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== Meta analysis about research outcome related to industry funding ==
== This article seems biased. (I am 76.171.244.110) ==

for example here's an opinionated statement:
"These health risk claims have been examined and '''debunked''' by numerous scientific research projects" Rather then saying "this is fact" please present the facts or word it more appropriately like, "These health risks claims have been examined by numerous scientific research projects, the majority of which concluded these claims to be false." but please take into account valid evidence when deciding upon the majority: http://www.cspinet.org/reports/chemcuisine.htm#aspartame The center of science for the public interest, a reputable non-profit organization concluded that aspartame is one of the few food additives that should be completely avoided due with the following statement relevant to their decision: "The bottom line is that three independent studies have found that consumption of aspartame causes cancer in rodents. However, the questions raised by government and industry reviewers about this important food additive can only be solved by new reliable, high-quality studies by other independent scientists." <span style="font-size: smaller;" class="autosigned">— Preceding ] comment added by ] (]) 09:39, 3 January 2013 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
:This has been discussed extensively in the past. There have been isolated studies that showed aspartame might cause cancer in rodents, but they have not been replicated and are ignored by the scientific community, so we cannot give any credence to claims based on their results. ] (]) 10:28, 3 January 2013 (UTC)
::"discussed extensively in the past" is not on the talk page, why don't you provide some references? <span style="font-size: smaller;" class="autosigned">— Preceding ] comment added by ] (]) 14:41, 3 January 2013 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
:::The first discussion thread on this page is about POV issues and if you go to the top of the page you can read through 9 pages of archived discussions mostly raising the same issues. ] (]) 14:50, 3 January 2013 (UTC)
::::Ah, my apologies, I missed that because it was titled "michael newton reference". I would still like to see more information in this article though, particularly links to the data used in the ramazzini studies (the data that was provided). I have to wonder where the rise in carcinogenesis came from in the rats used in the ramazzini studies, even though they used some flawed practices that doesn't seem like it's basis enough to throw their entire study out the window, I think the data should be linked to in the article. {{unsigned|66.74.177.144}}

:::::Did they release data to the public? I'm not aware of any. --] (]) 12:44, 4 January 2013 (UTC)
::::::Even if the raw data are out there I don't think linking to them is a good idea without expert commentary. I think it would violate ]. ] (]) 13:10, 4 January 2013 (UTC)

:::::::You're right, I was just curious. I think they didn't even give EFSA and FDA all their data so the suggestion that they released data to the public was surprising. --] (]) 13:19, 4 January 2013 (UTC)
::::::::Fair enough. In my profession you are supposed to keep your raw data for 7 years, and give them to anyone who asks, not sure how it works in other sciences. ] (]) 13:51, 4 January 2013 (UTC)

== On Betty Martini's "Conspiracy Theory" ==

This article states that "critics such as activist Betty Martini have promoted claims, undocumented in the medical literature, that numerous health risks (such as multiple sclerosis, systemic lupus, methanol toxicity, blindness, spasms, shooting pains, seizures, headaches, depression, anxiety, memory loss, birth defects and death) are associated with the consumption of aspartame in normal doses. ... Betty Martini's widely circulated conspiracy theory. Her undocumented claims are still repeated by thousands of self-published Web sites."
This is a false claim. Her claims come from FOIA requests like the following:
1) The following FDA report received via FOIA request on aspartame symptoms - cynically, on the upper right hand corner of the fourth page, it states, "92 documented symptoms on the FDA report - from coma and seizures to blindness and death": http://www.mpwhi.com/92_aspartame_symptoms.pdf

2) The following FDA report showing aspartame toxicity, including data omitted from the standard rhetoric that pushed the product into the market, the last part beginning at p. 81, the result of a FOIA request by Dr. John Olney, is important, as it shows discrepancies between stated and actual data, and obfuscation on the part of Searle (and poor quality controls), and how this was kept under wraps by the FDA: http://www.dorway.com/bresslercomplete.pdf

Many studies also show toxic effects from Aspartame. From them we find that:

Artificial sweetener consumption is associated with urinary tract tumors: http://www.ncbi.nlm.nih.gov/pubmed/18495230

Aspartame may be linked to increasing brain cancer rates: http://www.ncbi.nlm.nih.gov/pubmed/8939194

Consumption of greater than 2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women: http://www.ncbi.nlm.nih.gov/pubmed/20884773

In men, greater than 1 daily serving of diet soda increased risks of non-Hodgkin lymphoma and multiple myleoma: http://www.ncbi.nlm.nih.gov/pubmed/23097267

The elimination of MSG and Aspartame from the diets of patients with fibromyalgia is a successful treatment option: http://www.ncbi.nlm.nih.gov/pubmed/11408989

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice: http://www.ncbi.nlm.nih.gov/pubmed/20886530

Aspartame affects genes associated with cancer and may increase gene expression in organs with a high proliferation rate (even at the recommended daily maximum dose): http://www.ncbi.nlm.nih.gov/pubmed/17354619

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males:http://www.ncbi.nlm.nih.gov/pubmed/22509243

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts: http://www.ncbi.nlm.nih.gov/pubmed/9714421

Aspartame intake corresponding to common doses results in signs of neurotoxicity in rats:http://www.ncbi.nlm.nih.gov/pubmed/18343556

Aspartame is associated with neurological dysfunction: http://www.ncbi.nlm.nih.gov/pubmed/17673349

