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{{Short description|Chemical compound}}
{{more citations needed|date=January 2021}}
{{Drugbox {{Drugbox
| Watchedfields = changed
| verifiedrevid = 415659048 | verifiedrevid = 443864211
| IUPAC_name = 7-Hydroxy-4-methylchromen-2-one | IUPAC_name = 7-Hydroxy-4-methylchromen-2-one
| image = Hymecromone.png | image = Hymecromone.png
| synonyms = 4-Methylumbelliferone
<!--Clinical data-->
| CASNo_Ref = {{cascite|correct|CAS}}
| tradename =
| Drugs.com = {{drugs.com|international|hymecromone}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration =
<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 90-33-5
| ATC_prefix = A05
| ATC_suffix = AX02
| PubChem = 5280567
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB07118
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4444190 | ChemSpiderID = 4444190
| UNII_Ref = {{fdacite|correct|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3T5NG4Q468 | UNII = 3T5NG4Q468
| KEGG_Ref = {{keggcite|correct|kegg}}
| InChI = 1/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3
| KEGG = D00170
| smiles = O=C/2Oc1cc(O)ccc1\C(=C\2)C
| ChEBI_Ref = {{ebicite|correct|EBI}}
| InChIKey = HSHNITRMYYLLCV-UHFFFAOYAZ
| ChEBI = 17224
| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 12208 | ChEMBL = 12208
<!--Chemical data-->
| C=10 | H=8 | O=3
| smiles = CC1=CC(=O)OC2=C1C=CC(=C2)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3 | StdInChI = 1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = HSHNITRMYYLLCV-UHFFFAOYSA-N | StdInChIKey = HSHNITRMYYLLCV-UHFFFAOYSA-N
| synonyms = 4-Methylumbelliferone
| CAS_number = 90-33-5
| ATC_prefix = A05
| ATC_suffix = AX02
| PubChem = 5280567
| DrugBank =
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00170
| C=10|H=8|O=3
| molecular_weight = 176.17 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category=
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration =
}} }}


'''Hymecromone''' (4-methylumbelliferone) is a drug used in ] therapy. It is used as ] and ] drugs and as a standard for the fluorometric determination of enzyme activity. '''Hymecromone''' (4-methylumbelliferone) is a drug used in ] therapy. It is used as ] and ] drugs and as a standard for the fluorometric determination of enzyme activity.<ref name="pmid7390976">{{cite journal | vauthors = Yang Y, Hamaguchi K | title = Hydrolysis of 4-methylumbelliferyl N-acetyl-chitotrioside catalyzed by hen and turkey lysozymes. pH dependence of the kinetics constants | journal = Journal of Biochemistry | volume = 87 | issue = 4 | pages = 1003–14 | date = April 1980 | pmid = 7390976 | doi = 10.1093/oxfordjournals.jbchem.a132833 }}</ref>


Hymecromone is crystalline solid with a melting point of 194-195 °C. It is soluble in ] and ]. Hymecromone is a crystalline solid with a melting point of 194–195&nbsp;°C. It is soluble in ] and ].

==See also==
*]
*]

==References==
{{Reflist}}


{{Bile and liver therapy}} {{Bile and liver therapy}}
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] ]
] ]


{{gastrointestinal-drug-stub}}


{{gastrointestinal-drug-stub}}
]
]

Latest revision as of 16:14, 21 October 2024

Chemical compound
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Hymecromone" – news · newspapers · books · scholar · JSTOR (January 2021) (Learn how and when to remove this message)
Pharmaceutical compound
Hymecromone
Clinical data
Other names4-Methylumbelliferone
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 7-Hydroxy-4-methylchromen-2-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.806 Edit this at Wikidata
Chemical and physical data
FormulaC10H8O3
Molar mass176.171 g·mol
3D model (JSmol)
SMILES
  • CC1=CC(=O)OC2=C1C=CC(=C2)O
InChI
  • InChI=1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3
  • Key:HSHNITRMYYLLCV-UHFFFAOYSA-N
  (verify)

Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity.

Hymecromone is a crystalline solid with a melting point of 194–195 °C. It is soluble in methanol and glacial acetic acid.

See also

References

  1. Yang Y, Hamaguchi K (April 1980). "Hydrolysis of 4-methylumbelliferyl N-acetyl-chitotrioside catalyzed by hen and turkey lysozymes. pH dependence of the kinetics constants". Journal of Biochemistry. 87 (4): 1003–14. doi:10.1093/oxfordjournals.jbchem.a132833. PMID 7390976.
Bile and liver therapy (A05)
Bile therapy
Liver therapy
Types of coumarins
Aglycones
O-Methylated
Glycosides
Derivatives
Furanocoumarins
Aglycones
O-Methylated
Furanocoumarin glycosides
Meroterpene furanocoumarin ether
Oligomers
Synthetic


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