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{{short description|Science-based medicine advocate}}
{{Infobox scientist {{Infobox scientist
|image=CSICON 2012-Teaching Pseudoscience Panel-David Gorski.JPG | name = David Gorski
| image = Gorski1.jpeg
|name=David Henry Gorski
| caption = Gorski in 2016
|birth_date =
| birth_name = David Henry Gorski
|birth_place =
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|nationality=]
| birth_place =
|field=]<br>]
| nationality = American
|work_institutions=]<br>]
|alma_mater=]<br>] | education = {{ublist|] (])|] (])}}
|doctoral_advisor=Kenneth Walsh | doctoral_advisor = ]
|awards= | awards =
| footnotes =
|prizes =
| field = ]
|footnotes =
| work_institutions = {{ublist|]|]}}
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}} }}


'''David H. Gorski''' is an American ], Professor of surgery at ],<ref name="cancer grad prog"/> and a surgical oncologist at the ], specializing in ].<ref>{{cite web |publisher=], ] |url=http://www.karmanos.org/Physicians/Details.aspx?sid=1&physician=70 |title=David Gorski M.D., Ph.D. |work=Physician Details |accessdate=17 May 2013 |year=2013}}</ref> He is a ] of ] and the ]. He is the author of a ], ''Respectful Insolence'',<ref name="respectful-insolence">{{cite web |last=Gorski |first=David |title=Respectful Insolence |url=http://scienceblogs.com/insolence/author/oracknows/ |publisher=] |accessdate=10 June 2013}}</ref> and is the managing editor of the website, ''Science-Based Medicine''.<ref name="science-based-medicine-editor">{{cite news|last=Szabo|first=Lisa|title=How to guard against a quack|url=http://www.usatoday.com/story/news/nation/2013/06/18/how-to-spot-a-quack/2429471/|accessdate=22 June 2013|newspaper=]|publisher=<!-- omitted for brevity ]-->|date=18 June 2013}}</ref><ref>{{cite web|title=David H. Gorski, MD, PhD&nbsp;– Managing Editor|url=http://www.sciencebasedmedicine.org/index.php/editorial-staff/david-h-gorski-md-phd-managing-editor/|publisher=Science-Based Medicine|accessdate=10 June 2013}}</ref> '''David Henry Gorski''' is an American ] and professor of surgery at ].<ref>{{cite web |title=David Gorski |date=25 October 2019 |url=https://cancerbiologyprogram.med.wayne.edu/profile/dz8037 |publisher=Wayne State University – School of Medicine – Cancer Biology Program |access-date=9 August 2021 |language=en}}</ref> He specializes in ] at the ].<ref>{{cite web |publisher=], ] |url=https://www.karmanos.org/karmanos/karmanos-physician-directory/gorski-david-7481 |title=David Gorski M.D., Ph.D. |work=Physician Details |access-date=9 August 2021 |year=2013}}</ref> Gorski is an outspoken ] and critic of ] and the ]. He writes as Orac at ''Respectful Insolence'' and as himself at ''],'' where he is the managing editor.<ref name="science-based-medicine-editor">{{cite news|last=Szabo|first=Lisa|title=How to guard against a quack|url=https://www.usatoday.com/story/news/nation/2013/06/18/how-to-spot-a-quack/2429471/|access-date=22 June 2013|newspaper=]|publisher=<!-- omitted for brevity ]-->|date=18 June 2013}}</ref><ref>{{cite web|title=David H. Gorski, MD, PhD&nbsp;– Managing Editor|url=https://www.sciencebasedmedicine.org/editorial-staff/david-h-gorski-md-phd-managing-editor/|website=Science-Based Medicine|date=5 October 2008 |access-date=10 June 2013}}</ref><ref>{{Cite web|title=Respectful Insolence|url=https://respectfulinsolence.com/|access-date=2021-07-09|website=RESPECTFUL INSOLENCE|language=en-US}}</ref>


==Early life and education==
==Education==
Gorski received his ] from the ] in 1988. He then completed his ] in general surgery at the ], taking time off in the middle to acquire a ] in ] from ] in 1994 with a dissertation entitled: "Homeobox Gene Expression and Regulation in Vascular Myocytes".<ref name=ohiolink>{{cite web |url=https://etd.ohiolink.edu/ap:10:0::NO:10:P10_ACCESSION_NUM:case1057944521 |last= Gorski |first= D. |year= 1994 |title=Homeobox gene expression and regulation in vascular myocytes |format= Electronic Thesis or Dissertation |publisher= Case Western Reserve University}}</ref> After completing his residency, he completed a ]ship in surgical oncology at the ].<ref name="cancer grad prog"/><ref name="faculty-page">{{cite web |publisher=Department of Surgery / ], Wayne State University |year=2005 |url=http://www.med.wayne.edu/surgery/faculty/DGorski.html |title=David Gorski, M.D. |work=Faculty |accessdate=20 March 2013}}</ref> Gorski attended a ] high school.<ref name=":0">{{Cite magazine |last=Hongoltz-Hetling |first=Matthew |date=2023-02-28 |title=A Doctor's War Against the Right-Wing Medical-Freedom Movement |magazine=The New Republic |url=https://newrepublic.com/article/170255/doctors-war-right-wing-medical-freedom-movement |access-date=2023-04-09 |issn=0028-6583}}</ref> He went on to study medicine at the ], earning an MD in 1988.<ref>{{Cite web |date=2019-10-25 |title=David Gorski |url=https://cancerbiologyprogram.med.wayne.edu/profile/dz8037 |access-date=2023-04-09 |website=Cancer Biology Program |language=en}}</ref> He entered a residency in general surgery in 1989 at the ]. Gorski completed a PhD in ] at ] in 1994. His dissertation was entitled "Homeobox Gene Expression and Regulation in Vascular Myocytes."<ref name="ohiolink">{{cite book|title=Homeobox gene expression and regulation in vascular myocytes|last=Gorski|first=D.|year=1994|publisher=Case Western Reserve University|oclc = 31923610}}</ref> Gorski continued his residency (1993–96) and completed a ] research fellowship (1996–99) at ].<ref name="cancer grad prog" /><ref name="faculty-page">{{cite web|url=http://www.med.wayne.edu/surgery/faculty/DGorski.html|title=David Gorski, M.D.|year=2005|work=Faculty|publisher=Department of Surgery / ], Wayne State University|archive-url=https://web.archive.org/web/20130125033701/http://www.med.wayne.edu/surgery/faculty/DGorski.html|archive-date=25 January 2013|url-status=dead|access-date=20 March 2013}}</ref>

Prior to 2005, he was active on the early internet message boards of ] participating in ].<ref name=":0" />


==Career== ==Career==
In the mid 2000s, Gorski taught surgery as an associate professor at the ]<ref>{{Cite web |date=2005 |title=Graduate School-New Brunswick 2005-2007 Programs, Faculty, and Courses Cell and Developmental Biology 148 |url=https://catalogs.rutgers.edu/generated/nb-grad_0507/pg24131.html |access-date=2023-04-09 |website=catalogs.rutgers.edu}}</ref> and the ], at ].<ref name=":1">{{Cite journal |last1= Bepler |first1= Gerold |author-link1= Gerold Bepler |title= Barbara Ann Karmanos Cancer Center names Dr. David Gorski leader of breast multidisciplinary team |url= http://www.prnewswire.com/news-releases/barbara-ann-karmanos-cancer-center-names-dr-david-gorski-leader-of-breast-multidisciplinary-team-115018114.html |date= 1 February 2011 |publisher= ] |access-date= 18 June 2013 }}</ref>
Gorski was previously Assistant Professor of Surgery at the ] and the ] in New Brunswick, NJ, as well as a member of the Joint Graduate Program in Cell & Developmental Biology at [[Rutgers Uni


In 2007 he received the Advanced ] Award in Breast Cancer from the ].<ref name="US Fed News">{{cite journal | date=11 June 2007 | access-date=14 June 2013 | first1=Michele | last1=Fisher | url=http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm | title=New Jersey surgical oncologist receives prestigious award at international conference | publisher=] | quote=CINJ scientist receives a near half-million dollars for future breast cancer research. | archive-url=https://web.archive.org/web/20130205153112/http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm | archive-date=5 February 2013| author2-link=Cancer Institute of New Jersey }}</ref> He was awarded research grants by ] in 2008, 2009, and 2010.<ref name="bcrf" />
Sanofi-Gorski


In 2008, Gorski joined the ]<ref name=":2">{{Cite web |date=September 29, 2021 |title=Meet the provider: David Gorski, M.D. |url=https://www.waynehealthcares.org/meet-the-provider-david-gorski-m-d/ |access-date=2023-04-10 |website=www.waynehealthcares.org}}</ref> and became affiliated with the ].<ref name=":1" /> He is a professor of surgery and oncology at the Wayne State University School of Medicine,<ref name="cancer grad prog">{{cite web |work= Cancer Biology Graduate Program |title= David H. Gorski |url= http://cancerbiologyprogram.med.wayne.edu/faculty/gorski.php |publisher= ] |year= 2013 |access-date= 14 June 2013 |archive-url= https://web.archive.org/web/20120722100844/http://cancerbiologyprogram.med.wayne.edu/faculty/gorski.php |archive-date= 22 July 2012 |url-status= dead }}</ref> whose laboratory conducts research on ] regulation of vascular ] cell phenotype, as well as the role of ] in breast cancer.<ref name="cancer grad prog" /> In 2009, he was appointed the cancer liaison physician for the ] Committee on Cancer.<ref>{{cite web|url=https://www.med.wayne.edu/news/2009/01/07/dr-david-gorski-appointed-cancer-liaison-physician-for-karmanos/|title=Dr. David Gorski appointed Cancer Liaison Physician for Karmanos|date=7 January 2009|work=Prognosis E-News|publisher=Wayne State University School of Medicine|archive-url=https://web.archive.org/web/20170801083903/https://www.med.wayne.edu/news/2009/01/07/dr-david-gorski-appointed-cancer-liaison-physician-for-karmanos/|archive-date=August 1, 2017|url-status=live|access-date=May 17, 2013}}</ref>
Well, it so happens Sanofi-Aventis – the world’s largest vaccine maker - is involved in several partnerships under which the company may be required to pay a total of €31 million ($39 million USD) from 2008 to 2013. Gorski’s employer, Wayne State University, is one of the partners, and he is conducting a clinical trial of one of the company’s drugs. Therefore, like Offit (who concealed the millions he received in Merck royalty payments because Merck paid the royalties to a third party, not Offit directly) Gorski has a reasonable expectation to receive money from a vaccine maker, even if it is through a third party. A look at the summary description of the Gorski Lab reveals that his research focus is drug discovery and development. However, he is not developing a new drug, but rather, developing new uses for an existing one. Such a process is far more profitable to the drug manufacturer as it eliminates the costs of developing a new substance from scratch, thereby maximizing profits for the company.


