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| In ], the '''lagging strand''' is the ] strand at the opposite side of the ] from the ]. It goes from 3' to 5' (these numbers indicate the position of the ] in respect to the ] atoms it contains). | |||
| When replicating, the original DNA splits in two, forming two "prongs" which resemble a fork (i.e. the "]"). DNA has a ladder-like structure; imagine a ladder broken in half vertically, along the steps. Each half of the ladder now requires a new half to match it. | |||
| ], the main ] enzyme, can not work in the 3'- 5' direction of the template strand, and so replication of the lagging strand is more complicated than of the ]. On the leading strand, Pol III "reads" the DNA and adds ] to it continuously. | |||
| On the lagging strand, ] "reads" the DNA and adds RNA to it in short bursts. Pol III lengthens the bursts, forming ]s. ] then "reads" the fragments, removes the RNA using its ] domain, and adds its own nucleotides (this is necessary because RNA and DNA use slightly different kinds of nucleotides). ] joins the fragments together. | |||
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| * WEHI-TV | |||
| {{DNA replication}} | |||
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Latest revision as of 05:25, 3 May 2012
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