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| '''Polyaminopropyl biguanide''' ('''PAPB''') is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of ]. The polymer display some antibacterial activity however much lower than PHMB. <ref>Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867</ref> | '''Polyaminopropyl biguanide''' ('''PAPB''') is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of ]. The polymer display some antibacterial activity however much lower than PHMB. <ref>Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867</ref> | ||
| As of May 2024, |
As of May 2024, PAPB is not approved as a biocidal active substance under EU regulations. <ref> European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances </ref> | ||
| ==Name controversy== | ==Name controversy== | ||
Latest revision as of 15:41, 24 May 2024
This article is about polymer containing propyl linker between guanidine groups. For PHMB the antimicrobial polymer incorectly named Polyaminopropyl biguanide, see Polyhexanide.
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| Names | |
|---|---|
| Other names Polyamine-propyl-biguanidine | |
| Identifiers | |
| CAS Number | |
| Abbreviations | PAPB |
| ChemSpider |
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| ECHA InfoCard | 100.118.649 
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| UNII | |
| Properties | |
| Chemical formula | (C5H11N5)n |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
 N verify (what is ?)
Infobox references
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Polyaminopropyl biguanide (PAPB) is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of polyhexamethylene biguanide. The polymer display some antibacterial activity however much lower than PHMB. As of May 2024, PAPB is not approved as a biocidal active substance under EU regulations.
Name controversy
In some sources, particularly in lists of cosmetic ingredients (INCI), the name polyaminopropyl biguanide is wrongly associated with polyhexamethylene biguanide (PHMB)
References
- Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867
- European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances
- Cosmetic Ingredient Review Expert Panel (May 12, 2014). "Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics" (PDF). Cosmetic Ingredient Review (CIR). Retrieved 2024-05-07.
- Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia (2021). "Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)". Contact Dermatitis. 84 (5): 326–331. doi:10.1111/cod.13728. PMC 8048451. PMID 33098110.