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'''Neuronal Alpha-Synuclein Disease''' is a proposed new combined definition of ] and ] based on <ref>{{Cite web |title=Major Shift in the Clinical Definition of PD Triggers Debate |url=https://www.medscape.com/viewarticle/major-shift-clinical-definition-parkinsons-triggers-debate-2024a1000cv1?form=fpf |access-date=2024-12-26 |website=Medscape |language=en}}</ref><ref>{{cite web|url=https://www.medpagetoday.com/neurology/parkinsonsdisease/108446|title=New Parkinson's Definition Proposed Based on Biomarkers|date=January 26, 2024}}</ref><ref>{{Cite journal |last=Simuni |first=Tanya |last2=Chahine |first2=Lana M |last3=Poston |first3=Kathleen |last4=Brumm |first4=Michael |last5=Buracchio |first5=Teresa |last6=Campbell |first6=Michelle |last7=Chowdhury |first7=Sohini |last8=Coffey |first8=Christopher |last9=Concha-Marambio |first9=Luis |last10=Dam |first10=Tien |last11=DiBiaso |first11=Peter |last12=Foroud |first12=Tatiana |last13=Frasier |first13=Mark |last14=Gochanour |first14=Caroline |last15=Jennings |first15=Danna |date=2024-02-01 |title=A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research |url=https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00405-2/fulltext |journal=The Lancet Neurology |language=English |volume=23 |issue=2 |pages=178–190 |doi=10.1016/S1474-4422(23)00405-2 |issn=1474-4422 |archive-url=http://web.archive.org/web/20240201122650/https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00405-2/fulltext |archive-date=2024-02-01}}</ref><ref>{{Cite journal |last=Pagano |first=Gennaro |last2=Dam |first2=Tien |last3=Kerchner |first3=Geoffrey A. |last4=Galpern |first4=Wendy R. |last5=Biagioni |first5=Milton |last6=Karan |first6=Rajesh |last7=Jennings |first7=Danna |last8=Peterschmitt |first8=M. Judith |last9=Nikolcheva |first9=Tania |last10=Brundin |first10=Patrik |date=2024-12-20 |title=Biologically defined neuronal synuclein disease as a tool to advance drug development |url=https://www.nature.com/articles/s41531-024-00845-5 |journal=npj Parkinson's Disease |language=en |volume=10 |issue=1 |pages=1–3 |doi=10.1038/s41531-024-00845-5 |issn=2373-8057}}</ref> '''Neuronal Alpha-Synuclein Disease''' is a proposed new combined definition of ] and ] based on biology instead of ].<ref>{{Cite web |title=Major Shift in the Clinical Definition of PD Triggers Debate |url=https://www.medscape.com/viewarticle/major-shift-clinical-definition-parkinsons-triggers-debate-2024a1000cv1?form=fpf |access-date=2024-12-26 |website=Medscape |language=en}}</ref><ref>{{cite web|url=https://www.medpagetoday.com/neurology/parkinsonsdisease/108446|title=New Parkinson's Definition Proposed Based on Biomarkers|date=January 26, 2024}}</ref><ref>{{Cite journal |last=Simuni |first=Tanya |last2=Chahine |first2=Lana M |last3=Poston |first3=Kathleen |last4=Brumm |first4=Michael |last5=Buracchio |first5=Teresa |last6=Campbell |first6=Michelle |last7=Chowdhury |first7=Sohini |last8=Coffey |first8=Christopher |last9=Concha-Marambio |first9=Luis |last10=Dam |first10=Tien |last11=DiBiaso |first11=Peter |last12=Foroud |first12=Tatiana |last13=Frasier |first13=Mark |last14=Gochanour |first14=Caroline |last15=Jennings |first15=Danna |date=2024-02-01 |title=A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research |url=https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00405-2/fulltext |journal=The Lancet Neurology |language=English |volume=23 |issue=2 |pages=178–190 |doi=10.1016/S1474-4422(23)00405-2 |issn=1474-4422 |archive-url=http://web.archive.org/web/20240201122650/https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00405-2/fulltext |archive-date=2024-02-01}}</ref><ref>{{Cite journal |last=Pagano |first=Gennaro |last2=Dam |first2=Tien |last3=Kerchner |first3=Geoffrey A. |last4=Galpern |first4=Wendy R. |last5=Biagioni |first5=Milton |last6=Karan |first6=Rajesh |last7=Jennings |first7=Danna |last8=Peterschmitt |first8=M. Judith |last9=Nikolcheva |first9=Tania |last10=Brundin |first10=Patrik |date=2024-12-20 |title=Biologically defined neuronal synuclein disease as a tool to advance drug development |url=https://www.nature.com/articles/s41531-024-00845-5 |journal=npj Parkinson's Disease |language=en |volume=10 |issue=1 |pages=1–3 |doi=10.1038/s41531-024-00845-5 |issn=2373-8057}}</ref>

Revision as of 20:09, 26 December 2024

Neuronal Alpha-Synuclein Disease is a proposed new combined definition of Parkinson's disease and Lewy Body dementia based on biology instead of symptomatology.

  1. "Major Shift in the Clinical Definition of PD Triggers Debate". Medscape. Retrieved 2024-12-26.
  2. "New Parkinson's Definition Proposed Based on Biomarkers". January 26, 2024.
  3. Simuni, Tanya; Chahine, Lana M; Poston, Kathleen; Brumm, Michael; Buracchio, Teresa; Campbell, Michelle; Chowdhury, Sohini; Coffey, Christopher; Concha-Marambio, Luis; Dam, Tien; DiBiaso, Peter; Foroud, Tatiana; Frasier, Mark; Gochanour, Caroline; Jennings, Danna (2024-02-01). "A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research". The Lancet Neurology. 23 (2): 178–190. doi:10.1016/S1474-4422(23)00405-2. ISSN 1474-4422. Archived from the original on 2024-02-01.
  4. Pagano, Gennaro; Dam, Tien; Kerchner, Geoffrey A.; Galpern, Wendy R.; Biagioni, Milton; Karan, Rajesh; Jennings, Danna; Peterschmitt, M. Judith; Nikolcheva, Tania; Brundin, Patrik (2024-12-20). "Biologically defined neuronal synuclein disease as a tool to advance drug development". npj Parkinson's Disease. 10 (1): 1–3. doi:10.1038/s41531-024-00845-5. ISSN 2373-8057.