Aspartame produces methanol as a metabolite, which can be converted into the cytotoxic chemicals formaledhyde and formate: http://www.ncbi.nlm.nih.gov/pubmed/11991085

This important one - Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation: http://www.ncbi.nlm.nih.gov/pubmed/22922192

Life-span exposure to low doses of aspartame beginning during prenatal life increases leukemia and lymphoma rates in rats: http://www.ncbi.nlm.nih.gov/pubmed/17805418

Long term consumption of aspartame causes liver injury and oxidative stress in the rat liver:http://www.ncbi.nlm.nih.gov/pubmed/21376768

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity:http://www.ncbi.nlm.nih.gov/pubmed/16352620

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels: http://www.ncbi.nlm.nih.gov/pubmed/23088901

Aspartame contains 11% methanol by weight, which converts to formaldehyde in organs other than the liver: http://www.ncbi.nlm.nih.gov/pubmed/19896282

Aspartame is broken down into formaldehyde in various tissues and may contribute to migraines: http://www.ncbi.nlm.nih.gov/pubmed/18627677

Aspartame may be associated with certain mental disorders, compromised learning and emotional functioning: http://www.ncbi.nlm.nih.gov/pubmed/17684524

Aspartame metabolites have an adverse effect on human red blood cell enzyme activity: http://www.ncbi.nlm.nih.gov/pubmed/16129618

Aspartame bioassay findings portend human cancer hazards: http://www.ncbi.nlm.nih.gov/pubmed/18085058

Individuals with mood disorders are particularly vulnerable to adverse effects of aspartame: http://www.ncbi.nlm.nih.gov/pubmed/8373935

The consumption of aspartame is associated with higher serum levels of a benzene metabolite associated with blood disorders and leukemia: http://www.ncbi.nlm.nih.gov/pubmed/16484134

Among other things.
] (]) 05:46, 12 January 2013 (UTC)
:If you check the archives you will see that dorway is not a reliable source, I am pretty sure mpwhi.com would not be an RS either. The article is well sourced. ] (]) 12:28, 12 January 2013 (UTC)
:: The two items I linked to contain the scanned copies of articles from FOIA requests that refute the notion that Martini's claims are undocumented. Those websites are used for no other purpose. Those scanned copies substantiate the claims of the person being critiqued.] (]) 12:33, 12 January 2013 (UTC)
::::Pottinger - no historian worth his or her salt would accept a pdf posted on an activist organization website as reliable. Maybe a historian would use that as a basis to make his or her own FOIA request. But it is laughably unreliable on its own.] (]) 23:07, 17 January 2013 (UTC)
::: Cherry picking individual primary studies won't be of much use either. (Some of which don't even mention aspartame, but instead mention just 'artificial sweeteners') ] (]) 12:37, 12 January 2013 (UTC)
:::: The two items linked to above, from dorway and Martini's site, show that her claims are documented, and thus refute the claim in this article. If you critique a person for having a view contrary to mainstream institutions, but will not allow that person's documentation substantiating that view to be reproduced, then that is hardly neutral. This is not any article from those sites - it is clear FOIA scanned request copies substantiating the claims of the promoter of the idea, who is attacked. The urinary tract tumor artificial sweetener study mentions Cyclamate, Saccharin, Aspartame, and Acesulfame-K. Aspartame is the artificial sweetener of choice for diet sodas, hence the second study.] (]) 13:00, 12 January 2013 (UTC)
::::: Now, I understand wikipedia's policy on primary sources vs. secondary sources, but the point of that was to show that there are more then a few studies that come up with adverse effects, hence this is not an anomaly. My main point though relates to the two items of Martini substantiating her claims.] (]) 13:22, 12 January 2013 (UTC)
:You need to provide review studies that look at all studies and determine whether the findings above have been repeated in other studies. Many adverse studies have been found to have poor methodology. Statistically, there is a high probability that if thousands and thousands of studies are conducted with small populations that some will provide adverse results. The FDA report btw "documents" the 7,232 reports of adverse reactions to apartame received between 1980 and 1995, of which 92 were of the serious nature you mentioned. Compare that with 6,000 UFO sightings in 2011. ] (]) 13:30, 12 January 2013 (UTC)
:: The number 92, as it pertains to the FDA report, documents a list of '''symptoms''', not the number of people with those symptoms, which is spread across the symptoms listed.] (]) 14:48, 12 January 2013 (UTC)
:::Please review ]. None of these sources qualify for inclusion in this article. There is a clear scientific consensus that aspartame is safe for consumption at current doses, you will need more than individual primary studies to overturn this; if you find secondary reviews that state otherwise, we can consider, otherwise we are spinning our wheels here. ] (]) 14:53, 12 January 2013 (UTC)
::::The number of symptoms is meaningless. When something is associated with 92 or 10,000 symptoms in a few individuals each, it is meaningless from an epidemiological standpoint. The CDC investigation of the complaints turned up nothing. That is the content of the medical literature.

