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{{Short description|Species of plant}}
{{Taxobox
{{Speciesbox
| color = lightgreen
| name = ''Uncaria tomentosa'' |image = Uncaria tomentosa.png
⚫ |genus = Uncaria
| image = Thorns U tomentosa.jpg
⚫ |species = tomentosa
| image_width = 240px
|authority = (] ex ]) ]<ref name=GRIN>{{GRIN | access-date=2008-03-01}}</ref>
| image_caption =
| regnum = ]ae
| divisio = ]
| classis = ]
| ordo = ]
| familia = ]
⚫ | genus = '']''
⚫ | species = '''''U. tomentosa'''''
| binomial = ''Uncaria tomentosa''
| binomial_authority = (Willd. ex Schult.) ]
}} }}


'''''Uncaria tomentosa''''' is a ] found in the tropical jungles of South and Central America. It is known as '''cat's claw''' or '''uña de gato''' in ] because of its claw-shaped thorns.<ref name=GRIN/><ref name="drugs">{{cite web | title=Cat's claw | publisher=Drugs.com | date=6 September 2021 | url=https://www.drugs.com/npp/cat-s-claw.html | access-date=16 August 2022}}</ref> The plant ] is used in ] for a variety of ailments, and is sold as a ].<ref name=drugs/><ref name="ema">{{cite web |title=Assessment report on ''Uncaria tomentosa'' (Willd. ex Schult.) DC., cortex |url=https://www.ema.europa.eu/documents/herbal-report/draft-assessment-report-uncaria-tomentosa-willd-ex-schult-dc-cortex_en.pdf |publisher=European Medicines Agency |access-date=11 January 2019 |date=10 March 2015}}</ref><ref name="nccih">{{cite web |title=Cat's claw |url=https://www.nccih.nih.gov/health/cats-claw |publisher=National Center for Complementary and Integrative Health, US National Institutes of Health |access-date=17 August 2022 |date=1 May 2020}}</ref>
'''''Uncaria tomentosa''''' ('''Cat's Claw''' or '''Uña de Gato''') is a ] in the family ], native to ] and ] from ] south to ], occurring in ]s.


Evidence of anti-inflammatory action is limited to cell culture studies.<ref>{{cite journal |last1=Sandoval-Chacón |first1=M |last2=Thompson |first2=JH |last3=Zhang |first3=XJ |last4=Liu |first4=X |last5=Mannick |first5=EE |last6=Sadowska-Krowicka |first6=H |last7=Charbonnet |first7=RM |last8=Clark |first8=DA |last9=Miller |first9=MJ |title=Antiinflammatory actions of cat's claw: the role of NF-κB |journal=Alimentary Pharmacology & Therapeutics |date=December 1998 |volume=12 |issue=12 |pages=1279–1289 |doi=10.1046/j.1365-2036.1998.00424.x |pmid=9882039 |s2cid=24640166 }}</ref><ref>{{cite journal |last1=Miller |first1=Mark J. S. |last2=Zhang |first2=Xiao-Jing |last3=Charbonnet |first3=Randi M. |last4=Clark |first4=David A. |last5=Sandoval |first5=Manuel |title=The Anti-Inflammatory Actions of the Herbal Medicine, Cat's Claw, Are Due to a Suppression of NF-κB Activation and Inhibition of Gene Expression |journal=Pediatric Research |date=April 1999 |volume=45 |issue=7 |pages=114 |doi=10.1203/00006450-199904020-00676 |s2cid=72216843 |doi-access=free }}</ref> and has not been demonstrated in randomized control human trials.{{citation needed|date=March 2023}} Cat's claw is being studied for a number of other possible uses, including HIV, Crohn disease, multiple sclerosis, systemic lupus erythematosus (SLE or lupus), endometriosis, kidney problems, bladder cancer, and Alzheimer disease. More research is needed before scientists can say whether it is effective.<ref>{{cite news |title=Cat's claw Information |url=https://www.mountsinai.org/health-library/herb/cats-claw |work=Mount Sinai Health System }}</ref><ref>{{cite news |last1=Patel |first1=Kamal |title=Research Breakdown on Cat's claw |url=https://examine.com/supplements/cats-claw/research/ |work=Examine }}</ref>
It is a ] growing to 30 m tall, climbing by means of hooked thorns (the "cat's claws" of the common name) on the stems at the base of the leaves. The ] are in opposite pairs or whorls of three, simple, with a smooth margin.


