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| The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" /> | The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" /> | ||
| ==Research== | |||
| UCH-L1 has been studied, in a 2020 paper by Sharma, et al for its association with ] (])<ref>{{cite journal |last1=Sharma |first1=Amit |last2=Liu |first2=Hongde |last3=Tobar-Tosse |first3=Fabian |last4=Chand Dakal |first4=Tikam |last5=Ludwig |first5=Michael |last6=Holz |first6=Frank G. |last7=Loeffler |first7=Karin U. |last8=Wüllner |first8=Ullrich |last9=Herwig-Carl |first9=Martina C. |title=Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration |journal=International Journal of Molecular Sciences |date=30 May 2020 |volume=21 |issue=11 |pages=3910 |doi=10.3390/ijms21113910 |doi-access=free |pmid=32486284 |pmc=7312489 |issn=1422-0067}}</ref> | |||
| A 2024 paper by Li, et al indicates possible contribution to ] progression. Apparently via stabilizing proteins that promote cell proliferation (in TNBC, UCHL1 deubiquitinates and stabilizes KLF5, as a consequence there is resistance to ]).<ref>{{cite journal |last1=Li |first1=Juan |last2=Liang |first2=Yu |last3=Zhou |first3=Shijie |last4=Chen |first4=Jie |last5=Wu |first5=Chihua |title=UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5 |journal=Breast Cancer Research |date=11 March 2024 |volume=26 |issue=1 |pages=44 |doi=10.1186/s13058-024-01800-1 |doi-access=free |pmid=38468288 |issn=1465-542X}}</ref> | |||
| == Therapy == | |||
| USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an ''in vitro'' model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy. <ref>{{cite journal | vauthors = García-Santisteban I, Peters GJ, Giovannetti E, Rodríguez JA | title = USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy | journal = Molecular Cancer | volume = 12 | issue = 1 | pages = 91 | date = August 2013 | pmid = 23937906 | pmc = 3750636 | doi = 10.1186/1476-4598-12-91 }}</ref> | |||
| == References == | == References == | ||
Latest revision as of 21:25, 14 December 2024
Protein-coding gene in the species Homo sapiens| USP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | USP1, UBP, ubiquitin specific peptidase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603478; MGI: 2385198; HomoloGene: 2528; GeneCards: USP1; OMA:USP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.
The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
Research
UCH-L1 has been studied, in a 2020 paper by Sharma, et al for its association with neurodegenerative diseases (Parkinson's disease)
A 2024 paper by Li, et al indicates possible contribution to cancer progression. Apparently via stabilizing proteins that promote cell proliferation (in TNBC, UCHL1 deubiquitinates and stabilizes KLF5, as a consequence there is resistance to endocrine therapy).
References
- ^ GRCh38: Ensembl release 89: ENSG00000162607 – Ensembl, May 2017
- ^ GRCm38: Ensembl release 89: ENSMUSG00000028560 – Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
- ^ "Entrez Gene: USP1 ubiquitin specific peptidase 1".
- Sharma, Amit; Liu, Hongde; Tobar-Tosse, Fabian; Chand Dakal, Tikam; Ludwig, Michael; Holz, Frank G.; Loeffler, Karin U.; Wüllner, Ullrich; Herwig-Carl, Martina C. (30 May 2020). "Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration". International Journal of Molecular Sciences. 21 (11): 3910. doi:10.3390/ijms21113910. ISSN 1422-0067. PMC 7312489. PMID 32486284.
- Li, Juan; Liang, Yu; Zhou, Shijie; Chen, Jie; Wu, Chihua (11 March 2024). "UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5". Breast Cancer Research. 26 (1): 44. doi:10.1186/s13058-024-01800-1. ISSN 1465-542X. PMID 38468288.
Further reading
- D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology. 33 (5): 337–352. doi:10.1080/10409239891204251. PMID 9827704.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Fujiwara T, Saito A, Suzuki M, Shinomiya H, Suzuki T, Takahashi E, et al. (November 1998). "Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease". Genomics. 54 (1): 155–158. doi:10.1006/geno.1998.5554. PMID 9806842.
- Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R (February 2005). "The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway". Molecular Cell. 17 (3): 331–339. doi:10.1016/j.molcel.2005.01.008. hdl:1874/17796. PMID 15694335. S2CID 19117200.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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