::::Willful misinterpretation of the medical literature is not documentation. Take the study that shows "aspartame may be linked to increasing brain cancer rates"; that one was debunked years ago. The trend started before aspartame was introduced and was already leveling off. Despite increased consumption, the incidence of brain tumors has been tailing off since 1987. In a study of pediatric brain tumors, controls were more likely to drink diet soda more than weekly and maternal consumption was higher in the control group (although neither at a statistically significant level). Anyone making the claim that the medical literature supports the notion of an association with brain tumors is not using the medical literature. Or take the claim that "in men, greater than 1 daily serving of diet soda increased risks of non-Hodgkin lymphoma and multiple myleoma". That was a negative study. There was a control for lifestyle: regular soda consumption. While there was a slight increase in risk in the group consuming diet soda, barely over the threshold of statistical significance, the regular soda group showed a higher risk for non-Hodgkin lymphoma. Calling this an adverse effect is not supported by the medical literature. What you are describing is a ] interpretation of the medical literature, the cherry-picking of tidbits and passages to create an illusion, not documentation in the medical literature.] (]) 15:13, 12 January 2013 (UTC)
::::: Can you give me the original source this comes from?: http://img.medscape.com/fullsize/migrated/540/146/nf540146.fig3.gif
:::::: The brain tumor opinion piece was problematic from the day it was published (that whole effect-preceding-cause thing). The fringe theorists cling to it, even though the medical literature has dismissed it.] (]) 20:45, 12 January 2013 (UTC)
::::::: And with the exception of what you pointed out, which did show adverse effects from aspartame (though it also noted adverse effects with the soda), what was described was pretty consistent with the abstracts. (I find this one interesting: http://www.ncbi.nlm.nih.gov/pubmed/17354619)] (]) 21:02, 12 January 2013 (UTC)
:::::::: An association is not an effect. That conflation of correlation and causation is the stock and trade of fringe ]. An extremely weak association between diet soda and a condition is not a demonstration that aspartame causes the condition, especially when the condition appears at a higher rate in a group not receiving aspartame. This disconnect between the activists and the medical literature has been well demonstrated in this thread. ] This article and its talk page are not the place for ] animal studies which may or may not have physiological significance; this article (and the rest of Misplaced Pages) uses ] to interpret that data.] (]) 21:37, 12 January 2013 (UTC)
The high quality reviews you mention are industry funded, with conflict of interest.
The following echoes my concerns PMID 18085058
The statement "especially when the condition appears at a higher rate in a group not receiving aspartame" is incorrect - the abstract states, comparing it to the group that did not receive diet soda "in men, ≥1 daily serving of diet soda increased risks of NHL (RR: 1.31; 95% CI: 1.01, 1.72) and multiple myeloma (RR: 2.02; 95% CI: 1.20, 3.40) in comparison with men who did not consume diet soda."
Here are independent human studies showing negative effect, where this is clear from the abstract - PMID 8373935, PMID 7936222, PMID 1579221, http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2524.1988.hed2801010.x/abstract
I have highlighted many others. Of these, the most interesting to me is the following - PMID 11408989
Independent studies keep coming up, year after year, showing problems - like this most recent one, which is not at all ambiguous PMID 23280025
Now, where Betty Martini comes in is that she has done the work in obtaining the copies of the congressional documents and FDA investigations noting that during the approval process, toxicity was known, and obfuscated. How the CDC put up a summary on the report that contradicted the investigation, then left the investigation off their web site, etc. I do not have the time to engage in a further in depth debate on this. Obviously, somebody like her would have to take up the mantle.] (]) 13:34, 13 January 2013 (UTC)
:It does not matter whether studies are industry funded, but the degree of acceptance they have obtained in academic writing. Companies often fund studies outside academic research that are published by thinktanks, which are not reliable. ] (]) 14:10, 13 January 2013 (UTC)

== EFSA re-evaluation: draft scientific opinion published ==

Last week, EFSA published as part of a . From what I see (haven't had the time to read the whole report) they're going to reconfirm EU's ADI of 40 mg/kg bw per day. --] (]) 11:05, 14 January 2013 (UTC)

== in spite of this ==

You say,

"In 1987, the U.S. Government Accountability Office concluded that the food additive approval process had been followed properly for aspartame. In spite of this, critics such as activist Betty Martini have promoted claims, undocumented in the medical literature,"

Your statement "in spite of this" is illogical. The Government Accountability Office never ruled on the health of aspartame. They never ruled even on the creditability of the data presented They only said proper procedures had been followed.

If i follow proper procedures to buy a gun and then shoot someone should i be let off because I "followed proper procedures"

You should correct this. ] (]) 02:49, 15 January 2013 (UTC)
:I think it is fine the way it is. ] (]) 03:15, 15 January 2013 (UTC)


I would like to add a few meta analysis about aspartame and the research outcome in relation to industry funding. It seems odd to me that nearly every industry funded study is in favor of aspartame while most independently funded studies are not. Any objections to include these meta analysis in the article?
== BLPN thread started by a frequent contributor to this talk page ==
https://lightenyourtoxicload.com/wp-content/uploads/2014/07/Dr-Walton-survey-of-aspartame-studies.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015869/
--] (]) 08:07, 19 April 2020 (UTC)


