orthomed treatments, just POV & sound byte bashing) and not acceptable as as a reliable source.discussed at length--TheNautilus (talk) 00:30, 11 January 2008 (UTC)

If Mosher is more or less irrelevant to OMP, the let's take him out of the page. Putting him in the criticisms section on this page makes it look like he's criticizing the APA for it's role in dismissing OMP. If I understand your text, Mosher left the APA for reasons totally unrelated to OMP. Makes him good for the APA page, and a section on criticisms there, but not for OMP.

Cancer.org could be useful for three things - one, we can mine it for sources. Two, it's a potential source for the history of OMM/P. Three, it's a major position piece on OMM from a major national organization. Though given your concerns, if it is to be cited on the page, it should be used carefully, and would be more appropriate for the OMM page than this one. Ditto for BC Cancer. Thanks for the links to the discussion, I trust there's merit there so I'll leave the cancer links alone unless I see a good reason to bring them back up. Given it's a provincial agency, it's too specific for the (OMM or cancer) page to even cite as an opponent to ortho anything. WLU (talk) 01:34, 11 January 2008 (UTC)

You are right that citing Mosher can be taken as implying that Mosher approved of OMP. This should be changed immediately. What is desparately needed, however, is a source for Mosher's statement that he'd gone into the panel saying that even if every other shrink in the US would adopt OMP, he would refuse to believe in OMP. This, and Mosher's later repudiation of the APA, which hosted the panel, are directly pertinent to the credibility of the APA's OMP panel, and OMP itself.--Alterrabe (talk) 12:20, 11 January 2008 (UTC)

BC CA's OMM page is a previously discredited webpage for failing WP:V on 4 specifically discussed items where there are an additional half dozen seriously erroneous items with enough time ("strike" 4 is enough) and was reviewed by a number of WP MDs including oncologists and medical researchers.

cancer.org simply broadcasts its apparent confusion about OMM, starting with the first sentence, for example confusing orthomolecular medicine as all megadosages generally vs providing optimum molecular environment which includes withdrawal of deletrious substances, sometimes zero dosage, as well as specific protocols and using safer forms, rather than random mega- use or self destructive attempts. With many OMM substances, someone swallowing a whole bottle may more risk choking on the tablets. Another of cancer.org's misconceptions confutes OMM with non-orthomolecular overdoses where iron is not the common supplement or multimineral in OMM that it is in conventional medical OTC (OMM types long ago developed low iron & *iron free* supplements for over half the population), ditto magnesium based antacid poisonings where OMM is far more likely to recommend digestive aids such as betaine hydrochloride to augment for age or illness related parietal cell out declines in stomach acid (or enzymes for other dyspepsia), and malabsorption. I can't say I recall OMM recommending antacids either (vs specific diet).--TheNautilus (talk) 13:06, 11 January 2008 (UTC)

Sure, not that I'm not advocating either page be added to the page as either a reference or an external link. At this point, the only use I see for them would be possibly looking into their references section for more stuff on OMP. WLU (talk) 16:14, 11 January 2008 (UTC)

I've removed Mosher's text, if we do turn up the quote by Mosher about OMP, that's relevant, but I don't think the section removed was, or ever will be, considering Mosher's resignation was totally unrelated to OMP. WLU (talk) 16:17, 11 January 2008 (UTC)

The paragraph is about the quality of the 1973 report's criticism, the counterview of the OMP proponents, OMP proponents's supporting facts & incidents, and the bias of the APA and its rather unrestrained task farce. I've added more context on conflicts of interest that help make the relevance of Mosher's later repudiation of APA ("drug patsy") to his earlier part in the 1973 report, more clear. This is actually a short, mild review of the APA task force's bias as related by Hoffer & Osmond (publicly unchallenged as far as I am aware) where Mosher's comment more generally agrees with Hoffer's expressed concerns, in specific to Thomas Ban and the NIMH as reflected by APA. There's plenty of source material about bias there, it's kind of lengthy. And we have not even started on Pauling's review of scientific integrity, acuity and accuracy for the 1973 APA report, where Pauling has been very quietly vindicated on a number of points previously dismissived & overlooked.--TheNautilus (talk) 01:03, 12 January 2008 (UTC)

The best way to source criticism of the 1973 report, if criticism is truly deserved, would be from a peer-reviewed article that was re-analyzing some of the science offered in that report. It's not clear how relevant it is to quote Abram Hoffer saying that he believed Thomas Ban was biased, due to his receiving support from drug companies. The report is itself a scientific work, though it could have some defects. We should be looking for scientific rebuttals. EdJohnston (talk) 02:04, 12 January 2008 (UTC)

Again, as others have pointed out, what orthomolecular figures say & reasonably think about OMP is relevant in this article. Many of Hoffer's and Osmond's technical objections about the 1973 APA report have subsequently been shown to have merit in mainstream literature or NIMH trial descriptions, so Hoffer & Osmond's reply is not just some empty diatribe. Hoffer's recounting is an important set of historical & technical details in this otherwise mysterious & controverted area. My thinking is that some writing needs polish and (reading) more books (me too), perhaps mining their references, will help strengthen the historical references here over time. Hoffer & Osmond's discussions were not mere scurrilous theatrics, many of their points have been repeatedly driven home, and acknowledged for new mainstream trial descriptions or .--TheNautilus (talk) 13:11, 12 January 2008 (UTC)

<undent>The current version, even with the linking text and whatnot, still seems an odd inclusion for Mosher. From what I can see, the only thing we can reasonably say is that Mosher objected to OMP (possibly objecting to any therapy for schizophrenia that was drug based). I still don't think it's appropriate to discuss his resignation from the APA and patsy comment on this page as they are unrelated to OMP. He was disgusted with the APA, not with it's treatment of OMP. WLU (talk) 02:56, 12 January 2008 (UTC)

You may have missed that I included the word unanimously, which makes it clear that Mosher did not endorse OMP. I can't agree with your belief that Mosher's repudiating the APA is not noteworthy, particularly because he accused it of being captured by a "special interest." Mosher had been chief of schizophrenia research at the NIMH, *any* person in that position resigning amidst accusations that the system had been corrupted is noteworthy. That he helped to bury OMP makes it all the more ironic and interesting.--Alterrabe (talk) 03:23, 12 January 2008 (UTC)

I think it's noteworthy, but his criticisms of the APA are not necessarily noteworthy on this page. The APA page, yes, but not this one. The only use I see for Mosher on this page is to say that he did not support OMP, adding to the list of people who rejected it. His rejection of the APA seems completely separate to any thoughts he may have had about OMP, but placing the two together makes it look like he quit because of OMP. I'm having a go at re-wording. WLU (talk) 14:44, 12 January 2008 (UTC)

Current research

Obviously my concerns about OR still stand. I like the lead, but that's 'cause I think I wrote it.

For food allergies - there are three sources - Edelman, Pfeiffer and Kalaydjian. Kalaydjian, I notice, discusses only those patients with schizophrenia who have celiac disease. Edelman and Pfeiffer are both books, with no page references. I've no objection to them being used as references, but do they discuss only the intersection between celiac disease and schizophrenia as Kalaydjian does? Do Edelman and Pfeiffer discuss a subset of patients, or all patients with schizophrenia?

For copper - same concerns as before. No more specifically, Pfeiffer talked about a type of schizophrenia and dementia (which he called histapenia apparently). Schizophrenia and dementia are not the same thing as Alzheimer's disease, which is what Bush discusses (speaking of Bush, it'd be good to have primary sources here as well as the USA Today article). The other mental illness related to copper in this section is depression. There are four conditions here linked to copper. Copper#Toxicity lists Wilson's disease, and symptoms similar to arsenic poisoning, listing organ failure. Psychiatric symptoms appear to be limted to headaches, delerium, and for chronic poisoning, there are lots of cancers, but no psychological signs or symptoms. Chronic copper poisoning (under toxicity) appears to be rare and does not appear to involve psychological symptoms. This page links it only to possibly reduced intelligence. Wilson's disease apparently produces symptoms like Parkinson's, but it also lists "early dementia, mood disorders or psychosis and signs of asterixis (a flapping tremor of the hands)". Obviously dementia, mood disorders and psychosis show overlap between the symptoms of schizophrenia and alzheimers. I'm concerned about the portayal of orthomolecular psychiatry as vindicated by these findings when the support is more for isolated causes for single diseases than clear support for an entire (controversial) approach.

Basically, the involvement of copper in schizophrenia/dementia/hisapenia a la Pfeiffer needs to be clarified. Research on copper poisoning and alzheimer's needs to be clarified. The statement "..a development that does not prove Pfeiffer's histapenia claims" just looks weird; I understand that it's an attempt to avoid or preclude any OR/SYNTHy concerns, but as far as WP:OR is concerned, I think removal is more appropriate. WLU (talk) 21:29, 9 January 2008 (UTC)

Notable patients

My only problem with this section is the involvement of Kidder with the public clinic. This should be easy to verify from Kidder's home page, or the clinic's home page. Other than that, Vonnegut neeeds a page number. WLU (talk) 21:29, 9 January 2008 (UTC)

Just mark Mark V. ({cn}} if it really bothers you or consider looking it up yourself (you may be better situated in a larger univ library), it's a slow to go to remote libraries and dig this out, that certainly doesn't help the energy crisis.--TheNautilus (talk) 11:53, 10 January 2008 (UTC)