===Uses=== ==Description==
''Uncaria tomentosa'' is a ] deriving its name from hook-like thorns that resemble the claws of a cat.<ref name=drugs/> ''U. tomentosa'' can grow to a length of up to 30&nbsp;m (100&nbsp;ft), climbing by means of these thorns.<ref name=GRIN/> The ] are elliptic with a smooth edge, and grow in ]. Cat's claw is indigenous to the ], with its habitat being restricted primarily to the ] areas of South and Central America.<ref name=GRIN/>
It has been used for a variety of purposes, and was first used by the natives of Peru over 2,000 years ago.


==Taxonomy==
It is used in ] drugs, as well as in anti-cancer and anti-AIDS medicines. It contains several alkaloids that are responsible for its overall medical effects, as well as tannins and various phytochemicals.
There are two species of cat's claw commonly used in North America and Europe, ''Uncaria tomentosa'' and '']'', having different properties and uses.<ref name=drugs/> The two are frequently confused but ''U. tomentosa'' is the more commonly used in ].<ref>{{ cite journal |vauthors=Gattuso M, di Sapio O, Gattuso S, Pereyra LE | title = Morphoanatomical Studies of ''Uncaria tomentosa'' and ''Uncaria guianensis'' Bark and Leaves | journal = Phytomedicine | year = 2004 | volume = 11 | issue = 2–3 | pages = 213–223 | pmid = 15070175 | doi = 10.1078/0944-7113-00315 }}</ref><ref name="mda">{{cite web|url=http://www.mdanderson.org/education-and-research/resources-for-professionals/clinical-tools-and-resources/cimer/therapies/herbal-plant-biologic-therapies/cats-claw-scientific.html|archive-url=https://web.archive.org/web/20130826144058/http://www.mdanderson.org/education-and-research/resources-for-professionals/clinical-tools-and-resources/cimer/therapies/herbal-plant-biologic-therapies/cats-claw-scientific.html|url-status=dead|archive-date=26 August 2013|date=31 May 2006|publisher=M.D. Anderson Center|title= Detailed Scientific Review of Cat's Claw (archived)|access-date=10 January 2019}}</ref> ''U. tomentosa'' is further divided into two ]s that remain under preliminary research for their properties and compounds.<ref>{{ cite journal |vauthors=Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H | title = ''Uncaria tomentosa'' (Willd.) DC. — Ethnomedicinal Use and New Pharmacological, Toxicological and Botanical Results | journal = Journal of Ethnopharmacology | year = 1999 | volume = 64 | issue = 1 | pages = 23–34 | pmid = 10075119 | doi = 10.1016/S0378-8741(98)00096-8 | url = http://www.samento.com.ec/sciencelib/sarticles/Uncaria81B4.pdf }}</ref> There are other plants which are known as ] (or uña de gato) in Mexico and Latin America; however, they are entirely different ], belonging to neither the genus ''Uncaria'', nor to the family Rubiaceae.<ref name=mda/>


==Phytochemicals==
Studies of Cat's Claw show positive effects on the immune system and is helpful for viral and respiratory infections, has an anti-hypertensive properties, and some of the alkaloids may reduce the risk of cardiovascular incidents such as heart attacks and strokes by lowering heart rate, and blood pressure, increase circulation, and improve cholesterol levels.
]s in ''Uncaria tomentosa'' root bark include ] and ] ]s, ]s, ]s, ]s, ]s, and ]s, ]s, ]s, ]s, ]s, ], and ].<ref name=drugs/><ref name=mda/><ref name="livertox">{{cite book|title=Cat's claw |publisher=LiverTox, US National Institute of Diabetes and Digestive and Kidney Diseases|date=18 February 2019|pmid=31643645 |url= https://www.ncbi.nlm.nih.gov/books/NBK548323/}}</ref>