He became the co-director of the Michigan Breast Oncology Quality Initiative in 2013.<ref>{{cite web|url=http://www.karmanos.org/cancer-care/teams/Breast-Team|title=Breast Cancer Program|year=2013|publisher=Barbara Ann Kamanos Cancer Institute, Wayne State University|access-date=17 May 2013 |url-status=dead |archive-url=https://web.archive.org/web/20190108030724/https://www.karmanos.org/cancer-care/teams/Breast-Team |archive-date=8 January 2019}}</ref><ref>{{cite web|url=https://www.med.wayne.edu/news/2013/07/30/dr-gorski-named-co-director-of-michigan-breast-oncology-quality-initiative/|title=Karmanos Cancer Center's Dr. David Gorski appointed program co-director of Michigan Breast Oncology Quality Initiative|date=July 30, 2013|publisher=Karmanos Cancer Institute|archive-url=https://web.archive.org/web/20170801084315/https://www.med.wayne.edu/news/2013/07/30/dr-gorski-named-co-director-of-michigan-breast-oncology-quality-initiative/|archive-date=August 1, 2017|url-status=live|access-date=August 2, 2013}}</ref>


Gorski is listed as a founder of the Institute for Science in Medicine<ref>{{cite web |work= ISM Fellows |title= David H. Gorski, MD, PhD |url= http://www.scienceinmedicine.org/fellows/GorskiD.html |year= 2011 |publisher= Institute for Science in Medicine |access-date= 13 June 2013}}</ref> and as a member of the ].<ref name="bcrf">{{cite news |magazine= Pink Press |publisher= ] |page= 8 |title= 2007–2008 Grantees |url= http://www.bcrfcure.org/pdf/newsletter_winter08.pdf |archive-url= https://web.archive.org/web/20120807020004/http://www.bcrfcure.org/pdf/newsletter_winter08.pdf |archive-date= 2012-08-07 |date= Winter 2008 |access-date= 2013-06-26 |url-status= dead }} {{Dead link|date=January 2024 |bot=InternetArchiveBot |fix-attempted=yes }}{{cite news |magazine= Pink Press |publisher= The Breast Cancer Research Foundation |page= 9 |title= 2008–2009 Grantees |url= http://www.bcrfcure.org/pdf/newsletter_winter09.pdf |archive-url= https://web.archive.org/web/20120807020418/http://www.bcrfcure.org/pdf/newsletter_winter09.pdf |archive-date= 2012-08-07 |date= Winter 2009 |access-date= 2013-06-26 |url-status= dead }} {{Dead link|date=January 2024 |bot=InternetArchiveBot |fix-attempted=yes }}{{cite news |magazine= Pink Press |publisher= The Breast Cancer Research Foundation |page= 8 |title= 2009–2010 Grantees |url= http://www.bcrfcure.org/pdf/newsletter_winter10.pdf |archive-url= https://web.archive.org/web/20120807015558/http://www.bcrfcure.org/pdf/newsletter_winter10.pdf |archive-date= 2012-08-07 |date= Winter 2010 |access-date= 2013-06-26 |url-status= dead }} {{Dead link|date=January 2024 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>


===Research===
The potentially profitable drug Gorski is in the process of conducting a clinical trial for is the ALS drug Riluzole, made by Sanofi-Aventis and marketed as Rilutek. Amplifying the conflict further is that the same drug is also being studied for the treatment of autism. At Autism One, the National Institute of Mental Health was handing out recruitment pamphlets for children ages 7-17 to take part as subjects in a clinical trial of Riluzole for its effectiveness in the treatment of autism spectrum disorders, and repetitive and stereotypical behaviors in particular. Apparently, David Gorski has had his eye on that drug for a long time, but as a possible treatment for breast cancer. As suggested by a 2008-2009 webpage of a breast cancer website:
Gorski's 1999 article "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of ]s on the effectiveness of ], has been cited over 900 times according to PubMed.<ref name="gorski-1999">{{Cite journal |issn= <!-- omitted for brevity 0008-5472, 1538-7445 --> |volume= 59 |issue= 14 |pages= 3374–3378 |last1= Gorski |first1= David H. |last2= Beckett |first2= Michael A. |first3= Nora T. |last3= Jaskowiak |first4= Douglas P. |last4= Calvin |first5= Helena J. |last5= Mauceri |first6= Rabih M. |last6= Salloum |first7= Saraswathy |last7= Seetharam |first8= Ann |last8= Koons |first9= Danielle M. |last9= Hari |first10= Donald W. |last10= Kufe |first11= Ralph R. |last11= Weichselbaum |display-authors= 4|title= Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation| journal= Cancer Research |access-date= 21 June 2013| date= 15 July 1999 |url= http://cancerres.aacrjournals.org/content/59/14/3374.long |pmid= 10416597 |publisher= <!-- omitted for brevity American Association for Cancer Research-->}}</ref><ref>{{citation |title= Related Citations for PubMed (Select 10416597) |url= https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=10416597 |publisher= PubMed |access-date= 28 June 2013}}</ref> This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ] "by preventing repair of radiation damage to ],"<ref name="kerbel-2002">{{Cite journal |doi= 10.1038/nrc905 |issn= <!-- omitted for brevity 1474-175X --> |volume= 2 |issue= 10 |pages= 727–739 |last1= Kerbel |first1= Robert |first2= Judah |last2= Folkman |author-link2= Judah Folkman |title= Clinical translation of angiogenesis inhibitors |journal= ] |date= October 2002 |pmid= 12360276 |publisher= <!-- omitted for brevity ]-->|s2cid= 14513505 }}</ref> and in determining the potential of combinational therapies to allow reduction of the dosages in toxic conventional treatments<ref name="dvorak-2002">{{Cite journal |doi= 10.1200/JCO.2002.10.088 |issn= <!-- omitted for brevity 0732-183X, 1527-7755 --> |volume= 20 |issue= 21 |pages= 4368–4380 |last= Dvorak |first= Harold F. |title= Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy |journal= ] |date= 1 November 2002 |publisher= <!-- omitted for brevity ]--> |pmid= 12409337}}</ref> while sustaining tumor regression when combined with specific ] and ].<ref name="klement-2000">
{{Cite journal |issn= <!-- omitted for brevity 0021-9738 --> |volume= 105 |issue= 8 |pages= R15–R24 |last1= Klement |first1= Giannoula |first2= Sylvain |last2= Baruchel |first3= Janusz |last3= Rak |first4= Shan |last4= Man |first5= Katherine |last5= Clark |first6= Daniel J. |last6= Hicklin |first7= Peter |last7= Bohlen |first8= Robert S. |last8= Kerbel |display-authors=4|title= Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity |journal= ] |publisher= <!-- omitted for brevity ] -->| date= 15 April 2000 | pmid=10772661|doi= 10.1172/JCI8829| pmc= 517491}}</ref>


Gorski's work with Helena Mauceri and others, published in '']'' in 1998 as "Combined effects of angiostatin and ionizing radiation in antitumour therapy" studied the "combined effects of ]" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy"<ref name="mauceri-1998">{{cite journal |last1= Mauceri |first1= Helena J. |last2= Hanna |first2= Nader N. |last3= Beckett |first3= Michael A. |last4= Gorski |first4= David H. |last5= Staba |first5= Mary-Jane |last6= Stellato |first6= Kerri Anne |last7= Bigelow |first7= Kevin |last8= Heiman |first8= Ruth |last9= Gately |first9= Stephen |last10= Dhanabal |first10= Mohanraj |last11= Soff |first11= Gerald A. |last12= Sukhatme |first12= Vikas P. |last13= Kufe |first13= Donald W. |last14= Weichselbaum |first14= Ralph R. |display-authors=4|title= Combined effects of angiostatin and ionizing radiation in antitumour therapy |journal= ] |volume= 394 |date= 16 July 1998 |pages= 287–291 |doi= 10.1038/28412 |pmid= 9685160 |publisher= <!-- omitted for brevity Nature Publishing Group --> |issn= <!-- omitted for brevity 1476–4687 --> |issue= 6690|bibcode= 1998Natur.394..287M |s2cid= 4391890 }}</ref> led to investigation into the selective destruction of tumor cells, which according to a 1999 study by Gregg L. Semenza (citing Mauceri and others), "are more ] than normal cells," allowing for "tumor cells to be killed without major ]."<ref name="semenza-1999">{{Cite journal |last=Semenza |first=Gregg L. |year=1999 |title=Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1 |url= |journal=] |publisher=<!-- omitted for brevity ] --> |volume=15 |issue=1 |pages=551–578 |doi=10.1146/annurev.cellbio.15.1.551 |issn=<!-- omitted for brevity 1081-0706 --> |pmid=10611972}}</ref>
“Three years ago in another cancer (melanoma), Dr. Gorski's collaborators found that glutamate might have a role in promoting the transformation of the pigmented cells in the skin (melanocytes) into the deadly skin cancer melanoma. More importantly for therapy, it was found that this protein can be blocked with drugs, and, specifically, in melanoma cell lines and tumor models of melanoma using a drug originally designed to treat ALS and already FDA-approved for that indication (Riluzole) can inhibit the growth of melanoma.” HERE


In 2008, Gorski and Yun Chen published an article titled "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5" that investigated the use of ] to regulate ].<ref name="chen-2008">{{Cite journal |doi= 10.1182/blood-2007-07-104133 |issn= <!-- omitted for brevity 0006-4971 --> |volume= 111 |issue= 3 |pages= 1217–1226 |last1= Chen |first1= Yun |first2= David H. |last2= Gorski |title= Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 |journal= ] |publisher= <!-- omitted for brevity ] --> |date= 1 February 2008 |pmid= <!-- omitted for brevity 17957028 --> |pmc= 2214763}}</ref>
Subtract three years from 2008-2009 and you get 2005-2006 – when David Gorski started blogging heavily about vaccines. Currently, the Barbara Anne Karmanos Cancer Institute of Wayne State University is sponsoring the trial for Riluzole, and Wayne State is the only university listed in the Yahoo! Finance stock summary of Sanofi-Aventis as being in a financial partnership with the company. Sanofi-Aventis owns Sanofi-Pasteur, the second largest manufacturer of vaccines in the world, including both thimerosal-preserved vaccines, and MMR vaccines. (Its first MMR vaccine, Immravax, was banned for causing viral meningitis in children.) David Gorski, while up front about the direct funding he received from drug companies 14 years ago for a patent as well as the funding he has received from the various institutions with which he has been affiliated, has not been up front about funding from drug companies received through his institution. According to the drug company’s website in 2008, “Sanofi-Aventis has entered into various other collaboration agreements with partners including Immunogen, Coley, Wayne State University, Innogenetics and Inserm, under which Sanofi-Aventis may be required to make total contingent payments of approximately €31 million over the next five years.” This is the same year it was announced that David Gorski would carry out a series of clinical trials for the company and its drug, Riluzole. HERE
In fact, one of the two primary interests of the Gorski lab is this Sanofi-Aventis drug. In the Wayne state description, the lab’s two interests are described, “First, we are interested in the transcriptional regulation of vascular endothelial cell phenotype.” Worth noting is that a patent relating to this was issued listing David Gorski as an inventor. In his blog bio, Gorski admits receiving money for the patent in 1994 from a drug company, but that was only during the provisional filing before the patent was issued. Whatever the compensation was, its timing does not suggest any licensing of the intellectual property rights.


