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{{Short description|Chemical compound}}
{{drugbox
{{Drugbox
| Verifiedfields = changed
⚫ | verifiedrevid = 443400546
⚫ | UNII_Ref = {{fdacite|changed|FDA}}
⚫ | IUPAC_name =
⚫ | image = <!--Almagate.svg-->

<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|almagate}}
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category =
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫ | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | legal_status =
⚫ | routes_of_administration = Oral

<!--Pharmacokinetic data-->
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =

<!--Identifiers-->
⚫ | CAS_number = 66827-12-1
⚫ | ATC_prefix = A02
⚫ | ATC_suffix = AD03
⚫ | PubChem = 71749
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫ | DrugBank =
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | ChemSpiderID = 64792
⚫ | UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 568Z59H7ZJ | UNII = 568Z59H7ZJ
⚫ | KEGG_Ref = {{keggcite|correct|kegg}}
⚫ | verifiedrevid = 399496073
⚫ | KEGG = D02821
⚫ | IUPAC_name =

⚫ | image = <!--Almagate.svg-->
<!--Chemical data-->
| InChI = 1/CH2O3.Al.3Mg.9H2O/c2-1(3)4;;;;;;;;;;;;;/h(H2,2,3,4);;;;;9*1H2/q;+3;3*+2;;;;;;;;;/p-9
⚫ | chemical_formula = Al<sub>2</sub>Mg<sub>6</sub>(OH)<sub>14</sub>(CO<sub>3</sub>)<sub>2</sub> · 4 H<sub>2</sub>O
⚫ | molecular_weight = 314.99
| molecular_weight_comment = g/mol
| smiles = .......C()=O.....O.O | smiles = .......C()=O.....O.O
| InChIKey = MTEOMEWVDVPTNN-MBBIINEJAH
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/CH2O3.Al.3Mg.9H2O/c2-1(3)4;;;;;;;;;;;;;/h(H2,2,3,4);;;;;9*1H2/q;+3;3*+2;;;;;;;;;/p-9 | StdInChI = 1S/CH2O3.Al.3Mg.9H2O/c2-1(3)4;;;;;;;;;;;;;/h(H2,2,3,4);;;;;9*1H2/q;+3;3*+2;;;;;;;;;/p-9
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MTEOMEWVDVPTNN-UHFFFAOYSA-E | StdInChIKey = MTEOMEWVDVPTNN-UHFFFAOYSA-E
⚫ | CAS_number = 66827-12-1
⚫ | ATC_prefix = A02
⚫ | ATC_suffix = AD03
⚫ | PubChem = 71749
⚫ | DrugBank =
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | ChemSpiderID = 64792
⚫ | KEGG_Ref = {{keggcite|changed|kegg}}
⚫ | KEGG = D02821
⚫ | chemical_formula = Al<sub>2</sub>Mg<sub>6</sub>(OH)<sub>14</sub>(CO<sub>3</sub>)<sub>2</sub> · 4 H<sub>2</sub>O
⚫ | molecular_weight = 314.99 g/mol
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category=
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫ | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | legal_status =
⚫ | routes_of_administration = Oral
}} }}
'''Almagate''' (trade name '''Almax''') is an ]- and ]-containing ]. It was first described in 1984.<ref>{{cite pmid|6548918}}</ref><ref>{{cite pmid|6439224}}</ref> '''Almagate''' (trade name '''Almax''') is an ]- and ]-containing ]. It was first described in 1984.<ref>{{cite journal | vauthors = Moragues J, Beneyto JE, Fábregas JL, Spickett RG | title = Characterization of a new crystalline synthetic gastric antacid, almagate | journal = Arzneimittel-Forschung | volume = 34 | issue = 10A | pages = 1346–9 | year = 1984 | pmid = 6548918 | url = http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+21645-51-2 | format = Free full text }}</ref><ref>{{cite journal | vauthors = Beneyto JE, Fábregas JL, Moragues J, Spickett RG | title = Evaluation of a new antacid, almagate | journal = Arzneimittel-Forschung | volume = 34 | issue = 10A | pages = 1350–4 | year = 1984 | pmid = 6439224 | url = http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+21645-51-2 | format = Free full text }}</ref>


== Adverse effects == == Adverse effects ==
Almagate is well tolerated. In a ], the most common ]s were diarrhea and nausea.<ref>{{cite pmid|6548926}}</ref> Almagate is well tolerated. In a ], the most common ]s were diarrhea and nausea.<ref>{{cite journal | vauthors = Suau A, Dominguez Martin A, Ferrando Cucarella J, Juncosa Iglesias L, Muñoz Benitez J, Nieto Calvet M, Pérez Gieb J, Pérez Mota A, Pineda Garcia A, Rodriguez Sanchez E | display-authors = 6 | title = Treatment of gastric pyrosis with almagate in patients with and without endoscopically demonstrable duodenal ulcer. A multicentre clinical trial | journal = Arzneimittel-Forschung | volume = 34 | issue = 10A | pages = 1380–3 | year = 1984 | pmid = 6548926 | url = http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+21645-51-2 | format = Free full text }}</ref>


== References == == References ==
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] ]
] ]



{{gastrointestinal-drug-stub}} {{gastrointestinal-drug-stub}}

]

Latest revision as of 07:22, 31 December 2023

Chemical compound Pharmaceutical compound
Almagate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaAl2Mg6(OH)14(CO3)2 · 4 H2O
Molar mass314.99 g/mol
3D model (JSmol)
SMILES
  • .......C()=O.....O.O
InChI
  • InChI=1S/CH2O3.Al.3Mg.9H2O/c2-1(3)4;;;;;;;;;;;;;/h(H2,2,3,4);;;;;9*1H2/q;+3;3*+2;;;;;;;;;/p-9
  • Key:MTEOMEWVDVPTNN-UHFFFAOYSA-E
  (verify)

Almagate (trade name Almax) is an aluminium- and magnesium-containing antacid. It was first described in 1984.

Adverse effects

Almagate is well tolerated. In a clinical trial, the most common adverse effects were diarrhea and nausea.

References

  1. Moragues J, Beneyto JE, Fábregas JL, Spickett RG (1984). "Characterization of a new crystalline synthetic gastric antacid, almagate" (Free full text). Arzneimittel-Forschung. 34 (10A): 1346–9. PMID 6548918.
  2. Beneyto JE, Fábregas JL, Moragues J, Spickett RG (1984). "Evaluation of a new antacid, almagate" (Free full text). Arzneimittel-Forschung. 34 (10A): 1350–4. PMID 6439224.
  3. Suau A, Dominguez Martin A, Ferrando Cucarella J, Juncosa Iglesias L, Muñoz Benitez J, Nieto Calvet M, et al. (1984). "Treatment of gastric pyrosis with almagate in patients with and without endoscopically demonstrable duodenal ulcer. A multicentre clinical trial" (Free full text). Arzneimittel-Forschung. 34 (10A): 1380–3. PMID 6548926.
Drugs for acid related disorders: Antacids (A02A)
Magnesium (increases motility)
Aluminium (decreases motility)
Calcium
Sodium
Combinations and complexes
of aluminium, calcium and magnesium
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