:I moved your thread to the bottom of the page, which is where new threads go. It increases the chance other editors will see it. ] (]) 09:04, 19 April 2020 (UTC)
Some editors here might find this thread of interest (I follow BLPN, though some of you may not). http://en.wikipedia.org/Wikipedia:Biographies_of_living_persons/Noticeboard#aspartame_controversy ] (]) 22:31, 17 January 2013 (UTC)
:{{u|Mikeschaerer}} also, your first link seems incomplete. However, lightenyourtoxicload.com seems unlikely to be a ]. ] (]) 09:05, 19 April 2020 (UTC)
::{{u|Mikeschaerer}} - I made at the Aspartame article. The "lightenyour..." source is not ], and the PMID 27606602 review is ] for aspartame itself, but rather is a review of bias in research. In my opinion, it doesn't meet ] as an "aspartame controversy". ] (]) 00:19, 22 April 2020 (UTC)
:::{{u|Zefr}} Could you elaborate why the source "lightenyour..." is not compliant with ]. Also what about this review? http://www.laleva.org/it/docs/Millstone_EFSA_Aspartame_9Jan2014.pdf --] (]) 14:03, 22 April 2020 (UTC)
::::The "lighten..." source has no bibliographic information, such as when/where it was published, whether it was peer-reviewed, etc., so remains without ]. For an encyclopedia, we need high-quality reviews by authoritative sources, ]. - mentioned in the first sentence of the Millstone paper (which also has no bibliographic info) - states, as does the FDA, that there is no concern about the safety of aspartame. These are acceptable ] sources, which confirm there is no scientifically-validated "controversy". --] (]) 14:33, 22 April 2020 (UTC)
:::::Well, for one, there are at least 17 peer-reviewed citations (in publications considered good enough for Google Scholar) for the Malton study dismissed here as "unlocatable", at least half of which are affirmative citations:


:::::On the other hand, while PMID 27606602 *IS* a general review of sweeteners, this peer-reviewed source (which is ]) also goes into detail on the aspartame controversy, on why the peer-reviewed article considers the methodology of the FDA *AND* the EFSA seriously flawed in regards to aspartame, both in how aspartame was originally introduced and in how studies corroborating harm of aspartame are dismissed as supposedly unsound, and cites a number of scientific and peer-reviewed sources who agree on that both the FDA and the EFSA exhibit gross disregard for proper methodology on the issue.
== Nancy Markle emails ==


:::::FYI, the EFSA themselves officially consider any critiques of their methodology as entirely irrelevant and not even worthy of serious consideration or any cause for self-criticism, by virtue of simply calling them just "reviews, presenting no new scientific evidence" or mere "opinion pieces": (see ''Appendix 1: Papers considered by the Organising Team but not included in the Report'', pp. 58-62). In other words, the EFSA doesn't give a damn about methodology, they just need an excuse to only support studies funded by aspartame manufacturers and industry utilizers. Their other trick, as openly outlined in the 2009 report, is to declare any peer-reviewed study corroborating harm and its observed biomolecular paths of action which they can't explain away with "flawed methodology" (on which they are critizized by all the above considerable sources as mentioned in the peer-reviewed ''PLUS One'' article) as "just anecdotal", no matter the amount of case studies presented in the given peer-reviewed source or the sound plausability of the biomolecular observations in accordance with what is scientifically known for certain about molecular biology in regards to the aspartame-related components and substances discussed (such as ]s of aspartame after it's been broken down by the human organism, for instance).
In the lead it states: "The unsubstantiated claims are still repeated by thousands of self-published Web sites." This is unsourced. No one knows what is still repeated on the Internet. My guess is that someone used Google (which is against Misplaced Pages's rules). I get 590 actual hits of links that contain the name Nancy Markle and "aspartame". This is not thousands if one even used this. These are all sites, pro and con, self-published and not self-published. Please remove this sentence. ] (]) 21:44, 19 January 2013 (UTC)
:: good point.
] (]) 02:59, 20 January 2013 (UTC)


:::::In short, all of this reeks strongly of the grave misconduct in regards to the other industry-sponsored supposed remedy to caries and obesity, which was ] that led to phenomena such as ] (see photos for it in the ] article, namely the "severe" cases), where supposed caries resistance was a trade-in for considerable other damage to human teeth integrity, bone structure, the central nervous system, liver, kidneys, and thyroid (see the general article on ] on that), and where all criticisms of it from within the scientific community and research into it was for a long time considered some laughable "conspiracy theory" supposedly related to the ]. --] (]) 18:18, 30 April 2022 (UTC)
== birth defects ==


== death ==
I suggest the words "birth defects" be removed from the following line "In spite of this, rumors, unsupported by medical evidence, propagate that numerous health conditions (such as multiple sclerosis, systemic lupus, methanol toxicity, blindness, spasms, shooting pains, seizures, headaches, depression, anxiety, memory loss, birth defects and death" be removed. The following link shows there was medical research devoted to birth defects.


Here is a 16 year study reported by the New York Times.
http://www.mailonsunday.co.uk/health/article-1293495/Do-sweeteners-bring-early-birth-How-fizzy-drinks-harm-unborn-child.html


https://www.nytimes.com/2019/09/06/health/diet-soda-health-death.html?searchResultPosition=1
] (]) 02:58, 20 January 2013 (UTC)


] (]) 13:15, 2 October 2021 (UTC)
:The MailOnline Website isn't remotely a reliable source per ], and even if it was, it doesn't say anything about birth defects. ] (]) 04:21, 20 January 2013 (UTC)
: That is hardly usable here. Let's look at the title and a few sentences from the article. They tell us that this is a very general study not applicable to Aspartame specifically.
{{quotebox|
Death by Diet Soda?


A new study that links artificially sweetened beverages to premature death is prompting public angst. Some scientists say it has significant flaws.
:The author writes, "we urge cautious interpretation until further studies have been conducted. Indeed, as with any other observational study, we cannot exclude the role of bias or unadjusted confounding. This is why we encourage replication of our findings." ] (]) 06:28, 20 January 2013 (UTC)


... a new study that found prodigious consumers of artificially sweetened drinks were 26 percent more likely to die prematurely than those who rarely drank sugar-free beverages.
You are correct on the Daily Mail here is the real link, http://ajcn.nutrition.org/content/92/3/626.full] Also your statement implies there exists no research on birth defects. You state, in effect, that rumors are unsupported by ANY medical evidence. This is not true regardless of wether the study is replicated.