==Skepticism of alternative medicine==
Also, according to the Gorski lab, “Our second area of interest is the role of metabotropic glutamate receptors (mGluRs) in breast cancer,” which relates directly to the therapy linking the use of Riluzole to breast cancer treatment. However, the description concludes, “In addition, we have noted that mGluR1 is expressed on vascular endothelial cells and have preliminary evidence that its inhibition is also antiangiogenic, thus linking our laboratory’s two interests and suggesting a broader application for metabotropic glutamate receptor targeting in cancer therapy.” In other words, David Gorski’s entire research focus, including a patent still listed in his name for which he admits receiving drug company money, ties into finding new uses for a drug made by Sanofi-Aventis, while the university housing his lab is in partnership with the company. HERE
], ], David Gorski, and ] on a panel at The Amaz!ng Meeting 2012]]
Gorski is a vocal ] of ] and has criticized ].<ref>{{Cite web |last=Hiltzik |first=Michael |date=2015-04-20 |title=A physicians' attack on Dr. Oz explodes into a new controversy |url=https://www.latimes.com/business/hiltzik/la-fi-mh-a-physicians-attack-on-dr-oz-explodes-into-a-new-controversy-20150420-column.html |access-date=2023-04-09 |website=Los Angeles Times |language=en-US}}</ref>


He has criticized the prevalence of pseudoscience in the medical field including the use of alternative therapies,<ref>{{citation |last= Page |first= Leigh |title= What to do when a patient wants 'alternative' medicine |url= http://www.medscape.com/viewarticle/805545 |date= 12 June 2013 |work= Medscape Business of Medicine |publisher= <!-- omitted for brevity Medscape --> |access-date= 25 June 2013|postscript=.}}</ref><ref>{{cite news |magazine= ] |last= Munger |first= Dave |title= Controls for acupuncture studies are improving. Their results are not. How are peer reviewers reacting? |url= http://seedmagazine.com/content/article/acupuncture_real_or_sham/ |date= 2 September 2009 |publisher= <!-- omitted for brevity Seed Media Group --> |issn= <!-- omitted for brevity 1499-0679 --> |access-date= 27 June 2013 |archive-url= https://web.archive.org/web/20180914203543/http://seedmagazine.com/content/article/acupuncture_real_or_sham/ |archive-date= 14 September 2018 |url-status= unfit }}</ref> ],<ref>{{citation |last= Salzberg |first= Steven|author-link= Steven Salzberg |title= Battlefield acupuncture: Pseudoscience for wounded troops |url= https://www.forbes.com/sites/sciencebiz/2010/02/15/battlefield-acupuncture-pseudoscience-for-wounded-troops/ |date= 15 February 2010 |work= ] |publisher= <!-- omitted for brevity Forbes Media --> |access-date= 25 June 2013 |postscript=.}}</ref> ],<ref>{{cite news |title= Bridal Hunger Games: Losing Weight in Time for the Wedding |url= https://www.nytimes.com/2012/04/15/fashion/weddings/Losing-Weight-in-Time-for-the-Wedding.html |last= Lee |first= Linda |newspaper= ] |date= 13 April 2012 |access-date= 25 June 2013}}</ref> and the use of ] to manage ].<ref>{{citation |last= Hansen |first= Lacy Jaye |date= 7 December 2012 |title= The GAPS diet claims you can eat away autism. But can you really? |url= http://www.dietsinreview.com/diet_column/12/the-gaps-diet-claims-you-can-eat-away-autism-but-can-you-really/ |work= Diets in Review.com | access-date = 25 June 2013|postscript=.}}</ref>
In spite of this easily-accessible information about his drug industry ties, Gorski’s denial of being in the pocket of the drug industry stretches so far beyond what he is even regularly accused of, that he will from time to time actually post a handful of links to the few token, laughably transparent posts out of the thousands he’s written which are at all critical of the drug industry. None concerned ongoing, unresolved controversies such as those surrounding autism, and none are critical of Sanofi. To David Gorski, Sanofi-Aventis is apparently untouchable. When a fellow blogger wrote a post entitled “Placing a vaccine order with crooks and liars” - questioning the government’s reliance on Sanofi-Aventis developing a swine flu vaccine just after the company was forced to pay nearly $100 million in compensation for cheating Medicaid, David Gorski was not amused. “Jumpin' Jesus on a pogo stick. The antivaccine nuts will have a field day with this,” he yelped.


=== Blogs ===
The blogger responded, “orac: Meaning we shouldn't call them on it?” David Gorski chastised even his fellow blogger: “I would have hoped that you would realize that that's not what I meant at all to the point where you wouldn't have even asked a question like that, but apparently I was wrong. I didn't realize your opinion of me was so low.” Apparently, the public image of Sanofi-Aventis is more important to Gorski than the fact that disabled people, including those with autism, were cheated out of millions of dollars.
Gorski is a prolific blogger.<ref name=":0" /> In 2004, he began writing a blog entitled ''Respectful Insolence'' at ] under the ] ]. ''Respectful Insolence'' was then moved to the ] website.<ref name="bremner">{{Cite web |last= Bremner |first= Doug|author-link=Doug Bremner|title= Blogging doctors rock on! |url= http://www.huffingtonpost.com/doug-bremner/blogging-doctors-rock-on_b_127675.html |work= The Huffington Post |date= 19 September 2008 |access-date=24 June 2013 }}</ref><ref>{{cite web |url= http://www.scienceblogs.com/insolence/author/oracknows/ |title= ''Respectful Insolence'' |last1= Gorski |first1= David |publisher= ScienceBlogs |access-date= 20 June 2013 |archive-url= https://web.archive.org/web/20130624051121/http://scienceblogs.com/insolence/author/oracknows/ |archive-date= 24 June 2013 |url-status= dead }}</ref> Alissa Quart, writing for '']'' in 2010, described Orac as a "self-appointed autism expert" known for attacking the "vaccines-cause-autism set" and who had recently celebrated when an opponent lost their medical license.<ref>{{Cite web |last=Quart |first=Alissa |date=July 2010 |title=The Trouble with Experts |url=https://www.cjr.org/60th/the-trouble-with-experts-jenny-mccarthy-mommy-bloggers.php/ |access-date=2023-04-09 |website=Columbia Journalism Review |language=en}}</ref> In 2015, writing for '']'', Jacob Brogan said Orac was a "doctor who blogs about skepticism and medicine".<ref>{{Cite news |last=Brogan |first=Jacob |date=2015-12-07 |title=Depression Is Real. "Hypersensitivity to Wi-Fi" Isn't. |language=en-US |work=Slate |url=https://slate.com/technology/2015/12/british-teenager-jenny-fry-didn-t-kill-herself-because-of-a-wi-fi-allergy.html |access-date=2023-04-09 |issn=1091-2339}}</ref>


In 2008 Gorski started blogging at '']'' under his real name while continuing to blog as Orac at ''Respectful Insolence.''<ref>{{cite web |title=Who is Orac? |url=https://respectfulinsolence.com/who-is-orac/ |publisher=Respectful Insolence |access-date=31 July 2018}}</ref><ref>{{cite book |last1=Beall |first1=Jeffrey |editor1-last=Kaufman |editor1-first=Allison B. |editor2-last=Kaufman |editor2-first=James C |title=Pseudoscience: The Conspiracy Against Science |date=2018 |publisher=MIT Press |isbn=978-0262344821 |chapter-url=https://books.google.com/books?id=iQFKDwAAQBAJ&pg=PA296 |language=en |chapter=Chapter 12: Scientific Soundness and the Problem of Predatory Journals}}</ref> He was later ] as Orac.<ref name=":0" /> As the managing editor{{clarify|What does it mean to be a 'managing editor' of a blog?|date=July 2024}} at ''Science-Based Medicine'', Gorski has posted on issues of medicine and pseudoscience, including the ], alternative therapies, and cancer research and treatment.<ref>{{citation |last= Jones |first= Val |title= Hostility Towards Scientists and Jenny McCarthy's Latest Video |url= http://www.medpagetoday.com/Blogs/KevinMD/14538 |work= KevinMD.com |editor= Kevin Pho |editor-link= Kevin Pho |publisher= MedPage Today |date= 4 June 2009 |access-date= 25 June 2013|postscript=.}}</ref><ref name="denialism" /> In 2010, Gorski recounted how members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging.<ref name="Gorski blog">{{cite web |url= http://www.sciencebasedmedicine.org/the-price-of-skepticism/ |title= The price of opposing medical pseudoscience |website= Science-Based Medicine |date= 18 June 2010 |access-date= 14 June 2013 |last= Gorski |first= David H.}}</ref>
His actual profession may have nothing to do with the disorder, but Sanofi-Aventis certainly plays a major role in the autism epidemic. So blogging like the kind Gorski has been engaged in would undoubtedly win him some major brownie points with the pharmaceutical company. This could be very beneficial to a researcher like him, given that he is conducting a clinical trial of Sanofi-Aventis’ drug while his employer is in a Sanofi-Aventis partnership that could be worth millions. Meanwhile, he is trashing alternative therapies for autism when the drug he is conducting a clinical trial on may become a treatment for autism. How none of this could be considered undisclosed COIs to David Gorski--while Dr. Andrew Wakefield’s connection to lawyers in relation to the retracted case report from the Lancet is a “fatal” COI--is absolutely bizarre. Gorski makes no mention of his current connections to the drug industry on his blog, including the possible application the drug he is focused on may have to autism.


Writing for '']'' in 2011, David H. Freedman described Gorski as one of the more "prickly anti-alternative-medicine warriors"<ref name="freedman-2012">{{Cite news |last= Freedman |first= David H. |title= Doctors who care: Does alternative medicine work? |url= http://www.utne.com/mind-body/alternative-medicine-zm0z12mjzros.aspx |magazine= ] |date= May–June 2012 |access-date= 24 June 2013 |publisher= <!-- omitted for brevity Ogden Publications --> |issn=<!-- omitted for brevity 8750-0256 --> }}</ref> and said he was "among a small, loud band of alt-med critics."<ref>{{Cite web |last=Freedman |first=David H. |date=2011-06-23 |title=What's Eating the Small, Loud Band of Alt-Med Critics? |url=https://www.theatlantic.com/health/archive/2011/06/whats-eating-the-small-loud-band-of-alt-med-critics/240860/ |access-date=2023-04-09 |website=The Atlantic |language=en}}</ref>
Yet a number of years back, David Gorski wrote on his blog as “Orac,” “Yes, in the case of a true ‘shill’ who does not reveal that he works for a pharmaceutical company and pretends to be ‘objective,’ it is quite appropriate to ‘out’ that person.” From reading this, one would think David Gorski would be happy to know that his undisclosed connections to Sanofi-Aventis – one of the largest vaccine makers in the world - have just been outed.


