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'''Vladimir Prelog''' (] ] – ] ]) was a renowned ] ] who worked in ], ] and ] and who won the ] in ] in ].


{{pp|small=yes}}
==Early years==
{{EngvarB|date=July 2017}}
{{Use dmy dates|date=June 2020}}
{{Infobox scientist
| name = Vladimir Prelog
| image = Vladimir Prelog ETH-Bib Portr 00214.jpg
| image_size =
| caption =
| birth_date = {{Birth date|df=yes|1906|07|23}}<ref name="Seiwerth: Prelog">{{cite journal |last1=Seiwerth |first1=Rativoj |title=Prelog's Zagreb School of Organic Chemistry (1935 – 1945)* |journal=Croatica Chemica Acta |date=October 30, 1995 |issue=CCACAA 69 (2) 379–397 (1996) |url=https://hrcak.srce.hr/file/201523 |access-date=15 September 2024 |publisher=Portal of Croatian scientific and professional journals - HRČAK |format=pdf |issn=0011-1643}}</ref>{{Short description|Croatian-Swiss chemist (1906–1998)}}
| birth_place = ], ], ]
| death_date = {{Death date and age|df=yes|1998|01|07|1906|07|23}}
| death_place = ], Switzerland
| field = ]
| work_institution = {{Plainlist|
* ]
* ]
* ]}}
| alma_mater = ] (Sc.D, 1929)
| doctoral_advisor = ]{{citation needed|date=November 2015}}
| doctoral_students =
| known_for = {{Plainlist|
* ]
* ]
* ]
* ]
* ]
* ]
* Prelog's rule
* Prelog-Djerassi lactone}}
| awards = {{Plainlist|
* ] (1949)
* ] (1962)<ref name="frs"/>
* ] (1964)
* ] (1967)
* ] (1974)
* ] (1975)
* ] (1992)}}
| spouse = {{marriage|Kamila Vitek|1933}}
}}
'''Vladimir Prelog''' {{post-nominals|post-noms=]}}<ref name="frs">{{Cite journal | last1 = Arigoni | first1 = D. | authorlink1 = Duilio Arigoni| last2 = Dunitz | first2 = J. D. | authorlink2 = Jack D. Dunitz| last3 = Eschenmoser | first3 = A. | authorlink3 = Albert Eschenmoser| title = Vladimir Prelog. 23 July 1906 – 7 January 1998: Elected For.Mem.R.S. 1962 | doi = 10.1098/rsbm.1999.0095 | journal = ] | volume = 46 | pages = 443 | year = 2000 | doi-access = free }}</ref> (23 July 1906 – 7 January 1998) was a Bosnian-Croatian-Swiss ] who received the 1975 Nobel Prize in ] for his research into the ] of organic molecules and reactions. Prelog was born, and spent his infancy, in ], and youth in ], ] and ].<ref name=Prelog>Vladimir Prelog (1975) , the Nobel Committee.</ref> He later lived and worked in Prague, Zagreb and ].{{r|"Seiwerth: Prelog"|p=2}}<ref name=James1993>{{Cite book|last=James|first=Laylin K.|title=Nobel Laureates in Chemistry, 1901–1992|publisher=American Chemical Society & Chemical Heritage Foundation|year=2006|isbn=0-8412-2459-5|url-access=registration|url=https://archive.org/details/isbn_9780841226906}}</ref><ref>{{Cite journal | last1 = Dunitz | first1 = J. D. | journal = Nature | volume = 391 | issue = 6667 | pages = 542 | doi = 10.1038/35279 | year = 1998 |title=Obituary: Vladimir Prelog (1906–98)| bibcode = 1998Natur.391..542D | s2cid = 4374006 | doi-access = free }}</ref>