The study, published in the journal JAMA Internal Medicine, followed 450,000 Europeans over 16 years and tracked mortality among soft-drink consumers of all persuasions — both those with a fondness for sugary beverages and those who favored sugar-free drinks.}}
] (]) 12:59, 20 January 2013 (UTC)
: The rest of the NYT article also refers to "other research in the United States has found a correlation between artificially sweetened beverages and premature death." Again, not specific to Aspartame and the number of confounders is enormous. The lifestyles of people who tend to drink large amounts of soft drinks, sugary or otherwise, isn't good, so there is no surprise here. Are large quantities of artificial sweeteners not good for our health? Probably. Large quantities of junk food and empty calories are not good. Large quantities of unsweetened fruit juices isn't good either. When free from the slowing effects of their natural fibers, they assault the pancreas and can cause blood sugar spikes. Any diabetic knows this. Too high a percentage of even "natural" sugars in the diet isn't good, and one can get far too much compared to what one would get just eating fruit as is. It's hard to "overdose" on apples or oranges in their natural state. {{;)}} The stomach can only hold so much at a time. -- ] (]) 17:19, 2 October 2021 (UTC)
:Yeah but you see, there is no evidence, the authors practically admit that. You have been grasping at straws for years now, you might consider moving on. Seriously. ] (]) 13:55, 20 January 2013 (UTC)


== Removal from the alternative medicine navbox ==
::And this is no small study either. Almost 60,000 pregnant women took part. Interesting that they write: "the safety of artificial sweeteners has been disputed". According to the Misplaced Pages Controversy article, it's undisputed. No evidence? The researchers came to this conclusion: "Daily intake of artificially sweetened soft drinks may increase the risk of preterm delivery." We are not looking for evidence, we are simply here to report the controversy. Why are you attacking anyone who tries to make the article more neutral? ] (]) 14:01, 20 January 2013 (UTC)
:::'May' is not 'does' Please also see the quote from TFD above. ] (]) 14:26, 20 January 2013 (UTC)


@]
::::Preterm delivery is not a birth defect.--] (]) 14:54, 20 January 2013 (UTC)


The navboxes have long included a variety of topics related to alternative medicine, including general controversies, purported poisons, or related people. ] (]) 13:52, 19 July 2022 (UTC)
:::::On a pack of cigarettes, it says: Tobacco MAY harm your health. Are you going to hide behind legal terms now? We are here to report the controversy, nothing else. Leave the rest to lawyers. This is getting too ridiculous again. ] (]) 15:52, 20 January 2013 (UTC)
::::::Yes, you are correct, it is getting ridiculous. Please move on. This is the longest case I have ever seen of ]. ] (]) 16:08, 20 January 2013 (UTC)


:::::::If there's a request that says "Please remove birth defects because this study says there's a correlation between premature birth and diet soda consumption", how is it "ridiculous" or "hiding behind legal terms" if I point out that premature birth is not a birth defect? --] (]) 17:02, 20 January 2013 (UTC) :Possibly. However, given that Misplaced Pages isn't a reliable source, inclusion of an 'alternate medicine' navbox in an article on aspartame would seem to require a better justification than that. Can you point to sources that describe aspartame as an 'alternative medicine'? ] (]) 14:10, 19 July 2022 (UTC)
::Would you then also suggest the removal of ], ], ], ], and ] from ]? Because like ], those articles also don't directly mention "alternative medicine", per-se. ] (]) 14:23, 19 July 2022 (UTC)
:::I would suggest you answer the question I actually asked. Citing external ] sources that describe aspartame as 'alternate medicine'. ] (]) 14:29, 19 July 2022 (UTC)
::::Here are a couple: <ref>{{Cite book |last=Leader |first=Dr David |url=https://books.google.com/books?id=8z88CwAAQBAJ&pg=PA19&dq=alternative+medicine+aspartame&hl=fr&sa=X&ved=2ahUKEwiVvvj8l4X5AhXEJ0QIHXExDVQ4ChDoAXoECAQQAg#v=onepage&q=alternative%20medicine%20aspartame&f=false |title=The Alternative Medicine Cabinet: Your Reference Guide to All-Natural Self Care |date=2015-06-30 |publisher=Lulu.com |isbn=978-1-4834-3257-1 |pages=19-20 |language=en}}</ref><ref>{{Cite book |last=Bowling |first=Allen C. |url=https://books.google.com/books?id=-qt0qjtyzqQC&pg=PA79&dq=alternative+medicine+aspartame&hl=fr&sa=X&ved=2ahUKEwiWn8K6moX5AhWvDkQIHfqzDroQ6AF6BAgGEAI#v=onepage&q=alternative%20medicine%20aspartame&f=false |title=Complementary and Alternative Medicine and Multiple Sclerosis |date=2010-04-20 |publisher=ReadHowYouWant.com |isbn=978-1-4587-5343-4 |pages=79-83 |language=en}}</ref> ] (]) 14:47, 19 July 2022 (UTC)
:::::I asked for ] sources stating that aspartame is an alternative medicine. As far as I can see, neither of the sources you cite states anything of the sort, instead (correctly) describing it as an artificial sweetener. I also doubt either would meet ] criteria anyway. ] (]) 15:09, 19 July 2022 (UTC)
::::::I think you misunderstand: the ] is about aspartame being called a poison by alternative medicine practitioners. I also don't see why those sources would fail ]. ] (]) 15:14, 19 July 2022 (UTC)
:::::::No, it is (amongst other things) about aspartame being called a poison by conspiracy theorists. Some may well be alternative medicine practitioners, a great many clearly weren't. And I'm sure, given the scope of 'alternative medicine', there are practitioners who have no opinion about aspartame, one way or another. ] (]) 15:27, 19 July 2022 (UTC)
::::::::That's reasonable; so it will stay with conspiracy theories but not alternative medicine. ] (]) 15:29, 19 July 2022 (UTC)


:::Comment: WP considers (at least atm) altmed and ] to be pretty much the same, so vaccine stuff fits pretty well IMO. Aspartame is less obvious, I think, afaik it isn't used to treat patients. In the past there have been discussions at ] that concluded that the sidebar didn't fit there. ] (]) 15:08, 19 July 2022 (UTC)
::::::::Exactly. Please stop wasting our time with this pointless nonsense. If people can't be bothered to read the article (which doesn't say what the OP claims), the sources they link, or the Misplaced Pages policies - which make entirely clear that rubbish like Mail Online isn't a reliable source anyway - why the heck should we bother responding? ] (]) 17:27, 20 January 2013 (UTC)
::::Well in this case vaccine hesitancy and aspartame controversy are both recommended by alternative medicine practitioners, so the topics should equally qualify for the navboxes. ] (]) 15:16, 19 July 2022 (UTC)


I would like to the take the opportunity and propose the removal of ], ], ], and ] from the alternative medicine navboxes for the same reason as was given aspartame in this discussion. ] (]) 15:32, 19 July 2022 (UTC)


:This is the talk page for the aspartame article, not the alternate medicine navbox. ] (]) 15:53, 19 July 2022 (UTC)
I do not understand. This is what the journal article says.
"Results: There was an association between intake of artificially sweetened carbonated and noncarbonated soft drinks and an increased risk of preterm delivery (P for trend: le 0.001, both variables). In comparison with women with no intake of artificially sweetened carbonated soft drinks, the adjusted odds ratio for women who consumed ge 1 serving of artificially sweetened carbonated soft drinks/d was 1.38 (95% CI: 1.15, 1.65). The corresponding odds ratio for women who consumed ge 4 servings of artificially sweetened carbonated soft drinks/d was 1.78 (95% CI: 1.19, 2.66). The association was observed for normal-weight and overweight women. A stronger increase in risk was observed for early preterm and moderately preterm delivery than with late-preterm delivery. No association was observed for sugar-sweetened carbonated soft drinks (P for trend: 0.29) or for sugar-sweetened noncarbonated soft drinks (P for trend: 0.93).


{{reflist-talk}}
Conclusions: Daily intake of artificially sweetened soft drinks may increase the risk of preterm delivery. Further studies are needed to reject or confirm these findings."


== new link ==
Please tell me why this is ridiculous ] (]) 19:28, 20 January 2013 (UTC)


here is an interesting link.
:Because studies may produce all kinds of finds, but require interpretation, replication of findings and acceptance in the academic community. BTW the U.S. stopped saying that smoking ''may be'' hazardous to health in 1970. ] (]) 19:54, 20 January 2013 (UTC)
::Exactly. Arydberg, you do not understand how science works. Many things are found, once, they have to be replicated. That is precisely why 'Further studies are needed to reject or confirm these findings' is in the paper. ] (]) 19:59, 20 January 2013 (UTC)


https://www.endalldisease.com/aspartame-linked-to-leukemia-lymphoma-in-groundbreaking-study/ ] (]) 17:34, 5 August 2022 (UTC)
:::It is ridiculous because '''<big>preterm delivery is not a birth defect</big>'''. ] (]) 20:31, 20 January 2013 (UTC)


:Nothing remotely relevant to article content: see ]. ] (]) 17:57, 5 August 2022 (UTC)
::::Here's a fair and balanced source: http://www.foxnews.com/health/2012/08/30/sweetened-drinks-may-be-linked-to-premature-births/ Now you can add this somewhere in the article because it's another controversy... BTW, governments know that tobacco DOES harm, but the Industry keeps claiming it MAY. ] (]) 22:15, 20 January 2013 (UTC)
::::Tobacco is irrelevant here. And, see above re preterm delivery is not a birth defect. ] (]) 22:44, 20 January 2013 (UTC)

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To-do list for Aspartame controversy: edit·history·watch·refresh· Updated 2012-03-11


Here are some tasks awaiting attention:
  • Cleanup : Scientific publications -- weak Gone --SV Resolution(Talk) 15:29, 30 April 2009 (UTC) Alleged conflict of intrerest prior to 1996 -- should this be merged into discussion of approval?
  • Expand : Why the US approval process caused controversy
    • Charges of COI in DOJ handling of FDA's Fraud allegations against Searle.
    • Charges of COI in hirings of 6 FDA personnel (described in GAO 86 report to Metzenbaum)
    • Studies by Olney and others dismissed.
    • Expand and integrate the timeline in the article
    • Charges of COI when new FDA commissioner overturned unanimous decision of PBOI
    Senator Metzenbaum's role in returning the controversy to the news. Why the Ramazzinni studies contribute to the controversy
    • Allegations of COI in industry-funded critiques of Soffritti studies
    ...
  • NPOV : Remember that parts of this article that deal with medical safety follow WP:MEDRS and should rely on secondary sources and must reflect the preponderance of medical opinion, while other parts of this article that deal with historical, social, legal, etc. aspects explain the controversy should rely on secondary sources as much as possible but are not subject to WP:MEDRS.
  • Verify : Different types of sources are appropriate to different sections of this article.
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Meta analysis about research outcome related to industry funding

