Misplaced Pages

GPR37: Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editNext edit →Content deleted Content addedVisualWikitext
Revision as of 19:48, 28 October 2019 editBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,738 edits consistent citation formatting and removed further reading citation now included in-line← Previous edit Revision as of 01:36, 7 November 2019 edit undoHeadbomb (talk | contribs)Edit filter managers, Autopatrolled, Extended confirmed users, Page movers, File movers, New page reviewers, Pending changes reviewers, Rollbackers, Template editors454,149 edits Alter: journal. Add: year, pmc, pages, volume, bibcode. | You can use this tool yourself. Report bugs here. | via #UCB_GadgetNext edit →
Line 4: Line 4:
== Interactions == == Interactions ==


GPR37 has been shown to ] with ]<ref name=pmid12150907>{{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Mol. Cell | volume = 10 | issue = 1 | pages = 55–67 | date = July 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}</ref> and ].<ref name=pmid12150907/><ref name=pmid11439185>{{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | date = June 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}</ref> GPR37 has been shown to ] with ]<ref name=pmid12150907>{{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Molecular Cell| volume = 10 | issue = 1 | pages = 55–67 | date = July 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}</ref> and ].<ref name=pmid12150907/><ref name=pmid11439185>{{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | date = June 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}</ref>
GPR37 is a receptor for ]. It was previously thought to be a receptor for ], a ] found in the ], but early reports of head activator in mammals were never confirmed.<ref>{{cite journal |first1=Rebecca C.|last1=Meyer |first2=Michelle M.|last2=Giddens |first3=Stacy A.|last3=Schaefer |first4=Randy A.|last4=Hall |title=GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin |date=4 June 2013 |journal=Proceedings of the National Academy of Sciences |volume=110 |issue=23 |pages=9529–34 |doi=10.1073/pnas.1219004110 |pmid=23690594 |pmc=3677493}} GPR37 is a receptor for ]. It was previously thought to be a receptor for ], a ] found in the ], but early reports of head activator in mammals were never confirmed.<ref>{{cite journal |first1=Rebecca C.|last1=Meyer |first2=Michelle M.|last2=Giddens |first3=Stacy A.|last3=Schaefer |first4=Randy A.|last4=Hall |title=GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin |date=4 June 2013 |journal=Proceedings of the National Academy of Sciences |volume=110 |issue=23 |pages=9529–34 |doi=10.1073/pnas.1219004110 |pmid=23690594 |pmc=3677493|bibcode=2013PNAS..110.9529M }}
</ref> </ref>


GPR37 signaling has been shown to modulate the migration of ] (OECs) and ] (GnRH) cells in mice.<ref>{{cite journal | vauthors = Saadi H, Shan Y, Wray S | title = GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice | journal = Front Cell Neurosci. | pmid = 31143101 | doi = 10.3389/fncel.2019.00200 }}</ref> GPR37 signaling has been shown to modulate the migration of ] (OECs) and ] (GnRH) cells in mice.<ref>{{cite journal | vauthors = Saadi H, Shan Y, Wray S | title = GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice | journal = Frontiers in Cellular Neuroscience| volume = 13 | pages = 200 | pmid = 31143101 | pmc = 6521704 | doi = 10.3389/fncel.2019.00200 | year = 2019 }}</ref>


