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Duloxetine: Difference between revisions

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'''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. '''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.


Revision as of 16:15, 16 August 2005

Duloxetine chemical structure of duloxetine
Duloxetine

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Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.

Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.

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