==Early life==
Prelog was born in ], ], at that time within the ]. In ], as a child, Prelog moved to ]. Educated in ] and ], he graduated from the ] in ] (]) in ], receiving a degree as a chemical ]. His teacher was Emil Votoček, while his assistant Rudolf Lukeš introduced him to the world of ].
] which Prelog was born]]
] Nobel laureates ] and Vladimir Prelog at ]]]
Prelog was born in Sarajevo, ], at that time within ], to Croat parents who were working there. His father, Milan, a native of ],<ref>Horvatić, Petar: . Narod.hr. Accessed 2 October 2018</ref> was a history professor at a ] in ] and later at the ].<ref name="James1993"/>{{Rp|578}} As an 8-year-old boy, he stood near the place where the ] occurred.{{r|Prelog}}.{{sfn|Frängsmyr|Forsén|1993|p=201}}


===Education===
After gaining the ] in chemistry, he started to work in the private plant laboratory of G.J. Dríza in Prague, in charge of the production of rare chemicals that were not available on the market at that time. His pastime was spent in his own research, where he started investigating ] from the ] bark.
] to ], Ivan Miković, Grga Tuškan and Vladimir Prelog in Mirogoj Cemetery]]
Prelog started elementary school in Sarajevo. In 1915, at the beginning of the first World War, at {{age|1906|07|23|1915|8|0}} Prelog moved to ] (then part of the ]) with his parents.{{r|Prelog}} In Zagreb he graduated from elementary school and, from 1916 to 1919, attended gymnasium there. From 1919 to 1921 his father got a job in ], so family moved there, and Prelog spent those two years attending Osijek gymnasium. There his professor Ivan Kuria sparked his interest and enthusiasm for chemistry.{{r|"Seiwerth: Prelog"|p=2}}


It was in 1921 that, at the age of {{age|1906|07|23|1922|5|0}}, and with his teacher’s help, he published a short communication entitled »Eine Titriervorrichtung« (Preparation for ]) in the prestigious German journal »Chemiker-Zeitung«.{{r|"Seiwerth: Prelog"|p=4|quote=faximile with contents of the published paper}} <!-- Rewritten to avoid the word "solution", as it's not clear whether or not it describes a liquid mixture of substances.--> <!-- The word solution is *exactly* the word that is needed, because it, and titration, exactly concerns **measuring concentrations of solutions (*not* mixtures) in liquids** -->
==Work in Zagreb==


Prelog and Kuria became friends, and continued communicating by letters after Prelog left Osijek.{{r|"Seiwerth: Prelog"|p=2,3|quote from a letter, and facsimile of part of one}}. In a letter from March 16, 1922, Prelog wrote:
In ], he was invited to join the Technical Faculty (''Tehnički Fakultet'') of the ], where he took the post of lecturer in ]. He also taught students of ].
{{Bquote|I am very busy at the moment. In addition to my routine studies, I have enrolled as an extramural student in the crafts school and I spend whole afternoons three times a week learning how to file, hammer and do all the other things that an eager young locksmith should know. I am doing it to be able to, should I feel like it, return to the homeland after finishing my studies. In this way, I also fence myself off such idle pastimes like dancing.« He continues by describing how he spent the winter enjoying winter sports and how he now, in spring, looks forward to bathing, climbing the Triglav and Grintavec mountains and sailing on lakes Bled and Bohinj. He concludes the letter by giving an enthusiastic account of his visit to the Chemical Analytical Institute in Zagreb: »I think this is the best equipped institute in SHS*. This wealth in platinum (a 300 g water beaker), optical instruments refractometers, spectroscopes, microscopes, etc., etc.) and all the analytical devices that God and the German have created – I have nowhere seen nything like that. It is run by Mr. Eisenhut.{{r|"Seiwerth: Prelog"|P=3}} }}


Prelog completed his high school education in Zagreb in 1924. Following his father's wishes, he moved to ], where he received his diploma in chemical engineering from the ] in 1928. He received his ] in 1929. His teacher was ], while his assistant and mentor Rudolf Lukeš introduced him to the world of ].<ref name="James1993"/>{{Rp|578}}
With the help of collaborators and students, and financially sponsored by the pharmaceutical factory "]" (currently ]), he started research of ] and its compounds. Final works with the industry yielded a financially successful production of ], one of the first commercial ]s.