== References == == References ==
Line 15: Line 15:
== Further reading == == Further reading ==
{{refbegin | 2}} {{refbegin | 2}}
* {{cite journal | vauthors = Zeng Z, Su K, Kyaw H, Li Y | title = A novel endothelin receptor type-B-like gene enriched in the brain | journal = Biochem. Biophys. Res. Commun. | volume = 233 | issue = 2 | pages = 559–67 | year = 1997 | pmid = 9144577 | doi = 10.1006/bbrc.1997.6408 }} * {{cite journal | vauthors = Zeng Z, Su K, Kyaw H, Li Y | title = A novel endothelin receptor type-B-like gene enriched in the brain | journal = Biochemical and Biophysical Research Communications| volume = 233 | issue = 2 | pages = 559–67 | year = 1997 | pmid = 9144577 | doi = 10.1006/bbrc.1997.6408 }}
* {{cite journal | vauthors = Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF | title = A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system | journal = Brain Res. Mol. Brain Res. | volume = 54 | issue = 1 | pages = 152–60 | year = 1998 | pmid = 9526070 | doi = 10.1016/S0169-328X(97)00336-7 | url = https://zenodo.org/record/1259931 }} * {{cite journal | vauthors = Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF | title = A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system | journal = Molecular Brain Research| volume = 54 | issue = 1 | pages = 152–60 | year = 1998 | pmid = 9526070 | doi = 10.1016/S0169-328X(97)00336-7 | url = https://zenodo.org/record/1259931 }}
* {{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | year = 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }} * {{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | year = 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}
* {{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Mol. Cell | volume = 10 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }} * {{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Molecular Cell| volume = 10 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}
* {{cite journal | vauthors = Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B | title = Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila | journal = Neuron | volume = 37 | issue = 6 | pages = 911–24 | year = 2003 | pmid = 12670421 | doi = 10.1016/S0896-6273(03)00143-0 }} * {{cite journal | vauthors = Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B | title = Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila | journal = Neuron | volume = 37 | issue = 6 | pages = 911–24 | year = 2003 | pmid = 12670421 | doi = 10.1016/S0896-6273(03)00143-0 }}
* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51901–10 | year = 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }} * {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = Journal of Biological Chemistry| volume = 278 | issue = 51 | pages = 51901–10 | year = 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
* {{cite journal | vauthors = Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y | title = Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress | journal = J. Neurochem. | volume = 97 | issue = 5 | pages = 1259–68 | year = 2006 | pmid = 16539653 | doi = 10.1111/j.1471-4159.2006.03782.x }} * {{cite journal | vauthors = Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y | title = Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress | journal = Journal of Neurochemistry| volume = 97 | issue = 5 | pages = 1259–68 | year = 2006 | pmid = 16539653 | doi = 10.1111/j.1471-4159.2006.03782.x }}
* {{cite journal | vauthors = Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y | title = A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin | journal = J. Neurochem. | volume = 99 | issue = 6 | pages = 1456–69 | year = 2006 | pmid = 17059562 | doi = 10.1111/j.1471-4159.2006.04155.x | url = http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/17141/1/JN99-6-2006.pdf | hdl = 2115/17141 }} * {{cite journal | vauthors = Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y | title = A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin | journal = Journal of Neurochemistry| volume = 99 | issue = 6 | pages = 1456–69 | year = 2006 | pmid = 17059562 | doi = 10.1111/j.1471-4159.2006.04155.x | url = http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/17141/1/JN99-6-2006.pdf | hdl = 2115/17141 }}
{{refend}} {{refend}}



Revision as of 01:36, 7 November 2019

GPR37
Identifiers
AliasesGPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDsOMIM: 602583; MGI: 1313297; HomoloGene: 3875; GeneCards: GPR37; OMA:GPR37 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)
Chromosome 7 (human)Genomic location for GPR37Genomic location for GPR37
Band7q31.33Start124,743,885 bp
End124,765,792 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for GPR37Genomic location for GPR37
Band6 A3.1|6 11.65 cMStart25,665,877 bp
End25,690,728 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • inferior ganglion of vagus nerve

  • optic nerve

  • middle frontal gyrus

  • subthalamic nucleus

  • Medulla Oblongata

  • ventral tegmental area

  • superior vestibular nucleus

  • external globus pallidus

  • inferior olivary nucleus
Top expressed in
  • deep cerebellar nuclei

  • lumbar subsegment of spinal cord

  • globus pallidus

  • lateral geniculate nucleus

  • utricle

  • vestibular sensory epithelium

  • pontine nuclei

  • medial geniculate nucleus

  • anterior horn of spinal cord

  • ventral tegmental area
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2861

14763

Ensembl

ENSG00000170775

ENSMUSG00000039904

UniProt

O15354

Q9QY42

RefSeq (mRNA)

NM_005302

NM_010338

RefSeq (protein)

NP_005293

NP_034468

Location (UCSC)Chr 7: 124.74 – 124.77 MbChr 6: 25.67 – 25.69 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.

Interactions

GPR37 has been shown to interact with HSPA1A and Parkin (ligase). GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.

GPR37 signaling has been shown to modulate the migration of olfactory ensheathing cells (OECs) and gonadotropin-releasing hormone (GnRH) cells in mice.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000170775Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000039904Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
  6. "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
  7. ^ Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
  8. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
  9. Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. Bibcode:2013PNAS..110.9529M. doi:10.1073/pnas.1219004110. PMC 3677493. PMID 23690594.
  10. Saadi H, Shan Y, Wray S (2019). "GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice". Frontiers in Cellular Neuroscience. 13: 200. doi:10.3389/fncel.2019.00200. PMC 6521704. PMID 31143101.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

Cell surface receptor: G protein-coupled receptors
Class A: Rhodopsin-like
Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Class B: Secretin-like
Adhesion
Orphan
Other
Class C: Metabotropic glutamate / pheromone
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened
Stub icon

This transmembrane receptor-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: