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Latest revision as of 05:49, 5 September 2024 edit undoBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,603 edits consistent citation formatting |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{cs1 config|name-list-style=vanc|display-authors=6}} |
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{{Infobox_gene}} |
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{{Infobox_gene}} |
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'''Brain-specific angiogenesis inhibitor 3''' is a ] that in humans is encoded by the ''BAI3'' ].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1-2 | pages = 103–108 | date = Apr 1998 | pmid = 9533023 | doi = 10.1159/000134693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577}}</ref> |
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'''Brain-specific angiogenesis inhibitor 3''' is a ] that in humans is encoded by the ''BAI3'' ].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1–2 | pages = 103–108 | date = Apr 1998 | pmid = 9533023 | doi = 10.1159/000134693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577}}</ref> |
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BAI1, a p53-target gene, encodes brain-specific ] inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez" /> The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.<ref>{{cite journal | first1 = V | last1 = Lanoue |first2 = A |last2 = Usardi |first3 = S M |last3=Sigoillot | first4 = M | last4= Talleur |first5= K | last5 = Iyer | first6 = J |last6=Mariani| first7=P |last7=Isope| first8=G |last8 = Vodjdani |last9= Heintz| first9=N |last10=Selimi| first10=F | title = The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons | journal = Molecular Psychiatry | volume = 18 |pages = 943--950 | date = 2013 | doi= }}</ref> |
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BAI1, a p53-target gene, encodes brain-specific ] inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.<ref name="entrez" /> The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.<ref>{{cite journal | vauthors = Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F | title = The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons | journal = Molecular Psychiatry | volume = 18 | issue = 8 | pages = 943–950 | date = August 2013 | pmid = 23628982 | pmc = 3730300 | doi = 10.1038/mp.2013.46 }}</ref> |
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The adhesion GPCR BaI3 is an orphan receptor that has a long ] consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.<ref>{{cite journal | vauthors = Bolliger MF, Martinelli DC, Südhof TC | title = The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 6 | pages = 2534–2539 | date = February 2011 | pmid = 21262840 | doi = 10.1073/pnas.1019577108 }}</ref> BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses. |
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The adhesion GPCR BaI3 is an orphan receptor that has a long ] consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.<ref>{{cite journal | vauthors = Bolliger MF, Martinelli DC, Südhof TC | title = The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 6 | pages = 2534–2539 | date = February 2011 | pmid = 21262840 | doi = 10.1073/pnas.1019577108 | pmc = 3038708 | bibcode = 2011PNAS..108.2534B | doi-access = free }}</ref> BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses. |
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== References == |
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== References == |