I don't really think the MV reference is critical, it'd just be nice. Incidentally, I spent some time looking for a reference to Margot Kidder helping start up a clinic in Kent, and found nothing. Even what I believe is the clinic itself (website) doesn't seem to discuss her. Per WP:BLP, I'll remove it, though if anyone can find a solid referernce it can obviously be re-added. WLU (talk) 13:24, 10 January 2008 (UTC)

Archive

I was going to try to reduce the length of the talk page by archiving everything that predated the latest flurry of posting. Then I realized the latest flurry was the reason why the page was so long (89K!) Are there any issues that people feel are resolved? I'd say 1-3, 5-9, 12, and that's about it. It's a quick survey, there may be more that have been resolved or supplanted. WLU (talk) 22:18, 9 January 2008 (UTC)

I agree that this article needs a lot of work. Unfortunately, I'm only able to do so much. The article has grown haphazardly, and the lead reflects this. It may be a good idea to at some point sit down and reorganize the whole article.

Ideally I should sit down with all the OMP books I have and flesh out a history. The boundaries between bipolar disorder and schizophrenia are not clear cut, and many cases of bipolar disorder would have been "schizophrenic" 20-40 even 50 years ago, when this research was done. Bipolar disorder is more politically correct than the other. The blurring or combining of the two is a historical artifact.

What Hoffer, Pfeiffer and others report that they did is that they took these illnesses, and were able to identify individual causes and treatments that worked for 85 and more %.

The reason for mentioning mainstream treatments for depression is the following. OMP - among other things - prescribes tryptophan, which is then converted into serotonin, obviously raising serotonin levels. Mainstream medicine prescribes ssris, which raise serotonin the brain by preventing its reuptake. They essentially do the same thing, but one approach has barely any side-effects, is a lot cheaper, and requires no MD. This is pertinent to understanding OMP.

The whole article needs a thorough reworking and professionalization. It won't be easy to find sources for OMP's history. Mosher was an interesting fellow: he went into the meeting reportedly saying that even if every other shrink in the US began to treat schizophrenia and bipolar disorder with nutrients, he'd refuse to do so. He then accused the APA of being 100% in the pockets of drug companies. He's highly relevant, both as an expert on the panel who did not have an open mind and as a prominent psychiatrist who was marginalized and found that non-pharmaceutical based ideas got no funding. Ironically, both Mosher and the OMP advocates seem to have been right. Many if not most cases of pyroluria are worsened or become acute under severe stress. Giving patients time without stress helps them recover, as does giving them the nutrients that they excrete in copious quantities when stressed.

There are many more sources on the celiac disease - schizophrenia link. Most cases of celiacs have serious symptoms besides delusions. But every once in a while a keen clinician will pick up a patient who has celiac disease, with delusions being the only symptom. Pfeiffer essentially said that celiac disease with psychiatric symptoms being the only ones was *much* more common that psychiatrists had noted until then. There was a shrink at U Penn who proved as much as well.

Dohan FC (1970). Coeliac disease and schizophrenia. Lancet, 1970 April 25;1(7652):897–8. PMID :4191543

• Dohan FC (1973). Coeliac disease and schizophrenia. British Medical Journal, 3(5870): 51–52. PMID :4740433
• Dohan FC (1979). Celiac-type diets in schizophrenia. Am J Psychiatry, 1979 May;136(5):732–3. PMID :434265

To be precise. Pfeiffer called low histamine histapenia. Histapenia generally isn't a problem. But he found that many of his patients with histapenia accumulated toxic levels of copper. This is a problem. Pfeiffer saw histadelia (elevated histapenia) and histapenia ( low histamine) as disorders of methylation, a process in which histamine is produced. To be honest, I am convinced that there's more to this than Pfeiffer caught on to.

I think it's important to make it clear that even if Bush is right, this doesn't prove that OMP is right. I doubt that every case of Wilson's has hand-flapping, or at least not until the very late stages. Illnesses generally have a wide spectrum of symptoms. But I believe that you can't discuss OMP and copper toxicities without discussing Bush and copper toxicity, and Wilson's disease. For the same reason that you can't discuss tryptophan in depression without mentioning that the SSRIs accomplish the same thing if you want to explain how OMP and mainstream psych compliment each other.

I am working on finding more documentation for Kidder.--Alterrabe (talk) 22:21, 9 January 2008 (UTC)

OK. Regards Kidder, I may have mis-understood her role as it may be for 'Washington State as a whole' rather than a specific center, but either way BLP says that stuff about living people must be sourced rather than tagged. From Jimbo himself no less! Once we've clarified, it'll be a good addition and there does seem to be a fair amount of news stories.

If S and BP were fuzzy before, then we need a citation to state this, and then it should be explained as such. I wasn't aware of the fuzziness, but when I was studying psych I didn't focus on it beyond textbooks so I can't be much help here. Note the final paragraph in this section, it appears to have some useful references beyond what we've already got.