I would like to add a few meta analysis about aspartame and the research outcome in relation to industry funding. It seems odd to me that nearly every industry funded study is in favor of aspartame while most independently funded studies are not. Any objections to include these meta analysis in the article? https://lightenyourtoxicload.com/wp-content/uploads/2014/07/Dr-Walton-survey-of-aspartame-studies.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015869/ --Mikeschaerer (talk) 08:07, 19 April 2020 (UTC)

I moved your thread to the bottom of the page, which is where new threads go. It increases the chance other editors will see it. Gråbergs Gråa Sång (talk) 09:04, 19 April 2020 (UTC)
Mikeschaerer also, your first link seems incomplete. However, lightenyourtoxicload.com seems unlikely to be a WP:RS. Gråbergs Gråa Sång (talk) 09:05, 19 April 2020 (UTC)
Mikeschaerer - I made this revert at the Aspartame article. The "lightenyour..." source is not WP:RS, and the PMID 27606602 review is WP:OFFTOPIC for aspartame itself, but rather is a review of bias in research. In my opinion, it doesn't meet WP:WEIGHT as an "aspartame controversy". Zefr (talk) 00:19, 22 April 2020 (UTC)
Zefr Could you elaborate why the source "lightenyour..." is not compliant with WP:RS. Also what about this review? http://www.laleva.org/it/docs/Millstone_EFSA_Aspartame_9Jan2014.pdf --Mikeschaerer (talk) 14:03, 22 April 2020 (UTC)
The "lighten..." source has no bibliographic information, such as when/where it was published, whether it was peer-reviewed, etc., so remains without WP:V. For an encyclopedia, we need high-quality reviews by authoritative sources, WP:MEDASSESS. The 2013 EFSA assessment of aspartame - mentioned in the first sentence of the Millstone paper (which also has no bibliographic info) - states, as does the FDA, that there is no concern about the safety of aspartame. These are acceptable WP:MEDRS sources, which confirm there is no scientifically-validated "controversy". --Zefr (talk) 14:33, 22 April 2020 (UTC)
Well, for one, there are at least 17 peer-reviewed citations (in publications considered good enough for Google Scholar) for the Malton study dismissed here as "unlocatable", at least half of which are affirmative citations:
On the other hand, while PMID 27606602 *IS* a general review of sweeteners, this peer-reviewed source (which is PLOS One) also goes into detail on the aspartame controversy, on why the peer-reviewed article considers the methodology of the FDA *AND* the EFSA seriously flawed in regards to aspartame, both in how aspartame was originally introduced and in how studies corroborating harm of aspartame are dismissed as supposedly unsound, and cites a number of scientific and peer-reviewed sources who agree on that both the FDA and the EFSA exhibit gross disregard for proper methodology on the issue.
FYI, the EFSA themselves officially consider any critiques of their methodology as entirely irrelevant and not even worthy of serious consideration or any cause for self-criticism, by virtue of simply calling them just "reviews, presenting no new scientific evidence" or mere "opinion pieces": Report on the meetings on aspartame with National Experts, 2009 (see Appendix 1: Papers considered by the Organising Team but not included in the Report, pp. 58-62). In other words, the EFSA doesn't give a damn about methodology, they just need an excuse to only support studies funded by aspartame manufacturers and industry utilizers. Their other trick, as openly outlined in the 2009 report, is to declare any peer-reviewed study corroborating harm and its observed biomolecular paths of action which they can't explain away with "flawed methodology" (on which they are critizized by all the above considerable sources as mentioned in the peer-reviewed PLUS One article) as "just anecdotal", no matter the amount of case studies presented in the given peer-reviewed source or the sound plausability of the biomolecular observations in accordance with what is scientifically known for certain about molecular biology in regards to the aspartame-related components and substances discussed (such as metabolites of aspartame after it's been broken down by the human organism, for instance).
In short, all of this reeks strongly of the grave misconduct in regards to the other industry-sponsored supposed remedy to caries and obesity, which was dental fluorosis that led to phenomena such as Colorado brown stain (see photos for it in the dental fluorosis article, namely the "severe" cases), where supposed caries resistance was a trade-in for considerable other damage to human teeth integrity, bone structure, the central nervous system, liver, kidneys, and thyroid (see the general article on fluoride toxicity on that), and where all criticisms of it from within the scientific community and research into it was for a long time considered some laughable "conspiracy theory" supposedly related to the Red Scare. --46.93.153.58 (talk) 18:18, 30 April 2022 (UTC)

death

Here is a 16 year study reported by the New York Times.

https://www.nytimes.com/2019/09/06/health/diet-soda-health-death.html?searchResultPosition=1

Claustro123 (talk) 13:15, 2 October 2021 (UTC)

That is hardly usable here. Let's look at the title and a few sentences from the article. They tell us that this is a very general study not applicable to Aspartame specifically.