==Traditional medicine==
Some ingredients appear to act as anti-inflammatory, antioxidant and anticancer agents. As a homeopathic treatment, Cat's Claw can be used to treat intestinal ailments such as Crohn's disease, gastric ulcers and tumors, parasites, colitis, gastritis, diverticulitis and leaky bowel syndrome. Other possible uses include the treatment of AIDS in combination with AZT, the treatment and prevention of arthritis and rheumatism, diabetes, PMS, chronic fatigue syndrome, lupus, and prostrate conditions.
Cat's claw ] has been used as a traditional medicine in ]n countries over centuries for its supposed health benefits, and is a common herbal supplement.<ref name=drugs/><ref name=nccih/><ref name=mda/> As of 2021, there is no ] that it has any benefit in treating human diseases.<ref name=drugs/><ref name=nccih/>


==Interactions==
The parts used medicinally include the inner bark and root, taken in the form of capsules, tea and extract.
Cat's claw has extensive ] with numerous ]s.<ref name=drugs/> Its safety over long-term use or during pregnancy has not been scientifically determined.<ref name=drugs/><ref name=nccih/>


==Adverse effects==
Individuals ] to plants in the family ] and different species of '']'' may be more likely to have ] to cat's claw.<ref name=drugs/> Allergic reactions can include ], ], and skin ].<ref name=drugs/> Gastrointestinal discomfort, ], headache, impaired kidney and hormonal effects, and ] are other possible effects.<ref name=drugs/><ref name=nccih/>

People requiring ], ], or ] should not use cat's claw.<ref name=drugs/><ref name=nccih/>

==See also==
* ]


==References== ==References==
{{Reflist}}
*

*
==External links==
*
* {{cite journal |last1=Santa Maria |first1=A |last2=Lopez |first2=A |last3=Diaz |first3=M.M |last4=Albán |first4=J |last5=Galán de Mera |first5=A |last6=Vicente Orellana |first6=J.A |last7=Pozuelo |first7=J.M |title=Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro |journal=Journal of Ethnopharmacology |date=August 1997 |volume=57 |issue=3 |pages=183–187 |doi=10.1016/S0378-8741(97)00067-6 |pmid=9292411 }}
* {{cite journal |last1=Yunis Aguinaga |first1=Jefferson |last2=Claudiano |first2=Gustavo S. |last3=Marcusso |first3=Paulo F. |last4=Ikefuti |first4=Cynthia |last5=Ortega |first5=George G. |last6=Eto |first6=Silas F. |last7=da Cruz |first7=Claudinei |last8=Moraes |first8=Juliet R. E. |last9=Moraes |first9=Flávio R. |last10=Fernandes |first10=João B. K. |title=Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques |journal=Journal of Toxicology |date=2014 |volume=2014 |page=412437 |doi=10.1155/2014/412437 |pmid=24734041 |pmc=3964835 |doi-access=free }}
*{{Commons category-inline|Uncaria tomentosa}}
*


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Latest revision as of 15:38, 14 July 2024

Species of plant

Uncaria tomentosa
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Gentianales
Family: Rubiaceae
Genus: Uncaria
Species: U. tomentosa
Binomial name
Uncaria tomentosa
(Willd. ex Schult.) DC.

Uncaria tomentosa is a woody vine found in the tropical jungles of South and Central America. It is known as cat's claw or uña de gato in Spanish because of its claw-shaped thorns. The plant root bark is used in herbalism for a variety of ailments, and is sold as a dietary supplement.

Evidence of anti-inflammatory action is limited to cell culture studies. and has not been demonstrated in randomized control human trials. Cat's claw is being studied for a number of other possible uses, including HIV, Crohn disease, multiple sclerosis, systemic lupus erythematosus (SLE or lupus), endometriosis, kidney problems, bladder cancer, and Alzheimer disease. More research is needed before scientists can say whether it is effective.

Description

Uncaria tomentosa is a liana deriving its name from hook-like thorns that resemble the claws of a cat. U. tomentosa can grow to a length of up to 30 m (100 ft), climbing by means of these thorns. The leaves are elliptic with a smooth edge, and grow in opposing pairs. Cat's claw is indigenous to the Amazon rainforest, with its habitat being restricted primarily to the tropical areas of South and Central America.