For depression and tryptophan, make sure it is sourced - even though both manipulate serotonin, I'm cautious to label them as exactly the same thing. Note references 26-29 in this version as possible sources. Again, I don't think it's valid for us to point out the links, but sourcing others who have is perfectly fine.

Comments on pyroluria have to be cautious ones, as it is itself a controversial diagnosis. Speaking of which, User:TimVickers has edited pyroluria, so is familiar with OMP and OMM to a certain degree. On top of that, he's a well-respected admin and very dedicated to being fair and civil. Alt, I know you've seen his work on pyro, and TheNautalis as well, what do people think of asking him about the page as a starting point, for at least the OR issues? I'd ask SandyGeorgia as well, but she's pretty occupied these days. User:Jfdwolff is also usually very responsive, but I've a longer history with him and obviously that's a bit COI-ish. TimVickers I've only talked to a couple times spread out over more than a year so I don't know if he would remember my name.

I find your last paragraph...I don't really have an adjective. I agree with your comments, which is why I'm somewhat struck...based on them, I think we would both agree that the information on Bush, Alzheimer's, Wilson's and OMP should be on the copper page. The disagreement is if it can also be placed on this page. To my reading, all the points I've flagged as OR-ish look like they're pushing a vindication OMP. OMP may indeed be a 'true' approach, meaning effective and useful in diagnosis and treatment, but right now it is not verifiable as such. Putting references on the page that do not mention OMP explicitly, particularly a lot of them, is still problematic in my mind. What do they add to the page except to give the impression that OMP is correct? How can any source add to a page when it doesn't discuss the page's subject explicitly? In my view, this is the OR part. Were there no other contributors, I would simply remove it. Given our ongoing (polite and civil) loggerheads, I'm not doing so but I am stating that it's beyond my experience and mastery of policy to state once and for all which one of us is more 'right' in subject portrayal and interpretation of policy. So, shall we discuss with TimVickers? Did you want to bring in a different admin or ask several? Particularly if you've limited time, I think it's better spent expanding the areas of OMP and OMM that can be verifiably expanded than adding text which are about 50/50 on their chances of passing a peer-review. WLU (talk) 17:36, 10 January 2008 (UTC)

Regarding Kidder, I'd never disregard Jimbo's wishes. As far as tryptophan and the ssris, they are NOT exactly the same; but tryptophan augmentation accomplishes what SSRI makers used to describe as SSRIs therapeutic mode of action. There were umpteen advertisements explaining how depression was due to a serotonin deficiency (a claim you no longer see that often.) This doesn't mean that SSRIs and tryptophan supplements are the same thing, but what it does mean is that OMP (about which nothing good may be said in mainstream medicine) and mainstream medicine are, at least in this one area, extremely close. This is of crucial importance for a reader who has questions whether OMP is kook heaven or a neglected and much maligned healing art. I suspect this question is foremost on the minds of most readers unfamiliar with OMP.

What do they add to the page except to give the impression that OMP is correct?

Look, I readily understand disagreeing with a bald statement that Ashley Bush is reporting promising results treating Alzheimer's as a copper toxicity, ergo the orthomolecular research that some cases of schizophrenia are caused by copper toxicities must be correct, which would constitute vindication, or confirmation. In fact, to do so would be a logical a fallacy with which I'd strongly take ussue.

But that's not what I'm doing. Allow me to explain myself by way of analogy. In the Middle Ages, Copernicus challenged the belief that the sun revolves around the earth, a claim that was highly controversial. Although it proved nothing, scientists discussing Copernicus' theory (most scientists rejected it) would have found it highly germane to mention that Aristarchus of Samos had propounded a similar theory in 270 BC, and that Eratosthenes had measured the distance between the earth and the sun. Neither of these facts proved that Copernicus' theory was right, but it allowed thoughtful readers to have a better understanding of his theory and its place in the history of science, and understand that other scientists had performed experiments and crafted a thesis that supported Copernicus' thesis. Doing so prevented Copernicus from being portrayed as a lone nutter. Omitting the Bush and Walsh research makes OMP seem much more out in left field than it is. In other words, Bush and Walsh are highly germane to the article.

I do not think it would be fair to Tim Vickers to ask him to adjudicate this dispute. If he goes one way, he opens himself to those who believe in OMP possibly believing that his other endeavors colored his decision; if he goes the other he may well raise some eyebrows in academia. Take it from me, there is politics in science, and second guessing decisions that your department head helped make is an excellent way to get a reputation as a maverick who is best kept out of one's way. Perhaps an editor who approaches medicine as a customer?

