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| ''There are also several chemically unrelated tetracyclic ]s based on ].'' | ''There are also several chemically unrelated tetracyclic ]s based on ].'' | ||
| ]]] | ]]] | ||
| '''Tetracyclic antidepressants''' (TeCAs) are a class of ] ]s. They are named after their molecular structure, which contains four rings of atoms. They are closely related to the ]s (TCAs). | |||
| ⚫ | == List of TeCAs == | ||
| ] (trade named Ludiomil), and ] (trade named Remeron in the USA, Remergil, Remeron and Zispin in Europe, and Avanza in Australia) are the only two drugs from this group widely used for the treatment of ]. ] was previously available internationally, however in it has been phased out in favor of mirtazapine in most markets. | |||
| * Pharmaceuticals | |||
| ** ] (Asendin, Asendis, Defanyl, Demolox, Moxadil) | |||
| ** ] (Deprilept, Ludiomil, Psymion) | |||
| ** ] (Tolvon) | |||
| ** ] (Remeron, Remergil, Zispin, Avanza) | |||
| * Research Chemicals | |||
| ** ] | |||
| ** ] | |||
| === Comparison === | |||
| Research on other tetracyclic antidepressant compounds (for example ]) have been reported in the scientific literature. These other tetracyclic antidepressants are not available for clinical use. | |||
| A number of TeCAs have been compared below:<ref name="pmid9537821">{{cite journal | author = Tatsumi M, Groshan K, Blakely RD, Richelson E. | title = Pharmacological profile of antidepressants and related compounds at human monoamine transporters. | journal = Eur J Pharmacol. | volume = 340 | issue = 2-3 | pages = 249-258 | year = 1997 | pmid = 9537821 }}</ref><ref name="pmid9400006">{{cite journal | author = Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. | title = Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | journal = J Pharmacol Exp Ther. | volume = 283 | issue = 3 | pages = 1305-1322 | year = 1997 | pmid = 9400006 }}</ref><ref name="pmid7855217">{{cite journal | author = Cusack B, Nelson A, Richelson E. | title = Binding of antidepressants to human brain receptors: focus on newer generation compounds. | journal = Psychopharmacology (Berl). | volume = 114 | issue = 4 | pages = 559-565 | year = 1994 | pmid = 7855217 }}</ref><ref name=bookEssentials of clinical psychopharmacology>{{cite book | author = Alan F. Schatzberg, Charles B. | title = Essentials of clinical psychopharmacology | publisher = American Psychiatric Pub | year = 2006 | page = 7 | isbn = 1585622435, 9781585622436 }}</ref> | |||
| ⚫ | ==List of TeCAs== | ||
| According to ] the tetracyclic antidepressants have the following effects: | |||
| {| class="wikitable" | {| class="wikitable" | ||
| | ''' ''' || ''']''' || ''']''' || ''']/] |
| ''' Compound ''' || ''']''' || ''']''' || ''']''' || ''']''' || ''']''' || ''']''' || ''']''' || ''']''' || ''']''' || ''']''' | ||
| |- | |- | ||
| | ] || |
| ] || 58 || 16 || 4,310 || 25 || 1,000 || 50 || 2,600 || ? || ? || ? | ||
| |- | |- | ||
| | ] || |
| ] || 5,800 || 11.1 || 1,000 || 2 || 570 || 90 || 9,400 || ? || ? || ? | ||
| |- | |- | ||
| | ] || |
| ] || 4,000 || 71 || 9,400 || ? || ? || ? || ? || ? || ? || ? | ||
| |- | |||
| ⚫ | | ] || >1,500 || 1,250~ || >1,500 || 1~ || 1,000~ || 500~ || 100~ || >1,500 || 10~ || >1,500 | ||
| |- | |||
| | ] || 3,900 || 4.9 || 4,340 || ? || ? || ? || ? || ? || ? || ? | |||
| |- | |- | ||
| ⚫ | | ] || |
||
| |} | |} | ||
| The values above are expressed as ]s. It should be noted that less is more. SERT, NET, and DAT correspond to the abilities of the compounds to inhibit the reuptake of serotonin, norepinephrine, and dopamine, respectively. The other values correspond to their affinity for various receptors. | |||
| ==References== | ==References== | ||
Revision as of 01:56, 3 June 2009
There are also several chemically unrelated tetracyclic antibiotics based on Tetracycline.
Tetracyclic antidepressants (TeCAs) are a class of antidepressant drugs. They are named after their molecular structure, which contains four rings of atoms. They are closely related to the tricyclic antidepressants (TCAs).
List of TeCAs
- Pharmaceuticals
- Amoxapine (Asendin, Asendis, Defanyl, Demolox, Moxadil)
- Maprotiline (Deprilept, Ludiomil, Psymion)
- Mianserin (Tolvon)
- Mirtazapine (Remeron, Remergil, Zispin, Avanza)
- Research Chemicals
Comparison
A number of TeCAs have been compared below:Cite error: The <ref> tag has too many names (see the help page).
| Compound | SERT | NET | DAT | H1 | M1-5 | α1 | α2 | 5-HT1A | 5-HT2 | D2 |
| Amoxapine | 58 | 16 | 4,310 | 25 | 1,000 | 50 | 2,600 | ? | ? | ? |
| Maprotiline | 5,800 | 11.1 | 1,000 | 2 | 570 | 90 | 9,400 | ? | ? | ? |
| Mianserin | 4,000 | 71 | 9,400 | ? | ? | ? | ? | ? | ? | ? |
| Mirtazapine | >1,500 | 1,250~ | >1,500 | 1~ | 1,000~ | 500~ | 100~ | >1,500 | 10~ | >1,500 |
| Oxaprotiline | 3,900 | 4.9 | 4,340 | ? | ? | ? | ? | ? | ? | ? |
The values above are expressed as equilibrium dissociation constants. It should be noted that less is more. SERT, NET, and DAT correspond to the abilities of the compounds to inhibit the reuptake of serotonin, norepinephrine, and dopamine, respectively. The other values correspond to their affinity for various receptors.
References
- Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997). "Pharmacological profile of antidepressants and related compounds at human monoamine transporters". Eur J Pharmacol. 340 (2–3): 249–258. PMID 9537821.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. (1997). "Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites". J Pharmacol Exp Ther. 283 (3): 1305–1322. PMID 9400006.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Cusack B, Nelson A, Richelson E. (1994). "Binding of antidepressants to human brain receptors: focus on newer generation compounds". Psychopharmacology (Berl). 114 (4): 559–565. PMID 7855217.
{{cite journal}}: CS1 maint: multiple names: authors list (link)