Taxonomy

There are two species of cat's claw commonly used in North America and Europe, Uncaria tomentosa and Uncaria guianensis, having different properties and uses. The two are frequently confused but U. tomentosa is the more commonly used in traditional medicine. U. tomentosa is further divided into two chemotypes that remain under preliminary research for their properties and compounds. There are other plants which are known as cat's claw (or uña de gato) in Mexico and Latin America; however, they are entirely different plant species, belonging to neither the genus Uncaria, nor to the family Rubiaceae.

Phytochemicals

Phytochemicals in Uncaria tomentosa root bark include oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes, glycosides, tannins, polyphenols, catechins, rhynchophylline, and beta-sitosterol.

Traditional medicine

Cat's claw bark has been used as a traditional medicine in South American countries over centuries for its supposed health benefits, and is a common herbal supplement. As of 2021, there is no high-quality clinical evidence that it has any benefit in treating human diseases.

Interactions

Cat's claw has extensive interactions with numerous prescription drugs. Its safety over long-term use or during pregnancy has not been scientifically determined.

Adverse effects

Individuals allergic to plants in the family Rubiaceae and different species of Uncaria may be more likely to have adverse reactions to cat's claw. Allergic reactions can include itching, rash, and skin inflammation. Gastrointestinal discomfort, nausea, headache, impaired kidney and hormonal effects, and neuropathy are other possible effects.

People requiring anticoagulation, blood pressure, or immune therapy should not use cat's claw.

See also

References

  1. ^ "Uncaria tomentosa". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 2008-03-01.
  2. ^ "Cat's claw". Drugs.com. 6 September 2021. Retrieved 16 August 2022.
  3. "Assessment report on Uncaria tomentosa (Willd. ex Schult.) DC., cortex" (PDF). European Medicines Agency. 10 March 2015. Retrieved 11 January 2019.
  4. ^ "Cat's claw". National Center for Complementary and Integrative Health, US National Institutes of Health. 1 May 2020. Retrieved 17 August 2022.
  5. Sandoval-Chacón, M; Thompson, JH; Zhang, XJ; Liu, X; Mannick, EE; Sadowska-Krowicka, H; Charbonnet, RM; Clark, DA; Miller, MJ (December 1998). "Antiinflammatory actions of cat's claw: the role of NF-κB". Alimentary Pharmacology & Therapeutics. 12 (12): 1279–1289. doi:10.1046/j.1365-2036.1998.00424.x. PMID 9882039. S2CID 24640166.
  6. Miller, Mark J. S.; Zhang, Xiao-Jing; Charbonnet, Randi M.; Clark, David A.; Sandoval, Manuel (April 1999). "The Anti-Inflammatory Actions of the Herbal Medicine, Cat's Claw, Are Due to a Suppression of NF-κB Activation and Inhibition of Gene Expression". Pediatric Research. 45 (7): 114. doi:10.1203/00006450-199904020-00676. S2CID 72216843.
  7. "Cat's claw Information". Mount Sinai Health System.
  8. Patel, Kamal. "Research Breakdown on Cat's claw". Examine.
  9. Gattuso M, di Sapio O, Gattuso S, Pereyra LE (2004). "Morphoanatomical Studies of Uncaria tomentosa and Uncaria guianensis Bark and Leaves". Phytomedicine. 11 (2–3): 213–223. doi:10.1078/0944-7113-00315. PMID 15070175.
  10. ^ "Detailed Scientific Review of Cat's Claw (archived)". M.D. Anderson Center. 31 May 2006. Archived from the original on 26 August 2013. Retrieved 10 January 2019.
  11. Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H (1999). "Uncaria tomentosa (Willd.) DC. — Ethnomedicinal Use and New Pharmacological, Toxicological and Botanical Results" (PDF). Journal of Ethnopharmacology. 64 (1): 23–34. doi:10.1016/S0378-8741(98)00096-8. PMID 10075119.
  12. Cat's claw. LiverTox, US National Institute of Diabetes and Digestive and Kidney Diseases. 18 February 2019. PMID 31643645.

External links

Taxon identifiers
Uncaria tomentosa
Nauclea tomentosa
Categories: