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<blockquote></blockquote> --<small><span class="autosigned">— Preceding ] comment added by ] (] • ]) 11:29, 13 October 2010</span></small><!-- Template:Unsigned --> <blockquote></blockquote> --<small><span class="autosigned">— Preceding ] comment added by ] (] • ]) 11:29, 13 October 2010</span></small><!-- Template:Unsigned -->


== Duplicated content == == Medical, et al, section ==


⚫ Claims there is no topical treatment for 3rd degree burns. Hmmm. Children's Hospital of Philadelphia's web-article on 3D burns claims in the treatment section that treatment may include "antibiotic creams or ointments" (which by definition are topical). The false or at least certainly misleading claim (misleading since AB treat or prevent infections subsequent to a 3DB rather than the damage itself, but since it is part of the treatment (in some cases) and aids in healing, that distinction is almost impossible to justify). This article is not about burns, and I suggest the false and quite unnecessary claim be removed.] (]) 08:50, 30 July 2022 (UTC)
The "Explosive" section is duplicated at the beginning of the "Chemical intermediate" section.


:You're correct. Someone must have misinterpreted the source, which at the end correctly says that no ''dressings'' have been approved for third-degree burns. The source, I might add, is a press release for a glycerin-based dressing for use in first and second-degree burns, but you can't dress a third-degree burn because that would be like putting a bandage on gangrene. The dead and dying tissue has to be removed and new skin grafted into place. But topical ointments and gels? Sure, those have to be used. So I say go ahead and remove the sentence. You can easily do that yourself. Just leave a little edit summary at the box at the bottom pointing people to this discussion. ] (]) 20:32, 30 July 2022 (UTC)
One of them should have the duplicated content deleted, possibly the bit in the chemical intermediate section as it seems more appropriate in the explosives section. ] (]) 10:22, 23 December 2017 (UTC)
::Deleted sentence claiming "no topical treatment" as discussed <span style="border-radius:9em;background:#88ff00">] </span>(]) 06:51, 9 December 2022 (UTC)
==Allyl iodide==
Old, unlikely to be of broad interest, and pretty specialized so removed:
"<nowiki>], a chemical building block for ], ]s, ], and ], can be synthesized by using elemental ] and ] on glycerol.<ref>{{cite journal |last=Datta|first=Rasek Lal|title=The Preparation of Allyl Iodide|journal=Journal of the American Chemical Society|year=1914|volume=36|pages=1005–1007|doi=10.1021/ja02182a023|url=https://books.google.com/?id=BrI7AQAAMAAJ&pg=PA1005|issue=5}}</ref></nowiki>"--] (]) 14:42, 23 December 2017 (UTC)


== Confusion about exact nature of glycerol and glycerin ==
== How much Glycerol(in % of weight or volume) a typical cough syrup contains? ==


It seems that according to this Misplaced Pages article, glycerin and glycerol are exactly the same thing and that glycerol is a viscous liquid. However, I have read somewhere that glycerin is actually 5% water. I have also been told by someone that pure glycerol is actually a powder. Does anyone here know the authoritative truth about these things? ] (]) 13:25, 3 June 2023 (UTC)
Is cough syrup the only edible Glycerol product?
:Glycerol, glycerine and glycerin are synonyms. Pure glycerol is a sweet-tasting syrupy liquid at normal room temperature. ] 13:42, 3 June 2023 (UTC)
::Thank you, Plantsurfer, very much for your reply.
::What is your source for this information? ] (]) 15:18, 3 June 2023 (UTC)
:::https://pubchem.ncbi.nlm.nih.gov/compound/Glycerol. A good source for generic chem questions. --] (]) 15:28, 3 June 2023 (UTC)
:::Pubchem is good, as Smokefoot said, but another source is https://www.britannica.com/science/glycerol ] 16:06, 3 June 2023 (UTC)
::::Thank you, Smokefoot and Plantsurfer, very much indeed for your very helpful replies. ] (]) 16:32, 3 June 2023 (UTC)
::::I have a bottle of what is described on the label as "100% Vegetable Glycerine". Could this be 5% water? ] (]) 16:38, 3 June 2023 (UTC)
:::::No. If it was 5% water, then it would be 95% glycerine. ] 17:32, 3 June 2023 (UTC)


== Glycerol Toxicity ==
https://link.springer.com/article/10.1007/s00408-020-00390-x


