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{{short description|Expulsion of feces from the digestive tract}} | |||
{{For|the death metal band|Defecation (band)}} | |||
{{about|the bodily process|the band|Defecation (band)}}{{distinguish|defector|defalcation}} | |||
{{pp-vandalism|small=yes}} | |||
] of the ''anorecturm'' (] and ])]] | |||
'''Defecation''' (or '''defaecation''') follows ], and is a necessary process by which organisms eliminate a solid, semisolid, or liquid ] material known as ] from the ] via the ] or ]. The act has a variety of names ranging from the common, like '''pooping''' or '''crapping''', to the technical, e.g. '''bowel movement''', to the obscene ('']''), to the ] ("doing a number two", "dropping a deuce" or "taking a dump"), to the juvenile ("making doo-doo"). The topic, usually avoided in polite company, can become the basis for some ]. | |||
] | |||
<!-- Specifics: different species and times --> | |||
] defecating in flight]] | |||
]s expel ] with a frequency varying from a few times daily to a few times weekly.<ref>{{Cite web|title=The Basics of Constipation|url=https://www.webmd.com/digestive-disorders/understanding-constipation-basics|website=WebMD|language=en|access-date=2020-05-26}}</ref> Waves of ] (known as '']'') in the walls of the ] move fecal matter through the digestive tract towards the ]. Undigested food may also be expelled within the feces, in a process called '''''egestion'''''. When ]s defecate, they also expel ] and ]s in the same mass, whereas other animals may also ] at the same time, but spatially separated. Defecation may also accompany ] and ]. Babies defecate a unique substance called ] prior to eating external foods.<!-- Medical --> | |||
There are a number of medical conditions associated with defecation, such as ] and ], some of which can be serious. The feces expelled can carry diseases, most often through the contamination of food. '']'' is a particular concern. | |||
==The defecation cycle== | |||
<!-- Where? collection --> | |||
In the adult human, the process of defecation, or the defecation cycle, is normally a combination of both voluntary and involuntary processes. The defecation cycle is the interval of time between the completion of one bowel movement, and the completion of the following bowel movement. At the start of the cycle, the ] (anatomically also: ''ampulla recti'') acts as a temporary storage facility for the unneeded material. As additional fecal material enters the rectum, the rectal walls expand. A sufficient increase in fecal material in the rectum causes stretch receptors from the ] located in the rectal walls to trigger the contraction of rectal muscles, relaxation of the internal anal sphincter and an initial contraction of the skeletal muscle of the external sphincter. The relaxation of the internal anal sphincter causes a signal to be sent to the brain indicating an urge to defecate. | |||
Before ], human feces are most often collected into a ]. Thereafter, in many societies people commonly defecate into a ]. However, ], the practice of defecating outside without using a toilet of any kind, is still widespread in some ].<ref name="JMP2017">WHO and UNICEF (2017) . Geneva: World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF), 2017</ref> Some people defecate into ]. First world countries use ] and/or ]. | |||
If this urge is not acted upon, the material in the rectum is often returned to the ] by ] where more ] is absorbed, thus temporarily reducing pressure and stretching within the rectum. The additional fecal material is stored in the colon until the next mass 'peristaltic' movement of the transverse and descending colon. If defecation is delayed for a prolonged period the fecal matter may harden, resulting in ]. | |||
==Description== | |||
Once the voluntary signal to defecate is sent back from the brain, the final phase of the cycle begins. The rectum now contracts and shortens in ], thus forcing fecal material out of the rectum and out through the anal canal. The ] and ] anal sphincters along with the puborectalis muscle allow the feces to be passed by pulling the ] up over the exiting feces in shortening and contracting actions. | |||
{{multiple image|image1=Defecating lion in Warsaw Zoo.jpg|image2=Speke's Gazelle (Gazella spekei) (5532395054).jpg|image3=Defecating bison.jpg|image4=Canis lupus (1855281790).jpg|image5=White horse defecate on field.jpg|image6=DSC 8148 (4933509680).jpg|footer=Defecation postures of ]s|perrow=3|total_width=440px}} | |||
] | |||
===Physiology=== | |||
{{Further|Rectum#Function}} | |||
The ] stores fecal waste (also called stool) before it is excreted. As the waste fills the rectum and expands the rectal walls, stretch receptors in the rectal walls stimulate the desire to defecate. This urge to defecate arises from the reflex contraction of rectal muscles, relaxation of the ], and an initial contraction of the skeletal muscle of the ]. If the urge is not acted upon, the material in the rectum is often returned to the colon by ], where more water is absorbed and the feces are stored until the next mass peristaltic movement of the transverse and descending colon. | |||
When the rectum is full, an increase in pressure within the rectum forces apart the walls of the ], allowing the fecal matter to enter the canal. The rectum shortens as material is forced into the anal canal and peristaltic waves push the feces out of the rectum. The internal and external anal sphincters along with the ] allow the feces to be passed by muscles pulling the anus up over the exiting feces.<ref>{{cite web |url=https://medicine.umich.edu/sites/default/files/content/downloads/bowel-function.pdf |title=Bowel Function Anatomy |publisher=University of Michigan Health System |accessdate=2021-05-19 |quote=The levator ani and the puborectalis need to coordinate properly in order to expel contents from the anal canal. }}</ref> | |||
==Muscular aspects== | |||
Defecation is normally assisted by taking a deep breath and trying to expel this air against a closed glottis (]). This contraction of expiratory ] muscles, ], abdominal wall muscles, and ] diaphragm exert pressure on the digestive tract. ] at this point temporarily ceases as the lungs push the chest diaphragm down in order to exert the pressure. | |||
===Voluntary and involuntary control=== | |||
==Cardiovascular aspects== | |||
During defecation, the thoracic ] rises, and as a reflex response the amount of blood pumped by the heart decreases. Death has been known to occur in cases where defecation causes the blood pressure to rise enough to cause the rupture of an ] or to dislodge ] clots (see ]). Also, in release of the Valsalva maneuver blood pressure falls, this coupled often with standing up quickly to leave the toilet results in a common incidence of blackouts in this situation. | |||