Gorski contributed to the ]'s series of EBooks: ''Science Based Medicine Guides''.<ref name="science guides">{{cite web |title=JREF publishes three volumes on science-based medicine |url=http://archive.randi.org/site/index.php/jref-news/2023-jref-publishes-three-volumes-on-science-based-medicine.html |work=] |access-date=28 June 2013}}<br>{{cite web |author=<!-- no byline JREF Staff --> | title=JREF publishes three more science-based medicine volumes |work=James Randi Education Foundation |access-date=28 June 2013 |url=http://archive.randi.org/site/index.php/jref-news/2075-jref-publishes-three-more-science-based-medicine-volumes.html}}<br>{{cite web |author=<!-- no byline JREF Staff --> |title=Science-based medicine Ebooks, volumes 7-12 now available |url=http://archive.randi.org/site/index.php/jref-news/2130-science-based-medicine-ebooks-volumes-7-12-now-available.html |work=James Randi Education Foundation |access-date=28 June 2013}}</ref> He is a fellow of the ].<ref>{{cite web |title=CSI Fellows and Staff |url=http://www.csicop.org/about/csi_fellows_and_staff/ |date=2009 |work=Committee for Skeptical Inquiry |access-date=2 August 2013 |author=}}</ref> He was a speaker at ] in 2009, 2010, 2012 and 2013<ref>{{cite web |title=The Amaz!ing Meeting 2013: Schedule |url=http://www.amazingmeeting.com/tam2013/schedule |work=The Amza!ing Meeting website |year=2013 |access-date=24 June 2013 |publisher=James Randi Education Foundation |author= |archive-date=27 June 2013 |archive-url=https://web.archive.org/web/20130627051415/http://www.amazingmeeting.com/tam2013/schedule/ |url-status=dead }}</ref><ref name="tam sched">{{cite web |last= Novella |first= Steven |author-link= Steven Novella |title= Science-Based Medicine Conference |url= http://theness.com/neurologicablog/index.php/science-based-medicine-conference/ |work= Neurologica blog |publisher= ] |date= 6 March 2009 |access-date= 24 June 2013}}<br>{{Cite journal |last=Wagg |first=Jeffrey |title=The Amaz!ng Meeting 8, 2010 Schedule |url=http://www.randi.org/site/index.php/component/content/article/37-static/882-the-amazing-meeting-8-2010-schedule.html |journal=] |year=2010 |access-date=24 June 2013 }}<br>{{Cite journal |title=Expert panel trashes "alternative medicine" concept |url=http://www.ncahf.org/digest12/12-29.html |journal=Consumer Health Digest |issue=12–29 |date=23 August 2012 |publisher=] |access-date=25 June 2013 }}<br>{{cite web |title=The Amaz!ing Meeting 2012: Program |url= http://www.amazingmeeting.com/TAM2012/program |work= ] website |year=2012 |publisher=James Randi Education Foundation |access-date=24 June 2013}}</ref> and has been a participant on several panels on alternative medicine.<ref>{{cite web |url=https://www.mcgill.ca/science/events/trottier-symposium/2010/october18 |title=Drs. Ben Goldacre, David Gorski and Michael Shermer on the threat of pseudoscience |date=18 October 2010 |work=] |access-date=20 June 2013}}</ref><ref>{{cite web |title= David Gorski&nbsp;— NECSS |url= http://necss.org/speakers/david-gorski |website= Northeast Conference on Science and Skepticism website (NECSS) |publisher= ] and NYC Skeptics |access-date= 24 June 2013 |archive-date= 6 June 2013 |archive-url= https://web.archive.org/web/20130606065249/http://necss.org/speakers/david-gorski/ |url-status= dead }}</ref><ref>{{cite web |title=Speakers |url=http://www.csiconference.org/speakers.php |work=CSICon 2012 website |publisher=] |year=2012 |access-date=24 June 2013 |archive-url=https://web.archive.org/web/20130902062840/http://csiconference.org/speakers.php |archive-date=2 September 2013 |url-status=dead }}</ref> He called attention to a 2005 paper by ] on problems with published research.<ref name="bestsci">{{cite book |last1=Roach |first1=Mary |url=https://books.google.com/books?id=yuMW5r7C29EC |title=The Best American Science and Nature Writing 2011 |last2=Folger |first2=Tim |publisher=Houghton Mifflin Harcourt |year=2011 |isbn=978-0-547-67846-7 |pages=123–124 |author-link=Mary Roach |author-link2=Tim Folger |access-date=21 June 2013}}</ref>
So I e-mailed him:


Gorski has advocated for ] of ] results and for using only ] to treat disease.<ref>{{citation |last= Miller |first= Naseem |title= Most drug trial results analyzed by FDA hidden from view |url= http://www.publicintegrity.org/2010/05/14/2673/most-drug-trial-results-analyzed-fda-hidden-view |orig-year= 14 May 2010 |date= 16 March 2011 |work= Accountability |publisher= ] | access-date= 26 June 2013|postscript=.}}</ref> He has been critical of ] support of the National Center for Complementary and Alternative Medicine (NCCAM), which became the ].<ref name = "denialism">{{cite book |first= Michael |last= Specter |title= Denialism: How Irrational Thinking Harms the Planet and Threatens Our Lives |url= https://books.google.com/books?id=J-VMNrt3JyIC |access-date= 21 June 2013 |year=2009 |publisher= Penguin Group US |isbn= 978-1-101-15102-0}}</ref> He has criticized the ] (NIH) and NCCAM for funding and publishing research on unproven therapies not supported by science-based evidence,<ref name = "systematic">{{cite journal |title= Systematic reviews of animal models: Methodology versus epistemology |last1= Greek |first1= Ray |last2= Menache |first2= Andre |journal= ] |publisher= <!-- omitted for brevity ] --> |year= 2013 |volume= 10 |issue= 3 |pages= 206–221 |doi= 10.7150/ijms.5529 |pmid= 23372426 |issn= <!-- omitted for brevity 1449-1907 --> |pmc=3558708}}</ref><ref name = "NCCAM">{{citation |last= Husten |first = Larry |title= The Raging Debate Over The NIH's TACT Chelation Trial |url= https://www.forbes.com/sites/larryhusten/2013/04/02/a-guide-to-the-raging-debate-over-the-nihs-tact-chelation-trial/ |date= 1 April 2013 |work= Forbes.com | access-date=26 June 2013 |postscript=.}}<br>{{cite book |last1= Berezow |first1= Alex B. |last2= Campbell |first2= Hank |title= Science Left Behind: Feel-Good Fallacies and the Rise of the Anti-Scientific Left|url=https://archive.org/details/scienceleftbehin00bere|url-access= registration |access-date=2013-06-21 |year= 2012 |publisher= PublicAffairs |isbn= 978-1-61039-165-8}}<br>{{cite book |last =Kay |first= Alison J. |title= What If There's Nothing Wrong? |url= https://books.google.com/books?id=ZjtGMrFZ3RYC |access-date=21 June 2013 |year=2012 |publisher= Balboa Press |isbn= 978-1-4525-6147-9 |page= 283}}</ref> and has commented on ] and methods of alternative medicine.<ref name = "study">{{citation |last= Khorana |first= Alok |title= Alternative medicine and trials of dubious ethicality |url= http://boards.medscape.com/forums/?128@@.29f63208!comment=1 |work= OncNotes |publisher= ] |date= 16 September 2009 |access-date= 25 June 2013|postscript=.}}<br>{{citation |last= Schneider |first= Lee |title= Snake oil medicine |url= http://www.huffingtonpost.com/lee-schneider/snake-oil-medicine_b_302024.html |date= 30 September 2009 |work= ] | access-date = 27 June 2013|postscript=.}}<br>{{citation |last= Keller |first= Daniel M. |title= Integrative Medicine Use Up, but Outcomes Still Uncertain |url= http://www.medscape.com/viewarticle/758725 |date= 15 February 2012 |work= Medscape Medical News |publisher= <!-- omitted for brevity Medscape --> |access-date= 25 June 2013|postscript=.}}</ref>
Dr. Gorski,versity]] in Piscataway, NJ and The Cancer Institute of New Jersey.<ref>{{Cite journal |last1= Bepler |first1= Gerold |authorlink1= Gerold Bepler |last2= Karmanos Cancer Institute |title= Barbara Ann Karmanos Cancer Center names Dr. David Gorski leader of breast multidisciplinary team |url= http://www.prnewswire.com/news-releases/barbara-ann-karmanos-cancer-center-names-dr-david-gorski-leader-of-breast-multidisciplinary-team-115018114.html |date= 1 February 2011 |publisher= ] |accessdate= 18 June 2013 |postscript=.}}</ref> He became the Medical Director of the Alexander J. Walt Comprehensive Breast Center at the ] in 2010<ref>{{cite web |publisher= Barbara Ann Kamanos Cancer Institute, Wayne State University |url= http://www.karmanos.org/cancer-care/teams/Breast-Team |title= Breast Cancer Program |year= 2013 | accessdate= 17 May 2013}}</ref> and was appointed co-director of the Michigan Breast Oncology Quality Initiative in 2013.<ref>{{cite web|title=Karmanos Cancer Center’s Dr. David Gorski appointed program co-director of Michigan Breast Oncology Quality Initiative|url=http://www.karmanos.org/News/Default.aspx?id=37&sid=1&nid=359&showBack=true&PageIndex=0&Categories=1|publisher=Karmanos Cancer Institute|accessdate=2 August 2013}}</ref> Gorski is a Professor of Surgery and Oncology at the ],<ref name="cancer grad prog">{{cite web |work= Cancer Biology Graduate Program |title= David H. Gorski |url= http://cancerbiologyprogram.med.wayne.edu/faculty/gorski.php |publisher= ] |year= 2013 |accessdate= 14 June 2013}}</ref> whose laboratory conducts research on ] regulation of vascular ] cell phenotype, as well as the role of ] in breast cancer.<ref name="cancer grad prog"/> He is the cancer liaison physician for the ] Committee on Cancer,<ref>{{cite web |work= Prognosis E-News |title= Dr. David Gorski appointed Cancer Liaison Physician for Karmanos |url= http://prognosis.med.wayne.edu/article/dr-david-gorski-appointed-cancer-liaison-physician-for-karmanos |date= 7 January 2009 |publisher= Wayne State University School of Medicine |accessdate= 17 May 2013}}</ref> the founder of the Institute for Science in Medicine<ref>{{cite web |work= ISM Fellows |title= David H. Gorski, MD, PhD |url= http://www.scienceinmedicine.org/fellows/GorskiD.html |year= 2011 |publisher= Institute for Science in Medicine |accessdate= 13 June 2013}}</ref> and a member of the ].<ref name="bcrf">{{cite news |magazine= Pink Press |publisher= ] |page= 8 |title= 2007 - 2008 Grantees |url= http://www.bcrfcure.org/pdf/newsletter_winter08.pdf |archiveurl=https://s3.amazonaws.com/bcrf-static/pdf/newsletter_winter08.pdf | archivedate=2013-09-11 |date= Winter 2008}}<br>{{cite news |magazine= Pink Press |publisher= The Breast Cancer Research Foundation |page= 9 |title= 2008 - 2009 Grantees |url= http://www.bcrfcure.org/pdf/newsletter_winter09.pdf |archiveurl=https://s3.amazonaws.com/bcrf-static/pdf/newsletter_winter09.pdf | archivedate=2013-09-11 |date= Winter 2009}}<br>{{cite news |magazine= Pink Press |publisher= The Breast Cancer Research Foundation |page= 8 |title= 2009 - 2010 Grantees |url= http://www.bcrfcure.org/pdf/newsletter_winter10.pdf |archiveurl=https://s3.amazonaws.com/bcrf-static/pdf/newsletter_winter10.pdf | archivedate=2013-09-11 |date= Winter 2010}}</ref>
BIG pharma ties and corruption