I hope at some point to see a page dedicated to ongoing research on copper toxicity, but it won't be today or tomorrow.--Alterrabe (talk) 20:23, 10 January 2008 (UTC)

For Kidder, I do think her advocacy for OMP, which I've read some of while doing some quick googling, is definitely notable. The mention of an advocacy for the Kent facility specifically is more what I object to, so tomorrow I'll try to add a sentence 'Kidder has advocated for OMP' or something similar, with one of the news refs I read today.

I'd say that it's up to Tim to decide if this will affect him or not - this isn't an academic dispute, it's a wikidispute (and I doubt we'll bring his academic career crashing down around him by asking for his input in this matter). And it's not really a dispute, and he's not really going to be adjudicating. We'd be asking him for his opinion on a purely wiki matter, as an admin and a respected editor. It'd be hugely quicker than a RFC, which spares us all much time and typing. We're chasing our tails and metaphors with the ongoing OR discussion, let's just ask Tim or another admin for their opinion. I like Tim because of his reputation for fairness and civility, but we could also WP:AN, which attracts a general audience. Tim is a biochemist I believe, not a doctor, so he's got relevant experience. With AN, you'd get a grab-bag. Still, I'd trust most admins to be able to give a solid opinion on the page. Though Tim is my first preference, AN might be the best way to get an opinion with no worries about COI or preconceptions. WLU (talk) 20:37, 10 January 2008 (UTC)

I've put some more thought into this. First of all, I haven't helped my case by being somewhat verbose. I think that putting Bush's research into the OMP article is close enough to WP:SYN to be confusing.

If you consult WP:SYN you'll read "Editors should not make the mistake of thinking that if A is published by a reliable source, and B is published by a reliable source, then A and B can be joined together in an article to advance position C. This would be synthesis of published material serving to advance a position, which constitutes original research. "A and B, therefore C" is acceptable only if a reliable source has published this argument in relation to the topic of the article.

What I've done, however is to include A, and include B, and allowed the reader to draw conclusions. "A and B, therefore C" is NOT the same as "A and B, therefore A, though disputed, may be likelier." I'm not using Bush to push a red herring position C, such as the notion that Alzheimer's and schizophrenia are identical, but rather to better delineate position A. This is a small, but crucial difference. The other argument I could anticipate, but can't quite agree with, is that Bush's work is not "directly related" to the topic of the article. If OMP wasn't so controversial, and often labeled "quackery" I believe that Bush's work would not be directly related to OMP. Bush's work is directly related to controversies about theories that copper toxicity can cause neuropsychiatric disorders, which is a thesis of OMP.

Tim Vickers is most welcome to opine on this, if he wishes, but if he doesn't persuade me, I will seek other opinions.--Alterrabe (talk) 13:17, 11 January 2008 (UTC)

The problem is, I see it as OR. We're disagreeing over our basic beliefs on OR, so let's get an outside opinion. I'll pop by Tim, and if you disagree then you can certainly seek other venues. I'm sure Tim will be able to provide the most fruitful. WLU (talk) 16:11, 11 January 2008 (UTC)

References that point to Eva Edelman's book

I got hold of a 1998 edition of Edelman's book at the Boston Public Library and will be able to add page numbers for the individual citations soon. There is nothing in the 1998 version about Mark Vonnegut. Does anyone reading this have the 2001 edition at their fingertips? That is the one included in our reference list (ref #9). Curiously, the Edelman book is not widely held in East Coast US libraries, as verified through worldcat.com. Though it's an enthusiastic work, Edelman's book is well organized and has a lot of references. If nobody has access to a version that actually mentions Mark Vonnegut I think that sentence should be removed from the article, since that is currently the only source for our comment about his use of the method. EdJohnston (talk) 20:47, 10 January 2008 (UTC)

I think we can AGF that it's in the 2001 edition for now. Note that if the information in the article is sourced to Edelman, but that source cites a journal article or other source, our preferred citation is the primary one. That is, whenever possible Edelman should be replaced by the source that Edelman herself cites. Make sure to leave the 2001 version up in at least the Vonnegut section, I would replace the remainder with the 1998 citation :{{cite book |author=Eva Edelman |title=Natural Healing for Schizophrenia & Other Common Mental Disorders|publisher=Borage Books |location= Eugene, Or|year= 1998 |pages=238 |isbn=0965097668 |oclc= |doi=}} WLU (talk) 20:54, 10 January 2008 (UTC)

TimVickers

Well, I was going to say that I've alerted TV, but obviously he's already here in all his terror and glory. WLU (talk) 16:46, 11 January 2008 (UTC)

Just a bit jet-lagged to be honest. The gluten thing was overstated, but the relationship between copper and AD is certainly a genuine area of research, although local deficiency seems a more likely hypothesis than increases in this metal. I added some citations, if anybody wants the Pdfs for full-text of these reviews just e-mail me. Tim Vickers (talk) 16:57, 11 January 2008 (UTC)