==Neurological aspects== | |||
When defecating, the external sphincter muscles relax. The anal and urethal sphincter muscles are closely linked, and experiments by Dr. Harrison Weed at the Ohio State University Medical Center have shown that they can only be contracted together, not individually, and that they both show relaxation during urination{{Fact|date=December 2007}}. This explains why defecation is frequently accompanied by ], and why urination is frequently accompanied by ]. | |||
The ] is under voluntary control whereas the ] is involuntary. In ]s, the defecation occurs by ] without the voluntary control of the external anal sphincter. Defecation is voluntary in adults. Young children learn voluntary control through the process of ]. Once trained, loss of control, called ], may be caused by physical injury, nerve injury, prior surgeries (such as an ]), ], ], loss of storage capacity in the ], intense fright, ], ] or ] factors, ], or ].<ref>{{cite web|author=<!--Staff writer(s); no by-line.--> |title=Fecal incontinence - Causes|url=http://www.mayoclinic.org/diseases-conditions/fecal-incontinence/basics/causes/con-20034575|publisher=Mayo Foundation for Medical Education and Research|access-date=9 September 2014}}</ref> | |||
Sometimes, due to the inability to control one's bowel movement or due to excessive fear, defecation (usually accompanied by urination) occurs involuntarily, soiling a person's undergarments. This may cause significant embarrassment to the person if this occurs in the presence of other people or a public place. | |||
The loss of voluntary control of defecation is experienced frequently by those undergoing a terminal illness. <ref>Joanne Lynn, MD. Merck. October 2007. . Uploaded 3/1/09. </ref> | |||
==Posture |
===Posture=== | ||
{{main article|Human defecation postures}} | |||
] | |||
The positions and modalities of defecation are ]. ]s are used by the vast majority of the world, including most of Africa, Asia, and the Middle East.<ref>{{cite book|last1=Kira|first1=Alexander|title=The Bathroom|date=1976|publisher=Viking Pr|location=New York, N.Y.|isbn=978-0-670-00612-0|pages=115–116|edition=2. ed. New and expanded}}</ref> The use of sit-down ]s in the ] is a relatively recent development, beginning in the 19th century with the advent of indoor plumbing.<ref>{{cite book |editor1=C. Singer |editor2=E Holmyard |editor3=A Hall |editor4=T. Williams |year=1958 |orig-year=1954 |title=A History of Technology |volume=IV: The Industrial Revolution, 1750-1850 |publisher=Oxford Clarendon Press |pages=507–508 |oclc=886036895}}</ref> | |||
] defecating on a ]]] | |||
] defecating]] | |||
==Disease== | |||
{{main|Defecation posture}} | |||
Regular bowel movements determine the functionality and the health of the alimentary tracts in human body. Defecation is the most common regular bowel movement which eliminates waste from the human body. The frequency of defecation is hard to identify, which can vary from daily to weekly depending on individual bowel habits, the impact from the environment and genetic.<ref>{{cite book |doi=10.1016/B978-0-12-803968-7.00026-5 |chapter=Defecation and Stools in Vegetarians |title=Vegetarian and Plant-Based Diets in Health and Disease Prevention |year=2017 |last1=Nath |first1=Preetam |last2=Singh |first2=Shivaram Prasad |pages=473–481 |isbn=978-0-12-803968-7 }}</ref> If defecation is delayed for a prolonged period the fecal matter may harden, resulting in ]. If defecation occurs too fast, before excess liquid is absorbed, ] may occur.<ref>{{cite news|author=NIH|url=https://www.nlm.nih.gov/medlineplus/bowelmovement.html|title=Bowel Movement|journal=MedlinePlus|access-date=13 September 2014}}</ref> Other associated symptoms can include abdominal bloating, abdominal pain, and abdominal distention.<ref>{{cite journal |last1=Lacy |first1=Brian E. |last2=Mearin |first2=Fermín |last3=Chang |first3=Lin |last4=Chey |first4=William D. |last5=Lembo |first5=Anthony J. |last6=Simren |first6=Magnus |last7=Spiller |first7=Robin |title=Bowel Disorders |journal=Gastroenterology |date=May 2016 |volume=150 |issue=6 |pages=1393–1407.e5 |doi=10.1053/j.gastro.2016.02.031 |pmid=27144627 |url=http://pdfs.semanticscholar.org/b584/2e286d265c0cd50e3d56ad9a0ce61686d376.pdf }}</ref> Disorders of the bowel can seriously impact quality of life and daily activities. The causes of functional bowel disorder are multifactorial, and dietary habits such as food intolerance and low fiber diet are considered to be the primary factors.<ref>{{cite journal |last1=Grace |first1=Sandra |last2=Barnes |first2=Larisa |last3=Reilly |first3=Wayne |last4=Vlass |first4=Ann |last5=de Permentier |first5=Patrick |title=An integrative review of dietetic and naturopathic approaches to functional bowel disorders |journal=Complementary Therapies in Medicine |date=December 2018 |volume=41 |pages=67–80 |doi=10.1016/j.ctim.2018.09.004 |pmid=30477867 |s2cid=53768740 }}</ref> | |||
=== Constipation === | |||
The positions and modalities of defecation are ]. The natural and instinctive method used by all primates, including humans, is the squatting position. ]s, sometimes referred to as 'natural-position toilets', are still used by the vast majority of the world, including most of Africa, Asia and the Middle East.<ref>Kira A. The Bathroom. Harmondsworth: Penguin, 1976, revised edition, pp.115,116. | |||
{{main|Constipation}} | |||
</ref> The widespread use of seated-position ]s in the ] is a recent development, beginning in the 19th century with the advent of indoor plumbing.<ref>A History of Technology, Vol.IV: The Industrial Revolution, 1750-1850. (C. Singer, E Holmyard, A Hall, T. Williams eds) Oxford Clarendon Press, pps. 507-508, 1958</ref> | |||
Constipation, also known as defecatory dysfunction, is difficulty experienced when passing stools. It is one of the most notable alimentary disorders that affects different age groups in the population. Common constipation is associated with abdominal distention, pain or bloating.<ref name=":13">{{Cite journal|last1=Hay|first1=Tyler|last2=Bellomo|first2=Ranaldo|last3=Rechnitzer|first3=Tom|last4=See|first4=Emily|last5=Abdelhamid|first5=Yasmine Ali|last6=Deane|first6=Adam|date=January 2019|title=Constipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis|journal=Journal of Critical Care|volume=52|pages=242–250|doi=10.1016/j.jcrc.2019.01.004|pmid=30665795|s2cid=58667995}}</ref> Research has revealed that chronic constipation complied with higher risk of cardiovascular events such as coronary heart disease and ischemic stroke, while associating with an increasing risk of mortality.<ref>{{Cite journal|last1=Sumida|first1=Keiichi|last2=Molnar|first2=Miklos Z|last3=Potukuchi|first3=Praveen K|last4=Thomas|first4=Fridtjof|last5=Ling|first5=Jun Lu|last6=Yamagata|first6=Kunihiro|last7=Zadeh|first7=Kamyar Kalantar|last8=Kovesdy|first8=Casba P|date=February 2019|title=Constipation and risk of death and cardiovascular events|journal=Atherosclerosis|volume=281|pages=114–120|doi=10.1016/j.atherosclerosis.2018.12.021|pmid=30658186|pmc=6399019}}</ref> Besides dietary factors, psychological traumas and 'pelvic floor disorders' can also cause chronic constipation and defecatory disorder respectively.<ref name=":13" /> Multiple interventions, including physical activities, 'high-fibre diet', probiotics<ref>{{cite journal |last1=Hod |first1=Keren |last2=Ringel |first2=Yehuda |title=Probiotics in functional bowel disorders |journal=Best Practice & Research Clinical Gastroenterology |date=February 2016 |volume=30 |issue=1 |pages=89–97 |doi=10.1016/j.bpg.2016.01.003 |pmid=27048900 }}</ref> and drug therapies can be widely and efficiently used to treat constipation and defecatory disorder. | |||
=== Inflammatory bowel diseases === | |||
Bockus Gastroenterology, the standard textbook on the subject, states: | |||
{{main|Inflammatory bowel disease}} | |||
<blockquote>"The ideal posture for defecation is the squatting position, with the thighs flexed upon the abdomen. In this way the capacity of the abdominal cavity is greatly diminished and intra-abdominal pressure increased, thus encouraging expulsion ..."<ref>Bockus. Gastroenterology. p. 754 2nd ed. Saunders, Philadelphia and London, 1964</ref></blockquote> | |||
Inflammatory disease is characterized as long-lasting, chronic inflammation throughout the gastrointestinal tract. ] (CD) and ] (UC) are two universal types of inflammatory bowel disease that have been studied over a century. They are closely related to different environmental risk factors, family genetics, and lifestyle choices such as smoking.<ref>{{Cite journal|last=Fiocchi|first=Claudio|date=1998|title=Inflammatory bowel disease: Etiology and pathogenesis|journal=Gastroenterology|volume=115|issue=1|pages=182–205|doi=10.1016/S0016-5085(98)70381-6|pmid=9649475}}</ref> Crohn's disease has been found to be related to immune disorders particularly.<ref name=":3">{{Cite journal|last1=Baumgart|first1=Daniel C|last2=Sandborn|first2=William J|date=November 2012|title=Crohn's disease|journal=The Lancet|volume=380|issue=9853|pages=1590–1605|doi=10.1016/S0140-6736(12)60026-9|pmid=22914295|s2cid=18672997|doi-access=free}}</ref> Different levels of cumulative intestinal injuries can cause different complications, such as fistulae, damage of bowel function, symptom recurrence, disability, etc.<ref>{{Cite journal|last1=Agrawal|first1=Manasi|last2=Colombel|first2=Jean-Frederic|date=2019|title=Treat-to-Target in Inflammatory Bowel Diseases, What Is the Target and How Do We Treat?|journal=Gastrointestinal Endoscopy Clinics of North America|volume=29|issue=3|pages=421–436|doi=10.1016/j.giec.2019.02.004|pmid=31078245|s2cid=132251418}}</ref> Patients can be children or adults. Recent research shows that immunodeficiency and monogenic disorders are the causes in young patients with inflammatory bowel diseases.<ref>{{Cite journal|last1=Kelsen|first1=Juridth R|last2=Russo|first2=Pierre|last3=Sullivan|first3=Kathleen E|date=February 2019|title=Early-Onset Inflammatory Bowel Disease|journal=Immunology and Allergy Clinics of North America|volume=39|issue=1|pages=63–79|doi=10.1016/j.iac.2018.08.008|pmid=30466773|pmc=6954002}}</ref> | |||
Common symptoms of inflammatory bowel diseases differ by the infection level, but may include severe abdominal pain, diarrhea, fatigue, and unexpected weight loss. ] can lead to infection of any part of the digestive tract, including ileum to anus.<ref>{{Cite journal|title=Crohn's disease|journal=Medicine|volume=47|issue=6|last1=Mak|first1=Wing Yan|last2=Hart|first2=Alisa L|last3=Ng|first3=Siew C|year=2019|pages=377–387|doi=10.1016/j.mpmed.2019.03.007|s2cid=242228134}}</ref> Internal manifestations include diarrhea, abdomen pain, fever, chronic anaemia, etc. External manifestations include impact on skin, joints, eyes, and liver. Significantly reduced microbiota diversity inside the gastrointestinal tract can also be observed. Ulcerative colitis mainly affects the function of the large bowel, and its incidence rate is three times greater than that of Crohn's disease.<ref name=":5">{{Cite journal|last=Steed|first=Helen|date=May 2019|title=Ulcerative colitis|journal=Medicine|volume=47|issue=6|pages=371–376|doi=10.1016/j.mpmed.2019.03.001|s2cid=243328622}}</ref> In terms of clinical features, over 90 percent of patients exhibit constant diarrhea, rectal bleeding, softer stool, mucus in the stool, tenesmus, and abdominal pain.<ref name=":5" /> The symptoms may continue for around 6 weeks or even longer. | |||
==Other considerations== | |||
The ] and ] may be ] with ], similar paper products, or other absorbent material. In some cultures water is used (e.g. as with a ]) either in addition or exclusively. In Japan and South Korea, some toilets known as ] are designed to wash and dry the anus of the user after defecation (''see ]''). | |||
The inflammatory bowel diseases could be effectively treated by 'pharmacotherapies' to relieve and maintain the symptoms, which showed in 'mucosal healing' and symptoms elimination.<ref name=":7">{{Cite journal|last1=Jeong|first1=Dong Yeon|last2=Kim|first2=Seung|last3=Son|first3=Min Ji|last4=Son|first4=Chei Yun|last5=Kim|first5=Jong Yeob|last6=Kronbichler|first6=Andreas|last7=Lee|first7=Keum Hwa|last8=Shin|first8=Jae II|date=May 2019|title=Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review|journal=Autoimmunity Reviews|volume=18|issue=5|pages=439–454|doi=10.1016/j.autrev.2019.03.002|pmid=30844556|s2cid=73466469}}</ref> However, an optimal therapy for curing both inflammatory diseases are still under research due to the heterogeneity in clinical feature.<ref name=":7" /> Although both UC and CD are sharing similar symptoms, the medical treatment of them are distinctively different.<ref name=":7" /> Dietary treatment can benefit for curing CD by increase the dietary zinc and fish intake, which is related to mucosal healing of the bowel.<ref name=":3" /> Treatments vary from drug treatment to surgery based on the active level of the CD. UC can also be relieved by using immunosuppressive therapy for mild to moderate disease level and application of biological agents for severe cases.<ref name=":5" /> | |||
