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| | bgcolor="#ddeeff" | ]{{sub|18}}]{{sub|19}}]]], ] | |||
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| bgcolor="#ddeeff" | 333.38 | ||
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| bgcolor="#ddeeff" | 8-17 hours | ||
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| bgcolor="#ddeeff" | C (USA) | ||
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| bgcolor="#ddeeff" | Prescription only (USA) | ||
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| | bgcolor="#eeeeee" | Routes of administration | | bgcolor="#eeeeee" | Routes of administration | ||
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| bgcolor="#ddeeff" | Oral | ||
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| '''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. | '''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD), pain related to ] ] and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. | ||
| Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. | Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. | ||
Revision as of 19:53, 3 September 2005
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| IUPAC chemical name | |
| CAS number ? |
ATC code ? |
| Chemical formula | C18H19NOS, HCl |
| Molecular weight | 333.38 |
| Bioavailability | ? |
| Metabolism | ? |
| Elimination half-life | 8-17 hours |
| Excretion | ? |
| Pregnancy category | C (USA) |
| Legal status | Prescription only (USA) |
| Routes of administration | Oral |
Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.
Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.
Duloxentine is also approved by the FDA for the treatment of diabetic neuropathy.
External links
- Manufacturer website
- Cymbalta Antidepressant Medication
- Duloxetine - medlineplus.org
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