Gorski has criticized popularization of pseudoscience by the media and celebrities such as ],<ref name="oprah">{{citation |title=Media and bloggers accuse Oprah of medical malpractice |url=http://thyroid.about.com/b/2009/06/02/oprah-medical-malpractice.htm |work=About.com: Thyroid Disease |last=Shomon |first=Mary |author-link=Mary Shomon |date=2 June 2009 |access-date=25 June 2013 |postscript=. |archive-date=12 April 2014 |archive-url=https://web.archive.org/web/20140412062911/http://thyroid.about.com/b/2009/06/02/oprah-medical-malpractice.htm |url-status=dead }}<br>{{cite news |last=Gorski |first=David |title=Is Oprah Winfrey giving us bad medicine? |url=https://www.thestar.com/news/insight/2009/06/07/is_oprah_winfrey_giving_us_bad_medicine.html |newspaper=] |date=7 June 2009 |access-date=21 June 2013 |publisher=<!-- omitted for brevity ] --> }}<br>{{cite news |last=Amarasingam |first=Amarnath |title=Oprah: High priestess of the New Age |url=https://www.washingtonpost.com/blogs/on-faith/post/oprah-high-priestess-of-the-new-age/2011/05/25/AGJOBHBH_blog.html |newspaper=] |date=25 May 2011 |publisher=<!-- omitted for brevity ] --> |access-date=21 June 2013 |archive-date=11 January 2012 |archive-url=https://web.archive.org/web/20120111102010/http://www.washingtonpost.com/blogs/on-faith/post/oprah-high-priestess-of-the-new-age/2011/05/25/AGJOBHBH_blog.html |url-status=dead }}</ref> ],<ref>{{citation |last1=Fahey |first1=Jonathan |last2=Whelan |first2=David |title=In Pictures: Celebs Who Take On Science |url=https://www.forbes.com/2010/01/14/science-jenny-mccarthy-business-healthcare-hollywood-autism_slide_8.html |page=8 (Bill Maher) |date=14 January 2010 |work=] |publisher=<!-- omitted for brevity Forbes Media --> |access-date=26 June 2013 |postscript=.}}</ref> ],<ref>{{citation |last= Miller |first= Henry I. |author-link= Henry I. Miller |title= Can tiny amounts of poison actually be good for you? |url= https://www.forbes.com/sites/henrymiller/2011/12/21/can-tiny-amounts-of-poison-actually-be-good-for-you/ |archive-url= https://web.archive.org/web/20120103154203/http://www.forbes.com/sites/henrymiller/2011/12/21/can-tiny-amounts-of-poison-actually-be-good-for-you/ |url-status= dead |archive-date= January 3, 2012 |date= 21 December 2011 |work= Forbes.com |publisher= <!-- omitted for brevity Forbes Media --> |access-date= 27 June 2013 |postscript=.}}</ref> and '']''.<ref>{{citation |last= Whelan |first= David |title= AOL-Huffington on health: Does Tim Armstrong think vaccines cause Autism? |url= https://www.forbes.com/sites/davidwhelan/2011/02/09/aol-huffington-on-health-does-tim-armstrong-think-vaccines-cause-autism |date= 9 February 2011 |work= Forbes.com |publisher= <!-- omitted for brevity Forbes Media --> |access-date= 26 June 2013|postscript=. }}</ref> In June 2013, he expressed support for ] speaking out against poor medical practices and the sale of unproven treatments.<ref>{{citation |last= Pho |first= Kevin |author-link= Kevin Pho |title= Two nurses face jail time for reporting a doctor to the Texas Medical Board |url= http://www.kevinmd.com/blog/2009/10/nurses-face-jail-time-reporting-doctor-texas-medical-board.html |work= KevinMD.com |publisher= MedPage Today |date= 15 October 2009 |access-date= 25 June 2013|postscript=.}}</ref> Gorski was interviewed by ] in 2012.<ref>{{cite episode | url=http://www.publicrealityradio.org/programs/culturewarsradio/episodes/8-14-2012-dr-david-gorski-and- | title=Dr. David Gorski and Mike Farrell | date=14 August 2012 | access-date=16 June 2013 | last=Brayton | first=Ed (host) | series=Culture Wars Radio | network=WPRR, Public Reality Radio | type=podcast | archive-url=https://web.archive.org/web/20121113211638/http://www.publicrealityradio.org/programs/culturewarsradio/episodes/8-14-2012-dr-david-gorski-and- | archive-date=13 November 2012}}</ref> He criticized the ] for their co-sponsorship of an Integrative Medicine Day.<ref>{{Cite web |last=Gorski |first=David |date=2012-10-22 |title=The American Medical Student Association: On "integrating" quackery with science-based medicine |url=https://sciencebasedmedicine.org/the-american-medical-student-association-a-corrosive-force/ |access-date=2022-12-29 |website=sciencebasedmedicine.org |language=en-US}}</ref>
In 2007 Gorski received the Advanced ] Award in Breast Cancer from the ].<ref name="US Fed News">{{cite journal | date=11 June 2007 | accessdate=14 June 2013 | first1=Michele | last1=Fisher | url=http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm | title=New Jersey surgical oncologist receives prestigious award at international conference | publisher=] | last2=] | postscript=. | quote=CINJ scientist receives a near half-million dollars for future breast cancer research. | archiveurl=https://web.archive.org/web/20130205153112/http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm | archivedate=5 February 2013}}</ref> Gorski was also awarded research grants by ] in 2008, 2009, and 2010.<ref name="bcrf" />


In September 2014, Gorski and fellow skeptic ] published an article in '']'' denouncing the study of ] as harmful to science.<ref>{{cite journal|last1=Gorski|first1=David H.|last2=Novella|first2=Steven P.|title=Clinical trials of integrative medicine: testing whether magic works?|journal=Trends in Molecular Medicine|doi=10.1016/j.molmed.2014.06.007|pmid=25150944|volume=20|issue=9|date=Sep 2014|pages=473–6}}</ref><ref>{{cite web | url=http://www.telegraphindia.com/1140821/jsp/nation/story_18743298.jsp#.U_d9XrxdXN4 | archive-url=https://web.archive.org/web/20140823170355/http://www.telegraphindia.com/1140821/jsp/nation/story_18743298.jsp#.U_d9XrxdXN4 | url-status=dead | archive-date=August 23, 2014 | title=US doctors spark homeopathy row | work=] | date=20 August 2014 | access-date=22 August 2014 | author=Mudur, GS}}</ref> The following month Gorski also published an article critical of integrative oncology.<ref>{{Cite journal |last=Gorski |first=David H. |date=October 2014 |title=Integrative oncology: really the best of both worlds? |url=https://www.nature.com/articles/nrc3822 |journal=Nature Reviews Cancer |language=en |volume=14 |issue=10 |pages=692–700 |doi=10.1038/nrc3822 |pmid=25230880 |s2cid=33539406 |issn=1474-1768}}</ref> Six of his colleagues responded to express concerns with his view on integrative oncology.<ref>{{Cite journal |last1=Greenlee |first1=Heather |last2=Zick |first2=Suzanna M. |last3=Rosenthal |first3=David |last4=Cohen |first4=Lorenzo |last5=Cassileth |first5=Barrie |last6=Tripathy |first6=Debu |date=March 2015 |title=Integrative oncology — strong science is needed for better patient care |journal=Nature Reviews Cancer |language=en |volume=15 |issue=3 |pages=165 |doi=10.1038/nrc3822-c1 |pmid=25693833 |s2cid=8053861 |issn=1474-1768|doi-access=free }}</ref>


== Personal life ==
Gorski is married.<ref name=":0" /><ref name=":2" /> His views have gradually shifted from conservative to center-left Democrat.<ref name=":0" />