===Irritable bowel syndrome=== | |||
{{main|Irritable bowel syndrome}} | |||
Irritable bowel syndrome is diagnosed as an intestinal disorder with chronic abdominal pain and inconsistency in form of stool, and is a common bowel disease that can be easily diagnosed in modern society.<ref name=":4">{{cite book |doi=10.1016/B978-0-323-54731-4.00076-1 |chapter=Irritable Bowel Syndrome |title=Atlas of Common Pain Syndromes |year=2019 |last1=Waldman |first1=Steven D. |pages=294–297 |isbn=978-0-323-54731-4 |s2cid=239092846 }}</ref> The variation in incident rate can be explained by different diagnostic criteria in different countries, with the 18–34 age group being recognized as the high frequency incident group.<ref name=":4" /> The definite cause of irritable bowel syndrome remains a mystery; however, it has been found to relate to multiple factors, such as 'alternation of mood and pressure, sleep disorders, food triggers, changing of dysbiosis and even sexual dysfunction'.<ref name=":4" /> One third of irritable bowel syndrome patients has family history with the disease suggesting that genetic predisposition could be a significant cause for irritable bowel syndrome.<ref name=":6">{{Cite journal|last1=Farmer|first1=Adam D|last2=Ruffle|first2=James K|date=May 2019|title=Irritable bowel syndrome|journal=Medicine|volume=47|issue=6|pages=350–353|doi=10.1016/j.mpmed.2019.03.009|pmid=27159638|pmc=5001845}}</ref> | |||
Patients with irritable bowel syndrome commonly experience abdominal pain, changes to stool form, recurrent abdominal bloating and gas,<ref name=":6" /> co-morbid disorders and alternation in bowel habits that caused diarrhea or constipation.<ref name=":4" /> However, anxiety and tension can also be detected, although patients with irritable bowel disease seem healthy. Apart from these typical symptoms, rectal bleeding, unexpected weight loss and increased inflammatory markers require further medical examination and investigation.<ref name=":4" /> | |||
Treatment for irritable bowel disease is multimodal. Dietary intervention and pharmacotherapies can both relieve the symptoms to a certain degree. Avoiding allergic food groups can be beneficial by reducing fermentation in the digestive tract and gas production, hence effectively alleviating abdominal pain and bloating.<ref name=":4" /> Drug interventions, such as laxatives, loperamide,<ref name=":4" /> and lubiprostone<ref name=":6" /> are applied to relieve intense symptoms including diarrhea, abdominal pain and constipation. Psychological treatment, dietary supplements<ref name=":4" /> and gut-focused hypnotherapy<ref name=":6" /> are recommended for targeting depression, mood disorders and sleep disturbance. | |||
=== Bowel obstruction === | |||
{{main|Bowel obstruction}} | |||
Bowel obstruction is a bowel condition which is a blockage that can be found in both the small intestines and large intestines. Increase of contractions can relieve blockages; however, continuous contractions with decreasing functionality may lead to terminated mobility of the small intestines, which then forms the obstruction. At the same time, the lack of contractility encourages liquid and gas accumulation.<ref name=":14">{{Cite journal|last1=Long|first1=Brit|last2=Robertson|first2=Jennifer|last3=Koyfman|first3=Alex|date=February 2019|title=Emergency Medicine Evaluation and Management of Small Bowel Obstruction: Evidence-Based Recommendations|journal=The Journal of Emergency Medicine|volume=56|issue=2|pages=166–176|doi=10.1016/j.jemermed.2018.10.024|pmid=30527563|s2cid=54480601}}</ref> and "electrolyte disturbances".<ref name=":15">{{cite book |doi=10.1016/B978-0-323-40232-3.00072-8 |chapter=Small Bowel Obstruction |title=Shackelford's Surgery of the Alimentary Tract, 2 Volume Set |year=2019 |last1=Johnston |first1=Lily E. |last2=Hanks |first2=John B. |pages=842–850 |isbn=978-0-323-40232-3 |s2cid=81585148 }}</ref> Small bowel obstruction can result in severe renal damage and hypovolemia.<ref name=":15" /> while evolving into "mucosal ischemia and perforation".<ref name=":14" /> Patients with small bowel obstruction were found to experience constipation, strangulation and abdominal pain and vomiting.<ref name=":14" /> Surgical intervention is primarily used to cure severe small bowel obstruction condition. Nonoperative therapy included nasogastric tube decompression, water-soluble-contrast medium process or symptomatic management can be applied to treat less severe symptoms<ref name=":14" /> | |||
According to research, large bowel obstruction is less common than small bowel obstruction, but is still associated with a high mortality rate.<ref name=":16">{{cite journal |last1=Farkas |first1=Nicholas G. |last2=Welman |first2=Ted Joseph P. |last3=Ross |first3=Talisa |last4=Brown |first4=Sarah |last5=Smith |first5=Jason J. |last6=Pawa |first6=Nikhil |title=Unusual causes of large bowel obstruction |journal=Current Problems in Surgery |date=February 2019 |volume=56 |issue=2 |pages=49–90 |doi=10.1067/j.cpsurg.2018.12.001 |pmid=30777150 |s2cid=59277670 }}</ref> Large bowel obstruction, also known as colonic obstruction, includes acute colonic obstruction, where a blockage is formed in the colon. Colonic obstructions frequently occur within the elder population, often accompanied by significant 'comorbidities'.<ref>{{Cite journal|last1=Frago|first1=Ricardo|last2=Ramirez|first2=Elena|last3=Millan|first3=Monica|last4=Kreisler|first4=Esther|last5=Valle|first5=Emilio del|last6=Biondo|first6=Sebastiano|date=January 2014|title=Current management of acute malignant large bowel obstruction: a systematic review|journal=The American Journal of Surgery|volume=207|issue=1|pages=127–138|doi=10.1016/j.amjsurg.2013.07.027|pmid=24124659}}</ref> Although colonic malignancy is revealed as the major cause of the colonic obstruction, volvulus has also been founded as a secondary common cause around the world.<ref name=":16" /> In addition, lower mobility, unhealthy mentality and restricted living environment are also listed as risk factors. Surgery and colonic stent placements are widely applied for curing colonic obstructions.<ref>{{Cite journal|last1=Laboa|first1=Maria Navajas|last2=Calzada|first2=Aitor Orive|last3=Landaluce|first3=Aitor|last4=Estevez|first4=Inaki Zabalza|last5=Larena|first5=Jose Alejandro|last6=Arevalo-Serna|first6=Juan Antonio|last7=Bridet|first7=Lionel|last8=Lopez-Lopez|first8=Maria|last9=Burgos|first9=Soraya Torres|date=March 2015|title=Colonic obstruction caused by endometriosis solved with a colonic stent as a bridge to surgery|journal=Arab Journal of Gastroenterology|volume=16|issue=1|pages=33–35|doi=10.1016/j.ajg.2014.10.004|pmid=25791032}}</ref> | |||