Upon leaving the Czech Technical University, Prelog worked in the plant laboratory of the private firm of G.J. Dríza in Prague; few academic positions were available due to the ]. Prelog was in charge of the production of rare chemicals that were not commercially available at that time. He worked for Driza from 1929 until 1935. During the time, he got his first doctoral candidate, a company owner at Driza. He performed research in his spare time, investigating ] in ] bark.{{citation needed|date=May 2015}}
Scientific work here was crowned with the first synthesis of ], a ] with an unusual ] structure, being isolated from ] ]s.


==Career and research==
The results of Prelog's work have been published in the top European chemical literature and journals, while the ] developed in Zagreb at that time was well known and identifiable around the world.
]
Prelog wanted to work in an academic environment, so he accepted the position of lecturer at the University of Zagreb in 1935.{{sfn|Frängsmyr|Forsén|1993|p=201}} At the ] in Zagreb, he lectured on organic chemistry and ].<ref name="James1993"/>{{Rp|578}}


With the help of collaborators and students, Prelog started researching ] and its related compounds. He was financially supported by the ] "Kaštel", currently ]. He developed a financially successful method of producing Streptazol, one of the first commercial ]s. In 1941, while at Zagreb, Prelog developed the first ] of ], a ] with an unusual structure that was isolated from ]n ]s.<ref>{{cite journal|vauthors=Prelog V, Seiwerth R |title= Über die Synthese des Adamantans|journal= Berichte|year= 1941|volume= 74|pages= 1644–1648|doi = 10.1002/cber.19410741004|issue= 10}}</ref><ref>{{cite journal|vauthors=Prelog V, Seiwerth R |title= Über eine neue, ergiebigere Darstellung des Adamantans|journal= Berichte|year= 1941|volume= 74|pages= 1769–1772|doi = 10.1002/cber.19410741109|issue= 11}}</ref>
==Work in Zurich==


===Zürich===
In ], he accepted the invitation of ] and left for ], ], to the ] (''ETH'', or Eidgenössische Technische Hochschule). He was promoted, starting as private senior lecturer and ending up becoming ].
In 1941, in the midst of ], Prelog was invited to lecture in Germany by ]. Shortly afterwards, ], whom Prelog asked for help, invited Prelog to visit him on his way to Germany. He and his wife used those invitations to escape to ] in Switzerland. With Ružička's help, he gained support from ] and started to work in the Organic Chemistry Laboratory in the ] (''ETH'', or ''Eidgenössische Technische Hochschule''). Prelog was able to separate the ] ]s of ] in 1944 by ] on an ] substrate.


With this ], he was able to prove that not only ] but also ] atoms can be the chiral centre in a molecule, which had been speculated for several years.<ref>{{Cite journal | last1 = Prelog | first1 = V. | authorlink1 = Vladimir Prelog| last2 = Wieland | first2 = P. | doi = 10.1002/hlca.194402701143 | title = Über die Spaltung der Tröger'schen Base in optische Antipoden, ein Beitrag zur Stereochemie des dreiwertigen Stickstoffs | journal = Helvetica Chimica Acta | volume = 27 | pages = 1127–1134 | year = 1944 }}</ref> His relationship with Ružička helped him climb up the academic hierarchical ladder. Starting as an assistant, he became ''Privat-Dozent'', ''Titularprofessor'', associate professor, and in 1952 full professor. In 1957 he succeeded Ružička as head of the Laboratory.{{sfn|Frängsmyr|Forsén|1993|p=202}} Since Prelog disliked administrative duties, he implemented rotating chairmanship in the ETH.<ref name="James1993"/>{{Rp|578}} Prelog joined the ETH at the right time, since Ružička's Jewish co-workers left the country and went to the United States, so Prelog filled the vacuum they left.<ref name="James1993"/>{{Rp|580}}
After Ružička's retirement in ], Prelog took over the organic chemistry laboratory where he expanded its activity to unusual areas: ]s, alkaloids, ]s, and the isolation and study of biochemically active compounds found in smaller quantities in animal organisms. He also studied the structure of ]s and the ] of ] reactions.


