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{{Short description|Combination drug}}
{{Unreferenced|date=February 2011}}
{{Use dmy dates|date=December 2024}}

{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Drugbox
{{Infobox drug
| Watchedfields = changed
| verifiedrevid = 408681660 | verifiedrevid = 451334370

⚫ <!--Combo data-->
| type = combo | type = combo
⚫ | component1 = Trimethoprim
⚫ | class1 = ] ]
| component2 = Polymyxin
⚫ | class2 = ]


<!--Clinical data--> <!-- Combo data -->
| tradename = | component1 = Polymyxin B
⚫ | class1 = ]
| licence_EU = <!-- EMEA requires brand name -->
⚫ | component2 = Trimethoprim
| licence_US =
⚫ | class2 = ] ]

⚫ <!-- Clinical data -->
| tradename = Polytrim
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US =
| pregnancy_category = | pregnancy_category =
⚫ | dependency_liability =
⚫ | routes_of_administration = ]s
⚫ | ATC_prefix = S01
⚫ | ATC_suffix = AA30

| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = | legal_US = Rx only
| legal_US_comment = <ref name="Polytrim FDA label">{{cite web | title=Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) Sterile | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=652205 | access-date=6 December 2024}}</ref>
| legal_status = | legal_status =
⚫ | dependency_liability =
⚫ | routes_of_administration = ]s


<!--Identifiers--> <!--Identifiers-->
| CAS_number = 103172-75-4
⚫ | ATC_prefix = S01
⚫ | ATC_suffix = AA30
| PubChem = 24848162 | PubChem = 24848162
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref =
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = | KEGG = D11086
| synonyms =


<!--Chemical data--> <!--Chemical data-->
}} }}
⚫ The ] combination ''']/]''' (], trade name '''Polytrim''') is an ] solution for topical ] use in the treatment of ] ] ] and ].


⚫ '''Polymyxin B/trimethoprim''', sold under the brand name '''Polytrim''' is an ] solution for topical ] use in the treatment of ] ] ] and ].<ref name="Polytrim FDA label" />
⚫ ]

⚫ ]
In 2022, it was the 252nd most commonly prescribed medication in the United States, with more than 1{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Polymyxin B; Trimethoprim Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/PolymyxinBTrimethoprim | access-date = 30 August 2024 }}</ref>
⚫ ]

]
== Medical uses ==
Polymyxin B/trimethoprim is ] in the treatment of surface ocular bacterial infections,<ref name="Yolton_1992">{{cite journal | vauthors = Yolton DP | title = New antibacterial drugs for topical ophthalmic use | journal = Optometry Clinics | volume = 2 | issue = 4 | pages = 59–72 | date = 1992 | pmid = 1286241 | doi = | url = }}</ref> including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: '']'', '']'', '']'', '']'', '']'', and '']''.<ref name="Polytrim FDA label" />

==References==
{{Reflist}}

{{Portal bar | Medicine}}
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{{DEFAULTSORT:Polymyxin B Trimethoprim}}
⚫ ]
⚫ ]
⚫ ]
] ]
] ]
] ]




Latest revision as of 13:19, 27 December 2024

Combination drug

Pharmaceutical compound
Trimethoprim/polymyxin B
Combination of
Polymyxin BCell envelope antibiotic
TrimethoprimNucleic acid inhibitor antibiotic
Clinical data
Trade namesPolytrim
Routes of
administration		Topical eye drops
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG
CompTox Dashboard (EPA)
  (verify)

Polymyxin B/trimethoprim, sold under the brand name Polytrim is an antimicrobial solution for topical ophthalmic use in the treatment of acute bacterial conjunctivitis and blepharoconjunctivitis.

In 2022, it was the 252nd most commonly prescribed medication in the United States, with more than 1 million prescriptions.

Medical uses

Polymyxin B/trimethoprim is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae, and Pseudomonas aeruginosa.

References

  1. ^ "Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) Sterile". DailyMed. Retrieved 6 December 2024.
  2. "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  3. "Polymyxin B; Trimethoprim Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
  4. Yolton DP (1992). "New antibacterial drugs for topical ophthalmic use". Optometry Clinics. 2 (4): 59–72. PMID 1286241.
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