===Other=== | |||
Attempting forced expiration of breath against a closed airway (the ]) is sometimes practiced to induce defecation while on a ]. This contraction of expiratory ] muscles, ], abdominal wall muscles, and ] diaphragm exerts pressure on the digestive tract. ] at this point temporarily ceases as the lungs push the chest diaphragm down to exert the pressure. ]<ref name="pmid27716918">{{cite journal|vauthors=Fisher-Hubbard AO, Kesha K, Diaz F, Njiwaji C, Chi P, Schmidt CJ|year=2016|title=Commode Cardia-Death by Valsalva Maneuver: A Case Series|journal=]|volume=61|issue=6|pages=1541–1545|doi=10.1111/1556-4029.13196|pmid=27716918|s2cid=4727369|hdl=2027.42/134829|hdl-access=free}}</ref> and other cardiovascular complications<ref name="pmid27151226">{{cite journal|vauthors=Ikeda T, Oomura M, Sato C, Anan C, Yamada K, Kamimoto K|year=2016|title=Cerebral infarction due to cardiac myxoma developed with the loss of consciousness immediately after defecation-a case report|journal=Rinsho Shinkeigaku|volume=56|issue=5|pages=328–333|doi=10.5692/clinicalneurol.cn-000856|pmid=27151226|doi-access=free}}</ref> can in rare cases occur due to attempting to defecate using the Valsalva maneuver. ] is another pathological syndrome associated with the Valsalva maneuver.<ref>{{cite journal|last1=Gibran|first1=S K|last2=Kenawy|first2=N|last3=Wong|first3=D|last4=Hiscott|first4=P|year=2007|title=Changes in the retinal inner limiting membrane associated with Valsalva retinopathy|journal=]|volume=91|issue=5|pages=701–2|doi=10.1136/bjo.2006.104935|pmc=1954736|pmid=17446519}}</ref><ref name="pmid19747224">{{cite journal|author=Connor AJ|year=2010|title=Valsalva-related retinal venous dilation caused by defaecation|journal=]|volume=88|issue=4|pages=328–33|doi=10.1111/j.1755-3768.2009.01624.x|pmid=19747224|s2cid=26590048|doi-access=free}}</ref> Thoracic ] rises and as a reflex response the amount of blood pumped by the heart decreases. Death has been known to occur in cases where defecation causes the blood pressure to rise enough to cause the rupture of an ] or to dislodge blood clots (see ]). Also, in releasing the Valsalva maneuver blood pressure falls; this, coupled with standing up quickly to leave the toilet, can result in a blackout.{{citation needed|date=February 2013}} | |||
] | |||
== Society and culture == | |||
===Open defecation=== | |||
{{main|Open defecation}} | |||
] is the human practice of defecating outside (in the open environment) rather than into a ]. People may choose fields, bushes, forests, ditches, streets, canals or other open space for defecation. They do so because either they do not have a toilet readily accessible or due to traditional cultural practices.<ref name="ClasenBoisson2014">{{cite journal | vauthors = Clasen T, Boisson S, Routray P, Torondel B, Bell M, Cumming O, Ensink J, Freeman M, Jenkins M, Odagiri M, Ray S, Sinha A, Suar M, Schmidt WP | display-authors = 6 | title = Effectiveness of a rural sanitation programme on diarrhoea, soil-transmitted helminth infection, and child malnutrition in Odisha, India: a cluster-randomised trial | journal = The Lancet. Global Health | volume = 2 | issue = 11 | pages = e645-53 | date = November 2014 | pmid = 25442689 | doi = 10.1016/S2214-109X(14)70307-9 | doi-access = free | url = https://researchonline.lshtm.ac.uk/id/eprint/2026643/1/Effectiveness%20of%20a%20rural%20sanitation%20programme_GOLD%20VoR.pdf }}</ref> The practice is common where ] infrastructure and services are not available. Even if toilets are available, ] efforts may still be needed to promote the use of toilets. | |||
Open defecation can pollute the environment and cause health problems. High levels of open defecation are linked to high ], poor ], ], and large disparities between rich and poor.<ref name="JMP2014">{{cite book|url=http://www.susana.org/en/resources/library/details/2036|title=Progress on drinking water and sanitation, 2014 Update|date=2014|publisher=WHO/UNICEF Joint Monitoring Programme for Water Supply and Sanitation (JMP)|isbn=9789241507240|access-date=2020-04-21|archive-date=2015-04-02|archive-url=https://web.archive.org/web/20150402115029/http://www.susana.org/en/resources/library/details/2036|url-status=dead}}</ref>{{rp|page=11}} | |||
Ending open defecation is an indicator being used to measure progress towards the ]. ] and lack of sanitation are statistically linked. Therefore, eliminating open defecation is thought to be an important part of the effort to eliminate poverty.<ref name="Ahmad">{{cite news|url=https://www.devex.com/news/how-to-eliminate-open-defecation-by-2030-84634|title=How to eliminate open defecation by 2030| vauthors = Ahmad J |date=30 October 2014|access-date=2 May 2016|website=devex}}</ref> | |||
=== Anal cleansing after defecation === | |||
{{main article|Anal hygiene}} | |||
The ] and ] may be ] after defecation with ], similar paper products, or other absorbent material. In many cultures, such as Hindu and Muslim, water is used for anal cleansing after defecation, either in addition to using toilet paper or exclusively. When water is used for anal cleansing after defecation, toilet paper may be used for drying the area afterwards. Some doctors and people who work in the science and ] fields have stated that switching to using a ] as a form of anal cleansing after defecation is both more hygienic and more environmentally friendly.<ref>{{cite news |last= Rickett |first= Oscar |date= 11 February 2018 |title= The bottom line: why it's time the bidet made a comeback |url= https://www.theguardian.com/lifeandstyle/shortcuts/2018/feb/11/the-bottom-line-why-its-time-the-bidet-made-a-comeback |work= The Guardian |access-date= 29 May 2019}}</ref> | |||
=== Mythology and tradition === | |||
]'' is a defecating figurine in Spanish ]s.]] | |||
Some peoples have culturally significant stories in which defecation plays a role. For example: | |||
*In an ] and ] legend from the island of ], ], ], the mythical girl ] defecates valuable objects.<ref>{{cite book |doi=10.1093/acref/9780195156690.001.0001 |title=The Oxford Companion to World Mythology |year=2005 |isbn=978-0-19-515669-0 }}</ref> | |||
*One of the ] (]) relates to the '']'', a ] depicting the act of defecation which appears in ]s in ] and neighbouring ]. The exact origin of the ''caganer'' is lost, but the tradition has existed since at least the 18th century.<ref name="BBC News">{{cite web|url=https://www.bbc.co.uk/news/world-europe-12059969|title=A traditional Nativity scene, Catalan-style|website=BBC News |date=23 December 2010|access-date=23 December 2010}}</ref> | |||