===Later work in Switzerland===
His research has contributed to the explanation of the structure of ]s, ], quinine, ], ] and other alkaloids introducing so-called Prelog's regulation, which defines the ]al relations between reactants and products. Working with ] and ], he formulated the so-called ], applied generally in ].
Prelog's main interest was focused on ]. He found an ideal topic in the elucidation of the structure of ]; he continued his work on '']'' alkaloids and started to investigate ]. He showed that ]'s formula for strychnine was not correct. Although the formula he proposed was also not the right one, the discovery increased his international prestige. Later he worked on elucidating the structures of aromatic ] with ], Oskar Jeger and ].<ref name="James1993"/>{{Rp|580}}


At mid-century, the instrumental revolution necessitated a new approach to structural elucidation. Purely chemical methods had become outdated and had lost some of their intellectual appeal. Recognizing the growing importance of microbial metabolites, Prelog started working on these compounds, which possess unusual structures and interesting biological properties. It led him into antibiotics, and he subsequently elucidated the structures of such compounds as ], ], and ]. For Prelog, natural products represented more than a chemical challenge. He considered them a record of billions of years of evolution.<ref name="James1993"/>{{Rp|580}}
Thanks to him and Ružička, Zurich has become one of the most significant centers of modern ].


In 1944 at the ETH, Prelog managed to separate enantiomers with "asymmetric" trivalent ] by column ] at a time when this method was still in its infancy. His work on medium-sized alicyclic and heterocyclic rings established him as a pioneer in stereochemistry and conformational theory and brought an invitation to give the first Centenary Lecture of the Chemical Society in London in 1949. He synthesised medium-sized ring compounds with 8 to 12 members from dicarboxylic acid esters by ] and explained their unusual chemical reactivity by a "nonclassical" strain because of energetically unfavorable conformations. He also contributed to the understanding of Bredt's rule by showing that a double bond may occur at the bridgehead if the ring is large enough.<ref name="James1993"/>{{Rp|580-581}}
==Nobel Prize winner==


In his research of asymmetric syntheses, Prelog studied enantioselective reactions and established rules for the relationship between configuration of educts and products. From Prelog's researches into the stereospecificity of microbiological reductions of alicyclic ketones and the enzymic oxidation of alcohols, he contributed not only to the knowledge of the mechanism of stereospecificity of enzymic reactions in general but also to the structure of the active site of the enzyme.<ref name="James1993"/>{{Rp|581}}
Prelog received the ] ] for chemistry for his works in the field of natural compounds and stereochemistry, sharing it with the ]/] research chemist ].


Specifying the growing number of ] of organic compounds became for Prelog one of his important aims. In 1954 he joined ] and ] in their efforts to build a system for specifying a particular stereoisomers by simple and unambiguous descriptors that could be easily assigned and deciphered: The ] (Cahn-Ingold-Prelog) was developed for defining absolute configuration using "sequence rules". Together they published two papers. After Cahn and Ingold died, Prelog published a third paper on the topic.<ref name="James1993"/>{{Rp|581}} In 1959, Prelog obtained Swiss citizenship.{{sfn|Frängsmyr|Forsén|1993|p=202}}
His scientific opus encompasses more than 400 works. Lecturer of distinctive style and eloquence, he trained many generations of chemists. In ], he became an honorary member of the ].


==Private life== ==Awards and honours==
Prelog was elected to the ] in 1960<ref>{{Cite web |title=Vladimir Prelog |url=https://www.amacad.org/person/vladimir-prelog |access-date=2022-07-26 |website=American Academy of Arts & Sciences |language=en}}</ref> and the United States ] in 1961.<ref>{{Cite web |title=V. Prelog |url=http://www.nasonline.org/member-directory/deceased-members/45939.html |access-date=2022-07-26 |website=www.nasonline.org}}</ref>


Prelog was elected a ] for his contribution to the development of modern stereochemistry.<ref name="frs" />
As a private person, he was the source of anecdotes about almost all eminent chemists all over the world. An intellectual with a wide cultural background, he never insisted on authority and was unused to confrontation. As an introspective person, ironic and suspicious of high social, political or religious aspirations, Prelog rarely allowed people insight into his inner life. He was one of the 109 Nobel Prize winners who signed the peace appeal for Croatia in ].