Are you satisfied that the section is now OK, or will you be making more edits or suggestions at a later date? WLU (talk) 17:00, 11 January 2008 (UTC)

It looks OK, since this is a page on the beliefs of orthomolecular psychiatry, more emphasis on these ideas than mainstream research is justified, however the mainstream research was not presented accurately in the previous version. Tim Vickers (talk) 17:04, 11 January 2008 (UTC)

Mark Vonnegut

We are still not sure that Eva Edelman's book, the 2001 edition, says anything about Mark Vonnegut's adherence to OMP. The comment about Vonnegut has been in the article for much longer than it has been cited to Edelman. Since Vonnegut *does* have a biographical memoir called The Eden Express (1975), which is one of the references in our Mark Vonnegut article, I found that book. Here are a couple of passages:

"The doctor who had apparently been able to bring me out of it has been working from a biochemical model." (page 193)

"..the objective evidence for schizophrenia being biochemical is overwhelming" (page 210).

A few pages later he recommends orthomolecular methods to a friend, (using the term 'orthomolecular'), and approvingly cites Hoffer and Osmond, How to live with schizophrenics, and Carl Pfeiffer, The schizophrenias, yours and mine.

Still not clear how important it is to give OMP a 'celebrity endorsement', and others may have more experience on this point. If Vonnegut changed his mind later about OMP, that's not shown in the book. (Between 1975 and the present, a period not covered in the memoir, he obviously had plenty of time to change his views). EdJohnston (talk) 20:05, 11 January 2008 (UTC)

Ed

I've misplaced my 2001 Edelman, but I distinctly remember reading about the Eden Express in it. Citing the Eden Express, a primary source, is even better than citing Edelman. On most other topics, I wouldn't be keen at all to include celebrities and their opinions. In this case, however, I think it's pretty important, because OMP is so controversial. As the article expands and improves it may become superfluous, but at present it does add to the OMP article.--Alterrabe (talk) 20:51, 11 January 2008 (UTC)

To comment - this isn't about celebrity endorsements (though obviously it can look like that, so we have to be careful about the wording, so it doesn't), it's about notable people who are on the public record as having used OMP. WLU (talk) 21:03, 11 January 2008 (UTC)

Homocysteine recycling

Homocystine recycling depends on the enzyme 5-Methyltetrahydrofolate-homocysteine methyltransferase, which uses 5-Methyltetrahydrofolate to methylate homocystine. This substrate is a form of folic acid - vitamin B9 - not vitamin B6, which is pyridoxal phosphate. Are you sure Carl Pfeiffer used B6, and not B9, since B6 could have no effect on homocystine metabolism. Tim Vickers (talk) 22:08, 11 January 2008 (UTC)

That is indeed my recollection. Here's one of several patients who reports using B6 and not B9. --Alterrabe (talk) 22:16, 11 January 2008 (UTC)

This page also references B6. --Alterrabe (talk) 22:17, 11 January 2008 (UTC)

That's very odd. There must be some kind of mistake here since the two vitamins are completely different molecules. Could we check the original, where did Pfeiffer publish this research? Tim Vickers (talk) 22:20, 11 January 2008 (UTC)

Looking at that second link you provided it mentions folic acid but says not to use this as a supplement in "Histadelia". Tim Vickers (talk) 22:25, 11 January 2008 (UTC)

Folic acid is often high in histadelia, for whatever that's worth. Eva Edelman goes into some detail as to what folic acid levels are found in histapenia and histadelia. This site has nice things to say about B6 and its effects on homocysteine. Pfeiffer, by the way, was chair of the Pharmacology Dept at Emory, before he left academia to devote his life to the treatment of schizophrenics.--Alterrabe (talk) 22:40, 11 January 2008 (UTC)

We need a source though, we can't say that B6 reduces HCy and that Met increases methylation unless a reliable source has published some data that supports this. Tim Vickers (talk) 23:40, 11 January 2008 (UTC)

Pubmed

I'm starting to look through for journal results, I've added one in schizophrenia, I've also found the below, it could be added to at least a couple sections, but this also somewhat understates the findings of the review article as it cites a lot of conditions. Right now I'll add it as an addendum to bipolar, but it could clearly go in other places.

• Kidd PM (2007). "Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids". Altern Med Rev. 12 (3): 207–27. PMID 18072818.

This journal, though not useful for medical information, might have some valuable information about the rejection of OMP by mainstream meds, assuming someone can get the full text (Tim? Could you, then e-mail it to me?)

• Rudnick A (2002). "The molecular turn in psychiatry: a philosophical analysis". J Med Philos. 27 (3): 287–96. PMID 12187435.

In spanish and about OM in general, but possibly useful to better justify some of the basic points.