=== Psychology === | |||
Some aspects of ] surround the act of defecation. There is an inherent desire for privacy among humans. ] stipulated a second stage of development, the ], which centers around the release of waste from the bladder and bowels. He categorized two types: '']'' and ]. | |||
==See also== | |||
{{div col|colwidth=30em}} | |||
* '']'' | |||
* ] | |||
* ] | |||
* ] | |||
* ] | |||
* ] - a feeling of incomplete defecation | |||
* ] | |||
* '']'' | |||
* ] | |||
* ] | |||
{{div col end}} | |||
==References== | ==References== | ||
{{ |
{{Reflist|30em}} | ||
{{Reflist}} | |||
*Deeb, Benjamin (2004). "Healthy to the Core: How to Measure Effective Defecation." Greenwood Press. | |||
*Widmaier, Raff, Strang (2006). "Vanders Human Physiology, the mechanisms of body function. Chapter 15. McGraw Hill. | |||
==Further reading== | |||
* Eric P. Widmaier; Hershel Raff; Kevin T. Strang (2006). ''Vanders' Human Physiology: The Mechanisms of Body Function.'' Chapter 15. 10th ed. McGraw Hill. {{ISBN|9780071116770}}. | |||
{{toilets}} | |||
{{Authority control}} | |||
{{Wiktionary}} | |||
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Latest revision as of 00:41, 2 December 2024
Expulsion of feces from the digestive tract This article is about the bodily process. For the band, see Defecation (band).Not to be confused with defector or defalcation.
Defecation (or defaecation) follows digestion, and is a necessary process by which organisms eliminate a solid, semisolid, or liquid waste material known as feces from the digestive tract via the anus or cloaca. The act has a variety of names ranging from the common, like pooping or crapping, to the technical, e.g. bowel movement, to the obscene (shitting), to the euphemistic ("doing a number two", "dropping a deuce" or "taking a dump"), to the juvenile ("making doo-doo"). The topic, usually avoided in polite company, can become the basis for some potty humor.
Humans expel feces with a frequency varying from a few times daily to a few times weekly. Waves of muscular contraction (known as peristalsis) in the walls of the colon move fecal matter through the digestive tract towards the rectum. Undigested food may also be expelled within the feces, in a process called egestion. When birds defecate, they also expel urine and urates in the same mass, whereas other animals may also urinate at the same time, but spatially separated. Defecation may also accompany childbirth and death. Babies defecate a unique substance called meconium prior to eating external foods.
There are a number of medical conditions associated with defecation, such as diarrhea and constipation, some of which can be serious. The feces expelled can carry diseases, most often through the contamination of food. E. coli is a particular concern.
Before toilet training, human feces are most often collected into a diaper. Thereafter, in many societies people commonly defecate into a toilet. However, open defecation, the practice of defecating outside without using a toilet of any kind, is still widespread in some developing countries. Some people defecate into the ocean. First world countries use sewage treatment plants and/or on-site treatment.
Description
Defecation postures of mammalsPhysiology
Further information: Rectum § FunctionThe rectum ampulla stores fecal waste (also called stool) before it is excreted. As the waste fills the rectum and expands the rectal walls, stretch receptors in the rectal walls stimulate the desire to defecate. This urge to defecate arises from the reflex contraction of rectal muscles, relaxation of the internal anal sphincter, and an initial contraction of the skeletal muscle of the external anal sphincter. If the urge is not acted upon, the material in the rectum is often returned to the colon by reverse peristalsis, where more water is absorbed and the feces are stored until the next mass peristaltic movement of the transverse and descending colon.
When the rectum is full, an increase in pressure within the rectum forces apart the walls of the anal canal, allowing the fecal matter to enter the canal. The rectum shortens as material is forced into the anal canal and peristaltic waves push the feces out of the rectum. The internal and external anal sphincters along with the puborectalis muscle allow the feces to be passed by muscles pulling the anus up over the exiting feces.
Voluntary and involuntary control
The external anal sphincter is under voluntary control whereas the internal anal sphincter is involuntary. In infants, the defecation occurs by reflex action without the voluntary control of the external anal sphincter. Defecation is voluntary in adults. Young children learn voluntary control through the process of toilet training. Once trained, loss of control, called fecal incontinence, may be caused by physical injury, nerve injury, prior surgeries (such as an episiotomy), constipation, diarrhea, loss of storage capacity in the rectum, intense fright, inflammatory bowel disease, psychological or neurological factors, childbirth, or death.
Sometimes, due to the inability to control one's bowel movement or due to excessive fear, defecation (usually accompanied by urination) occurs involuntarily, soiling a person's undergarments. This may cause significant embarrassment to the person if this occurs in the presence of other people or a public place.
Posture
Main article: Human defecation posturesThe positions and modalities of defecation are culture-dependent. Squat toilets are used by the vast majority of the world, including most of Africa, Asia, and the Middle East. The use of sit-down toilets in the Western world is a relatively recent development, beginning in the 19th century with the advent of indoor plumbing.
Disease
Regular bowel movements determine the functionality and the health of the alimentary tracts in human body. Defecation is the most common regular bowel movement which eliminates waste from the human body. The frequency of defecation is hard to identify, which can vary from daily to weekly depending on individual bowel habits, the impact from the environment and genetic. If defecation is delayed for a prolonged period the fecal matter may harden, resulting in constipation. If defecation occurs too fast, before excess liquid is absorbed, diarrhea may occur. Other associated symptoms can include abdominal bloating, abdominal pain, and abdominal distention. Disorders of the bowel can seriously impact quality of life and daily activities. The causes of functional bowel disorder are multifactorial, and dietary habits such as food intolerance and low fiber diet are considered to be the primary factors.