Prelog received the 1975 ]<ref>{{cite web|url=http://www.nobel.se/chemistry/laureates/1975/prelog-autobio.html|title=Vladimir Prelog}}</ref><ref>{{cite web|url=http://www.nobel-winners.com/Chemistry/vladimir_prelog.html|title=Vladimir Prelog|first=Timeline of Nobel Winners|last=Company|website=www.nobel-winners.com}}</ref><ref> {{Webarchive|url=https://web.archive.org/web/20150924080653/http://www.posta.hr/default.aspx?id=3622&m=417 |date=24 September 2015 }}, posta.hr. Retrieved 29 June 2015.{{in lang|hr}}</ref> for his research into the ] of organic molecules and reaction,<ref>{{Cite book |last=Rezende |first=Lisa |url=https://books.google.com/books?id=079t8r9RIcIC |title=Chronology of Science |date=2006 |publisher=Infobase Publishing |isbn=978-1-4381-2980-8 |pages=352 |language=en}}</ref> sharing it with the Australian/British research chemist ].<ref name="James1993"/>{{Rp|571}} He was elected to the ] the following year.<ref>{{Cite web |title=APS Member History |url=https://search.amphilsoc.org/memhist/search?creator=Vladimir+Prelog&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced |access-date=2022-07-26 |website=search.amphilsoc.org}}</ref>
Vladimir Prelog died in ], (]), at the age of 92. An urn containing Prelog's ashes was ceremoniously interred at the ] in ] on ]th, ].


In 1986, he became an honorary member of the ].{{citation needed|date=May 2015}} Prelog was also a member of ].<ref>{{Cite web|url=https://www.sanu.ac.rs/clan/prelog-vladimir/|title=Prelog Vladimir|website=www.sanu.ac.rs|access-date=2019-12-14}}</ref>
==External links==


==Personal life==
*
In 1933, Prelog married Kamila Vitek.<ref name="James1993"/>{{Rp|578}} The couple had a son Jan (born 1949).{{sfn|Frängsmyr|Forsén|1993|p=202}}
*
*


An intellectual with a wide cultural background, Prelog was one of the 109 Nobel Prize winners who signed the ] for Croatia in 1991.{{citation needed|date=September 2018}}
{{Nobel Prize in Chemistry}}
{{Croatia-bio-stub}}


Vladimir Prelog died in ], at the age of 91. An urn containing Prelog's ashes was ceremoniously interred at the ] in ] on 27 September 2001. In 2008, a memorial to Prelog was unveiled in ].<ref>, matis.hr. Retrieved 16 May 2015.{{in lang|hr}}</ref>
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==References==
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{{Reflist|35em}}
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==Bibliography==
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* {{Cite book | title=Chemistry: 1971-1980 | editor-first1=Tore | editor-last1=Frängsmyr | editor-first2=Sture | editor-last2=Forsén | publisher=World Scientific | date=1993 | isbn=9789810207861}}
]

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==External links ==
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* {{Nobelprize}} including the Nobel Lecture, 12 December 1975 ''Chirality in Chemistry''
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{{commons category|Vladimir Prelog}}

{{Authority control}}
{{Nobel Prize in Chemistry Laureates 1951-1975}}
{{1975 Nobel Prize winners}}

{{DEFAULTSORT:Prelog, Vladimir}}
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Latest revision as of 10:56, 22 December 2024

Vladimir Prelog
Born(1906-07-23)23 July 1906Croatian-Swiss chemist (1906–1998)
Sarajevo, Condominium of Bosnia and Herzegovina, Austria-Hungary
Died7 January 1998(1998-01-07) (aged 91)
Zürich, Switzerland
Alma materCzech Technical University in Prague (Sc.D, 1929)
Known for
Spouse Kamila Vitek ​(m. 1933)​
Awards
Scientific career
FieldsBiochemistry
Institutions
Doctoral advisorEmil Votoček

Vladimir Prelog ForMemRS (23 July 1906 – 7 January 1998) was a Bosnian-Croatian-Swiss organic chemist who received the 1975 Nobel Prize in chemistry for his research into the stereochemistry of organic molecules and reactions. Prelog was born, and spent his infancy, in Sarajevo, and youth in Zagreb, Osijek and Prague. He later lived and worked in Prague, Zagreb and Zürich.