• Martínez Bradshaw A (2005). "". Rev Enferm (in Spanish; Castilian). 28 (3): 48–50. PMID 15871343.{{cite journal}}: CS1 maint: unrecognized language (link)

Obviously critical, came up when I searched for 'orthomolecular', no abstract, useful for the 'criticisms' section but would need the full text (Tim?).

• Braganza SF, Ozuah PO (2005). "Fad therapies". Pediatr Rev. 26 (10): 371–6. PMID 16199591.

I've also turned up a couple odd Pubmed articles that are in Dutch, so I've asked User:Jfdwolff to have a read and see if there's anything useful for this article (he's a Dutch doctor). WLU (talk) 19:45, 12 January 2008 (UTC)

My understanding is that our current diet generally doesn't get the right omega3:omega6 ratio which affects most organs, particularly the brain. Getting this balance right allows improvements in many illnesses. There even is evidence that some cases of cancer remit on a therapy including many omega 3 fatty acids. Szent-Györgyi who was on close terms with Pauling and good terms with Warburg believed cancer was a bioelectronic phenomenon; not having enough omega3s impedes some electron transfers.

As to the other changes. Why remove the fact that OM psychiatrists do *NOT* categorically reject medication?--Alterrabe (talk) 20:24, 12 January 2008 (UTC)

Fish oil as a "fad therapy" reflecting poorly on OMP from the PIR paper? The authors, Braganza & Ozuah, upon publication, had to backtrack and eat some crow almost immediately, see their acknowledgement in PIR's Rapid Response comments. Although they mention publication lag, good science ability involves being able to discern clear trends and possibilities from less than lead pipe cinch data (or "authoritative" conclusions) hitting you hard on the head so soon, and making allowances for or mention of relevant less certain data to avoid embarrassing yourself. Luckier or more prescient authors might have left it out of a "fad" article in the first place.--TheNautilus (talk) 22:03, 12 January 2008 (UTC)

Is the comment about removing medication aimed at me? I had left it in the article - my last edit of today to the page had two mentions of medication that I can find, Schizophrenia and . I edited to try to split it from a single section covering three topics, to three topics each with one, and have no problem with a stronger statement about OMP's opposition to, or emphasis on a more nuanced use of, medication.

I wouldn't say B&O ate crow, particularly considering their reply. Not having access to the full text of the article, I can't say if the three comments made in response to errors in the article represent the entire contents of the article, obviously it's use will have to properly represent its contents. WLU (talk) 00:03, 13 January 2008 (UTC)

First, your reference to the article in the May 2005 issue of Pediatrics, (1) which examined supplementation with fish oil in children who have developmental coordination disorder, was published after submission of our article for PIR. Our statement that data are insufficient to support the use of docosahexaenoic (DHA) in children was based on two double-blind, randomized controlled clinical trials by Voigt et al (2) and Hirayama et al, (3)which did not find significant improvement in ADHD symptoms in children supplemented with DHA. Hence, we concluded that additional research needed to be conducted to evaluate the role of DHA and other fatty acids. The recent publication in Pediatrics adds good evidence to support the use of fatty acids for children who have developmental coordination disorder.

Having to acknowledge any bona fide treatment in the general age group with disorders, so soon, undercuts the rather broad & baldly accusatory "Fad therapies" title which tends to impugn the treatment substance as much as the detailed treatment of a specific diagnosis in a somewhat related population where the claim is "insufficient data" rather than either a larger, more clear, null result or an actual contraindication.--TheNautilus (talk) 12:54, 14 January 2008 (UTC)

<undent>Jfdwolff has commented on the Dutch articles, his reply is here if anyone's interested in reading it. As is, it looks like they're not really going to be helpful for the current incarnation of the page, though they may be useful in fleshing out the 'Relationship to mainstream psychiatry' section at some point in the future. WLU (talk) 17:27, 14 January 2008 (UTC)

Boyd Haley and amalgams

Boyd Haley believes that amalgams are unhealth, though he points specifically to the mercury in amalgams. Does this jive with the OM beliefs regarding amalgams and/or mercury? If it is mercury that the OMPists object to, then there's more information and pubmed studies that can be referenced, if it's something else in the amalgam then my only question is, is it worth trying to insert Haley into the text somewhere? WLU (talk) 15:14, 17 January 2008 (UTC)

Pfeiffer wrote books in which he didn't mention amalgams as a source of mercury in humans. Amalgam and its many problems (more or less uncontroversial in Germany) aren't a core belief of OMP. I suspect they made their way into the JOM partly because it's a journal dedicated to non-mainstream medicine. Amalgam illness partly falls into toxicology, partly into environmental illness, and partly dentistry. I wouldn't bother with Haley. Haley is a friend of Hal Huggins, who in turn is a friend of Sibelrud, who published in the JOM. --Alterrabe (talk) 15:32, 17 January 2008 (UTC)

I've commented out the sentence and reference In 2006 a FDA panel refused to endorse the FDA's findings that amalgam fillings are safe."Questions and Answers on Dental Amalgam". Food and Drug Administration. 2006-10-30. Retrieved 2008-01-04. as from what I read in the document, it does not say this at all. The 'worst' that page says is:

the panel did raise concerns about the lack of knowledge concerning the effects of dental amalgam on specific groups, including pregnant women, small children, and people who are especially sensitive to mercury. During the meeting, FDA presented a draft white paper that reviewed the scientific literature from 1997 to the present on the safety of dental amalgam. FDA asked the panel for its opinion on this paper. The panel recommended that the FDA reevaluate the literature. Specifically, they wanted to know if there was additional information available regarding the effects of dental amalgam on pregnant women, small children, and sensitive individuals, and on exposure levels during initial placement or removal of amalgam fillings. (question 4)

I wouldn't stretch that to a refusal, at worst it's a call for more information, an acknowledgement that the information is limited. WLU (talk) 20:36, 17 January 2008 (UTC)

I've re-worded - the statement didn't say the amalgams were unsafe, they were concerned that they could not say conclusively that they were. I think the current wording better represents the position on the web document. WLU (talk) 20:42, 17 January 2008 (UTC)

This article was a POV-fork

Not a separate article from Orthomolecular medicine unless you want to build a Misplaced Pages:Walled garden, I redirected the article back to its appropriate place. ScienceApologist (talk) 19:01, 24 November 2008 (UTC)

• There seem to be hundreds of scholarly sources for this topic which will easily support a separate article. Redirection is not appropriate. Colonel Warden (talk) 14:09, 26 November 2008 (UTC)

• • The article is in much better shape than it used to be. ScienceApologist (talk) 15:02, 26 November 2008 (UTC)

• • • Actually Private Warden, there's about no scholarly sources. Unless, you mean there's some sources (not very scholarly) that the field exists in the mind of certain individuals. OrangeMarlin 04:36, 27 February 2009 (UTC)

I would recommend merging with Orthomolecular medicine. Keepcalmandcarryon (talk) 00:22, 28 February 2009 (UTC)

I'm sorry: I don't understand how it's considered a POV-fork; could someone explain? I see no particular reason why POVs described in this article would be different from those described in orthomolecular medicine. Do you mean it's a POV fork from some other article besides that one?

I favour keeping this as a separate article. The amount of material is too large to merge easily. The amount of source material out there on orthomolecular psychiatry is fairly large, I believe, enough to justify a separate article. ☺Coppertwig (talk) 01:00, 28 February 2009 (UTC)

I support the merger proposal. Verbal chat 12:07, 28 February 2009 (UTC)

There is quite a bit of duplication between this article and orthomolecular medicine; for some specifics, I like the presentation better in this article. Merging the two would create an article of higher quality.

@Coppertwig, orthomolecular psychiatry is a fork, in my opinion, because it shows the same POV tendencies as orthomolecular medicine does. Why not also create "orthomolecular oncology", "orthomolecular immunology", "orthomolecular toxicology", etc.? Because all of these categories are minor parts of orthomolecular medicine, itself just a term invented by some rather fringe scientists and not accepted by mainstream medicine. The publications in these "disciplines" have been published, for the most part, in one special-interest journal established by one of the early fringe scientists as a response to what he and his colleagues considered a conspiracy by mainstream science to reject their papers by peer review....and what the alleged conspirators probably considered the normal response to a bunch of mediocre research. All forms orthomolecular xxxxxiatry and orthomolecular xxxxxology (if they exist at all, as someone said before, outside the minds of a few alternative doctors), are just part of orthomolecular medicine, and one article on the fringe phenomenon will probably do. Keepcalmandcarryon (talk) 15:41, 28 February 2009 (UTC)

POV forks are two articles on the same topic written from different perspectives; but here, according to what you say, we have two articles on different topics written from the same perspective, therefore not a POV fork.

The question is whether there's enough material for a separate article. I'm under the impression that orthomolecular psychiatry is a very large part of orthomolecular medicine. There might or might not be enough material to support separate articles on other aspects (I haven't looked into that), but I believe there is for orthomolecular psychiatry. ☺Coppertwig (talk) 16:26, 28 February 2009 (UTC)

No, it's the same subject and topic - just this one has slightly more specificity. This should be reintegrated into the parent article. This is a fringe topic and we don't need multiple articles on it. Verbal chat 16:41, 28 February 2009 (UTC)

I'm in the process of reintegrating. Any help with the talk page would be appreciated. Keepcalmandcarryon (talk) 23:56, 1 March 2009 (UTC)

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