Constipation
Main article: ConstipationConstipation, also known as defecatory dysfunction, is difficulty experienced when passing stools. It is one of the most notable alimentary disorders that affects different age groups in the population. Common constipation is associated with abdominal distention, pain or bloating. Research has revealed that chronic constipation complied with higher risk of cardiovascular events such as coronary heart disease and ischemic stroke, while associating with an increasing risk of mortality. Besides dietary factors, psychological traumas and 'pelvic floor disorders' can also cause chronic constipation and defecatory disorder respectively. Multiple interventions, including physical activities, 'high-fibre diet', probiotics and drug therapies can be widely and efficiently used to treat constipation and defecatory disorder.
Inflammatory bowel diseases
Main article: Inflammatory bowel diseaseInflammatory disease is characterized as long-lasting, chronic inflammation throughout the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two universal types of inflammatory bowel disease that have been studied over a century. They are closely related to different environmental risk factors, family genetics, and lifestyle choices such as smoking. Crohn's disease has been found to be related to immune disorders particularly. Different levels of cumulative intestinal injuries can cause different complications, such as fistulae, damage of bowel function, symptom recurrence, disability, etc. Patients can be children or adults. Recent research shows that immunodeficiency and monogenic disorders are the causes in young patients with inflammatory bowel diseases.
Common symptoms of inflammatory bowel diseases differ by the infection level, but may include severe abdominal pain, diarrhea, fatigue, and unexpected weight loss. Crohn's disease can lead to infection of any part of the digestive tract, including ileum to anus. Internal manifestations include diarrhea, abdomen pain, fever, chronic anaemia, etc. External manifestations include impact on skin, joints, eyes, and liver. Significantly reduced microbiota diversity inside the gastrointestinal tract can also be observed. Ulcerative colitis mainly affects the function of the large bowel, and its incidence rate is three times greater than that of Crohn's disease. In terms of clinical features, over 90 percent of patients exhibit constant diarrhea, rectal bleeding, softer stool, mucus in the stool, tenesmus, and abdominal pain. The symptoms may continue for around 6 weeks or even longer.
The inflammatory bowel diseases could be effectively treated by 'pharmacotherapies' to relieve and maintain the symptoms, which showed in 'mucosal healing' and symptoms elimination. However, an optimal therapy for curing both inflammatory diseases are still under research due to the heterogeneity in clinical feature. Although both UC and CD are sharing similar symptoms, the medical treatment of them are distinctively different. Dietary treatment can benefit for curing CD by increase the dietary zinc and fish intake, which is related to mucosal healing of the bowel. Treatments vary from drug treatment to surgery based on the active level of the CD. UC can also be relieved by using immunosuppressive therapy for mild to moderate disease level and application of biological agents for severe cases.
Irritable bowel syndrome
Main article: Irritable bowel syndromeIrritable bowel syndrome is diagnosed as an intestinal disorder with chronic abdominal pain and inconsistency in form of stool, and is a common bowel disease that can be easily diagnosed in modern society. The variation in incident rate can be explained by different diagnostic criteria in different countries, with the 18–34 age group being recognized as the high frequency incident group. The definite cause of irritable bowel syndrome remains a mystery; however, it has been found to relate to multiple factors, such as 'alternation of mood and pressure, sleep disorders, food triggers, changing of dysbiosis and even sexual dysfunction'. One third of irritable bowel syndrome patients has family history with the disease suggesting that genetic predisposition could be a significant cause for irritable bowel syndrome.
Patients with irritable bowel syndrome commonly experience abdominal pain, changes to stool form, recurrent abdominal bloating and gas, co-morbid disorders and alternation in bowel habits that caused diarrhea or constipation. However, anxiety and tension can also be detected, although patients with irritable bowel disease seem healthy. Apart from these typical symptoms, rectal bleeding, unexpected weight loss and increased inflammatory markers require further medical examination and investigation.
Treatment for irritable bowel disease is multimodal. Dietary intervention and pharmacotherapies can both relieve the symptoms to a certain degree. Avoiding allergic food groups can be beneficial by reducing fermentation in the digestive tract and gas production, hence effectively alleviating abdominal pain and bloating. Drug interventions, such as laxatives, loperamide, and lubiprostone are applied to relieve intense symptoms including diarrhea, abdominal pain and constipation. Psychological treatment, dietary supplements and gut-focused hypnotherapy are recommended for targeting depression, mood disorders and sleep disturbance.
Bowel obstruction
Main article: Bowel obstructionBowel obstruction is a bowel condition which is a blockage that can be found in both the small intestines and large intestines. Increase of contractions can relieve blockages; however, continuous contractions with decreasing functionality may lead to terminated mobility of the small intestines, which then forms the obstruction. At the same time, the lack of contractility encourages liquid and gas accumulation. and "electrolyte disturbances". Small bowel obstruction can result in severe renal damage and hypovolemia. while evolving into "mucosal ischemia and perforation". Patients with small bowel obstruction were found to experience constipation, strangulation and abdominal pain and vomiting. Surgical intervention is primarily used to cure severe small bowel obstruction condition. Nonoperative therapy included nasogastric tube decompression, water-soluble-contrast medium process or symptomatic management can be applied to treat less severe symptoms
According to research, large bowel obstruction is less common than small bowel obstruction, but is still associated with a high mortality rate. Large bowel obstruction, also known as colonic obstruction, includes acute colonic obstruction, where a blockage is formed in the colon. Colonic obstructions frequently occur within the elder population, often accompanied by significant 'comorbidities'. Although colonic malignancy is revealed as the major cause of the colonic obstruction, volvulus has also been founded as a secondary common cause around the world. In addition, lower mobility, unhealthy mentality and restricted living environment are also listed as risk factors. Surgery and colonic stent placements are widely applied for curing colonic obstructions.
Other
Attempting forced expiration of breath against a closed airway (the Valsalva maneuver) is sometimes practiced to induce defecation while on a toilet. This contraction of expiratory chest muscles, diaphragm, abdominal wall muscles, and pelvic diaphragm exerts pressure on the digestive tract. Ventilation at this point temporarily ceases as the lungs push the chest diaphragm down to exert the pressure. Cardiac arrest and other cardiovascular complications can in rare cases occur due to attempting to defecate using the Valsalva maneuver. Valsalva retinopathy is another pathological syndrome associated with the Valsalva maneuver. Thoracic blood pressure rises and as a reflex response the amount of blood pumped by the heart decreases. Death has been known to occur in cases where defecation causes the blood pressure to rise enough to cause the rupture of an aneurysm or to dislodge blood clots (see thrombosis). Also, in releasing the Valsalva maneuver blood pressure falls; this, coupled with standing up quickly to leave the toilet, can result in a blackout.