==Publications==
===Research===
* {{cite journal|last1=Speyer|first1=Cecilia L.|last2=Nassar|first2=Mahdy A.|last3=Hachem|first3=Ali H.|last4=Bukhsh|first4=Miriam A.|last5=Jafry|first5=Waris S.|last6=Khansa|first6=Rafa M.|last7=Gorski|first7=David H.|title=Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1|journal=Breast Cancer Research and Treatment|date=4 May 2016|volume=157|issue=2|pages=217–228|doi=10.1007/s10549-016-3816-x|pmid=27146584|s2cid=23986691}}
Gorski's article, "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of ]s on the effectiveness of ] has been cited over 900 times according to PubMed.<ref name="gorski-1999">{{Cite journal |issn= <!-- omitted for brevity 0008-5472, 1538-7445 --> |volume= 59 |issue= 14 |pages= 3374–3378 |last= Gorski |first= David H. |last2= Beckett |first2= Michael A. |first3= Nora T. |last3= Jaskowiak |first4= Douglas P. |last4= Calvin |first5= Helena J. |last5= Mauceri |first6= Rabih M. |last6= Salloum |first7= Saraswathy |last7= Seetharam |first8= Ann |last8= Koons |first9= Danielle M. |last9= Hari |first10= Donald W. |last10= Kufe |first11= Ralph R. |last11= Weichselbaum |display-authors= 4|title= Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation| journal= Cancer Research |accessdate= 21 June 2013| date= 15 July 1999 |url= http://cancerres.aacrjournals.org/content/59/14/3374.long |pmid= 10416597 |publisher= <!-- omitted for brevity American Association for Cancer Research-->}}</ref><ref>{{citation |title= Related Citations for PubMed (Select 10416597) |url= http://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=10416597 |publisher= PubMed |accessdate= 28 June 2013}}</ref> This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ] "by preventing repair of radiation damage to ],"<ref name="kerbel-2002">{{Cite journal |doi= 10.1038/nrc905 |issn= <!-- omitted for brevity 1474-175X --> |volume= 2 |issue= 10 |pages= 727–739 |last= Kerbel |first= Robert |first2= Judah |last2= Folkman |authorlink2= Judah Folkman |title= Clinical translation of angiogenesis inhibitors |journal= ] |accessdate= 18 June 2013 |date= October 2002 |url= http://www.nature.com/nrc/journal/v2/n10/abs/nrc905.html |pmid= 12360276 |publisher= <!-- omitted for brevity ]-->}}</ref> and in determining the potential of combinational therapies to allow reduction of the dosages required in toxic conventional treatments<ref name="dvorak-2002">{{Cite journal |doi= 10.1200/JCO.2002.10.088 |issn= <!-- omitted for brevity 0732-183X, 1527-7755 --> |volume= 20 |issue= 21 |pages= 4368–4380 |last= Dvorak |first= Harold F. |title= Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy |journal= ] |accessdate= 20 June 2013 |date= 1 November 2002 |url= http://jco.ascopubs.org/content/20/21/4368 |publisher= <!-- omitted for brevity ]--> |pmid= 12409337}}</ref> while sustaining tumor regression when combined with specific ] and ].<ref name="klement-2000">
* {{cite journal |vauthors=Welch HG, Gorski DH, Albertsen PC | year = 2015 | title = Trends in Metastatic Breast and Prostate Cancer—Lessons in Cancer Dynamics | journal = N Engl J Med | volume = 373 | issue = 18| pages = 1685–1687 | pmid = 26510017 | doi=10.1056/NEJMp1510443}}
{{Cite journal |issn= <!-- omitted for brevity 0021-9738 --> |volume= 105 |issue= 8 |pages= R15–R24 |last= Klement |first= Giannoula |first2= Sylvain |last2= Baruchel |first3= Janusz |last3= Rak |first4= Shan |last4= Man |first5= Katherine |last5= Clark |first6= Daniel J. |last6= Hicklin |first7= Peter |last7= Bohlen |first8= Robert S. |last8= Kerbel |display-authors=4|title= Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity |journal= ] |publisher= <!-- omitted for brevity ] -->| date= 15 April 2000 |pmid= <!-- omitted for brevity 10772661 --> |doi= 10.1172/JCI8829| pmc= 517491}}</ref>
* {{cite journal | author = Gorski D. H. | year = 2014 | title = Integrative oncology: really the best of both worlds? | journal = Nat Rev Cancer | volume = 14 | issue = 10| pages = 692–700 | pmid = 25230880 | doi=10.1038/nrc3822| s2cid = 33539406 }}

* 2018 ''Pseudoscience: The Conspiracy Against Science'' "Integrative' Medicine: Integrating Quackery with Science-Based Medicine" :MIT Press: edited by Allison B. Kaufman, ]: {{ISBN|978-0262037426}}<ref>{{cite journal |last1=Bigliardi |first1=Stefano |title=The Advocates of Pseudoscience Are Not Monsters – but Pseudoscience Is |journal=Skeptical Inquirer |date=2019 |volume=43 |issue=6 |pages=58–59 |publisher=Center for Inquiry}}</ref>
Gorski's work with Helena Mauceri and others, published in ] as, ''Combined effects of angiostatin and ionizing radiation in antitumour therapy'' on research into the "combined effects of ]" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy"<ref name="mauceri-1998">{{cite journal |last1= Mauceri |first1= Helena J. |last2= Hanna |first2= Nader N. |last3= Beckett |first3= Michael A. |last4= Gorski |first4= David H. |last5= Staba |first5= Mary-Jane |last6= Stellato |first6= Kerri Anne |last7= Bigelow |first7= Kevin |last8= Heiman |first8= Ruth |last9= Gately |first9= Stephen |last10= Dhanabal |first10= Mohanraj |last11= Soff |first11= Gerald A. |last12= Sukhatme |first12= Vikas P. |last13= Kufe |first13= Donald W. |last14= Weichselbaum |first14= Ralph R. |display-authors=4|title= Combined effects of angiostatin and ionizing radiation in antitumour therapy |url= http://www.nature.com/nature/journal/v394/n6690/abs/394287a0.html |journal= ] |volume= 394 |date= 16 July 1998 |pages= 287–291 |doi= 10.1038/28412 |pmid= 9685160 |accessdate= 20 June 2013 |publisher= <!-- omitted for brevity Nature Publishing Group --> |issn= <!-- omitted for brevity 1476–4687 --> |issue= 6690}}</ref> led to investigation into the selective destruction of tumor cells, which according to a study by Gregg L. Semenza (citing Mauceri and others), "are more ] than normal cells," allowing for "tumor cells to be killed without major ]."<ref name="semenza-1999">{{Cite journal |doi= 10.1146/annurev.cellbio.15.1.551 |volume= 15 |issue= 1 |pages= 551–578 |last= Semenza |first= Gregg L. |title= Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1 |journal= ] |publisher= <!-- omitted for brevity ] -->|accessdate= 20 June 2013 |year= 1999 |url= http://www.annualreviews.org/doi/abs/10.1146/annurev.cellbio.15.1.551 |pmid= 10611972 |issn= <!-- omitted for brevity 1081-0706 -->}}</ref>

The article, ''Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5'' by Gorski and Yun Chen, into the use of ] to regulate ]<ref name="chen-2008">{{Cite journal |doi= 10.1182/blood-2007-07-104133 |issn= <!-- omitted for brevity 0006-4971 --> |volume= 111 |issue= 3 |pages= 1217–1226 |last= Chen |first= Yun |first2= David H. |last2= Gorski |title= Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 |journal= ] |publisher= <!-- omitted for brevity ] --> |date= 1 February 2008 |pmid= <!-- omitted for brevity 17957028 --> |pmc= 2214763}}</ref> led to research by Jason E. Fish's group at the ], into the use of microRNA to regulate blood vessel development, limiting tumor growth. Citing Chen and Gorski's research, Fish wrote that "several broadly expressed microRNAs regulate ] endothelial cell behavior, including proliferation, migration, and the ability to form ] networks", and sought to describe the '']'' functionality of a specific set of microRNAs and their targets; the group was able to isolate a particular microRNA (miR-126) as the most highly enriched in endothelial cells.<ref name="fish-2008">{{Cite journal |doi= 10.1016/j.devcel.2008.07.008 |issn= <!-- omitted for brevity 1534-5807 --> |volume= 15 |issue= 2 |pages= 272–284 |last= Fish |first= Jason E. |first2= Massimo M. |last2= Santoro |first3= Sarah U. |last3= Morton |first4= Sangho |last4= Yu |first5= Ru-Fang |last5= Yeh |first6= Joshua D. |last6= Wythe |first7= Kathryn N. |last7= Ivey |first8= Benoit G. |last8= Bruneau |first9= Didier Y.R. |last9= Stainier |first10= Deepak |last10= Srivastava |display-authors=4 | title= miR-126 Regulates Angiogenic Signaling and Vascular Integrity |journal= Developmental Cell |publisher= <!-- omitted for brevity ] --> |accessdate= 22 June 2013| date= 12 August 2008| url= http://www.sciencedirect.com/science/article/pii/S1534580708002876 |pmid= <!-- omitted for brevity 18694566 -->| pmc= 2604134}}</ref>

==Skepticism of CAM==
], ], David Gorski, and ] on a panel at The Amaz!ng Meeting 2012]]
Gorski is an outspoken ] of ]. In 2006, Gorski, under the ] "Orac”, began writing a blog entitled ''Respectful Insolence'' at the ] website.<ref name="bremner">{{Cite web |last= Bremner |first= Doug|authorlink=Doug Bremner|title= Blogging doctors rock on! |url= http://www.huffingtonpost.com/doug-bremner/blogging-doctors-rock-on_b_127675.html |work= The Huffington Post |date= 19 September 2008 |accessdate=24 June 2013 |postscript=. }}</ref><ref>{{cite web|url=http://www.scienceblogs.com/insolence/author/oracknows/ |title= ''Respectful Insolence'' |last1= Gorski |first1= David |date= |website= |publisher= ScienceBlogs |accessdate= 20 June 2013}}</ref> In 2008 Gorski used his real name when he started blogging at ''Science-Based Medicine'' (he continues to use 'Orac' for ''Respectful Insolence''). He is currently their managing editor, and has posted on issues at the intersection of medicine and ], including the anti-vaccination movement, alternative therapies, and cancer research and treatment.<ref>{{citation |last= Jones |first= Val |title= Hostility Towards Scientists and Jenny McCarthy's Latest Video |url= http://www.medpagetoday.com/Blogs/KevinMD/14538 |work= KevinMD.com |editor= Kevin Pho |editor-link= Kevin Pho |publisher= MedPage Today |date= 4 June 2009 |accessdate= 25 June 2013|postscript=.}}</ref><ref name = "denialism"/> According to Gorski, in 2010 members of the anti-vaccine blog ] wrote to the board of directors at Wayne State University and asked that he be prevented from blogging.<ref name="Gorski blog">{{cite web |url= http://www.sciencebasedmedicine.org/the-price-of-skepticism/ |title= The price of opposing medical pseudoscience |publisher= ''Science-Based Medicine'' |date= 18 June 2010 |accessdate= 14 June 2013 |last= Gorski |first= David H.}}</ref> He has contributed considerable parts of the ]'s series of EBooks, the ''Science Based Medicine Guides''.<ref name = "science guides">{{cite web |author= JREF Staff |title= JREF publishes three volumes on science-based medicine |url= http://67.228.115.46/site/index.php/jref-news/2023-jref-publishes-three-volumes-on-science-based-medicine.html |publisher=] |accessdate= 28 June 2013}}<br>{{cite web |author= <!-- no byline JREF Staff --> | title= JREF publishes three more science-based medicine volumes |publisher= James Randi Education Foundation |accessdate= 28 June 2013 |url= http://67.228.115.46/site/index.php/jref-news/2075-jref-publishes-three-more-science-based-medicine-volumes.html}}<br>{{cite web |author= <!-- no byline JREF Staff --> |title= Science-based medicine Ebooks, volumes 7-12 now available |url= http://67.228.115.46/site/index.php/jref-news/2130-science-based-medicine-ebooks-volumes-7-12-now-available.html |publisher= James Randi Education Foundation |accessdate= 28 June 2013}}</ref> He is also a fellow of the ].<ref>{{cite web|title=CSI Fellows and Staff|url=http://www.csicop.org/about/csi_fellows_and_staff/|accessdate=2 August 2013}}</ref>