Early life

The house in Sarajevo which Prelog was born
Plaques dedicated to Bosnian Nobel laureates Ivo Andrić and Vladimir Prelog at ANUBiH

Prelog was born in Sarajevo, Condominium of Bosnia and Herzegovina, at that time within Austria-Hungary, to Croat parents who were working there. His father, Milan, a native of Zagreb, was a history professor at a gymnasium in Sarajevo and later at the University of Zagreb. As an 8-year-old boy, he stood near the place where the assassination of Franz Ferdinand occurred..

Education

Monument of the Croatian Academy of Sciences and Arts to Franjo Rački, Ivan Miković, Grga Tuškan and Vladimir Prelog in Mirogoj Cemetery

Prelog started elementary school in Sarajevo. In 1915, at the beginning of the first World War, at 9 Prelog moved to Zagreb (then part of the Austro-Hungary) with his parents. In Zagreb he graduated from elementary school and, from 1916 to 1919, attended gymnasium there. From 1919 to 1921 his father got a job in Osijek, so family moved there, and Prelog spent those two years attending Osijek gymnasium. There his professor Ivan Kuria sparked his interest and enthusiasm for chemistry.

It was in 1921 that, at the age of 15, and with his teacher’s help, he published a short communication entitled »Eine Titriervorrichtung« (Preparation for Titration) in the prestigious German journal »Chemiker-Zeitung«.

Prelog and Kuria became friends, and continued communicating by letters after Prelog left Osijek.. In a letter from March 16, 1922, Prelog wrote:

I am very busy at the moment. In addition to my routine studies, I have enrolled as an extramural student in the crafts school and I spend whole afternoons three times a week learning how to file, hammer and do all the other things that an eager young locksmith should know. I am doing it to be able to, should I feel like it, return to the homeland after finishing my studies. In this way, I also fence myself off such idle pastimes like dancing.« He continues by describing how he spent the winter enjoying winter sports and how he now, in spring, looks forward to bathing, climbing the Triglav and Grintavec mountains and sailing on lakes Bled and Bohinj. He concludes the letter by giving an enthusiastic account of his visit to the Chemical Analytical Institute in Zagreb: »I think this is the best equipped institute in SHS*. This wealth in platinum (a 300 g water beaker), optical instruments refractometers, spectroscopes, microscopes, etc., etc.) and all the analytical devices that God and the German have created – I have nowhere seen nything like that. It is run by Mr. Eisenhut.

Prelog completed his high school education in Zagreb in 1924. Following his father's wishes, he moved to Prague, where he received his diploma in chemical engineering from the Czech Technical University in 1928. He received his Sc.D in 1929. His teacher was Emil Votoček, while his assistant and mentor Rudolf Lukeš introduced him to the world of organic chemistry.

Upon leaving the Czech Technical University, Prelog worked in the plant laboratory of the private firm of G.J. Dríza in Prague; few academic positions were available due to the Great Depression. Prelog was in charge of the production of rare chemicals that were not commercially available at that time. He worked for Driza from 1929 until 1935. During the time, he got his first doctoral candidate, a company owner at Driza. He performed research in his spare time, investigating alkaloids in cacao bark.

Career and research

The structure of adamantane, first synthesised by Prelog in 1941.

Prelog wanted to work in an academic environment, so he accepted the position of lecturer at the University of Zagreb in 1935. At the Technical Faculty in Zagreb, he lectured on organic chemistry and chemical engineering.

With the help of collaborators and students, Prelog started researching quinine and its related compounds. He was financially supported by the pharmaceutical factory "Kaštel", currently Pliva. He developed a financially successful method of producing Streptazol, one of the first commercial sulfonamides. In 1941, while at Zagreb, Prelog developed the first synthesis of adamantane, a hydrocarbon with an unusual structure that was isolated from Moravian oil fields.