Society and culture
Open defecation
Main article: Open defecationOpen defecation is the human practice of defecating outside (in the open environment) rather than into a toilet. People may choose fields, bushes, forests, ditches, streets, canals or other open space for defecation. They do so because either they do not have a toilet readily accessible or due to traditional cultural practices. The practice is common where sanitation infrastructure and services are not available. Even if toilets are available, behavior change efforts may still be needed to promote the use of toilets.
Open defecation can pollute the environment and cause health problems. High levels of open defecation are linked to high child mortality, poor nutrition, poverty, and large disparities between rich and poor.
Ending open defecation is an indicator being used to measure progress towards the Sustainable Development Goal Number 6. Extreme poverty and lack of sanitation are statistically linked. Therefore, eliminating open defecation is thought to be an important part of the effort to eliminate poverty.
Anal cleansing after defecation
Main article: Anal hygieneThe anus and buttocks may be cleansed after defecation with toilet paper, similar paper products, or other absorbent material. In many cultures, such as Hindu and Muslim, water is used for anal cleansing after defecation, either in addition to using toilet paper or exclusively. When water is used for anal cleansing after defecation, toilet paper may be used for drying the area afterwards. Some doctors and people who work in the science and hygiene fields have stated that switching to using a bidet as a form of anal cleansing after defecation is both more hygienic and more environmentally friendly.
Mythology and tradition
Some peoples have culturally significant stories in which defecation plays a role. For example:
- In an Alune and Wemale legend from the island of Seram, Maluku Province, Indonesia, the mythical girl Hainuwele defecates valuable objects.
- One of the traditions of Catalonia (Spain) relates to the caganer, a figurine depicting the act of defecation which appears in nativity scenes in Catalonia and neighbouring areas with Catalan culture. The exact origin of the caganer is lost, but the tradition has existed since at least the 18th century.
Psychology
Some aspects of psychology surround the act of defecation. There is an inherent desire for privacy among humans. Freud stipulated a second stage of development, the Anal Stage, which centers around the release of waste from the bladder and bowels. He categorized two types: anal retentive and anal expulsive.
See also
- Artist's Shit
- Ecological sanitation
- Hemorrhoid
- Human waste
- Improved sanitation
- Rectal tenesmus - a feeling of incomplete defecation
- Reuse of human excreta
- Shit
- Sustainable sanitation
- Urination
References
- "The Basics of Constipation". WebMD. Retrieved 2020-05-26.
- WHO and UNICEF (2017) Progress on Drinking Water, Sanitation and Hygiene: 2017 Update and SDG Baselines. Geneva: World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF), 2017
- "Bowel Function Anatomy" (PDF). University of Michigan Health System. Retrieved 2021-05-19.
The levator ani and the puborectalis need to coordinate properly in order to expel contents from the anal canal.
- "Fecal incontinence - Causes". Mayo Foundation for Medical Education and Research. Retrieved 9 September 2014.
- Kira, Alexander (1976). The Bathroom (2. ed. New and expanded ed.). New York, N.Y.: Viking Pr. pp. 115–116. ISBN 978-0-670-00612-0.
- C. Singer; E Holmyard; A Hall; T. Williams, eds. (1958) . A History of Technology. Vol. IV: The Industrial Revolution, 1750–1850. Oxford Clarendon Press. pp. 507–508. OCLC 886036895.
- Nath, Preetam; Singh, Shivaram Prasad (2017). "Defecation and Stools in Vegetarians". Vegetarian and Plant-Based Diets in Health and Disease Prevention. pp. 473–481. doi:10.1016/B978-0-12-803968-7.00026-5. ISBN 978-0-12-803968-7.
- NIH. "Bowel Movement". MedlinePlus. Retrieved 13 September 2014.
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- Grace, Sandra; Barnes, Larisa; Reilly, Wayne; Vlass, Ann; de Permentier, Patrick (December 2018). "An integrative review of dietetic and naturopathic approaches to functional bowel disorders". Complementary Therapies in Medicine. 41: 67–80. doi:10.1016/j.ctim.2018.09.004. PMID 30477867. S2CID 53768740.
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- Hod, Keren; Ringel, Yehuda (February 2016). "Probiotics in functional bowel disorders". Best Practice & Research Clinical Gastroenterology. 30 (1): 89–97. doi:10.1016/j.bpg.2016.01.003. PMID 27048900.
- Fiocchi, Claudio (1998). "Inflammatory bowel disease: Etiology and pathogenesis". Gastroenterology. 115 (1): 182–205. doi:10.1016/S0016-5085(98)70381-6. PMID 9649475.
- ^ Baumgart, Daniel C; Sandborn, William J (November 2012). "Crohn's disease". The Lancet. 380 (9853): 1590–1605. doi:10.1016/S0140-6736(12)60026-9. PMID 22914295. S2CID 18672997.
- Agrawal, Manasi; Colombel, Jean-Frederic (2019). "Treat-to-Target in Inflammatory Bowel Diseases, What Is the Target and How Do We Treat?". Gastrointestinal Endoscopy Clinics of North America. 29 (3): 421–436. doi:10.1016/j.giec.2019.02.004. PMID 31078245. S2CID 132251418.
- Kelsen, Juridth R; Russo, Pierre; Sullivan, Kathleen E (February 2019). "Early-Onset Inflammatory Bowel Disease". Immunology and Allergy Clinics of North America. 39 (1): 63–79. doi:10.1016/j.iac.2018.08.008. PMC 6954002. PMID 30466773.
- Mak, Wing Yan; Hart, Alisa L; Ng, Siew C (2019). "Crohn's disease". Medicine. 47 (6): 377–387. doi:10.1016/j.mpmed.2019.03.007. S2CID 242228134.
- ^ Steed, Helen (May 2019). "Ulcerative colitis". Medicine. 47 (6): 371–376. doi:10.1016/j.mpmed.2019.03.001. S2CID 243328622.
- ^ Jeong, Dong Yeon; Kim, Seung; Son, Min Ji; Son, Chei Yun; Kim, Jong Yeob; Kronbichler, Andreas; Lee, Keum Hwa; Shin, Jae II (May 2019). "Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review". Autoimmunity Reviews. 18 (5): 439–454. doi:10.1016/j.autrev.2019.03.002. PMID 30844556. S2CID 73466469.
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Further reading
- Eric P. Widmaier; Hershel Raff; Kevin T. Strang (2006). Vanders' Human Physiology: The Mechanisms of Body Function. Chapter 15. 10th ed. McGraw Hill. ISBN 9780071116770.