Gorski was a speaker at ] in 2009, 2010, 2012 and 2013.<ref>{{cite web |title= The Amaz!ing Meeting 2013: Schedule |url= http://www.amazingmeeting.com/tam2013/schedule |work= The Amza!ing Meeting website |year= 2013 |accessdate= 24 June 2013 |publisher= James Randi Education Foundation}}</ref><ref name = "tam sched">{{cite web |last= Novella |first= Steven |authorlink= Steven Novella |title= Science-Based Medicine Conference |url= http://theness.com/neurologicablog/index.php/science-based-medicine-conference/ |work= Neurologica blog |publisher= ] |date= 6 March 2009 |accessdate= 24 June 2013}}<br>{{Cite journal |last= Wagg |first= Jeffrey |title= The Amaz!ng Meeting 8, 2010 Schedule |url= http://www.randi.org/site/index.php/component/content/article/37-static/882-the-amazing-meeting-8-2010-schedule.html |publisher= ] |year= 2010 |accessdate= 24 June 2013 |postscript=.}}<br>{{Cite journal |title= Expert panel trashes "alternative medicine" concept |url= http://www.ncahf.org/digest12/12-29.html |work= Consumer Health Digest |issue= 12–29 |date= 23 August 2012 |publisher= ] |accessdate= 25 June 2013 |postscript=.}}<br>{{cite web |title= The Amaz!ing Meeting 2012: Program |url= http://www.amazingmeeting.com/TAM2012/program |work= ] website |year= 2012 |publisher= James Randi Education Foundation |accessdate= 24 June 2013}}</ref> He has also participated in numerous panels on alternative medicine.<ref>{{cite web |url=http://www.mcgill.ca/science/events/trottier-symposium/2010/october18 |title=Drs. Ben Goldacre, David Gorski and Michael Shermer on the threat of pseudoscience |date=18 October 2010 |work= |publisher=], McGill University |accessdate=20 June 2013}}</ref><ref>{{cite web |title= David Gorski&nbsp;— NECSS |url= http://necss.org/speakers/david-gorski |website= Northeast Conference on Science and Skepticism website (NECSS) |publisher= ] and NYC Skeptics |accessdate= 24 June 2013}}</ref><ref>{{cite web |title= Speakers |url= http://www.csiconference.org/speakers.php |work= CSICon 2012 website |publisher= ] |year= 2012 |accessdate= 24 June 2013}}</ref> He called attention to a paper by ] on problems with published research.<ref name = "bestsci">*{{cite book |last1= Roach |first1= Mary |authorlink= Mary Roach |last2= Folger |first2= Tim |authorlink2= Tim Folger |title= The Best American Science and Nature Writing 2011: The Best American Series |url= http://books.google.com/books?id=yuMW5r7C29EC |accessdate= 21 June 2013 |date= 4 October 2011 |publisher= Houghton Mifflin Harcourt |isbn= 978-0-547-67846-7 |pages= 123–124}}</ref>

Gorski has commented on the increasing infiltration of pseudoscience in the medical field with the use of alternative therapies,<ref>{{citation |last= Page |first= Leigh |title= What to do when a patient wants 'alternative' medicine |url= http://www.medscape.com/viewarticle/805545 |date= 12 June 2013 |work= Medscape Business of Medicine |publisher= <!-- omitted for brevity Medscape --> |accessdate= 25 June 2013|postscript=.}}</ref><ref>{{cite news |magazine= ] |last= Munger |first= Dave |title= Controls for acupuncture studies are improving. Their results are not. How are peer reviewers reacting? |url= http://seedmagazine.com/content/article/acupuncture_real_or_sham/ |date= 2 September 2009 |publisher= <!-- omitted for brevity Seed Media Group --> |issn= <!-- omitted for brevity 1499-0679 --> |accessdate= 27 June 2013}}</ref> the use of ] for treatment of soldiers,<ref>{{citation |last= Salzberg |first= Steven|authorlink= Steven Salzberg |title= Battlefield acupuncture: Pseudoscience for wounded troops |url= http://www.forbes.com/sites/sciencebiz/2010/02/15/battlefield-acupuncture-pseudoscience-for-wounded-troops/ |date= 15 February 2010 |work= ] |publisher= <!-- omitted for brevity Forbes Media --> |accessdate= 25 June 2013 |postscript=.}}</ref> "]" cleanses,<ref>{{cite news |title= Bridal Hunger Games: Losing Weight in Time for the Wedding |url= http://www.nytimes.com/2012/04/15/fashion/weddings/Losing-Weight-in-Time-for-the-Wedding.html |last= Lee |first= Linda |newspaper= ] |date= 13 April 2012 |accessdate= 25 June 2013}}</ref> and ] of ].<ref>{{citation |last= Hansen |first= Lacy Jaye |date= 7 December 2012 |title= The GAPS diet claims you can eat away autism. But can you really? |url= http://www.dietsinreview.com/diet_column/12/the-gaps-diet-claims-you-can-eat-away-autism-but-can-you-really/ |work= Diets in Review.com | accessdate = 25 June 2013|postscript=.}}</ref>

He advocates for openness of the results of ]s<ref>{{citation |last= Miller |first= Naseem |title= Most drug trial results analyzed by FDA hidden from view |url= http://www.publicintegrity.org/2010/05/14/2673/most-drug-trial-results-analyzed-fda-hidden-view |origyear= 14 May 2010 |date= 16 March 2011 |work= Accountability |publisher= ] | accessdate= 26 June 2013|postscript=.}}</ref> and the use of only ] to treat ]s.<ref>{{citation |last= Herper |first= Matthew |title= Bedbugs, Avastin, and a fight at the FDA |url= http://www.forbes.com/sites/matthewherper/2010/08/31/bedbugs-avastin-and-a-fight-at-the-fda/ |work= Forbes.com |publisher= <!-- omitted for brevity Forbes Media --> |date= 31 August 2010 |accessdate= 26 June 2013 |postscript=.}}</ref> He has been critical of ] support of the ] (NCCAM).<ref name = "denialism">{{cite book |first= Michael |last= Specter |title= Denialism: How Irrational Thinking Harms the Planet and Threatens Our Lives |url= http://books.google.com/books?id=J-VMNrt3JyIC |accessdate= 21 June 2013 |date= 29 October 2009 |publisher= Penguin Group US |isbn= 978-1-101-15102-0}}</ref> He has criticized the ] (NIH) and NCCAM for funding and publishing research on, “treatment modalities that are inherently unscientific, being as they are based on prescientific or demonstrably incorrect understandings of human physiology and disease”,<ref name = "systematic">{{cite journal |title= Systematic reviews of animal models: Methodology versus epistemology |url= http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558708/ |last1= Greek |first1= Ray |last2= Menache |first2= Andre |journal= ] |publisher= <!-- omitted for brevity ] --> |year= 2013 |volume= 10 |issue= 3 |pages= 206–221 |doi= 10.7150/ijms.5529 |PMID= 23372426 |issn= <!-- omitted for brevity 1449-1907 --> |pmc=3558708}}</ref><ref name = "NCCAM">{{citation |last= Husten |first = Larry |title= The Raging Debate Over The NIH's TACT Chelation Trial |url= http://www.forbes.com/sites/larryhusten/2013/04/02/a-guide-to-the-raging-debate-over-the-nihs-tact-chelation-trial/ |date= 1 April 2013 |work= Forbes.com |publisher= <!-- omitted for brevity Forbes Media --> | accessdate=26 June 2013 |postscript=.}}<br>{{cite book |last1= Berezow |first1= Alex B. |last2= Campbell |first2= Hank |title= Science Left Behind: Feel-Good Fallacies and the Rise of the Anti-Scientific Left|url=http://books.google.com/books?id=dJaA7aN6GdAC|accessdate=2013-06-21 |date= September 2012 |publisher= PublicAffairs |isbn= 978-1-61039-165-8}}<br>{{cite book |last =Kay |first= Alison J. |title= What If There's Nothing Wrong? |url= http://books.google.com/books?id=ZjtGMrFZ3RYC |accessdate=21 June 2013 |date= 20 November 2012 |publisher= Balboa Press |isbn= 978-1-4525-6147-9 |page= 283}}</ref> and has commented on the ], methods, and results of the study of alternative medicine.<ref name = "study">{{citation |last= Khorana |first= Alok |title= Alternative medicine and trials of dubious ethicality |url= http://boards.medscape.com/forums/?128@@.29f63208!comment=1 |work= OncNotes |publisher= ] |date= 16 September 2009 |accessdate= 25 June 2013|postscript=.}}<br>{{citation |last= Schneider |first= Lee |title= Snake oil medicine |url= http://www.huffingtonpost.com/lee-schneider/snake-oil-medicine_b_302024.html |date= 30 September 2009 |work= ] | accessdate = 27 June 2013|postscript=.}}<br>{{citation |last= Keller |first= Daniel M. |title= Integrative Medicine Use Up, but Outcomes Still Uncertain |url= http://www.medscape.com/viewarticle/758725 |date= 15 February 2012 |work= Medscape Medical News |publisher= <!-- omitted for brevity Medscape --> |accessdate= 25 June 2013|postscript=.}}</ref>

Gorski has spoken out against the popularization of what he describes as pseudoscience by the media and celebrities such as ],<ref name = "oprah">{{citation |title= Media and bloggers accuse Oprah of medical malpractice |url= http://thyroid.about.com/b/2009/06/02/oprah-medical-malpractice.htm |work= About.com: Thyroid Disease |last= Shomon |first= Mary |authorlink= Mary Shomon |date= 2 June 2009 |accessdate= 25 June 2013|postscript=.}}<br>{{cite news |last= Gorski |first= David |title= Is Oprah Winfrey giving us bad medicine? |url= http://www.thestar.com/news/insight/2009/06/07/is_oprah_winfrey_giving_us_bad_medicine.html |newspaper= ] |date= 7 June 2009 | accessdate= 21 June 2013 |publisher= <!-- omitted for brevity ] -->}}<br>{{cite news |last= Amarasingam |first= Amarnath |title= Oprah: High priestess of the New Age |url= http://www.washingtonpost.com/blogs/on-faith/post/oprah-high-priestess-of-the-new-age/2011/05/25/AGJOBHBH_blog.html |newspaper= ] |date= 25 May 2011 |publisher= <!-- omitted for brevity ] --> |accessdate= 21 June 2013}}</ref> ],<ref>{{citation |last= Fahey |first= Jonathan |last2= Whelan |first2= David |title= In Pictures: Celebs Who Take On Science |url= http://www.forbes.com/2010/01/14/science-jenny-mccarthy-business-healthcare-hollywood-autism_slide_8.html |page= 8 (Bill Maher) |date= 14 January 2010 |work= ] |publisher= <!-- omitted for brevity Forbes Media --> |accessdate= 26 June 2013|postscript=.}}</ref> ],<ref>{{citation |last= Miller |first= Henry I. |authorlink= Henry I. Miller |title= Can tiny amounts of poison actually be good for you? |url= http://www.forbes.com/sites/henrymiller/2011/12/21/can-tiny-amounts-of-poison-actually-be-good-for-you/ |date= 21 December 2011 |work= Forbes.com |publisher= <!-- omitted for brevity Forbes Media --> |accessdate= 27 June 2013 |postscript=.}}</ref> and the ].<ref>{{citation |last= Whelan |first= David |title= AOL-Huffington on health: Does Tim Armstrong think vaccines cause Autism? |url= http://www.forbes.com/sites/davidwhelan/2011/02/09/aol-huffington-on-health-does-tim-armstrong-think-vaccines-cause-autism |date= 9 February 2011 |work= Forbes.com |publisher= <!-- omitted for brevity Forbes Media --> |accessdate= 26 June 2013|postscript=. }}</ref> In June 2013 Gorski said he supported ] speaking out against poor medical practices and the sale of "dubious therapies."<ref>{{citation |last= Pho |first= Kevin |authorlink= Kevin Pho |title= Two nurses face jail time for reporting a doctor to the Texas Medical Board |url= http://www.kevinmd.com/blog/2009/10/nurses-face-jail-time-reporting-doctor-texas-medical-board.html |work= KevinMD.com |publisher= MedPage Today |date= 15 October 2009 |accessdate= 25 June 2013|postscript=.}}</ref>

