Article snapshot taken from Wikipedia with creative commons attribution-sharealike license.
Give it a read and then ask your questions in the chat.
We can research this topic together.
The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" />
The protein specifically deubiquitinates a protein in the ] (FA) DNA repair pathway. Alternate transcriptional ] have been characterized.<ref name="entrez" />
==Research==
USP1 has been studied, in a 2020 paper by Sharma, et al for its association with neurodegenerative diseases (Parkinson's disease)<ref>{{cite journal |last1=Sharma |first1=Amit |last2=Liu |first2=Hongde |last3=Tobar-Tosse |first3=Fabian |last4=Chand Dakal |first4=Tikam |last5=Ludwig |first5=Michael |last6=Holz |first6=Frank G. |last7=Loeffler |first7=Karin U. |last8=Wüllner |first8=Ullrich |last9=Herwig-Carl |first9=Martina C. |title=Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration |journal=International Journal of Molecular Sciences |date=30 May 2020 |volume=21 |issue=11 |pages=3910 |doi=10.3390/ijms21113910 |url=https://pubmed.ncbi.nlm.nih.gov/32486284/ |issn=1422-0067}}</ref>
Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1gene.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.
The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
Research
USP1 has been studied, in a 2020 paper by Sharma, et al for its association with neurodegenerative diseases (Parkinson's disease)
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology. 33 (5): 337–352. doi:10.1080/10409239891204251. PMID9827704.
Fujiwara T, Saito A, Suzuki M, Shinomiya H, Suzuki T, Takahashi E, et al. (November 1998). "Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease". Genomics. 54 (1): 155–158. doi:10.1006/geno.1998.5554. PMID9806842.