Death by Diet Soda?

A new study that links artificially sweetened beverages to premature death is prompting public angst. Some scientists say it has significant flaws.

... a new study that found prodigious consumers of artificially sweetened drinks were 26 percent more likely to die prematurely than those who rarely drank sugar-free beverages.

The study, published in the journal JAMA Internal Medicine, followed 450,000 Europeans over 16 years and tracked mortality among soft-drink consumers of all persuasions — both those with a fondness for sugary beverages and those who favored sugar-free drinks.

The rest of the NYT article also refers to "other research in the United States has found a correlation between artificially sweetened beverages and premature death." Again, not specific to Aspartame and the number of confounders is enormous. The lifestyles of people who tend to drink large amounts of soft drinks, sugary or otherwise, isn't good, so there is no surprise here. Are large quantities of artificial sweeteners not good for our health? Probably. Large quantities of junk food and empty calories are not good. Large quantities of unsweetened fruit juices isn't good either. When free from the slowing effects of their natural fibers, they assault the pancreas and can cause blood sugar spikes. Any diabetic knows this. Too high a percentage of even "natural" sugars in the diet isn't good, and one can get far too much compared to what one would get just eating fruit as is. It's hard to "overdose" on apples or oranges in their natural state. The stomach can only hold so much at a time. -- Valjean (talk) 17:19, 2 October 2021 (UTC)

Removal from the alternative medicine navbox

@AndyTheGrump

The navboxes have long included a variety of topics related to alternative medicine, including general controversies, purported poisons, or related people. Altanner1991 (talk) 13:52, 19 July 2022 (UTC)

Possibly. However, given that Misplaced Pages isn't a reliable source, inclusion of an 'alternate medicine' navbox in an article on aspartame would seem to require a better justification than that. Can you point to sources that describe aspartame as an 'alternative medicine'? AndyTheGrump (talk) 14:10, 19 July 2022 (UTC)
Would you then also suggest the removal of Big Pharma conspiracy theories, Oral polio vaccine AIDS hypothesis, Vaccines and autism, MMR vaccine and autism, and GMO conspiracy theories from Template:Alternative medicine sidebar? Because like Aspartame controversy, those articles also don't directly mention "alternative medicine", per-se. Altanner1991 (talk) 14:23, 19 July 2022 (UTC)
I would suggest you answer the question I actually asked. Citing external WP:RS sources that describe aspartame as 'alternate medicine'. AndyTheGrump (talk) 14:29, 19 July 2022 (UTC)
Here are a couple: Altanner1991 (talk) 14:47, 19 July 2022 (UTC)
I asked for WP:RS sources stating that aspartame is an alternative medicine. As far as I can see, neither of the sources you cite states anything of the sort, instead (correctly) describing it as an artificial sweetener. I also doubt either would meet WP:RS criteria anyway. AndyTheGrump (talk) 15:09, 19 July 2022 (UTC)
I think you misunderstand: the Aspartame controversy is about aspartame being called a poison by alternative medicine practitioners. I also don't see why those sources would fail WP:RS. Altanner1991 (talk) 15:14, 19 July 2022 (UTC)
No, it is (amongst other things) about aspartame being called a poison by conspiracy theorists. Some may well be alternative medicine practitioners, a great many clearly weren't. And I'm sure, given the scope of 'alternative medicine', there are practitioners who have no opinion about aspartame, one way or another. AndyTheGrump (talk) 15:27, 19 July 2022 (UTC)
That's reasonable; so it will stay with conspiracy theories but not alternative medicine. Altanner1991 (talk) 15:29, 19 July 2022 (UTC)
Comment: WP considers (at least atm) altmed and Pseudomedicine to be pretty much the same, so vaccine stuff fits pretty well IMO. Aspartame is less obvious, I think, afaik it isn't used to treat patients. In the past there have been discussions at Chemtrails that concluded that the sidebar didn't fit there. Gråbergs Gråa Sång (talk) 15:08, 19 July 2022 (UTC)
Well in this case vaccine hesitancy and aspartame controversy are both recommended by alternative medicine practitioners, so the topics should equally qualify for the navboxes. Altanner1991 (talk) 15:16, 19 July 2022 (UTC)

I would like to the take the opportunity and propose the removal of Oral polio vaccine AIDS hypothesis, Vaccines and autism, MMR vaccine and autism, and GMO conspiracy theories from the alternative medicine navboxes for the same reason as was given aspartame in this discussion. Altanner1991 (talk) 15:32, 19 July 2022 (UTC)

This is the talk page for the aspartame article, not the alternate medicine navbox. AndyTheGrump (talk) 15:53, 19 July 2022 (UTC)

References

  1. Leader, Dr David (2015-06-30). The Alternative Medicine Cabinet: Your Reference Guide to All-Natural Self Care. Lulu.com. pp. 19–20. ISBN 978-1-4834-3257-1.
  2. Bowling, Allen C. (2010-04-20). Complementary and Alternative Medicine and Multiple Sclerosis. ReadHowYouWant.com. pp. 79–83. ISBN 978-1-4587-5343-4.

new link

here is an interesting link.

https://www.endalldisease.com/aspartame-linked-to-leukemia-lymphoma-in-groundbreaking-study/ Claustro123 (talk) 17:34, 5 August 2022 (UTC)

Nothing remotely relevant to article content: see WP:MEDRS. AndyTheGrump (talk) 17:57, 5 August 2022 (UTC)
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