Gorski was interviewed by ] in 2012.<ref>{{cite episode |last= Brayton |first= Ed (host) |title= Dr. David Gorski and Mike Farrell |url= http://www.publicrealityradio.org/programs/culturewarsradio/episodes/8-14-2012-dr-david-gorski-and- |series= Culture Wars Radio |network= WPRR, Public Reality Radio |date= 14 August 2012 |accessdate= 16 June 2013 |format=podcast}}</ref> He called the co-sponsorship of Integrative Medicine Day by the American Medical Students Association “an infiltration of quackademic medicine” and was described by the pro-CAM science writer David H. Freedman as "one of the more prickly anti-alternative-medicine warriors."<ref name="freedman-2012">{{Cite news |last= Freedman |first= David H. |title= Doctors who care: Does alternative medicine work? |url= http://www.utne.com/mind-body/alternative-medicine-zm0z12mjzros.aspx |magazine= ] |date= May–June 2012 |accessdate= 24 June 2013 |publisher= <!-- omitted for brevity Ogden Publications --> |issn=<!-- omitted for brevity 8750-0256 --> |postscript=.}}</ref>

In 2014, Gorski and fellow skeptic ] published an article denouncing clinical trials of ] and arguing that such trials "degrade the scientific basis of medicine" by, according to the Calcutta Telegraph, "portraying formulations whose basis rests on pre-scientific thinking as though they were supported by science."<ref>{{cite journal|last1=Gorski|first1=David H.|last2=Novella|first2=Steven P.|title=Clinical trials of integrative medicine: testing whether magic works?|journal=Trends in Molecular Medicine|doi=10.1016/j.molmed.2014.06.007}}</ref><ref>{{cite web | url=http://www.telegraphindia.com/1140821/jsp/nation/story_18743298.jsp#.U_d9XrxdXN4 | title=US doctors spark homeopathy row | work=] | date=20 August 2014 | accessdate=22 August 2014 | author=Mudur, GS}}</ref>

==Views on other medical issues==
Gorski has been vocally critical of ]s, which expand access to experimental drugs for terminally ill patients.<ref>{{cite web | url=http://www.nytimes.com/2015/01/11/us/patients-seek-right-to-try-new-drugs.html | title=Patients Seek ‘Right to Try’ New Drugs | work=New York Times | date=11 January 2015 | accessdate=31 January 2015 | author=Turkewitz, Julie}}</ref> He has also voiced skepticism of the theory that ] played a role in the evolution of cancer.<ref>{{cite web | url=http://www.scientificamerican.com/article/did-cancer-evolve-to-protect-us/ | title=Did Cancer Evolve to Protect Us? | work=] | date=2 October 2014 | accessdate=31 January 2015 | author=Merali, Zeeya}}</ref>


==References== ==References==
{{Reflist|2}} {{reflist|30em}}


==External links== ==External links==
* , Gorski's blog. Publisher: ] * , Gorski's blog
* * at ''Science Based Medicine''
*
* {{Google Scholar id|7ASTqGoAAAAJ}}
*
*

{{Authority control}}


{{Persondata
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| SHORT DESCRIPTION = American surgeon
| DATE OF BIRTH =
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{{DEFAULTSORT:Gorski, David}} {{DEFAULTSORT:Gorski, David}}
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Latest revision as of 20:59, 21 November 2024

Science-based medicine advocate
David Gorski
Gorski in 2016
BornDavid Henry Gorski
NationalityAmerican
Education
Scientific career
FieldsSurgical oncology
Institutions
Doctoral advisorKenneth Walsh

David Henry Gorski is an American surgical oncologist and professor of surgery at Wayne State University School of Medicine. He specializes in breast cancer surgery at the Karmanos Cancer Institute. Gorski is an outspoken skeptic and critic of alternative medicine and the anti-vaccination movement. He writes as Orac at Respectful Insolence and as himself at Science-Based Medicine, where he is the managing editor.

Early life and education

Gorski attended a Roman Catholic high school. He went on to study medicine at the University of Michigan, earning an MD in 1988. He entered a residency in general surgery in 1989 at the University Hospitals of Cleveland. Gorski completed a PhD in cellular physiology at Case Western Reserve University in 1994. His dissertation was entitled "Homeobox Gene Expression and Regulation in Vascular Myocytes." Gorski continued his residency (1993–96) and completed a surgical oncology research fellowship (1996–99) at The University of Chicago.

Prior to 2005, he was active on the early internet message boards of Usenet participating in flame wars.

Career

In the mid 2000s, Gorski taught surgery as an associate professor at the Rutgers Cancer Institute of New Jersey and the Robert Wood Johnson Medical School, at Rutgers University.

In 2007 he received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology. He was awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010.

In 2008, Gorski joined the Wayne State University School of Medicine and became affiliated with the Karmanos Cancer Institute. He is a professor of surgery and oncology at the Wayne State University School of Medicine, whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer. In 2009, he was appointed the cancer liaison physician for the American College of Surgeons Committee on Cancer.

He became the co-director of the Michigan Breast Oncology Quality Initiative in 2013.

Gorski is listed as a founder of the Institute for Science in Medicine and as a member of the American Society of Clinical Oncology.

Research

Gorski's 1999 article "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies, has been cited over 900 times according to PubMed. This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells," and in determining the potential of combinational therapies to allow reduction of the dosages in toxic conventional treatments while sustaining tumor regression when combined with specific antibodies and radiation therapy.

Gorski's work with Helena Mauceri and others, published in Nature in 1998 as "Combined effects of angiostatin and ionizing radiation in antitumour therapy" studied the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy" led to investigation into the selective destruction of tumor cells, which according to a 1999 study by Gregg L. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects."

In 2008, Gorski and Yun Chen published an article titled "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5" that investigated the use of microRNA to regulate angiogenesis.

Skepticism of alternative medicine

One person standing at a podium and three people sitting at a table with microphones in front of them
Skeptics Steven Novella, Harriet Hall, David Gorski, and Rachael Dunlop on a panel at The Amaz!ng Meeting 2012

Gorski is a vocal skeptic of alternative medicine and has criticized pseudoscience.

He has criticized the prevalence of pseudoscience in the medical field including the use of alternative therapies, acupuncture, detoxification, and the use of dietary treatment to manage autism.

Blogs

Gorski is a prolific blogger. In 2004, he began writing a blog entitled Respectful Insolence at Blogspot under the pen name Orac. Respectful Insolence was then moved to the ScienceBlogs website. Alissa Quart, writing for Columbia Journalism Review in 2010, described Orac as a "self-appointed autism expert" known for attacking the "vaccines-cause-autism set" and who had recently celebrated when an opponent lost their medical license. In 2015, writing for Slate, Jacob Brogan said Orac was a "doctor who blogs about skepticism and medicine".

In 2008 Gorski started blogging at Science-Based Medicine under his real name while continuing to blog as Orac at Respectful Insolence. He was later doxed as Orac. As the managing editor at Science-Based Medicine, Gorski has posted on issues of medicine and pseudoscience, including the anti-vaccination movement, alternative therapies, and cancer research and treatment. In 2010, Gorski recounted how members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging.

Writing for The Atlantic in 2011, David H. Freedman described Gorski as one of the more "prickly anti-alternative-medicine warriors" and said he was "among a small, loud band of alt-med critics."

Gorski contributed to the James Randi Education Foundation's series of EBooks: Science Based Medicine Guides. He is a fellow of the Committee for Skeptical Inquiry. He was a speaker at The Amaz!ng Meeting in 2009, 2010, 2012 and 2013 and has been a participant on several panels on alternative medicine. He called attention to a 2005 paper by John Ioannidis on problems with published research.

Gorski has advocated for open research data of clinical trial results and for using only evidence-based medicine to treat disease. He has been critical of Senator Tom Harkin's support of the National Center for Complementary and Alternative Medicine (NCCAM), which became the National Center for Complementary and Integrative Health. He has criticized the National Institutes of Health (NIH) and NCCAM for funding and publishing research on unproven therapies not supported by science-based evidence, and has commented on medical ethics and methods of alternative medicine.

Gorski has criticized popularization of pseudoscience by the media and celebrities such as Oprah Winfrey, Bill Maher, Ann Coulter, and The Huffington Post. In June 2013, he expressed support for healthcare professionals speaking out against poor medical practices and the sale of unproven treatments. Gorski was interviewed by WPRR in 2012. He criticized the American Medical Student Association for their co-sponsorship of an Integrative Medicine Day.

In September 2014, Gorski and fellow skeptic Steven Novella published an article in Trends in Molecular Medicine denouncing the study of integrative medicine as harmful to science. The following month Gorski also published an article critical of integrative oncology. Six of his colleagues responded to express concerns with his view on integrative oncology.

Personal life

Gorski is married. His views have gradually shifted from conservative to center-left Democrat.

Publications

  • Speyer, Cecilia L.; Nassar, Mahdy A.; Hachem, Ali H.; Bukhsh, Miriam A.; Jafry, Waris S.; Khansa, Rafa M.; Gorski, David H. (4 May 2016). "Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1". Breast Cancer Research and Treatment. 157 (2): 217–228. doi:10.1007/s10549-016-3816-x. PMID 27146584. S2CID 23986691.
  • Welch HG, Gorski DH, Albertsen PC (2015). "Trends in Metastatic Breast and Prostate Cancer—Lessons in Cancer Dynamics". N Engl J Med. 373 (18): 1685–1687. doi:10.1056/NEJMp1510443. PMID 26510017.
  • Gorski D. H. (2014). "Integrative oncology: really the best of both worlds?". Nat Rev Cancer. 14 (10): 692–700. doi:10.1038/nrc3822. PMID 25230880. S2CID 33539406.
  • 2018 Pseudoscience: The Conspiracy Against Science "Integrative' Medicine: Integrating Quackery with Science-Based Medicine" :MIT Press: edited by Allison B. Kaufman, James C. Kaufman: ISBN 978-0262037426

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