Zürich

In 1941, in the midst of World War II, Prelog was invited to lecture in Germany by Richard Kuhn. Shortly afterwards, Lavoslav Ružička, whom Prelog asked for help, invited Prelog to visit him on his way to Germany. He and his wife used those invitations to escape to Zürich in Switzerland. With Ružička's help, he gained support from CIBA Ltd. and started to work in the Organic Chemistry Laboratory in the Swiss Federal Institute of Technology (ETH, or Eidgenössische Technische Hochschule). Prelog was able to separate the chiral enantiomers of Tröger's base in 1944 by chromatography on an optically active substrate.

With this chiral resolution, he was able to prove that not only carbon but also nitrogen atoms can be the chiral centre in a molecule, which had been speculated for several years. His relationship with Ružička helped him climb up the academic hierarchical ladder. Starting as an assistant, he became Privat-Dozent, Titularprofessor, associate professor, and in 1952 full professor. In 1957 he succeeded Ružička as head of the Laboratory. Since Prelog disliked administrative duties, he implemented rotating chairmanship in the ETH. Prelog joined the ETH at the right time, since Ružička's Jewish co-workers left the country and went to the United States, so Prelog filled the vacuum they left.

Later work in Switzerland

Prelog's main interest was focused on alkaloids. He found an ideal topic in the elucidation of the structure of solanine; he continued his work on Cinchona alkaloids and started to investigate strychnine. He showed that Robert Robinson's formula for strychnine was not correct. Although the formula he proposed was also not the right one, the discovery increased his international prestige. Later he worked on elucidating the structures of aromatic Erythrina alkaloids with Derek Barton, Oskar Jeger and Robert Burns Woodward.

At mid-century, the instrumental revolution necessitated a new approach to structural elucidation. Purely chemical methods had become outdated and had lost some of their intellectual appeal. Recognizing the growing importance of microbial metabolites, Prelog started working on these compounds, which possess unusual structures and interesting biological properties. It led him into antibiotics, and he subsequently elucidated the structures of such compounds as nonactin, boromycin, and rifamycins. For Prelog, natural products represented more than a chemical challenge. He considered them a record of billions of years of evolution.

In 1944 at the ETH, Prelog managed to separate enantiomers with "asymmetric" trivalent nitrogen by column chromatography at a time when this method was still in its infancy. His work on medium-sized alicyclic and heterocyclic rings established him as a pioneer in stereochemistry and conformational theory and brought an invitation to give the first Centenary Lecture of the Chemical Society in London in 1949. He synthesised medium-sized ring compounds with 8 to 12 members from dicarboxylic acid esters by acyloin condensation and explained their unusual chemical reactivity by a "nonclassical" strain because of energetically unfavorable conformations. He also contributed to the understanding of Bredt's rule by showing that a double bond may occur at the bridgehead if the ring is large enough.

In his research of asymmetric syntheses, Prelog studied enantioselective reactions and established rules for the relationship between configuration of educts and products. From Prelog's researches into the stereospecificity of microbiological reductions of alicyclic ketones and the enzymic oxidation of alcohols, he contributed not only to the knowledge of the mechanism of stereospecificity of enzymic reactions in general but also to the structure of the active site of the enzyme.

Specifying the growing number of stereoisomers of organic compounds became for Prelog one of his important aims. In 1954 he joined R. S. Cahn and Christopher Ingold in their efforts to build a system for specifying a particular stereoisomers by simple and unambiguous descriptors that could be easily assigned and deciphered: The CIP system (Cahn-Ingold-Prelog) was developed for defining absolute configuration using "sequence rules". Together they published two papers. After Cahn and Ingold died, Prelog published a third paper on the topic. In 1959, Prelog obtained Swiss citizenship.

Awards and honours

Prelog was elected to the American Academy of Arts and Sciences in 1960 and the United States National Academy of Sciences in 1961.

Prelog was elected a Foreign Member of the Royal Society (ForMemRS) in 1962 for his contribution to the development of modern stereochemistry.

Prelog received the 1975 Nobel Prize in Chemistry for his research into the stereochemistry of organic molecules and reaction, sharing it with the Australian/British research chemist John Cornforth. He was elected to the American Philosophical Society the following year.

In 1986, he became an honorary member of the Yugoslav Academy of Sciences and Arts. Prelog was also a member of Serbian Academy of Sciences and Arts.

