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==Career== ==Career==
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⚫ Fernandez developed the concept of the dehydron,<ref>Fernández A, Scott R. Dehydron: a structurally encoded signal for protein interaction. Biophys J. 2003 Sep;85(3):1914-28. PMID 12944304 </ref> a structural feature in a ] consisting of an intramolecular ] incompletely shielded from attack by water in the protein's ]. Dehydrons cause "epistructural tension" in proteins and thus promote ] and protein–] associations.<ref>Philip Ball for Nature News. 18 May 2011 </ref>

⚫ He developed the concept of the dehydron,<ref>Fernández A, Scott R. Dehydron: a structurally encoded signal for protein interaction. Biophys J. 2003 Sep;85(3):1914-28. PMID 12944304 </ref> a structural feature in a ] consisting of an intramolecular ] incompletely shielded from attack by water in the protein's ]. Dehydrons cause "epistructural tension" in proteins and thus promote ] and protein–] associations.<ref>Philip Ball for Nature News. 18 May 2011 </ref> Fernandez is an inventor on a ] for "wrapping technology", which uses the dehydron pattern to design small-molecule inhibitors for rational ].<ref></ref>{{Primary source inline|date=September 2015}}


==Awards== ==Awards==

Revision as of 16:46, 24 September 2015

Ariel Fernandez
Born(1957-04-08)April 8, 1957
Bahía Blanca, Argentina
NationalityArgentinian
CitizenshipArgentina, USA
Alma materYale University
Scientific career
FieldsBiophysics, statistical mechanics
ThesisStructural Stability of Chemical Systems at Critical Regimes (1984)

Ariel Fernandez (born Ariel Fernández Stigliano, April 8, 1957) is an Argentinian–American physical chemist.

Early life, education and early career

Fernandez received a Licenciado degree in Mathematics from the Universidad Nacional del Sur, Argentina. He then earned a Ph.D. from Yale University in 1984 with a thesis entitled Structural Stability of Chemical Systems at Critical Regimes and was a senior researcher in the division of Nobel laureate Manfred Eigen at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany. He held the Karl F. Hasselmann Professorship of Bioengineering at Rice University. He is a member of the National Scientific and Technical Research Council (CONICET) in Argentina.

Career

Fernandez has published more than 250 articles and has an h-index of 25. His research spans representation theory, applied mathematics, molecular biophysics, statistical mechanics and bioinformatics.

He developed the concept of the dehydron, a structural feature in a protein consisting of an intramolecular hydrogen bond incompletely shielded from attack by water in the protein's solvation shell. Dehydrons cause "epistructural tension" in proteins and thus promote protein–protein interactions and protein–ligand associations. Fernandez is an inventor on a US patent for "wrapping technology", which uses the dehydron pattern to design small-molecule inhibitors for rational drug design.

Awards

Fernandez was awarded the Camille and Henry Dreyfus Distinguished New Faculty in 1989; the Camille and Henry Dreyfus Teacher-Scholar in 1991; a Guggenheim fellowship in 1995; and is an Elected Fellow, American Institute for Medical and Biological Engineering (2006).

Published works

  • Transformative Concepts for Drug Design: Target Wrapping, by Ariel Fernandez (ISBN 978-3642117916, Springer-Verlag, Berlin, Heidelberg, 2010).
  • Biomolecular Interfaces. Berlin, Heidelberg: Springer-Verlag. 2015. ISBN 9783319168494.

See also

References

  1. ^ CV for Ariel Fernandez
  2. ^ Ariel Fernandez. Yale University Dissertation: Structural Stability of Chemical Systems at Critical Regimes (Dissipative Structures, Potential Energy Surfaces). Published/Created:1984
  3. "Administration and faculty" (PDF), Catalog 2010–2011, Rice University, retrieved 2014-12-02.
  4. Ariel Fernandez at CONICET (Argentine National Research Council)
  5. Profile for Ariel Fernandez on Scopus Page accessed 5 December 2014
  6. Ariel Fernandez Google Scholar Citations
  7. Fernández A, Scott R. Dehydron: a structurally encoded signal for protein interaction. Biophys J. 2003 Sep;85(3):1914-28. PMID 12944304 PMC1303363
  8. Philip Ball for Nature News. 18 May 2011 The Achilles' heel of biological complexity
  9. US Patent 8,466,154
  10. Camille Dreyfus Teacher-Scholar Awards Program Past Awards
  11. "Ariel Fernández". Fellows. John Simon Guggenheim Memorial Foundation. Retrieved 27 September 2012.
  12. "College of Fellows". Members. American Institute for Medical and Biological Engineering. Retrieved 27 September 2012.
  13. "Ariel Fernandez Bibliography". Retrieved 25 February 2014.

External links

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