The claim that it is "non-toxic" is apparently false. There are cases of glycerol toxicity in children who consume too much of it - typically in slushies (?) that use excessive glycerol (more than a typical recipe containing glycerol as a texture additive or sweetener substitute) to maintain a liquid state. Less info is available on whether it ever affects adults, but it has caused hypoglycemia and unresponsive unconsciousness in small children which is diagnosed as "glycerol toxicity" thereby indicating it is not in fact non-toxic. ] (]) 14:17, 31 January 2024 (UTC)
"Excipients such as sugars, glycerol, and menthol are now accepted as active ingredients in cough medicines and although there is some clinical support for the efficacy of menthol as an antitussive,, there is no published research on the benefits of sugars and glycerol and more research is needed in this area".


:Glycerin generally is considered non-toxic, with the word "toxic" generally reserved for poisons. Just about anything is bad for people if taken in excess. For example, water is typically considered to be the least toxic substance known, but even water can be overdosed on, which causes death very rapidly. (See: ]) Still, it's not a poison in the usual sense and in normal doses is considered non-toxic. Glycerin is similar. It probably wouldn't hurt to add some information on the possibility of overdosing on glycerin, but in general it's not a poison but a food substance, so I think describing it as non-toxic is still correct. ] (]) 18:30, 31 January 2024 (UTC)
--] (]) 18:56, 27 March 2021 (UTC)
:: Glycerol doesn't meet any definition of toxic substance. Non-toxic does not mean non-harmful. If you consume oxygen, water, salt, sugar, or anything else, in excess it can result in injury. The LD50 of oral glycerol is >20g/kg, which is more than other common non-toxic substance like table salt. The therapeutic dose, when used as an osmotic diuretic, is 1.5g/kg per dose every 4h. For your standard 10kg 1 year old that is about two teaspoons (11ml) per dose (that is enough to cause a mild increase in urinary output). Rats given 10g/kg per day per year suffered no ill effects. Chronic exposure adverse effects are mostly due to its caloric effects--it is usually completely absorbed within 30 minutes of ingestion and is metabolized like simple sugars. <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding ] comment added by ] (] • ]) 19:49, 1 March 2024 (UTC)</small> <!--Autosigned by SineBot-->

:Oh, god no. Not by a long shot. Glycerin itself is edible, although there are different grades, with food-grade glycerin being the purest. I don't know how much is found in cough syrup, and it's likely it varies from manufacturer to manufacturer, and even product to product. I highly doubt it's an active ingredient, but rather just used as a sweetener.

:Glycerin is found in a lot of foods. It occurs naturally in most meats and vegetables as triglycerides, which is broken down in the stomach to form glycerin and fats, and glycerin is easily absorbed by the small intestines, so it never makes it to the large intestines, unless used as a suppository. It's also a byproduct of fermentation, so you find it naturally is things like beer, wine, and vinegar.

:Glycerin is added to many foods as a sweetener, thickener, emulsifying agent, and many other uses. It's often added to dairy products, like cream, cheese and yogurt. It's used in jams ans jellies, processed fruits and vegetables, canned foods, dried foods, sauces, ketchups and mustards, baked goods, puddings, swetteners, butter, peanut butter, and the list goes on and on. Of course, there's a difference between food-grade glycerin and crude glyerin. ] (]) 20:04, 27 March 2021 (UTC)

== Medical, et al, section ==

⚫ Claims there is no topical treatment for 3rd degree burns. Hmmm. Children's Hospital of Philadelphia's web-article on 3D burns claims in the treatment section that treatment may include "antibiotic creams or ointments" (which by definition are topical). The false or at least certainly misleading claim (misleading since AB treat or prevent infections subsequent to a 3DB rather than the damage itself, but since it is part of the treatment (in some cases) and aids in healing, that distinction is almost impossible to justify). This article is not about burns, and I suggest the false and quite unnecessary claim be removed.] (]) 08:50, 30 July 2022 (UTC)

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Moved comment to talk

--— Preceding unsigned comment added by 75.72.222.46 (talk • contribs) 11:29, 13 October 2010

Medical, et al, section

Claims there is no topical treatment for 3rd degree burns. Hmmm. Children's Hospital of Philadelphia's web-article on 3D burns claims in the treatment section that treatment may include "antibiotic creams or ointments" (which by definition are topical). The false or at least certainly misleading claim (misleading since AB treat or prevent infections subsequent to a 3DB rather than the damage itself, but since it is part of the treatment (in some cases) and aids in healing, that distinction is almost impossible to justify). This article is not about burns, and I suggest the false and quite unnecessary claim be removed.174.131.48.89 (talk) 08:50, 30 July 2022 (UTC)