Personal life

In 1933, Prelog married Kamila Vitek. The couple had a son Jan (born 1949).

An intellectual with a wide cultural background, Prelog was one of the 109 Nobel Prize winners who signed the peace appeal for Croatia in 1991.

Vladimir Prelog died in Zürich, at the age of 91. An urn containing Prelog's ashes was ceremoniously interred at the Mirogoj cemetery in Zagreb on 27 September 2001. In 2008, a memorial to Prelog was unveiled in Prague.

References

  1. ^ Arigoni, D.; Dunitz, J. D.; Eschenmoser, A. (2000). "Vladimir Prelog. 23 July 1906 – 7 January 1998: Elected For.Mem.R.S. 1962". Biographical Memoirs of Fellows of the Royal Society. 46: 443. doi:10.1098/rsbm.1999.0095.
  2. ^ Seiwerth, Rativoj (30 October 1995). "Prelog's Zagreb School of Organic Chemistry (1935 – 1945)*" (pdf). Croatica Chemica Acta (CCACAA 69 (2) 379–397 (1996)). Portal of Croatian scientific and professional journals - HRČAK. ISSN 0011-1643. Retrieved 15 September 2024.
  3. ^ Vladimir Prelog (1975) Autobiography, the Nobel Committee.
  4. ^ James, Laylin K. (2006). Nobel Laureates in Chemistry, 1901–1992. American Chemical Society & Chemical Heritage Foundation. ISBN 0-8412-2459-5.
  5. Dunitz, J. D. (1998). "Obituary: Vladimir Prelog (1906–98)". Nature. 391 (6667): 542. Bibcode:1998Natur.391..542D. doi:10.1038/35279. S2CID 4374006.
  6. Horvatić, Petar: 23. srpnja 1906. rođen Vladimir Prelog – dobitnik Nobelove nagrade. Narod.hr. Accessed 2 October 2018
  7. ^ Frängsmyr & Forsén 1993, p. 201.
  8. Cite error: The named reference quote from a letter, and facsimile of part of one was invoked but never defined (see the help page).
  9. Prelog V, Seiwerth R (1941). "Über die Synthese des Adamantans". Berichte. 74 (10): 1644–1648. doi:10.1002/cber.19410741004.
  10. Prelog V, Seiwerth R (1941). "Über eine neue, ergiebigere Darstellung des Adamantans". Berichte. 74 (11): 1769–1772. doi:10.1002/cber.19410741109.
  11. Prelog, V.; Wieland, P. (1944). "Über die Spaltung der Tröger'schen Base in optische Antipoden, ein Beitrag zur Stereochemie des dreiwertigen Stickstoffs". Helvetica Chimica Acta. 27: 1127–1134. doi:10.1002/hlca.194402701143.
  12. ^ Frängsmyr & Forsén 1993, p. 202.
  13. "Vladimir Prelog". American Academy of Arts & Sciences. Retrieved 26 July 2022.
  14. "V. Prelog". www.nasonline.org. Retrieved 26 July 2022.
  15. "Vladimir Prelog".
  16. Company, Timeline of Nobel Winners. "Vladimir Prelog". www.nobel-winners.com. {{cite web}}: |last= has generic name (help)
  17. Croatian Nobel Prize Winners (list) Archived 24 September 2015 at the Wayback Machine, posta.hr. Retrieved 29 June 2015.(in Croatian)
  18. Rezende, Lisa (2006). Chronology of Science. Infobase Publishing. p. 352. ISBN 978-1-4381-2980-8.
  19. "APS Member History". search.amphilsoc.org. Retrieved 26 July 2022.
  20. "Prelog Vladimir". www.sanu.ac.rs. Retrieved 14 December 2019.
  21. Spomenik Prelogu u Pragu, matis.hr. Retrieved 16 May 2015.(in Croatian)

Bibliography

  • Frängsmyr, Tore; Forsén, Sture, eds. (1993). Chemistry: 1971-1980. World Scientific. ISBN 9789810207861.

External links

  • Vladimir Prelog on Nobelprize.org Edit this at Wikidata including the Nobel Lecture, 12 December 1975 Chirality in Chemistry
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