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Revision as of 09:23, 28 December 2024 editBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,751 edits corrected stereochemistry and added missing data to infoboxTag: nowiki added← Previous edit Revision as of 09:31, 28 December 2024 edit undoBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,751 editsm added missing ID to infoboxNext edit →
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| IUPHAR_ligand = | IUPHAR_ligand =
| DrugBank = DB13581 | DrugBank = DB13581
| ChemSpiderID = | ChemSpiderID = 28534065
| UNII = VI08KS44V0 | UNII = VI08KS44V0
| KEGG = D07078 | KEGG = D07078

Revision as of 09:31, 28 December 2024

Chemical compound

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Find sources: "Rociverine" – news · newspapers · books · scholar · JSTOR (March 2021)
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Pharmaceutical compound
Rociverine
Clinical data
ATC code
Identifiers
IUPAC name
  • 1-(diethylamino)propan-2-yl (1S,2S)-2-cyclohexyl-2-hydroxycyclohexane-1-carboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.053.356 Edit this at Wikidata
Chemical and physical data
FormulaC20H37NO3
Molar mass339.520 g·mol
3D model (JSmol)
SMILES
  • CCN(CC)CC(C)OC(=O)1CCCC1(C2CCCCC2)O
InChI
  • InChI=InChI=1S/C20H37NO3/c1-4-21(5-2)15-16(3)24-19(22)18-13-9-10-14-20(18,23)17-11-7-6-8-12-17/h16-18,23H,4-15H2,1-3H3/t16?,18-,20+/m1/s1
  • Key:XPYLKZZOBVLVHB-QDKIRNHSSA-N

Rociverine is an antispasmodic drug used to treat urinary, gastrointestinal and biliary spasms. It is antimuscarinic drug.

The (1R,2R) compound showed 240-fold greater affinity for the muscarinic receptor, but the (1S,2S) compound showed the best selectivity.

References

  1. "Rociverine".
  2. Toson G, Schiantarelli P, Murmann W (1978). "Rociverine, a new antispasmodic agent with balanced neurotropic and myotropic activity". Arzneimittel-Forschung. 28 (7): 1130–42. PMID 582702.
  3. Barbier P, Renzetti AR, Turbanti L, Di Bugno C, Fornai F, Vaglini F, et al. (July 1995). "Stereoselective inhibition of muscarinic receptor subtypes by the eight stereoisomers related to rociverine". European Journal of Pharmacology. 290 (2): 125–132. doi:10.1016/0922-4106(95)90024-1. PMID 8575526.


Drugs for functional gastrointestinal disorders (A03)
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium
compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
Muscarinic acetylcholine receptor modulators
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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