You're correct. Someone must have misinterpreted the source, which at the end correctly says that no dressings have been approved for third-degree burns. The source, I might add, is a press release for a glycerin-based dressing for use in first and second-degree burns, but you can't dress a third-degree burn because that would be like putting a bandage on gangrene. The dead and dying tissue has to be removed and new skin grafted into place. But topical ointments and gels? Sure, those have to be used. So I say go ahead and remove the sentence. You can easily do that yourself. Just leave a little edit summary at the box at the bottom pointing people to this discussion. Zaereth (talk) 20:32, 30 July 2022 (UTC)
Deleted sentence claiming "no topical treatment" as discussed  • Bobsd •  (talk) 06:51, 9 December 2022 (UTC)

Confusion about exact nature of glycerol and glycerin

It seems that according to this Misplaced Pages article, glycerin and glycerol are exactly the same thing and that glycerol is a viscous liquid. However, I have read somewhere that glycerin is actually 5% water. I have also been told by someone that pure glycerol is actually a powder. Does anyone here know the authoritative truth about these things? 95.172.233.137 (talk) 13:25, 3 June 2023 (UTC)

Glycerol, glycerine and glycerin are synonyms. Pure glycerol is a sweet-tasting syrupy liquid at normal room temperature. Plantsurfer 13:42, 3 June 2023 (UTC)
Thank you, Plantsurfer, very much for your reply.
What is your source for this information? 95.172.233.137 (talk) 15:18, 3 June 2023 (UTC)
https://pubchem.ncbi.nlm.nih.gov/compound/Glycerol. A good source for generic chem questions. --Smokefoot (talk) 15:28, 3 June 2023 (UTC)
Pubchem is good, as Smokefoot said, but another source is https://www.britannica.com/science/glycerol Plantsurfer 16:06, 3 June 2023 (UTC)
Thank you, Smokefoot and Plantsurfer, very much indeed for your very helpful replies. 95.172.233.137 (talk) 16:32, 3 June 2023 (UTC)
I have a bottle of what is described on the label as "100% Vegetable Glycerine". Could this be 5% water? 95.172.233.137 (talk) 16:38, 3 June 2023 (UTC)
No. If it was 5% water, then it would be 95% glycerine. Plantsurfer 17:32, 3 June 2023 (UTC)

Glycerol Toxicity

The claim that it is "non-toxic" is apparently false. There are cases of glycerol toxicity in children who consume too much of it - typically in slushies (?) that use excessive glycerol (more than a typical recipe containing glycerol as a texture additive or sweetener substitute) to maintain a liquid state. Less info is available on whether it ever affects adults, but it has caused hypoglycemia and unresponsive unconsciousness in small children which is diagnosed as "glycerol toxicity" thereby indicating it is not in fact non-toxic. 97.68.70.242 (talk) 14:17, 31 January 2024 (UTC)

Glycerin generally is considered non-toxic, with the word "toxic" generally reserved for poisons. Just about anything is bad for people if taken in excess. For example, water is typically considered to be the least toxic substance known, but even water can be overdosed on, which causes death very rapidly. (See: Water toxicity) Still, it's not a poison in the usual sense and in normal doses is considered non-toxic. Glycerin is similar. It probably wouldn't hurt to add some information on the possibility of overdosing on glycerin, but in general it's not a poison but a food substance, so I think describing it as non-toxic is still correct. Zaereth (talk) 18:30, 31 January 2024 (UTC)
Glycerol doesn't meet any definition of toxic substance. Non-toxic does not mean non-harmful. If you consume oxygen, water, salt, sugar, or anything else, in excess it can result in injury. The LD50 of oral glycerol is >20g/kg, which is more than other common non-toxic substance like table salt. The therapeutic dose, when used as an osmotic diuretic, is 1.5g/kg per dose every 4h. For your standard 10kg 1 year old that is about two teaspoons (11ml) per dose (that is enough to cause a mild increase in urinary output). Rats given 10g/kg per day per year suffered no ill effects. Chronic exposure adverse effects are mostly due to its caloric effects--it is usually completely absorbed within 30 minutes of ingestion and is metabolized like simple sugars. — Preceding unsigned comment added by DrKC MD (talk • contribs) 19:49, 1 March 2024 (UTC)
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